Light treatment device for treating Alzheimer's disease and related conditions thereof

Abstract

The utility model provides a light treatment device for treating Alzheimer's disease and related diseases, which comprises a bearing mechanism, an array of near-infrared irradiation units and a control part, and is characterized in that the bearing mechanism is configured to form an accommodating space for the head of an object; the array of the near-infrared irradiation units is borne on the bearing mechanism and is configured to emit near-infrared light into the accommodating space, and the array of the near-infrared irradiation units performs local concentrated irradiation or multi-region wide irradiation on the head of an object located in the accommodating space under the action of the control part. Local concentrated irradiation can be used for treating lesion areas, and multi-area wide irradiation can be used for modulating and exciting cell populations in a larger proportion. According to the method, the AD change response of the area corresponding to the symptom can be inhibited, and the change response can be transmitted and diffused to other cell populations on the AD development space trajectory, so that the AD inhibition effect in a larger range is realized, and the application scene is wider.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular, to a light treatment device for treating Alzheimer's disease and its associated diseases. BACKGROUND

[0002] Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disease that mainly affects the elderly, especially people over 60 years old. The disease is characterized by memory loss, loss of social and occupational function, reduced executive function, speech and motor defects, personality changes, and behavioral and psychological disorders. The deterioration process can last for 8-10 years, and there is currently no complete cure, which brings a heavy burden to families and society.

[0003] The existing technology has different and even contradictory statements on the irradiation mode and dose of near-infrared light treatment devices, which hinders the promotion and development of near-infrared light treatment devices and even near-infrared light treatment methods. CONTENT OF THE UTILITY MODEL

[0004] The present application provides a light treatment device for treating Alzheimer's disease and its associated diseases, comprising: a bearing mechanism configured to form an accommodation space for the head of a subject; an array of near-infrared irradiation units carried on the bearing mechanism and configured to emit near-infrared light into the accommodation space; and a control unit, wherein the array of near-infrared irradiation units performs local concentrated irradiation or multi-zone extensive irradiation on the head of the subject located in the accommodation space under the action of the control unit.

[0005] Local concentrated irradiation can be performed in a local area, such as but not limited to 30% to 65% of the surface area of the calvaria of the head of the subject, such as the prefrontal part (mainly connected with the frontal lobe function), the parietal part (mainly connected with the parietal lobe function), etc. A relatively high dose of treatment can be achieved. Multi-zone extensive irradiation can perform synergistic multi-zone irradiation on at least two of the prefrontal part (mainly connected with the frontal lobe function), the parietal part (mainly connected with the parietal lobe function), and the left and right lateral parts of the head (mainly connected with the left and right temporal lobe functions), and the irradiation range can reach more than 65% of the surface area of the calvaria of the head of the subject. By local concentrated irradiation or multi-zone extensive irradiation, the array of near-infrared irradiation units can be controlled to meet the predetermined synergistic irradiation conditions of the irradiation surface area ratio and the irradiation power level, thereby achieving "modulation" and "excitation" of a larger proportion of cell populations. Not only can the biochemical response of AD be inhibited at the irradiation site, but also the biochemical response (e.g., "modulation" and "excitation" of cell populations) can be transmitted and diffused to other cell populations on the spatial trajectory of AD development, thereby achieving an AD inhibition effect in a larger range. In other words, the light treatment device of the present application not only supports multi-zone extensive irradiation in a larger range, but also retains the function of local concentrated irradiation, making the use scenarios more diverse.

[0006] A series of simplified forms are introduced in the utility model content, which will be further described in detail in the specific embodiment part. The utility model content part does not mean to try to limit the key features and necessary technical features of the claimed technical solution, and more does not mean to try to determine the protection scope of the claimed technical solution.

[0007] The advantages and features of the present application will be described in detail below in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF DRAWINGS

[0008] The following drawings of the present application are hereby incorporated into the present application as part of the present application for understanding the present application. The embodiments of the present application and its description shown in the drawings are used to explain the principles of the present application. In the drawings,

[0009] Fig. 1(a) shows a schematic diagram of a light treatment device according to a first embodiment of the present application;

[0010] Fig. 1(b) shows a structural schematic diagram of a head-mounted device of the light treatment device according to the first embodiment of the present application;

[0011] Fig. 2(a) shows a schematic diagram of a light treatment device according to a second embodiment of the present application;

[0012] Fig. 2(b) shows a schematic diagram of a light treatment device according to a third embodiment of the present application;

[0013] Figure 3 Fig. 4 shows a bottom view of a headgear of a light treatment device according to a fourth embodiment of the present application;

[0014] Figure 4 Fig. 5 shows a division manner of a cranial anterior upper portion, a cranial top portion, a cranial left side portion and a cranial right side portion according to the present application. DETAILED DESCRIPTION

[0015] In the following description, a large number of details are provided in order to be able to thoroughly understand the present application. However, it can be appreciated by those skilled in the art that the following description only shows the preferred embodiments of the present application in some embodiments, and the present application can be implemented without one or more such details. In addition, in order to avoid confusion with the present application, some technical features known in the art are not described in detail.

