Automatic gastric emptying monitoring device of bionic digestive system

Abstract

The utility model relates to an automatic gastric emptying monitoring device of a bionic digestive system, which comprises a rotating disc, the rotating disc is rotationally arranged, the included angle between the center line of the rotating disc and the vertical direction is not zero, and a bionic stomach component is arranged on the rotating disc; the weighing assembly comprises a first container, a measuring instrument and a second container, the measuring instrument and the second container are contained in the first container, the measuring instrument is used for weighing the second container, the second container is communicated with the pylorus of the bionic stomach assembly, the first container comprises a container body and a rotating shaft, the container body is provided with a round hole, and the rotating shaft penetrates through the round hole and is rotationally connected with the container body; the rotating shaft is connected with the rotating disc and extends in the horizontal direction. According to the utility model, the weighing assembly is rotatably arranged on the turntable through the rotating shaft and the round hole, and the weighing assembly is adaptively adjusted to be in a horizontal state by utilizing the gravity of the weighing assembly, so that real-time online monitoring of gastric emptying data is realized, automatic sampling of the bionic gastric assembly is also realized, and the difficulty of sampling work is greatly reduced.

Description

Technical Field

[0001] This utility model relates to the field of biomimetic digestive system technology, and in particular to an automatic gastric emptying monitoring device for a biomimetic digestive system. Background Technology

[0002] In static in vitro digestion studies, the digestion process typically takes place in a fixed container, lacking dynamic mechanical movement and physiological regulation (such as gastric peristalsis and pyloric opening and closing). This makes it impossible to replicate the human physiological behavior of gastric emptying. Dynamic in vitro biomimetic digestive systems, however, can simulate environments close to the digestive system (such as the stomach and small intestine) and mimic the human body's autonomous gastric emptying process. To a certain extent, they can replace animal or human experiments, assisting researchers in developing functional foods and conducting research in nutrition. For example, patent CN108735060A discloses a biomimetic human esophagus and stomach digestive system, utilizing biomimetic stomach and esophageal components to simulate the human stomach digestive system, recreating the processes of gastric breakdown, digestion, and gastric emptying. Currently, in this system, gastric emptying data cannot be obtained online in real time; researchers need to periodically sample and weigh the data using an electronic balance. This method lacks automation, real-time capability, and convenience. Summary of the Invention

[0003] Therefore, the technical problem to be solved by this utility model is to overcome the problem that existing in vitro biomimetic digestive systems require experimenters to periodically sample and weigh the contents of the biomimetic stomach component, which results in the inability to weigh in real time and the cumbersome weighing process. This invention provides an automatic gastric emptying monitoring device for a biomimetic digestive system. The weighing component is rotated and mounted on a turntable via a rotating shaft and a circular hole. Gravity ensures that the weighing component remains horizontal, thus enabling real-time online monitoring of gastric emptying data. The turntable causes the biomimetic stomach component to rotate, discharging digestive products onto the weighing component. This also achieves automatic sampling of the biomimetic stomach component, greatly reducing the difficulty of the sampling process.

[0004] To solve the above-mentioned technical problems, this utility model provides an automatic gastric emptying monitoring device for a biomimetic digestive system, comprising:

[0005] A turntable is configured to rotate, and the angle between the center line of the turntable and the vertical direction is not zero. A bionic stomach component is provided on the turntable.

[0006] A weighing assembly includes a first container, a measuring instrument housed within the first container, and a second container. The measuring instrument is used to weigh the second container. The second container is connected to the pylorus of the bionic stomach assembly. The first container includes a container body and a rotating shaft. The container body has a circular hole, and the rotating shaft passes through the circular hole and is rotatably connected to the container body. The rotating shaft is connected to the turntable and extends in a horizontal direction.

[0007] In one embodiment of this utility model, the first container is configured as a hanging bucket, and the two ends of the rotating shaft pass through the circular lifting lug holes on both sides of the hanging bucket.

[0008] In one embodiment of this utility model, the second container is configured as a beaker.

[0009] In one embodiment of this utility model, the turntable is provided with a support rod, and the support rod is connected to the rotating shaft.

