522results about "Flat carrier supports" patented technology

A method of capturing analytes from a sample is provided. A first substrate including a sample is mounted on a first member of a sample handling device and mounting a second substrate including an array of capture probes on a second member of the sample handling device. A first reagent medium is applied to the first and / or second substrate and moving the first member and / or the second member to fluidically couple the sample and the array of capture probes via the first reagent medium. The sample and the array of capture probes are fluidically decoupled by moving the first member and / or the second member and a second reagent medium is applied to the first and / or second substrate and moving the first member and / or the second member to fluidically couple the sample and the array of capture probes via the second reagent medium. Related systems and apparatuses are also provided.

A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.

A substrate holder includes a base configured to receive a substrate; a cover configured to mateably engage with the base, the cover defining an opening formed by inner sidewalls; and a removable insert defining a surface, the removable insert being configured to be received within the opening of the cover. The removable insert includes a gasket; a projection coupled to the gasket; and at least two insert tabs extending from opposite sides of the removable insert, each insert tab being configured to engage with at least one of the inner sidewalls forming the opening of the cover.

A substrate holder includes a base configured to receive a substrate; a cover configured to mateably engage with the base, the cover defining an opening formed by inner sidewalls; and a removable insert defining a surface, the removable insert being configured to be received within the opening of the cover. The removable insert includes a gasket; a projection coupled to the gasket; and at least two insert tabs extending from opposite sides of the removable insert, each insert tab being configured to engage with at least one of the inner sidewalls forming the opening of the cover.

A substrate holder includes a base configured to receive a substrate; a cover configured to mateably engage with the base, the cover defining an opening formed by inner sidewalls; and a removable insert defining a surface, the removable insert being configured to be received within the opening of the cover. The removable insert includes a gasket; a projection coupled to the gasket; and at least two insert tabs extending from opposite sides of the removable insert, each insert tab being configured to engage with at least one of the inner sidewalls forming the opening of the cover.

Systems and methods that enable automated processing of specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to an automated staining system including a dispensing instrument that receives a processing module to deliver reagent to a reaction chamber of the slide processing module. The processing module can carry fresh reagents, waste material, and the side.

The application discloses a pollution-preventing detection device, method and application for rapid detection of nucleic acid amplification, which comprises a detection part and a mixed reaction cabin, and the mixed reaction cabin comprises a reaction cabin main body and a reaction cabin cover which is in sealed connection with the reaction cabin main body and can be detached; a channel for connecting a hybridization liquid containing part and a mixed reaction part is arranged between the reaction cabin cover and the reaction cabin main body; the detection part comprises a detection inner core and a detection box body containing the detection inner core; a transparent observation window is arranged on the detection box body and corresponds to the reaction area position of the detection inner core; a flow guide device matched with the mixed reaction cabin is further arranged on the detection box body; the flow guide device comprises a flow guide pipe and a flow guide part; one end of the flow guide part is connected with the flow guide pipe, and the other end is connected with the detection inner core; the hybridization liquid and the sample mixed liquid are guided to the detection inner core; and the detection inner core displays the final detection result in the area corresponding to the transparent observation window. The application realizes that the liquid in the reaction tube flows out to the designated detection card in a completely closed environment, and has the advantages of good sealing effect and prevention of primer aerosol pollution.

Provided are a chip positioning apparatus, a chip outer frame apparatus for a gene sequencer, and a gene sequencer. The chip positioning apparatus is used for positioning a chip, and comprises: a base used for carrying said chip; a first limiting structure fixedly connected to the base and used for abutting against the chip so as to limit the movement of the chip in a first direction and a second direction, the first direction and the second direction being perpendicular to one another; a second limiting structure movably connected to the base and used for abutting against the chip so as to limit the movement of the chip in the direction opposite the first direction and the direction opposite the second direction; and an execution structure connected to the base and abutting against and holding the second limiting structure, used for pushing the second limiting structure to move in the first direction and the second direction such that the second limiting structure abuts against the chip. By using the execution structure, the position of the chip in the first direction on the horizontal plane and the position of the chip in the second direction on the horizontal plane can be determined simultaneously, thus effectively improving chip positioning efficiency.