[0016] In order to keep the following description of the embodiments of the present application clear and concise, the present application omits the detailed description of known functions and known components.

[0017] The term "irradiation to the head of the subject" or "irradiation to the head of the subject" in the present application is intended to mean irradiation to the outer thin irradiation surface of the scalp of the head of the subject (i.e. irradiation to the scalp of the head of the subject) immediately adjacent to the hair (or the scalp where there is no hair) of the scalp of the head of the subject. The near-infrared light irradiation to the outer thin irradiation surface means that the irradiation energy of the near-infrared light is transmitted to the scalp of the head of the subject including the hair, the scalp, the skull and the brain tissue. Further, the energy transmitted after absorption by the hair and attenuation by the scalp and the skull, the remaining energy capable of acting on the cortex or even deeper parts of the brain tissue is related to the attenuation on the transmission path.

[0018] The light treatment device comprises a carrying mechanism 101 and an array of near-infrared irradiation units 102. The carrying mechanism 101 is configured to form an accommodation space for the head 103 of the subject and carries the array of near-infrared irradiation units 102. The array of near-infrared irradiation units 102 is configured to emit near-infrared light into the accommodation space. The carrying mechanism 101 and the array of near-infrared irradiation units 102 can adopt various configurations as required, for example, refer to FIG. 1(a), FIG. 2(a) and FIG. 2(b), which will be described in detail below, but the structure of the light treatment device is not limited thereto.

[0019] The light treatment device further comprises a control unit (not shown), wherein the array of near-infrared irradiation units 102 performs local concentrated irradiation or multi-zone extensive irradiation to the head of the subject located in the accommodation space under the action of the control unit. The control unit can be electrically connected to a user terminal 19 configured to be interacted by the user. Specifically, the user terminal 19 can be configured with a computer storage medium, and the computer storage medium stores executable instructions, and when the computer executable instructions are executed by a processor, various interaction steps with the user can be realized. The storage medium can include read-only memory (ROM), flash memory, random access memory (RAM), dynamic random access memory (DRAM) such as synchronous DRAM (SDRAM) or Rambus DRAM, static memory (e.g. flash memory, static random access memory), etc., on which computer executable instructions can be stored in any format. In some embodiments, the control unit is further configured to receive a confirmation operation of the user on the proposed infrared light treatment scheme via the user terminal 19; after receiving the confirmation operation, irradiation is performed according to the confirmed infrared light treatment scheme, for example, local concentrated irradiation or multi-zone extensive irradiation.

[0020] Specifically, the control unit for controlling the irradiation can be located on the user terminal 19, on the headgear 100, or in a host computer separate from the user terminal 19 (in the bottom box shown in Fig. 1(a)). For example, the control unit and the driving circuit can not be provided in the headgear 100, but can be wired to or arranged in the host computer to control and drive the individual near-infrared irradiation units via the wiring to provide the required time-averaged total irradiance and the time-space-averaged optical power density. For another example, the control unit and the driving circuit can be provided in the headgear to control and drive the individual near-infrared irradiation units to provide the required time-averaged total irradiance and the time-space-averaged optical power density. The entire light treatment device can be integrated in the headgear.

[0021] In the present application, the "time-averaged optical power density" is intended to mean the optical power density averaged with respect to time. For example, the "time-averaged optical power density" at a target site is intended to mean the optical power density averaged with respect to time at the target site. For another example, the "time-averaged optical power density" at a target portion is intended to mean the "time-averaged optical power density" at a representative position on the target portion. Specifically, the "time-averaged optical power density" at a target portion is 30-60 mW / cm 2 , meaning that the time-averaged optical power density at each representative position on the target portion, such as but not limited to the position corresponding to the center of the lamp panel, fluctuates within the range of 30-60 mW / cm 2 .

[0022] The "time-space-averaged optical power density" to a target region is intended to mean the time-averaged optical power density averaged with respect to the surface area of the target region, that is, the optical power density after performing the averaging operation with respect to both the surface area and the time.

