285results about "Flat carrier supports" patented technology

A substrate holder includes a base configured to receive a substrate; a cover configured to mateably engage with the base, the cover defining an opening formed by inner sidewalls; and a removable insert defining a surface, the removable insert being configured to be received within the opening of the cover. The removable insert includes a gasket; a projection coupled to the gasket; and at least two insert tabs extending from opposite sides of the removable insert, each insert tab being configured to engage with at least one of the inner sidewalls forming the opening of the cover.

The application discloses a pollution-preventing detection device, method and application for rapid detection of nucleic acid amplification, which comprises a detection part and a mixed reaction cabin, and the mixed reaction cabin comprises a reaction cabin main body and a reaction cabin cover which is in sealed connection with the reaction cabin main body and can be detached; a channel for connecting a hybridization liquid containing part and a mixed reaction part is arranged between the reaction cabin cover and the reaction cabin main body; the detection part comprises a detection inner core and a detection box body containing the detection inner core; a transparent observation window is arranged on the detection box body and corresponds to the reaction area position of the detection inner core; a flow guide device matched with the mixed reaction cabin is further arranged on the detection box body; the flow guide device comprises a flow guide pipe and a flow guide part; one end of the flow guide part is connected with the flow guide pipe, and the other end is connected with the detection inner core; the hybridization liquid and the sample mixed liquid are guided to the detection inner core; and the detection inner core displays the final detection result in the area corresponding to the transparent observation window. The application realizes that the liquid in the reaction tube flows out to the designated detection card in a completely closed environment, and has the advantages of good sealing effect and prevention of primer aerosol pollution.

Disclosed is a multiplex quantum dot-based quantitative test card, and a preparation method, apparatus, and use method thereof in the technical field of biological testing, the multiplex quantum dot-based quantitative test card including a multiplex card housing and a test strip, where the multiplex card housing is provided with a plurality of reaction slots configured to accommodate the test strip; the multiplex card housing further includes a plurality of sample loading ports and a plurality of observation windows, where the sample loading ports and the observation windows are in one-to-one correspondence with the reaction slots; and the test strip includes a conjugate pad coated with quantum dot-labeled antibodies, where the quantum dot-labeled antibodies serve as chromogenic substances.

A biodegradable and mouldable cassette for lateral flow assay device, and a lateral flow assay device comprising said cassette, and a kit comprising such a lateral flow assay device, for in vitro diagnostics of a biological sample comprising a diagnostic test strip inserted into the cassette. The cassette comprises a first cassette part and a second cassette part coupled to each other and defining a test chamber there between containing the diagnostic test strip. The cassette is made of a biodegradable material and at least one of the first cassette part and second cassette part is made of injection mouldable material, in particular gelatin or a gelatin composition.

The disclosed invention provides a cartridge, method and cartridge processing systems for molecular tests that include extracting one or more biological materials from a tissue. The cartridge includes a base having a receptacle inside the base, a lid placed over the receptacle, and a gasket in the base. The base includes a transparent window placed under the receptacle, and the receptacle contains a slide on which the tissue is disposed. A film is disposed on an inner surface of the lid, and the film is suitable to extract the one or more biological materials from the tissue. The gasket surrounds the slide, and the lid creates a sealed chamber around the gasket that encloses the slide, and vacuum suction is applied through a port of the base to press the film against the tissue on the slide.

A lysis capsule for performing a cell lysis procedure includes a hollow body having an open first end and an open second end, a first porous membrane covering the open first end, and a second porous membrane covering the open second end, and the hollow body defines a lysis chamber between the first and second porous membranes. A plurality of non-magnetic beads and at least one magnetic element are disposed within the lysis chamber, and the pores of the first and second porous membranes are sized to retain the non-magnetic beads and the magnetic element within the lysis chamber. An internal control may be contained within the lysis chamber to validate an assay result and / or to validate the effectiveness of the cell lysis procedure. The lysis capsule may be disposed within a sample chamber of a fluidic cartridge.

An adapter for incorporation into an open well flow cell, the adapter including a body having an upper surface, a lower surface spaced from the upper surface defining a thickness profile therebetween, at least one side extending about a perimeter of the body, an inlet formed in the body extending through the thickness of the upper surface and the lower surface, at least one foot extending from the lower surface, each foot of the at least one foot extending a vertical distance away from the lower surface and a protrusion extending from the upper surface. The adaptor configured to be placed over, or onto, an open well flow cell to form an effectively closed, and reversible, flow cell. A variety of structural features are included to inhibit / prohibit gas bubbles from evaporating from the fluid reagent within the cell, and / or providing egress or venting of such bubbles.