Disclosed is a multiplex quantum dot-based quantitative test card, and a preparation method, apparatus, and use method thereof in the technical field of biological testing, the multiplex quantum dot-based quantitative test card including a multiplex card housing and a test strip, where the multiplex card housing is provided with a plurality of reaction slots configured to accommodate the test strip; the multiplex card housing further includes a plurality of sample loading ports and a plurality of observation windows, where the sample loading ports and the observation windows are in one-to-one correspondence with the reaction slots; and the test strip includes a conjugate pad coated with quantum dot-labeled antibodies, where the quantum dot-labeled antibodies serve as chromogenic substances.

An assembly for securing a film to an object is provided. The assembly may comprise a lid comprising a surface configured to receive the film, where the surface comprises a plurality of vent openings through which positive pressure or vacuum may be applied to the film. The application of a vacuum may flatten the film against the surface. The assembly may also comprise a base comprising a cavity configured to receive and support a tray, and at least two receptacles configured to receive at least two pegs of the lid. The film may comprise a molecular array which may be immobilized on one side of the film.

A molecular diagnostic device and a detection card conveying seat for the same. The detection card conveying seat includes: a pressure plate, arranged with a first slide rail component, where the pressure plate is slidable along a sliding direction of the first slide rail component; and a transporting assembly, configured to place a detection card. The transporting assembly includes: a sliding frame, where the sliding frame is slidable together with the pressure plate along the sliding direction under an action of an abutting force; and a card tray, connected to the sliding frame and configured to place the detection card, where the pressure plate is configured to move toward the detection card and movable to a position abutting against the detection card, in condition of the sliding frame being subjected to a force that overcomes the abutting force.

A point-of-care analyzer is provided including an analysis unit that receives a biological sample for analysis, the analysis unit including an interrogation device; a housing at least partially surrounding the analysis unit, the housing defining a cartridge slot for receiving a cartridge comprising the biological sample; and a tray on the housing, the tray comprising an upper surface for holding the cartridge and one or more reagent holders for holding a consumable reagent.

Systems and methods for enhanced film sample gripping solutions are provided. An apparatus for processing a thin film sample may include a sample holder configured to engage the thin film sample, where the sample holder includes one or more holding members configured to receive the thin film sample in a flat position relative to the sample holder, and one or more securing members configured to secure the one or more holding members to the one or more holding members. The one or more securing members are configured to securely maintain the film sample in a flat position during manipulation of the sample holder. The sample holder may include one or more apertures between the one or more fixing members that enable access to both sides of the thin film sample at two or more locations on the thin film sample. The sample holder may include a width adjustment component configured to allow adaptation to different sample widths.

A resealable fluidic device for conducting assays of a biological sample comprises a frame having a sample opening; and a cover slide configured to be received in the frame; wherein the frame is configured to receive a base slide on which a biological sample is configured to be disposed; wherein the cover slide and the base slide are configured to form a flow cell chamber housing the biological sample, and the flow cell chamber is configured to be aligned with the sample opening when the frame, the cover slide, and the based slide are assembled.

An apparatus for removing contaminants from a slide comprises a manifold including at least one input port and at least one output port in fluid communication with the at least one input port, the at least one output port being adapted to direct a flow of gas onto a surface of the slide such that the flow of gas removes contaminants from the slide; an aperture for receiving the slide; and an enclosure adapted to capture the contaminants removed from the slide.

Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

A biodegradable and mouldable cassette for lateral flow assay device, and a lateral flow assay device comprising said cassette, and a kit comprising such a lateral flow assay device, for in vitro diagnostics of a biological sample comprising a diagnostic test strip inserted into the cassette. The cassette comprises a first cassette part and a second cassette part coupled to each other and defining a test chamber there between containing the diagnostic test strip. The cassette is made of a biodegradable material and at least one of the first cassette part and second cassette part is made of injection mouldable material, in particular gelatin or a gelatin composition.