[0023] The control unit can be implemented by various processors, and can be a processing device including one or more general-purpose processing devices, such as a microprocessor, a central processing unit (CPU), a graphics processing unit (GPU), etc., or one or more special-purpose processor devices, such as an application-specific integrated circuit (ASIC), a field-programmable gate array (FPGA), a digital signal processor (DSP), a system on chip (SoC), etc. Preferably, most of the computation and processing are concentrated in the user terminal 19 to reduce the computational load and the software and hardware cost of the headgear 100. The headgear 100 is suspended to the support 20 via the elastic member 21, and the support 20 adopts a three-section free-pivot structure to facilitate flexible adjustment of the position of the headgear 100. In some embodiments, the light treatment device also carries a refrigerator 23 to introduce cold air into the light treatment device to perform sufficient and comfortable cooling around the head 103 of the subject, for example, to stabilize the temperature at about 43 degrees Celsius, or even at about 41 degrees Celsius.

[0024] The local concentrated irradiation can be performed on a portion of the subject's head, such as but not limited to 30% to 65% (not including 65%) of the surface area of the scalp of the subject's head, for example less than 50%, less than 45%, less than 40%, and minimally 30%, for a relatively high dose of treatment. The multi-zone extensive irradiation can be performed on at least two of the subject's head, such as but not limited to the front of the head (mainly associated with the frontal lobe), the top of the head (mainly associated with the parietal lobe), and the left and right sides of the head (mainly associated with the temporal lobe), for a synergistic multi-zone irradiation, and the irradiation range can be more than 65% of the surface area of the scalp of the subject's head. By the local concentrated irradiation or the multi-zone extensive irradiation, the array of near-infrared irradiation units 102 can be controlled to meet the predetermined synergistic irradiation conditions of the irradiation surface area ratio and the irradiation power level, so as to achieve the "modulation" and "excitation" of a larger proportion of the cell population. Not only can the biochemical response of inhibiting AD be excited at the irradiation site, but also the biochemical response (e.g., the "modulation" and "excitation" of the cell population) can be transmitted and spread to other cell populations on the spatial trajectory of AD development, so as to achieve an AD inhibiting effect in a larger range. In other words, the light treatment device of the present application not only supports a larger range of multi-zone extensive irradiation, but also retains the function of local concentrated irradiation, and has a wider use scenario. By setting an array of near-infrared irradiation units of a suitable structure (see FIG. 1(b), FIG. 2(a), and FIG. 2(b)), the operation parameters of the array of near-infrared irradiation units can be controlled to meet the required predetermined synergistic irradiation conditions. The control of the near-infrared irradiation units can be achieved through, for example, an MCU and a driving circuit, which can be easily used by those skilled in the art, and will not be described here. Taking a lamp panel composed of a group of LED devices as an example of the near-infrared irradiation unit, selecting a suitable configuration of LED devices, for example, the time-averaged light power density of the exit surface is 70-120 mW / cm 2 , and a suitable number of lamp panels are arranged in a three-dimensional surround manner, the time-averaged total irradiation power and the space-time averaged light power density of the predetermined irradiation range can be achieved.

[0025] Exemplarily, the bearing mechanism 101 and the array of near-infrared irradiation units 102 are arranged on the head cap 100. FIG. 1(b) shows an exemplary structure of such a loose head cap 100. As can be seen, the head cap includes a middle shell as the bearing mechanism and near-infrared irradiation units mounted on the middle shell. The inner shell is the shell layer closest to the patient's head when worn by the patient, the middle shell and the inner shell form a cold air cavity, and the inner shell is arranged to be light-transmitting, so that the near-infrared light (e.g., wavelength of 800-850 nm) emitted by the near-infrared irradiation units can pass through the light-transmitting inner shell into the containing space to irradiate the patient's head with sufficient dose.

[0026] Fig. 2(a) shows a schematic diagram of a light treatment device according to a second embodiment of the present application. As shown in Fig. 2(a), the light treatment device further comprises a communication-connected headgear 100 and a portable control terminal 104.

[0027] Fig. 2(b) shows a schematic diagram of a light treatment device according to a third embodiment of the present application, the control and processing terminal of which can refer to the previous embodiments and is not shown here for simplicity of description. Unlike the headgear 100 shown in Fig. 1(b) and Fig. 2(a), the carrying mechanism 101 can further form a significantly wider accommodation space in the shape of an arch or an umbrella, and the distance to the subject's head 103 is also farther. Moreover, the carrying mechanism 101 is rigidly mounted to a support or a wall, and the array of near-infrared irradiation units 102 forms a separate irradiation module mounted to the inner wall of the carrying mechanism 101.

