166results about "Flat carrier supports" patented technology

A substrate holder includes a base configured to receive a substrate; a cover configured to mateably engage with the base, the cover defining an opening formed by inner sidewalls; and a removable insert defining a surface, the removable insert being configured to be received within the opening of the cover. The removable insert includes a gasket; a projection coupled to the gasket; and at least two insert tabs extending from opposite sides of the removable insert, each insert tab being configured to engage with at least one of the inner sidewalls forming the opening of the cover.

The application discloses a pollution-preventing detection device, method and application for rapid detection of nucleic acid amplification, which comprises a detection part and a mixed reaction cabin, and the mixed reaction cabin comprises a reaction cabin main body and a reaction cabin cover which is in sealed connection with the reaction cabin main body and can be detached; a channel for connecting a hybridization liquid containing part and a mixed reaction part is arranged between the reaction cabin cover and the reaction cabin main body; the detection part comprises a detection inner core and a detection box body containing the detection inner core; a transparent observation window is arranged on the detection box body and corresponds to the reaction area position of the detection inner core; a flow guide device matched with the mixed reaction cabin is further arranged on the detection box body; the flow guide device comprises a flow guide pipe and a flow guide part; one end of the flow guide part is connected with the flow guide pipe, and the other end is connected with the detection inner core; the hybridization liquid and the sample mixed liquid are guided to the detection inner core; and the detection inner core displays the final detection result in the area corresponding to the transparent observation window. The application realizes that the liquid in the reaction tube flows out to the designated detection card in a completely closed environment, and has the advantages of good sealing effect and prevention of primer aerosol pollution.

A biodegradable and mouldable cassette for lateral flow assay device, and a lateral flow assay device comprising said cassette, and a kit comprising such a lateral flow assay device, for in vitro diagnostics of a biological sample comprising a diagnostic test strip inserted into the cassette. The cassette comprises a first cassette part and a second cassette part coupled to each other and defining a test chamber there between containing the diagnostic test strip. The cassette is made of a biodegradable material and at least one of the first cassette part and second cassette part is made of injection mouldable material, in particular gelatin or a gelatin composition.

The disclosed invention provides a cartridge, method and cartridge processing systems for molecular tests that include extracting one or more biological materials from a tissue. The cartridge includes a base having a receptacle inside the base, a lid placed over the receptacle, and a gasket in the base. The base includes a transparent window placed under the receptacle, and the receptacle contains a slide on which the tissue is disposed. A film is disposed on an inner surface of the lid, and the film is suitable to extract the one or more biological materials from the tissue. The gasket surrounds the slide, and the lid creates a sealed chamber around the gasket that encloses the slide, and vacuum suction is applied through a port of the base to press the film against the tissue on the slide.

A lysis capsule for performing a cell lysis procedure includes a hollow body having an open first end and an open second end, a first porous membrane covering the open first end, and a second porous membrane covering the open second end, and the hollow body defines a lysis chamber between the first and second porous membranes. A plurality of non-magnetic beads and at least one magnetic element are disposed within the lysis chamber, and the pores of the first and second porous membranes are sized to retain the non-magnetic beads and the magnetic element within the lysis chamber. An internal control may be contained within the lysis chamber to validate an assay result and / or to validate the effectiveness of the cell lysis procedure. The lysis capsule may be disposed within a sample chamber of a fluidic cartridge.

A lateral flow test strip for detecting the presence or absence of a first target analyte within a sample is described. The lateral flow test strip comprises: an input configured to receive the sample; a conjugate pad comprising a conjugate biomolecule configured to bind to a first target analyte in the sample; a membrane comprising one or more test zones, wherein a first test zone comprises a first soluble coloured compound substantially co-located with a first non-visible capture biomolecule, wherein the first non-visible capture biomolecule is attached to the membrane and is configured to bind to the first target analyte, thereby immobilising the first labelled conjugate assembly at the first test zone, and wherein the first soluble coloured compound is configured to be removed from the first test zone by a fluid flow of the sample and transported along the lateral flow test strip.

Systems and methods that enable automated processing of specimens carried on microscope slides are described herein. In some embodiments, the system can include, for example, a slide ejector assembly having a slide staging device configured to receive a slide and an over-travel inhibitor that includes a first vacuum port positioned to draw a first vacuum between the slide and a standby platform as the slide is moved across at least a portion of the standby platform. The over-travel inhibitor includes a first sensor for detecting a presence of the slide on the standby platform. The system can also include a transfer assembly to transport slides away from the slide ejector assembly. The transfer assembly can include a floating transfer head having a vacuum port for drawing a partial vacuum for holding the slide.