The disclosed invention provides a cartridge, method and cartridge processing systems for molecular tests that include extracting one or more biological materials from a tissue. The cartridge includes a base having a receptacle inside the base, a lid placed over the receptacle, and a gasket in the base. The base includes a transparent window placed under the receptacle, and the receptacle contains a slide on which the tissue is disposed. A film is disposed on an inner surface of the lid, and the film is suitable to extract the one or more biological materials from the tissue. The gasket surrounds the slide, and the lid creates a sealed chamber around the gasket that encloses the slide, and vacuum suction is applied through a port of the base to press the film against the tissue on the slide.

Disclosed is a molecular diagnosis cartridge which is formed so that a molecular diagnosis chip can be easily inserted therein. The molecular diagnosis cartridge accommodating the molecular diagnosis chip comprises: a cartridge bottom member arranged on the lower portion; a hinge sub-ring arranged along the outer circumference of the cartridge bottom member; a cartridge outline member which is accommodated in a space defined by the hinge sub-ring fastened with the cartridge bottom member; a chip sliding member which has a shape surrounding the molecular diagnosis chip, is arranged on the cartridge outline member, and accommodates the molecular diagnosis chip that is inserted in an inclined direction; and a torsion spring-like member which is fastened with a kind of a seesaw axle protruding from the inner wall of the cartridge outline member, supports the chip sliding member to be inclined with respect to the cartridge bottom member in an open mode operation, and supports the chip sliding member to be parallel to the cartridge bottom member in a close mode operation. According to the present invention, the molecular diagnosis chip is inclinedly inserted in the chip sliding member, and easiness in insertion of the molecular diagnosis chip can be achieved. Also, as the cartridge cover is pressed, the chip sliding member accommodating the molecular diagnosis chip makes a seesaw movement on the basis of the seesaw axle and is moved to the cartridge bottom member, and thus, the molecular diagnosis chip arranged in the chip sliding member can be seated in the molecular diagnosis cartridge.

A cartridge for imaging a biological sample is disclosed. The cartridge includes a housing including: (i) a port and (ii) a recess for receiving the biological sample. The cartridge additionally includes a gasket surrounding at least a of portion the recess of the housing, wherein the gasket includes at least one wall defining a boundary of a reservoir, wherein the reservoir includes the recess, and wherein the reservoir is in fluid communication with the port. The cartridge further includes a sheet interfaced with the at least one wall of the gasket, wherein when the at least one wall is interfaced with the sheet, the reservoir is defined as an area between the at least one wall, the recess of the housing, and a surface of the sheet, and wherein the sheet is optically transparent.

A lysis capsule for performing a cell lysis procedure includes a hollow body having an open first end and an open second end, a first porous membrane covering the open first end, and a second porous membrane covering the open second end, and the hollow body defines a lysis chamber between the first and second porous membranes. A plurality of non-magnetic beads and at least one magnetic element are disposed within the lysis chamber, and the pores of the first and second porous membranes are sized to retain the non-magnetic beads and the magnetic element within the lysis chamber. An internal control may be contained within the lysis chamber to validate an assay result and / or to validate the effectiveness of the cell lysis procedure. The lysis capsule may be disposed within a sample chamber of a fluidic cartridge.

An adapter for incorporation into an open well flow cell, the adapter including a body having an upper surface, a lower surface spaced from the upper surface defining a thickness profile therebetween, at least one side extending about a perimeter of the body, an inlet formed in the body extending through the thickness of the upper surface and the lower surface, at least one foot extending from the lower surface, each foot of the at least one foot extending a vertical distance away from the lower surface and a protrusion extending from the upper surface. The adaptor configured to be placed over, or onto, an open well flow cell to form an effectively closed, and reversible, flow cell. A variety of structural features are included to inhibit / prohibit gas bubbles from evaporating from the fluid reagent within the cell, and / or providing egress or venting of such bubbles.

Various examples are provided related to slide preparation. In one example, a slide preparation apparatus includes a support surface, an upper surface opposite the support surface, and a sample tube holder. The upper surface can include a slide channel extending to a stop, a fiducial mark disposed in the slide channel, and a support bar extending across the slide channel. The sample tube holder can secure a sample tube in a vertical position adjacent to an end of the upper surface adjacent to the stop. When a syringe is supported by a sample tube positioned in the sample tube holder, a needle of the syringe can be aligned with the fiducial mark when it is seated in a guide groove of the support bar.