[0028] Exemplarily, the control unit is provided in a host, which can be the user terminal 19 described above, and the user can directly operate on the host. The host can be further electrically connected to the user terminal 19, and the user can operate through, for example, a mobile phone APP, a computer upper computer or an operation part connected to the host. The host can be connected to the headgear 100 via wired or wireless means. In this way, most of the calculation and processing are concentrated in the host, so as to reduce the calculation load and software and hardware cost of the headgear 100.

[0029] Exemplarily, the array of near-infrared irradiation units 102 emits near-infrared light under the action of the control unit, and the irradiation to the subject's head satisfies the synergistic irradiation condition of the irradiation surface area ratio and the irradiation power level. The irradiation surface area ratio is the ratio of the irradiation surface area to the reference head cover surface area, and the irradiation surface area ratio of local concentrated irradiation can be as low as 30%, and the multi-zone extensive irradiation can be as high as more than 65%.

[0030] The irradiation surface area ratio synergistically matched with the irradiation power level in this range can achieve the "modulation" and "excitation" of the sufficient proportion of cell populations. After the sufficient proportion of cell populations are "modulated" and "excited", not only the change response of AD inhibition occurs in themselves, but also the change response can be transmitted and diffused to other cell populations on the AD development spatial trajectory, so as to achieve the overall AD inhibition effect in the whole brain range. In this way, not only can the Aβ plaque aggregation in the neocortex be significantly reduced, the abnormal aggregation of tau protein in the neocortex, hippocampus and even marginal cortex can be significantly reduced, but also the AD-specific lesions of cell populations in the whole brain range can be inhibited and reduced, so as to effectively inhibit the progression of AD course. The applicant conducted clinical experiments on individual AD volunteers for local concentrated irradiation and multi-zone extensive irradiation of near-infrared light. Under the condition of satisfying various synergistic irradiation conditions according to the embodiments of the present application, many volunteers feedback that the spatial ability confusion and short-term memory loss have improved.

[0031] Exemplarily, the array of near-infrared irradiation units 102 comprises at least a top group and a front group, a left group and a right group under the top group to be lit up under the action of the control part to perform the multi-zone extensive irradiation. In other embodiments, the array of near-infrared irradiation units 102 further comprises a rear group arranged under the top group.

[0032] In an exemplary embodiment, the array of near-infrared irradiation units is arranged around the accommodation space. As shown in FIG. 1(b) and Figure 3 As shown, the full head irradiation can be achieved in the case that all the near-infrared irradiation units are lit up. Accordingly, the local concentrated irradiation can be performed by controlling only part of the near-infrared irradiation units to be lit up under the action of the control part. Exemplarily, the array of near-infrared irradiation units forms at least one group of a top group, a front group under the top group, or forms a left group together with a right group under the top group, or constitutes a combination of at least one group of the top group and the front group with the left group and / or the right group to be lit up under the action of the control part to perform the local concentrated irradiation.

[0033] In some embodiments, the adapted synergistic irradiation conditions can be provided for the local concentrated stimulation scheme and the multi-zone balanced stimulation scheme. The synergistic irradiation conditions of the irradiation surface area ratio and the irradiation power level can include at least one of the following schemes. Specifically, the irradiation surface area ratio of the local concentrated stimulation scheme is less than the multi-zone balanced stimulation scheme, and the matched irradiation power level is also higher than the multi-zone balanced stimulation scheme. For example, as the local concentrated stimulation scheme, the spatiotemporal average light power density required is 117 mW / cm 2 above in the case of the irradiation surface area ratio of 30% to 40%, and the spatiotemporal average light power density irradiated to the head of the object is 110 mW / cm 2 above in the case of the irradiation surface area ratio of 40% to 65%. Please note that the description of the range of % in this application is defined as follows. "Between A% to B%" is intended to include the percentage between A% to B%, but does not include A% and B%. "A% to B%" is intended to include the percentage between A% to B%, and includes both end values of A% and B%.

[0034] The multi-zone balanced stimulation scheme requires an average synergistic dose of 2750 W*% to 13600 W*%, which is the product of the irradiation surface area ratio (its percentage) and the average total power, so the unit is watt*percent. For example, the irradiation surface area ratio is 65%, so the percentage is 65, and the average synergistic dose is the average total power multiplied by 65 W*%.