Various examples are provided related to slide preparation. In one example, a slide preparation apparatus includes a support surface, an upper surface opposite the support surface, and a sample tube holder. The upper surface can include a slide channel extending to a stop, a fiducial mark disposed in the slide channel, and a support bar extending across the slide channel. The sample tube holder can secure a sample tube in a vertical position adjacent to an end of the upper surface adjacent to the stop. When a syringe is supported by a sample tube positioned in the sample tube holder, a needle of the syringe can be aligned with the fiducial mark when it is seated in a guide groove of the support bar.

Interoperable systems for performing sample preparation and analysis in a closed environment include a fluidic cartridge, including chambers for sample and reagents and sample processing, reaction chambers, chamber-connecting channels, and fluid control valves, actuators for closing and selectively opening one or more valves of the cartridge, a syringe pump and syringe driver for effecting fluid movement between chambers of the cartridge, thermal modules for heating or cooling reaction chambers disposed between the thermal modules, a thermal module actuator for moving the thermal modules into and out of thermal contact with the reaction chambers, a contact detector for detecting the presence of a fluidic cartridge between the thermal modules, optical fibers for transmitting optical signals through openings in at least one of the thermal modules, and optical devices for transmitting optical signals through the fibers to the reaction chambers and / or receiving optical signals transmitted by the optical fibers from the reaction chambers.

A lateral flow test strip for detecting the presence or absence of a first target analyte within a sample is described. The lateral flow test strip comprises: an input configured to receive the sample; a conjugate pad comprising a conjugate biomolecule configured to bind to a first target analyte in the sample; a membrane comprising one or more test zones, wherein a first test zone comprises a first soluble coloured compound substantially co-located with a first non-visible capture biomolecule, wherein the first non-visible capture biomolecule is attached to the membrane and is configured to bind to the first target analyte, thereby immobilising the first labelled conjugate assembly at the first test zone, and wherein the first soluble coloured compound is configured to be removed from the first test zone by a fluid flow of the sample and transported along the lateral flow test strip.

Systems and methods that enable automated processing of specimens carried on microscope slides are described herein. In some embodiments, the system can include, for example, a slide ejector assembly having a slide staging device configured to receive a slide and an over-travel inhibitor that includes a first vacuum port positioned to draw a first vacuum between the slide and a standby platform as the slide is moved across at least a portion of the standby platform. The over-travel inhibitor includes a first sensor for detecting a presence of the slide on the standby platform. The system can also include a transfer assembly to transport slides away from the slide ejector assembly. The transfer assembly can include a floating transfer head having a vacuum port for drawing a partial vacuum for holding the slide.

A test strip container (10) includes: an accommodating member (20) in which a test strip (90) is accommodated; a moving member (31) moving the test strip (90) therein; a door member (40) opening and closing at a side surface of the accommodating member (20) to discharge the test strip (90) out of the accommodating member (20), and cutting the interior and the exterior of the accommodating member (20) off from each other when closed; a door accommodating portion (27) covering the door member (40), in which the door member (40) can open and close; and a discharge opening (28) cutting the interior and an exterior of the door accommodating portion (27) off from each other when closed, and which is provided at the door accommodating portion (27) so as to open and close to discharge the test strip (90) to the exterior of the door accommodating portion (27), the discharge opening (28) being able to open when the accommodating member (20) is closed by the door member (40).

A tray insert for use with an apparatus configured to analyze a sample is disclosed. The tray insert includes a first surface comprising an elongated channel adapted to receive a reagent strip for sample analysis. Further, the insert includes a second surface, wherein the second surface is in a direction opposite to the first surface. Additionally, the insert includes a hollow enclosure between the first surface and the second surface, wherein the elongated channel on the first surface comprises a plurality of slots and wherein the slots comprise an opening on each end, wherein the opening enters the hollow enclosure.

Systems and methods that enable automated processing of specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to an automated staining system that includes an instrument including an end effector and a stainer unit-receiving station that receives a stainer unit such that the end effector delivers reagent from the reagent reservoirs to a reaction chamber of the slide stainer unit. The stainer unit can carry fresh reagents, waste material, and components used to handle the reagents.

The application discloses a slice rack, which comprises a slice rack body, a plurality of slice grooves are arranged on the slice rack body, a horizontal rectangular coordinate system is arranged and comprises an X direction and a Y direction, two opposite sides of the X direction are arranged as a first X direction side and a second X direction side, two opposite sides of the Y direction are arranged as a first Y direction side and a second Y direction side, a clamp jaw is arranged on the first Y direction side and the second Y direction side in each slice groove, one end of the clamp jaw is a connecting end connected with the slice rack body, the connecting end of the two clamp jaws in each slice groove is located on the first X direction side of the X direction in the slice groove, the other end of the clamp jaw is a free end and faces the second X direction side of the slice groove, and the clamp jaw can be bent and deformed around the connecting end of the clamp jaw. The slice rack has a simple structure, can be integrally formed by molding, is convenient to install the slice, and is convenient, fast and reliable in slice installation.