[0010] In one embodiment of this utility model, the end of the support rod is provided with a shaft hole, and the support rod is rotatably connected to the rotating shaft through the shaft hole.

[0011] In one embodiment of this utility model, the turntable is disposed in the biomimetic digestive system area, and the weighing component is disposed in the online weighing area.

[0012] In one embodiment of the present invention, a weighing pan housed within the first container is further included, the weighing pan supporting the second container, and the measuring instrument weighing the weighing pan and the second container.

[0013] In one embodiment of this utility model, the measuring instrument is configured as a cantilever beam weighing sensor.

[0014] In one embodiment of this utility model, the angle between the center line of the turntable and the vertical direction is ninety degrees.

[0015] In one embodiment of the present invention, a pyloric venting component is further provided on the turntable, the pyloric venting component being used to control the opening size and opening and closing frequency of the pyloric valve.

[0016] In one embodiment of this utility model, a base is fixedly disposed at the bottom of the container body, and the base is fixedly connected to the measuring instrument.

[0017] Compared with the prior art, the above-mentioned technical solution of this utility model has the following beneficial effects:

[0018] The automatic gastric emptying monitoring device of the bionic digestive system described in this utility model sets the weighing component on a turntable. By synchronously rotating the turntable, the weighing component and the bionic stomach component are automatically discharged from the bionic stomach component to the weighing component. This not only enables real-time online monitoring of gastric emptying data but also achieves automatic sampling of the bionic stomach component, greatly reducing the difficulty of sampling. The first container is movably connected to the turntable through a rotating shaft and a circular hole, ensuring that the first container is always automatically adjusted to a horizontal state during the rotation of the turntable. There is no need for manual adjustment of the position of the measuring instrument and the second container, which improves the stability and convenience of the weighing operation. Attached Figure Description

[0019] To make the content of this utility model easier to understand, the present utility model will be further described in detail below with reference to specific embodiments and accompanying drawings.

[0020] Figure 1 This is a schematic diagram of the automatic gastric emptying monitoring device of the bionic digestive system in a preferred embodiment of the present invention;

[0021] Figure 2 for Figure 1 The diagram shows the structure of the weighing assembly.

[0022] Figure 3 for Figure 1 A schematic diagram of one embodiment of the weighing component is shown.

[0023] Explanation of the reference numerals in the instruction manual: 1. Bionic digestive system area; 2. Online weighing area; 3. Turntable; 4. Pyloric effusion assembly; 5. Rotating shaft; 6. First container; 7. Second container; 8. Measuring instrument; 9. Support rod; 10. Weighing pan; 11. Support column; 12. Base; 13. Flexible tube; 14. Bionic stomach assembly; 15. Round hole; 16. Rotating shaft; 17. Limiting element; 18. Handle. Detailed Implementation

[0024] The present invention will be further described below with reference to the accompanying drawings and specific embodiments, so that those skilled in the art can better understand and implement the present invention. However, the embodiments are not intended to limit the present invention.

[0025] Reference Figure 1 and Figure 2 As shown, in one embodiment of this utility model, an automatic gastric emptying monitoring device for a biomimetic digestive system is disclosed, comprising,

[0026] Turntable 3 is rotatable and the angle between the center line of turntable 3 and the vertical direction is not zero. It can be understood that turntable 3 is set vertically or tilted. A bionic stomach component 14 is provided on turntable 3. The bionic stomach component 14 is used to simulate the digestion and crushing process of the human stomach. During sampling, the bionic stomach component 14 can use turntable 3 to achieve a rotation angle of 0~45° to complete the emptying of the product of bionic stomach component 14, reducing the sampling difficulty for experimental personnel.

[0027] The weighing component includes a first container 6, a measuring instrument 8 housed within the first container 6, and a second container 7. The second container 7 is connected to the pylorus of the bionic stomach component 14, allowing the digestive products of the bionic stomach component 14 to be discharged into the second container 7 through the pylorus. The measuring instrument 8 is used to weigh the second container 7 and the digestive products within it. The first container 6 includes a container body and a rotating shaft 5. The container body houses the second container 7 and the measuring instrument 8. The container body has a circular hole 15, through which the rotating shaft 5 passes and is rotatably connected to the container body. The rotating shaft 5 is connected to the turntable 3 and extends horizontally. During gastric emptying, as the turntable 3 slowly rotates, the first container 6 rotates around the rotating shaft 5 using its own weight to maintain a horizontal position, thereby ensuring that the measuring instrument 8 can always accurately weigh the second container 7. This achieves real-time online weighing of the digestive products of the bionic stomach component 14, solving the problem that researchers need to constantly adjust the position of the measuring instrument 8, and making gastric emptying monitoring automatic, real-time, and convenient.