[0035] Exemplarily, in the case of irradiation surface area ratio being above 65%, the average synergistic dose irradiated to the subject's head is 2750 W*% to 13600 W*%, the average synergistic dose being the product of the percentage of the irradiation surface area ratio and the average total power, and the spatio-temporal average light power density irradiated to the subject's head is 230 mw / cm 2 The following. As the distribution of the affected cell population is wider, for example, distributed in multiple brain regions, multiple brain function networks, etc., by delivering the above average synergistic dose, the cell population can be appropriately "modulated" and "stimulated", and the AD change response can be transmitted and spread to other cell populations in a wide area on the spatial trajectory of AD development. Please note that for various synergistic irradiation conditions of irradiation surface area ratio and irradiation power level, the spatio-temporal average light power density irradiated to the subject's head is 230 mw / cm 2 The following, in order to avoid thermal damage to tissue cells.

[0036] Exemplarily, the array of near-infrared irradiation units can execute one of the following irradiation modes under the action of the control unit. Since for each head cap 100, the irradiation area of the array of near-infrared irradiation units at different positions on the subject's head is relatively fixed, the spatio-temporal average light power density irradiated to the subject's head can also be determined according to the number and position of the turned-on near-infrared irradiation units. The irradiation modes include:

[0037] 1) only irradiating the upper anterior part of the subject's head, and the spatio-temporal average light power density irradiated to the subject's head is 117 mW / cm 2 above and 230 mW / cm 2 below;

[0038] 2) only irradiating the upper anterior part and the top of the subject's head, or only irradiating the upper anterior part, the left side and the right side of the subject's head, and the spatio-temporal average light power density irradiated to the subject's head is 110 mW / cm 2 above and 230 mW / cm 2 below;

[0039] 3) irradiating the upper anterior part, the left side, the right side and the top of the subject's head, and the average synergistic dose is 2750 W*% to 10400 W*%;

[0040] 4) irradiating the upper anterior part, the left side, the right side, the top and the back of the subject's head, and the average synergistic dose is 2750 W*% to 13600 W*%.

[0041] In particular, the synergistic irradiation condition of the irradiation surface area ratio and the irradiation power level can represent the correlation between the irradiation surface area ratio and the spatiotemporal average light power density, such as the synergistic irradiation condition adopted by the local concentrated stimulation scheme when the irradiation surface area ratio is between 30% to 40% or 40% to 65% as described above; or represent the product of the average total power irradiated to the head of the subject and the total irradiation surface area ratio, such as the synergistic irradiation condition adopted by the multi-zone balanced stimulation scheme when the irradiation surface area ratio is above 65% as described above. In other embodiments, the synergistic irradiation condition of the irradiation surface area ratio and the irradiation power level can adopt different definitions as needed, such as the integral of the power irradiated to each sub-zone of the head of the subject with respect to the irradiation surface area ratio of each sub-zone, or the distribution of the product of the power irradiated to each sub-zone of the head of the subject and the irradiation surface area ratio of each sub-zone, and the like. The synergistic irradiation condition refined to the sub-zone can more effectively identify the situation where the corresponding light power or light power density of the sub-zone is too low when the irradiation dose of each brain region deviates greatly, ensuring that there is no dead angle for the “modulation” and “excitation” of the cell population.

[0042] In which, the upper front part of the skull, the left side of the skull, the right side of the skull, the top of the skull and the back of the skull can be defined according to the 10-10 standard lead system in order to eliminate individual or population deviations of the head of the subject. See Figure 4 : the upper front part of the skull contains electrode positions FP2, FPZ, FP1, AF3, AF4, AF7, AF8, AFZ, FZ, F1, F2, F3, F4, F5, F6, FC1, FC2, FC3, FC4, FC5, FC6, FCZ, CZ, C1, C2; the top of the skull contains electrode positions C3, C4, C5, C6, CPZ, CP1, CP2, CP3, CP4, CP5, CP6, PZ, P1, P2, P3, P4; the left side of the skull contains electrode positions F7, FT7, T7, TP7, P5, and the right side of the skull contains electrode positions F8, FT8, T8, TP8, P6. Of course, methods of division by other means are not excluded.

[0043] Illustratively, the control unit is further configured to control the irradiation parameters of the array of near-infrared irradiation units such that when a first number of near-infrared irradiation units are turned on, the spatiotemporal average light power density provided by the exit surface thereof is lower than the spatiotemporal average light power density provided by the exit surface when a second number of near-infrared irradiation units are turned on, the second number being less than the first number by more than a predetermined number.