The present invention relates to a device for the rapid analysis of a biological sample, intended for the detection of the presence of at least one analyte in said biological sample. The rapid analysis device (1) comprises a housing (2) and a cap (8) defining an internal volume (8') suitable for enclosing an absorbent block (7). The cap (8) has at least one through-hole (81) opening into said internal volume (8') and adapted for the introduction of a liquid reagent (R) into the internal volume (8') of the cap (8). Figure for the abstract: 4

A fluid sample is dispensed into a sample chamber of a fluidic cartridge, the sample chamber containing non-magnetic beads, a magnetic element, and an internal control reagent contained within an internal control pellet including an internal control for validating an assay result and / or to validate the effectiveness of a cell lysis procedure. The magnetic element is exposed to a magnetic field, thereby causing movement of the magnetic element, which causes movement of the non-magnetic beads. Movement of the non-magnetic beads causes cells contained within the fluid sample to lyse and release nucleic acids. The internal control reagent dissolves in the presence of the fluid sample or movement of the non-magnetic beads disintegrates the internal control pellet, thereby releasing the internal control into the fluid sample. Movement of the magnetic element and the non-magnetic beads causes the internal control to be distributed within the fluid sample.

A device comprising a sample chamber 400 for receiving a sample collector 200, an accommodating chamber and a testing chamber 100. The sample chamber 400 is provided with a sealing film (fig 17b; 404

The invention proposes a device and a method for selective, specific and simultaneous sorting of target cells in a biological sample, versatile and economical. To this end, the device according to the invention comprises: • A first row (110) of at least two fluidic chambers (111) each comprising an inlet (112) fluidically connected to at least one reservoir (1) of a biological solution, and an outlet (113); • A last row (130) of fluidic chambers (131) equal in number to the number of chambers (111) of the first row (110), each fluidic chamber (131) of the last row (130) comprising an inlet (132) fluidically connected to an outlet (113) of a chamber (111) of the first row (110), and an outlet (133); • At least one solution collection reservoir, fluidically connected to each outlet (133) of the fluidic chambers of the second row;• At least one pump suitable for circulating a sample of the biological solution in the fluidic chambers of the first row and then the last row; the fluidic chambers each comprising a surface functionalized by molecules, at least some of which are capable of forming a bond with a receptor molecule carried by the target cells.;

Analyte testing devices, assemblies, methods, operations, and systems are shown and described. In a lateral flow reader to generate a test result from an assay when contacted with a sample and having a camera multiplexer circuit and a host controller. An assembly includes an interface connector; a self-contained optics module having a microcontroller in electrical communication with the interface connector and a host controller. Typically, an optical imaging device being in communication with an interface connector but independent of a microcontroller.

Provided is a system (100) for use in testing biological material. The system includes a substrate (102), and at least one support member (104) that has a biocompatible support portion (106) for supporting the biological material. The at least one support member is mountable to, and detachable from, the substrate. The at least one support member is detachable from the substrate at least by manual manipulation by a user, for example by the user pulling the at least one support member from the substrate using tweezers. Additionally provided is the support member per se. Further provided is a method of testing biological material using the system, as well as use of such a system for testing biological material.

A fluidic cartridge chamber contains non-magnetic beads and a magnetic element. Motion imparted to the magnetic element by a varying magnetic field imparts motion the non-magnetic beads, thereby lysing cells of a fluid sample within the chamber. An internal control is provided within the chamber to validate an assay result and / or to validate the effectiveness of cell lysis. The internal control may be in a non-liquid form deposited on a portion of the chamber, the non-magnetic beads, and / or the magnetic element and dissolves when contacted by a fluid sample. The internal control may be provided in a pellet form that dissolves when contacted by a fluid sample or is disrupted when exposed to lysing forces of the non-magnetic beads. A fluidic cartridge includes wells that are fluidly connected, and one well comprises an expansion well to which a chamber expander is attached to expand a volumetric capacity of the expansion well.

A cartridge assembly for blood analysis according to one aspect of the present disclosure includes a main cartridge including a main case having a sub-cartridge accommodation groove formed on one surface thereof, a plurality of reagent solution bags disposed inside the main case, a specimen supply part disposed inside the main case, and an opening / closing door which is elastically and rotatably coupled to another surface facing the one surface, a sub-cartridge which is inserted into the sub-cartridge accommodation groove so as to be detachable from the main cartridge and includes a sub-case and a plurality of quality control solution bags disposed inside the sub-case, and a sensor card detachably coupled to the main cartridge.