[0028] Furthermore, the turntable 3 is configured as a circular turntable 3, and the bionic stomach component 14 is disposed on one side of the circular turntable 3 in order to control the bionic stomach component 14 to rotate at a uniform speed and smoothly.

[0029] Reference Figure 2 As shown, the first container 6 is further configured as a bucket, which can accommodate the measuring instrument 8 and the second container 7, preventing the measuring instrument 8 and the second container 7 from falling and being damaged during the rotation of the turntable 3. The bucket structure is relatively sturdy and can bear the weight of the bionic stomach component 14 product. The two ends of the rotating shaft 5 pass through the circular lifting lug holes on both sides of the bucket, realizing the rotational connection between the rotating shaft 5 and the bucket.

[0030] Furthermore, the two ends of the rotating shaft 5 are provided with limiting parts for limiting the position of the bucket, to prevent the rotating shaft 5 from passing through the circular lifting lug hole.

[0031] Reference Figure 2 As shown, the second container 7 is further configured as a flat-bottomed beaker. The flat-bottomed beaker can be placed stably on the measuring instrument 8 and is not easy to tip over. The transparent material of the flat-bottomed beaker makes it easy to observe experimental phenomena and liquid color changes, and it is also easy to clean.

[0032] Reference Figure 1 As shown, the turntable 3 is further provided with an inclined support rod 9, which is used to connect the rotating shaft 5 and support the weighing component on one side of the bionic stomach component 14 to avoid interference between the first container 6 and the turntable 3.

[0033] Furthermore, in another embodiment, the support rod 9 is rotatably connected to the turntable 3 so that the height of the weighing assembly can be adjusted by rotating the support rod 9.

[0034] Furthermore, to facilitate the installation and disassembly of the weighing assembly, the end of the support rod 9 is provided with a shaft hole. The support rod 9 is rotatably connected to the rotating shaft 5 through the shaft hole. When installing the first container 6, the shaft hole can be aligned with the two circular lifting lug holes, and then the rotating shaft 5 can be passed through the shaft hole and the two circular lifting lug holes to complete the movable connection of the three. When disassembling the weighing assembly, the rotating shaft 5 can be pulled out, which improves the installation efficiency.

[0035] Reference Figure 1 As shown, the turntable 3 is further disposed in the biomimetic digestive system area 1, and the weighing component is disposed in the online weighing area 2. During online weighing, there is no need to transfer the sample, which reduces the risk of contamination and ensures the accuracy of the experimental results.

[0036] Reference Figure 2 As shown, it further includes a weighing pan 10 housed in the first container 6. The weighing pan 10 is used to horizontally support the second container 7 to prevent the second container 7 from tipping over. The measuring instrument 8 weighs the weighing pan 10 and the second container 7.

[0037] Reference Figure 2 As shown, the measuring instrument 8 is further configured as a cantilever beam load cell, which can provide high-precision measurement results, with a maximum range of 2000g and a measurement accuracy of 0.1g.

[0038] Reference Figure 1 As shown, the center line of the turntable 3 is at an angle of 90 degrees to the vertical direction, that is, the turntable 3 is set vertically so that the products produced by the bionic stomach component 14 can be completely emptied by rotating the turntable 3. In other embodiments, the turntable 3 can be set at an angle.

[0039] Reference Figure 1As shown, it further includes a pyloric emptying component 4 disposed on the turntable 3. The pyloric emptying component 4 is used to control the opening size and opening frequency of the pylorus. The pyloric emptying component 4 can simulate the physiological behavior of the human pylorus, including periodic opening and closing and different opening sizes, so that the experimental conditions are closer to the real digestive environment. The pyloric emptying component 4 and the circular turntable 3 together realize the gastric emptying function of the bionic stomach component 14.