[0044] It is easy to understand that the irradiation surface area ratio of the local concentrated stimulation scheme to the object's head is smaller than that of the multi-zone balanced stimulation scheme. Under the same spatiotemporal average light power density, the larger the irradiation surface area, the better the treatment effect. However, in the case of excessive spatiotemporal light power density, it will also cause discomfort to the object's head, and the heat will also be relatively more intense. According to the size of the irradiation surface area, the spatiotemporal light power density can be appropriately increased or decreased to improve the treatment experience.

[0045] As described above, the inventors have creatively found that for the process effect of light therapy in treating AD, the time-averaged irradiation power level delivered to the brain tissue and the irradiation surface area ratio are important factors for synergistic effect, and accordingly, the synergistic irradiation conditions required for the near-infrared light irradiation to the object's head can be characterized in various ways. For example, the time-averaged irradiation power level can be characterized as the spatiotemporal average light power density, or the total power, or a composite parameter (such as product, integral, etc.) after operation with the irradiation surface area. In some embodiments, the array of near-infrared irradiation units, under the action of the control unit, has an average irradiation total power of 23-140 W, or 29-120 W, or 31-100 W to the spatial irradiation surface at a predetermined average distance from the array of near-infrared irradiation units in the accommodation space. In some embodiments, the corresponding spatiotemporal average irradiation total power can also be adapted according to the course of AD.

[0046] Specifically, the predetermined average distance is 4 cm or more. When the object's head is in place in the accommodation space, the left and right sides are 1-5 cm away from the array of near-infrared irradiation units, and at the same time, the top is 6-15 cm away from the array of near-infrared irradiation units. The spatial irradiation surface can represent the surface of the object's head (especially the scalp) or the spatial irradiation surface close to the surface of the head (scalp). Specifically, the inventors have creatively found that in the headgear 100 as shown, at least a few centimeters or even close to 15 centimeters of space is reserved on the top of the head when the object's head is in place, which can reduce the sense of oppression of the object during light therapy, and the near-infrared light emitted by the array of near-infrared irradiation units on the top of the head can converge to the upper part of the object's head using this space, and still maintain sufficient spatiotemporal average light power density.

[0047] For AD patients whose target area is not clear or distributed discretely, the multi-zone balanced stimulation scheme is preferred. For example, the multi-zone wide irradiation includes irradiation to the front upper part of the skull, the left side of the skull, the right side of the skull, and the top of the skull, or irradiation to the front upper part of the skull, the left side of the skull, the right side of the skull, the top of the skull, and the back of the skull. The division of each part can refer to the description in other embodiments, but is not limited thereto. Under the action of the control unit, the array of near-infrared irradiation units makes the spatiotemporal average light power density irradiated to the front upper part of the skull 50-120 mW / cm 2, the time-space average light power density irradiated to the left side of the cranium and the right side of the cranium is 32-85 mW / cm 2 , the time-space average light power density irradiated to the left side of the cranium and the right side of the cranium is 32-85 mW / cm 2 For example, the time-space average light power density irradiated to the front upper part of the cranium can be any one of all numerical points in the numerical range of 50 to 120, starting from 50 and distributed at intervals of 0.5-1. Similarly, the time-space average light power density irradiated to the top of the cranium can be any one of all numerical points in the numerical range of 60 to 120, starting from 50 and distributed at intervals of 0.5-1; the time-space average light power density irradiated to the left side of the cranium and the right side of the cranium can be any one of all numerical points in the numerical range of 32 to 85, starting from 32 and distributed at intervals of 0.5-1.

[0048] In some embodiments, the array of near-infrared irradiation units is specifically configured to emit near-infrared light with a duty cycle of 30%-70%, a wavelength of 650-1100 nm, and a frequency falling within the frequency range of Alpha waves, the frequency range of Gamma waves, or the neighborhood of both, which will not be elaborated here.

[0049] The applicant uses the light therapy device as shown in FIG. 1(a) and FIG. 1(b) to irradiate the reference head model of the subject's head, at each part of the reference head model of the subject's head, the time-space average light power density measured by the light power meter and the time average light power density of the irradiation surface of the inner shell corresponding to the center position of the lamp panel are as shown in Table 1.