A tray insert for use with an apparatus configured to analyze a sample is disclosed. The tray insert includes a first surface comprising an elongated channel adapted to receive a reagent strip for sample analysis. Further, the insert includes a second surface, wherein the second surface is in a direction opposite to the first surface. Additionally, the insert includes a hollow enclosure between the first surface and the second surface, wherein the elongated channel on the first surface comprises a plurality of slots and wherein the slots comprise an opening on each end, wherein the opening enters the hollow enclosure.

Systems and methods that enable automated processing of specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to an automated staining system that includes an instrument including an end effector and a stainer unit-receiving station that receives a stainer unit such that the end effector delivers reagent from the reagent reservoirs to a reaction chamber of the slide stainer unit. The stainer unit can carry fresh reagents, waste material, and components used to handle the reagents.

The application discloses a slice rack, which comprises a slice rack body, a plurality of slice grooves are arranged on the slice rack body, a horizontal rectangular coordinate system is arranged and comprises an X direction and a Y direction, two opposite sides of the X direction are arranged as a first X direction side and a second X direction side, two opposite sides of the Y direction are arranged as a first Y direction side and a second Y direction side, a clamp jaw is arranged on the first Y direction side and the second Y direction side in each slice groove, one end of the clamp jaw is a connecting end connected with the slice rack body, the connecting end of the two clamp jaws in each slice groove is located on the first X direction side of the X direction in the slice groove, the other end of the clamp jaw is a free end and faces the second X direction side of the slice groove, and the clamp jaw can be bent and deformed around the connecting end of the clamp jaw. The slice rack has a simple structure, can be integrally formed by molding, is convenient to install the slice, and is convenient, fast and reliable in slice installation.

The present invention relates to a device for the rapid analysis of a biological sample, intended for the detection of the presence of at least one analyte in said biological sample. The rapid analysis device (1) comprises a housing (2) and a cap (8) defining an internal volume (8') suitable for enclosing an absorbent block (7). The cap (8) has at least one through-hole (81) opening into said internal volume (8') and adapted for the introduction of a liquid reagent (R) into the internal volume (8') of the cap (8). Figure for the abstract: 4

A fluid sample is dispensed into a sample chamber of a fluidic cartridge, the sample chamber containing non-magnetic beads, a magnetic element, and an internal control reagent contained within an internal control pellet including an internal control for validating an assay result and / or to validate the effectiveness of a cell lysis procedure. The magnetic element is exposed to a magnetic field, thereby causing movement of the magnetic element, which causes movement of the non-magnetic beads. Movement of the non-magnetic beads causes cells contained within the fluid sample to lyse and release nucleic acids. The internal control reagent dissolves in the presence of the fluid sample or movement of the non-magnetic beads disintegrates the internal control pellet, thereby releasing the internal control into the fluid sample. Movement of the magnetic element and the non-magnetic beads causes the internal control to be distributed within the fluid sample.

A device comprising a sample chamber 400 for receiving a sample collector 200, an accommodating chamber and a testing chamber 100. The sample chamber 400 is provided with a sealing film (fig 17b; 404

Analyte testing devices, assemblies, methods, operations, and systems are shown and described. In a lateral flow reader to generate a test result from an assay when contacted with a sample and having a camera multiplexer circuit and a host controller. An assembly includes an interface connector; a self-contained optics module having a microcontroller in electrical communication with the interface connector and a host controller. Typically, an optical imaging device being in communication with an interface connector but independent of a microcontroller.

Provided is a system (100) for use in testing biological material. The system includes a substrate (102), and at least one support member (104) that has a biocompatible support portion (106) for supporting the biological material. The at least one support member is mountable to, and detachable from, the substrate. The at least one support member is detachable from the substrate at least by manual manipulation by a user, for example by the user pulling the at least one support member from the substrate using tweezers. Additionally provided is the support member per se. Further provided is a method of testing biological material using the system, as well as use of such a system for testing biological material.

A fluidic cartridge chamber contains non-magnetic beads and a magnetic element. Motion imparted to the magnetic element by a varying magnetic field imparts motion the non-magnetic beads, thereby lysing cells of a fluid sample within the chamber. An internal control is provided within the chamber to validate an assay result and / or to validate the effectiveness of cell lysis. The internal control may be in a non-liquid form deposited on a portion of the chamber, the non-magnetic beads, and / or the magnetic element and dissolves when contacted by a fluid sample. The internal control may be provided in a pellet form that dissolves when contacted by a fluid sample or is disrupted when exposed to lysing forces of the non-magnetic beads. A fluidic cartridge includes wells that are fluidly connected, and one well comprises an expansion well to which a chamber expander is attached to expand a volumetric capacity of the expansion well.