[0040] Furthermore, the pylorus is connected to the second container 7 via a flexible hose 15.

[0041] Reference Figure 2 As shown, in order to improve the stability of the measuring instrument 8, a base 12 is further included, which is fixedly installed at the bottom of the container body and is fixedly connected to the measuring instrument 8.

[0042] Furthermore, the weighing sensor and the weighing pan 10 are supported by the support column 11.

[0043] In one embodiment of this utility model, the bucket is provided with a semi-circular handle 18, the middle part of which is fixedly connected to the support rod 9, and the semi-circular handle 18 is horizontally arranged so that its axis extends in the vertical direction, which can avoid the hose 13; two rotating shafts 16 are rotatably arranged at both ends of the semi-circular handle 18, and the two rotating shafts 16 pass through two circular lifting lug holes on both sides of the bucket, and the two ends of the two rotating shafts 16 are locked by limiting members 17.

[0044] Furthermore, the limiting component 17 is set as a nut.

[0045] The working principle of the automatic gastric emptying monitoring device of the biomimetic digestive system described in this utility model is as follows:

[0046] The opening size and frequency of the pylorus are set by the pylorus control component. During sampling, after the pylorus opens, the turntable 3 rotates slowly clockwise or counterclockwise, so that the products inside the bionic stomach component 14 are automatically discharged into the second container 7 through the pylorus. As the turntable 3 rotates, the first container 6 uses gravity to rotate around the rotating axis 5 to adaptively adjust to a horizontal state, ensuring that the measuring instrument 8 always remains horizontal so as to accurately weigh the products of the second container 7 and the bionic stomach component 14 in real time, and obtain the real-time online data of gastric emptying of the bionic stomach component 14.

[0047] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the protection scope of this invention.

Claims

1. An automatic gastric emptying monitoring device for a biomimetic digestive system, characterized in that, include, A turntable is configured to rotate, and the angle between the center line of the turntable and the vertical direction is not zero. A bionic stomach component is provided on the turntable. A weighing assembly includes a first container, a measuring instrument housed within the first container, and a second container. The measuring instrument is used to weigh the second container. The second container is connected to the pylorus of the bionic stomach assembly. The first container includes a container body and a rotating shaft. The container body has a circular hole, and the rotating shaft passes through the circular hole and is rotatably connected to the container body. The rotating shaft is connected to the turntable and extends in a horizontal direction.

2. The automatic gastric emptying monitoring device for a biomimetic digestive system according to claim 1, characterized in that, The first container is configured as a hanging bucket, and the two ends of the rotating shaft pass through the circular lifting lug holes on both sides of the hanging bucket.

3. The automatic gastric emptying monitoring device for a biomimetic digestive system according to claim 1, characterized in that, The second container is a beaker.

4. The automatic gastric emptying monitoring device for a biomimetic digestive system according to claim 1, characterized in that, The turntable is equipped with a support rod, which is connected to the rotating shaft.

5. The automatic gastric emptying monitoring device for a biomimetic digestive system according to claim 4, characterized in that, The end of the support rod is provided with a shaft hole, and the support rod is rotatably connected to the rotating shaft through the shaft hole.

6. The automatic gastric emptying monitoring device for a biomimetic digestive system according to claim 1, characterized in that, The turntable is located in the biomimetic digestive system area, and the weighing component is located in the online weighing area.

7. The automatic gastric emptying monitoring device for a biomimetic digestive system according to claim 1, characterized in that, It also includes a weighing pan housed in the first container, the weighing pan supporting the second container, and the measuring instrument weighing the weighing pan and the second container.

8. The automatic gastric emptying monitoring device for a biomimetic digestive system according to claim 1, characterized in that, The measuring instrument is a cantilever beam weighing sensor.

9. The automatic gastric emptying monitoring device for a biomimetic digestive system according to claim 1, characterized in that, The angle between the center line of the turntable and the vertical direction is ninety degrees.

10. An automatic gastric emptying monitoring device for a biomimetic digestive system according to claim 1, characterized in that, It also includes a pyloric venting assembly disposed on the turntable, the pyloric venting assembly being used to control the opening size and opening frequency of the pyloric valve.

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