[0050] Table 1 Time-space average light power density of the light therapy device at each part of the reference head model

[0051]

[0052]

[0053] As an example, the reference head phantom is made by 3D printing in comparison with the subject's head, and the surface material has a matching absorption rate of near-infrared light as that of the human head. The reference head phantom used in this test has a head width of 152 mm, a head length of 184 mm, a head circumference of 536.7 mm, a facial profile length of 109.3 mm, a head sagittal arc of 355.6 mm, an ear-to-ear arc of 324.1 mm, and a head height of 206 mm. At least some of the refined parameters are determined based on the P50 parameter values of females in this age group and the P50 parameter values of males in this age group. For example, the head width and the head length here are the average of the two corresponding P50 parameter values. The P50 parameter values of females in this age group are as follows: head width of 149 mm, head length of 180 mm, head circumference of 548 mm, facial profile length of 111 mm, head sagittal arc of 335 mm, ear-to-ear arc of 342 mm, and head height of 228 mm. The P50 parameter values of males in this age group are as follows: head width of 155 mm, head length of 188 mm, head circumference of 565 mm, facial profile length of 121 mm, head sagittal arc of 343 mm, ear-to-ear arc of 351 mm, and head height of 231 mm. It can be seen that the parameters of the reference head phantom have a good fit with the P50 parameters of females and males in this age group, and thus are more representative. Further, the cephalo-facial index of the parameters is 82%, which also corresponds to the range of the cephalo-facial index of the dominant head type in Chinese people (even East Asian population), i.e. the brachycephaly. Therefore, the parameters of the reference head phantom have particularly good representativeness in Chinese and East Asian populations. In some embodiments, for other populations with different cephalo-facial indexes, such as but not limited to the main human populations in Europe, South Asia, and Africa, the respective parameters can also be adaptively adjusted to have good representativeness.

[0054] The operating parameters of the light treatment device used in this test can be seen in Table 2 below:

[0055] Table 2 Operating parameters of the light treatment device

[0056]

[0057] In addition to the LED device, the near-infrared irradiation unit can also use a low-energy laser diode or an optical fiber that transmits near-infrared light from the outside, and the like, which will not be described here. In some embodiments, the array of near-infrared irradiation units can be specifically configured to emit continuous near-infrared light, or to emit pulsed near-infrared light.

[0058] In the description of the present application, it should be understood that the orientation words such as "front", "back", "upper", "lower", "left", "right", "transverse", "vertical", "vertical", "horizontal" and "top", "bottom" and the like indicated orientation or position relationship is generally based on the orientation or position relationship shown in the drawings, only for the convenience of describing the present application and simplifying the description, without making the opposite statement, these orientation words do not indicate and imply that the device or device must have a particular orientation or be constructed and operated in a particular orientation, therefore, it cannot be understood as a limitation on the scope of protection of the present application; the orientation words "inner", "outer" refer to the inner and outer of the contour of each component itself.

[0059] For the convenience of description, the area relative terms such as "on", "above", "upper surface", "upper" and the like can be used herein to describe the area position relationship of one or more components or features shown in the figure with other components or features. It should be understood that the area relative terms not only include the orientation of the components described in the figure, but also include different orientations in use or operation. For example, if the components in the figure are inverted as a whole, the components "above" or "above" other components or features will include the components "below" or "below" other components or structures. Thus, the exemplary term "above" can include both "above" and "below". In addition, the components or features can also be positioned at other different angles (for example, rotated by 90 degrees or other angles), and all these cases are intended to be included herein.

[0060] It should be noted that the terms used herein are only for the purpose of describing specific embodiments, and are not intended to limit the exemplary embodiments according to the present application. As used herein, the singular form is intended to include the plural form unless the context clearly indicates otherwise, and furthermore, it should be understood that when the terms "comprise" and / or "include" are used in the specification, it means that the features, steps, operations, components, assemblies and / or combinations thereof are present.

[0061] The present application has been described by the above examples, but it should be understood that the above examples are only for the purpose of example and illustration, and are not intended to limit the present application to the scope of the described embodiments. In addition, those skilled in the art can understand that the present application is not limited to the above examples, and more variations and modifications can be made according to the teachings of the present application, which are within the scope of the present application. The scope of protection of the present application is defined by the appended claims and their equivalent scope.

Claims

1. A light therapy device for the treatment of Alzheimer's disease and its associated conditions, characterized in that, The application comprises: a bearing mechanism configured to form a containing space for a subject's head; an array of near-infrared irradiation units carried on the bearing mechanism and configured to emit near-infrared light into the containing space; and a control unit, wherein the array of near-infrared irradiation units, under the action of the control unit, performs local concentrated irradiation or multi-zone extensive irradiation on the subject's head located in the containing space. At least the bearing mechanism and the array of near-infrared irradiation units are provided in a headgear.