Interoperable systems for performing sample preparation and analysis in a closed environment include a fluidic cartridge, including chambers for sample and reagents and sample processing, reaction chambers, chamber-connecting channels, and fluid control valves, actuators for closing and selectively opening one or more valves of the cartridge, a syringe pump and syringe driver for effecting fluid movement between chambers of the cartridge, thermal modules for heating or cooling reaction chambers disposed between the thermal modules, a thermal module actuator for moving the thermal modules into and out of thermal contact with the reaction chambers, a contact detector for detecting the presence of a fluidic cartridge between the thermal modules, optical fibers for transmitting optical signals through openings in at least one of the thermal modules, and optical devices for transmitting optical signals through the fibers to the reaction chambers and / or receiving optical signals transmitted by the optical fibers from the reaction chambers.

A lateral flow test strip for detecting the presence or absence of a first target analyte within a sample is described. The lateral flow test strip comprises: an input configured to receive the sample; a conjugate pad comprising a conjugate biomolecule configured to bind to a first target analyte in the sample; a membrane comprising one or more test zones, wherein a first test zone comprises a first soluble coloured compound substantially co-located with a first non-visible capture biomolecule, wherein the first non-visible capture biomolecule is attached to the membrane and is configured to bind to the first target analyte, thereby immobilising the first labelled conjugate assembly at the first test zone, and wherein the first soluble coloured compound is configured to be removed from the first test zone by a fluid flow of the sample and transported along the lateral flow test strip.

Systems and methods that enable automated processing of specimens carried on microscope slides are described herein. In some embodiments, the system can include, for example, a slide ejector assembly having a slide staging device configured to receive a slide and an over-travel inhibitor that includes a first vacuum port positioned to draw a first vacuum between the slide and a standby platform as the slide is moved across at least a portion of the standby platform. The over-travel inhibitor includes a first sensor for detecting a presence of the slide on the standby platform. The system can also include a transfer assembly to transport slides away from the slide ejector assembly. The transfer assembly can include a floating transfer head having a vacuum port for drawing a partial vacuum for holding the slide.

Analyte testing devices, assemblies, methods, operations, and systems are shown and described. In one embodiment, an apparatus to generate a test result from an assay, when contacted with a sample, includes a non-planar optics module, an imaging device, and a direct, dynamically-controlled lighting assembly. The assembly may include an aperture carrier heat block having a plurality of optical windows and enhancing manipulation of an assay about the assembly.

The present invention relates to an integrated FESEM and LDI-TOF-MS analysis system, and provides an integrated FESEM and LDI-TOF-MS analysis system that can perform FESEM analysis and LDI-TOF-MS analysis on a single sample to be analyzed without exposing the sample to the atmosphere.

The invention relates to a method, carrier assembly and system for imaging a sample for biological or chemical analysis. The method includes positioning a first carrier assembly on a system table. The first carrier assembly includes a support frame having an inner frame edge defining a window of the support frame. The first carrier assembly includes a first substrate located within the window and surrounded by the inner frame edge. The first substrate has a sample thereon. The method includes detecting an optical signal from a sample of a first substrate. The method further includes replacing the first carrier assembly on the system table with a second carrier assembly on the system table. The second carrier assembly includes a support frame and a tipping plate held by the support frame. The second carrier assembly has a second substrate held by the tipping plate, the second substrate having a sample thereon. The method further includes detecting an optical signal from the sample of the second substrate.

A test strip container (10) includes: an accommodating member (20) in which a test strip (90) is accommodated; a moving member (31) moving the test strip (90) therein; a door member (40) opening and closing at a side surface of the accommodating member (20) to discharge the test strip (90) out of the accommodating member (20), and cutting the interior and the exterior of the accommodating member (20) off from each other when closed; a door accommodating portion (27) covering the door member (40), in which the door member (40) can open and close; and a discharge opening (28) cutting the interior and an exterior of the door accommodating portion (27) off from each other when closed, and which is provided at the door accommodating portion (27) so as to open and close to discharge the test strip (90) to the exterior of the door accommodating portion (27), the discharge opening (28) being able to open when the accommodating member (20) is closed by the door member (40).