The invention discloses a device for testing an analyte in a liquid sample, comprising a carrier (800), wherein the carrier (800) comprises:a front face and a back face, wherein one or more clamping slots (803) for accommodating a test strip are provided in the front face, the test strip is used for testing the analyte in the liquid sample and comprises a sample pad (905), a label pad and a test pad (902) that are sequentially arranged from upstream to downstream, and the clamping slot (803) is provided with a bottom (807) and an opening (808); and a first covering layer (801), wherein the first covering layer (801) comprises a first covering area (829) and a first blocking area (820), the first covering area (829) covers the one or more clamping slots (803) to form one or more channels with one end being sealed and the other end being open, a part of the sample pad (905) is exposed from the opening (808) of the channel, and the first blocking area (820) covers a surface of the partially exposed sample pad (905).

The present invention relates to a functional element (64, 164) for a beta container (38, 138) of a transfer system (24, 124), wherein the functional element (64, 164) can be arranged on and / or in a beta port opening (48) of a beta port (44) of the beta container (38, 138), wherein the functional element (64, 164) has a functional element opening (68), wherein the functional element opening (68) is smaller than the beta port opening (48). Furthermore, the present invention relates to a functional element (264) for a beta container (238) of a transfer system (224), wherein the functional element (264) can be arranged on and / or in a beta port opening (48) of a beta port (44) of the beta container (238), wherein the functional element (264) has one or more culture medium carrier holders (268), wherein each culture medium carrier holder (268) is designed to hold a culture medium carrier.Furthermore, the present invention relates to a beta container (38, 138, 238) for a transfer system (24, 124, 224). Furthermore, the present invention relates to a transfer system (24, 124, 224). Furthermore, the present invention relates to a barrier system, in particular an isolator system.

Provided is a sample holder which facilitates replacement work of a sample by using a resin member, and that can suppress deterioration of the resin member due to X-rays. The sample holder for X-ray fluorescence analysis includes: a cylindrical member having an upper end surface with a hole partially formed therein, and a lower end which is opened; a saucer, which is arranged inside the cylindrical member, and on which a sample is to be placed; an elastic member configured to urge the saucer upward; a resin member, which includes a bow part and is configured to come into contact with a lower end of the elastic member; and a bottom plate arranged below the resin member. The cylindrical member, the saucer, and the bottom plate are each made of a metal. The bow part includes a claw portion provided at an end portion, and a pressed portion to be pressed inward, and is configured to be elastically deformed by pressing the pressed portion. The cylindrical member includes a fitting portion which allows the claw portion to be fitted to the fitting portion, and an exposure portion which allows the pressed portion to be exposed to an outside through the exposure portion. The resin member is arranged between the saucer and the bottom plate, and portions of the resin member other than the pressed portion are surrounded by the cylindrical member, the saucer, and the bottom plate.

A test strip container includes: an accommodating member in which a test strip is accommodated; a moving member moving the test strip therein; a door member opening and closing at a side surface of the accommodating member to discharge the test strip out of the accommodating member, and cutting the interior and the exterior of the accommodating member off from each other when closed; a door accommodating portion covering the door member, in which the door member can open and close; and a discharge opening cutting the interior and an exterior of the door accommodating portion off from each other when closed, and is provided at the door accommodating portion so as to open and close to discharge the test strip to the exterior of the door accommodating portion, the discharge opening being able to open when the accommodating member is closed by the door member.

Various examples of systems and methods are provided for slide processing. In one example, among others, a system for processing microscope slides includes a reservoir having a fluid and a treatment applicator that can dispense the fluid on a slide. The treatment applicator can include offset rails on opposite sides of an application surface, the offset rails and application surface defining a treatment channel when positioned on a surface of the slide; and an opening that can direct the fluid to the treatment channel. The opening can include a constriction configured to modulate flow of the fluid into the treatment channel. In another example, a method includes positioning a slide adjacent to a treatment applicator and dispensing a fluid into a treatment channel along the surface of the slide through an opening extending through the treatment applicator.

A placement table for placing the slide glass 1 transported by using a transport mechanism includes a base 21 having a flat plate shape, and a plurality of support portions 22 and a plurality of guide pins 23 provided on an upper surface of the base 21. The plurality of support portions 22 are provided to support a lower surface (1b) of the slide glass 1. The plurality of guide pins 23 are used to surround each side surface 1s of the slide glass 1 in a plan view. The plurality of guide pins 23 are each formed in a columnar shape, and are positioned closer to an outer peripheral side of the base 21 than the plurality of support portions 22.