A cartridge assembly for blood analysis according to one aspect of the present disclosure includes a main cartridge including a main case having a sub-cartridge accommodation groove formed on one surface thereof, a plurality of reagent solution bags disposed inside the main case, a specimen supply part disposed inside the main case, and an opening / closing door which is elastically and rotatably coupled to another surface facing the one surface, a sub-cartridge which is inserted into the sub-cartridge accommodation groove so as to be detachable from the main cartridge and includes a sub-case and a plurality of quality control solution bags disposed inside the sub-case, and a sensor card detachably coupled to the main cartridge.

The invention discloses a device for testing an analyte in a liquid sample, comprising a carrier (800), wherein the carrier (800) comprises:a front face and a back face, wherein one or more clamping slots (803) for accommodating a test strip are provided in the front face, the test strip is used for testing the analyte in the liquid sample and comprises a sample pad (905), a label pad and a test pad (902) that are sequentially arranged from upstream to downstream, and the clamping slot (803) is provided with a bottom (807) and an opening (808); and a first covering layer (801), wherein the first covering layer (801) comprises a first covering area (829) and a first blocking area (820), the first covering area (829) covers the one or more clamping slots (803) to form one or more channels with one end being sealed and the other end being open, a part of the sample pad (905) is exposed from the opening (808) of the channel, and the first blocking area (820) covers a surface of the partially exposed sample pad (905).

Provided is a sample holder which facilitates replacement work of a sample by using a resin member, and that can suppress deterioration of the resin member due to X-rays. The sample holder for X-ray fluorescence analysis includes: a cylindrical member having an upper end surface with a hole partially formed therein, and a lower end which is opened; a saucer, which is arranged inside the cylindrical member, and on which a sample is to be placed; an elastic member configured to urge the saucer upward; a resin member, which includes a bow part and is configured to come into contact with a lower end of the elastic member; and a bottom plate arranged below the resin member. The cylindrical member, the saucer, and the bottom plate are each made of a metal. The bow part includes a claw portion provided at an end portion, and a pressed portion to be pressed inward, and is configured to be elastically deformed by pressing the pressed portion. The cylindrical member includes a fitting portion which allows the claw portion to be fitted to the fitting portion, and an exposure portion which allows the pressed portion to be exposed to an outside through the exposure portion. The resin member is arranged between the saucer and the bottom plate, and portions of the resin member other than the pressed portion are surrounded by the cylindrical member, the saucer, and the bottom plate.

A test strip container includes: an accommodating member in which a test strip is accommodated; a moving member moving the test strip therein; a door member opening and closing at a side surface of the accommodating member to discharge the test strip out of the accommodating member, and cutting the interior and the exterior of the accommodating member off from each other when closed; a door accommodating portion covering the door member, in which the door member can open and close; and a discharge opening cutting the interior and an exterior of the door accommodating portion off from each other when closed, and is provided at the door accommodating portion so as to open and close to discharge the test strip to the exterior of the door accommodating portion, the discharge opening being able to open when the accommodating member is closed by the door member.

Provided is a sample holder which facilitates replacement work of a sample by using a resin member, and that can suppress deterioration of the resin member due to X-rays. The sample holder for X-ray fluorescence analysis includes: a cylindrical member having an upper end surface with a hole partially formed therein, and a lower end which is opened; a saucer, which is arranged inside the cylindrical member, and on which a sample is to be placed; an elastic member configured to urge the saucer upward; a resin member, which includes a bow part and is configured to come into contact with a lower end of the elastic member; and a bottom plate arranged below the resin member. The cylindrical member, the saucer, and the bottom plate are each made of a metal. The bow part includes a claw portion provided at an end portion, and a pressed portion to be pressed inward, and is configured to be elastically deformed by pressing the pressed portion. The cylindrical member includes a fitting portion which allows the claw portion to be fitted to the fitting portion, and an exposure portion which allows the pressed portion to be exposed to an outside through the exposure portion. The resin member is arranged between the saucer and the bottom plate, and portions of the resin member other than the pressed portion are surrounded by the cylindrical member, the saucer, and the bottom plate.

A specimen storage for storing an observation specimen obtained by providing an observation object on a light transmissive plate, comprises an opening and closing member that is movably attached to a main body of the specimen storage in one direction, and an abutting member configured to be able to abut on a case for housing observation specimens, wherein the opening and closing member is provided to be movable with respect to the main body so as to abut on the case when the opening and closing member is a closing state and to be separated from the case when the opening and closing member is an opening state.

The invention provides a device for detecting an analyte in a sample, comprising: a cavity for receiving a test element, the test element having a first position and a second position within the cavity, when in the first position the test element does not contact a fluid sample, when in the second position the test element contacts a fluid sample.

An apparatus (1110) for heating a plurality of specimens carried by a plurality of microscope slides and a method for drying a plurality of specimens carried by a plurality of microscope slides are disclosed. The apparatus (1110) is comprising a housing (1122) at least partially defining a circulation loop (1121); a blower (1110) positioned to produce fluid flow along the circulation loop (1121); a door assembly (1101) moveable between an open position and a closed position; a heater (1116) configured to heat the fluid flow such that the specimens are convectively heated by the fluid flow when the door assembly (1101) holds the slide carrier (1200) along the second portion of the circulation loop (1121); a turbulence promoter (1118) positioned downstream of the heater (1116) along the circulation loop (1121) and configured to create a turbulent fluid flow along a first portion of the circulation loop (1121); and a laminar flow promoter (1114) positioned downstream of the first portion of the circulation loop and configured to create a laminar fluid flow along a second portion of the circulation loop (1121).

The present invention is directed to a system for identifying embedding cassettes in a lab or in a hospital, the system comprising a set of cassettes, wherein each cassette contains a two-dimensional code onto a face of the cassette, which code has a number of possible combination higher than 109; an apparatus comprising at least one hub for storing cassettes; and a CCD for reading code of the cassettes; and a processor adapted for associating the bidimensional code of the cassette to the information relating to the histological content of the cassette, to the patient and to other possible information decided by the lab and / or hospital, wherein the system does not comprise a printer. The invention is also directed to a corresponding method performed on an apparatus for dispensing cassettes for histological inclusion.

The present invention relates to an incubator temperature control system and a manufacturing method thereof, and by forming a groove in a center portion of a heat transfer material and filling the groove with an insulating material, the present invention has an advantage of preventing heat from being transferred mainly to the center portion and allowing heat to be easily transferred to an edge portion.

The application discloses an automatic mobile line carrier secondary positioning structure, a fixed base is used for supporting a movable top block, the fixed base is installed on a loading station of the automatic mobile line, a support platform is used for bearing a planar micro-hole plate, when the automatic mobile line drives the support platform to translate along a straight line to the loading station, the movable top block and the support platform are mutually inserted and positioned through at least two groups of wedge-shaped positioning blocks and wedge-shaped positioning grooves, secondary positioning of the support platform and the planar micro-hole plate placed thereon is realized; elastic members are arranged between the fixed base and the movable top block, when the support platform contacts the movable top block, the movable top block compresses the elastic members, a buffering effect is achieved, and damage is avoided; through the arrangement of the movable top block, the support platform and the planar micro-hole plate are accurately positioned, and accurate drop of liquid drops can be ensured.

The disclosure describes apparatus and methods for multiplexed amplification and detection of nucleic acid targets in a sample. Embodiments of the present disclosure include a mechanical system configured to provide loading, vertical positioning and clamping of a chip; a thermal control system configured to maintain distinct temperatures of the chip, and an optical fluorescence imaging system.

A visualizer for use with an immunoassay rapid diagnostic test (RDT) with fluorescent probes includes a housing sized to enclose the RDT, an opening in the housing for insertion of the RDT, a viewing window in the housing positioned to align with a result window in the RDT when inserted in the housing, a UV / visible / infrared light source inside the housing for illuminating fluorescent probes in the result window so they may be viewed through the viewing window, and a switch for activating the light source. An RDT incorporating a UV / visible / infrared light source within its housing is also disclosed.

The present invention relates to a recyclable in vitro test system comprising a diagnostic unit which has a diagnostic reagent that can be converted into a diagnostic product by being brought into contact with a sample taken from an organism, or with sample material that can be obtained from such a sample, the diagnostic product itself being optically perceptible and / or being capable of inducing a reaction, the reaction product of which can be optically perceived, and a housing which surrounds at least part of the diagnostic unit. The housing has, as its main constituent, a polymer originating from a renewable raw-material source. The invention also relates to a method for recycling an in vitro test system, the method comprising the steps of: - providing an in vitro test system which is used to detect a property of an organism and which comprises a housing having, as its main constituent, a polymer originating from a renewable raw-material source; - dividing the housing into at least two housing fragments in order to thereby make a diagnostic unit at least in part accessible; - separating the diagnostic unit from the housing fragments; and - separately disposing of the diagnostic unit and the housing fragments.