2. The light therapy device of claim 1, wherein, The control unit is provided in a host computer connected to the headgear via wired or wireless means.

3. The light therapy device of claim 2, wherein, The array of near-infrared irradiation units, under the action of the control unit, emits near-infrared light, and the irradiation on the subject's head meets the synergistic irradiation condition of irradiation surface area ratio and irradiation power level, the irradiation surface area ratio is the ratio of irradiation surface area to reference head cover surface area, the irradiation surface area ratio of the local concentrated irradiation can be as low as 30%, and the multi-zone extensive irradiation can be as high as more than 65%.

4. The light therapy device of claim 1, wherein, The array of near-infrared irradiation units at least includes a top group and a front group, a left group and a right group below the top group, which are lit under the action of the control unit to perform the multi-zone extensive irradiation.

5. Light therapy device according to any of claims 1-4, characterized in that, The array of near-infrared irradiation units forms at least one group of a top group and a front group below the top group, or forms a left group and a right group below the top group, or forms a combination of at least one group of the top group and the front group and a left group and / or a right group, which are lit under the action of the control unit to perform the local concentrated irradiation.

6. Light therapy device according to any of claims 1-4, characterized in that, The synergistic irradiation condition met by the array of near-infrared irradiation units includes at least one of the following:

7. The light therapy device of claim 4, wherein, The array of near-infrared irradiation units, under the action of the control unit, performs one of the following irradiation modes: In the case where the irradiated surface area ratio of the emitted near-infrared light to the head of the subject is 30% to 40%, the spatiotemporal average light power density irradiated to the head of the subject is 117 mW / cm 2 The above and 230 mW / cm 2 The following; The spatio-temporal average optical power density irradiated to the subject's head is 110 mW / cm 2 above and 230 mW / cm 2 below; In the case where the irradiation surface area ratio is 65% or more, the spatio-temporal average synergistic dose of 2750 W*% to 13600 W*% is irradiated to the head of the subject, the spatio-temporal average synergistic dose being a product of the percentage of the irradiation surface area ratio and the average total power, and the spatio-temporal average light power density of 230 mw / cm2 or more is irradiated to the head of the subject. 2 The following.

8. The light therapy device of claim 4, wherein, irradiates the cranial anterior superior part, the cranial left side, the cranial right side and the cranial top of the subject's head, and the average synergistic dose is 2750W*% to 10400W*%; Only the cranial anterior upper portion of the subject's head is irradiated, and the spatio-temporal average optical power density irradiated to the subject's head is 117 mW / cm 2 Above and 230 mW / cm 2 Below; when irradiating only the cranial anterior upper portion and the cranial top portion of the subject's head, or when irradiating only the cranial anterior upper portion, the cranial left side portion, and the cranial right side portion of the subject's head, and the spatiotemporal average light power density irradiated to the subject's head is 110 mW / cm 2 above and 230 mW / cm 2 below; irradiates the cranial anterior superior part, the cranial left side, the cranial right side, the cranial top and the cranial posterior part of the subject's head, and the average synergistic dose is 2750W*% reference head cover surface area to 13600W*%. The control unit is further configured to control the irradiation parameters of the array of near-infrared irradiation units, so that when a first number of near-infrared irradiation units are lit, the spatio-temporal average light power density provided by the exit surface thereof is lower than that when a second number of near-infrared irradiation units are lit, the second number being less than the first number by a predetermined number or more.

9. Light therapy device according to any of claims 1-4, characterized in that, The array of near-infrared irradiation units, under the action of the control unit, has an average total irradiation power of 23-140W, or 29-120W, or 31-100W on the spatial irradiation surface in the containing space at a predetermined average distance from the array of near-infrared irradiation units.

10. Light therapy device according to any of claims 1-4, characterized in that, ​ 11. Light therapy device according to any of claims 1-4, characterized in that, The multi-zone broad irradiation includes: irradiating the upper front part of the skull, the left part of the skull, the right part of the skull and the top part of the skull of the head of the subject, or irradiating the upper front part of the skull, the left part of the skull, the right part of the skull, the top part of the skull and the back part of the skull of the head of the subject, when the head of the subject is located in the accommodating space, The array of near-infrared irradiation units, under the action of the control unit, irradiates the cranial anterior upper part with a spatiotemporal average light power density of 50-120 mW / cm 2 irradiates the cranial top part with a spatiotemporal average light power density of 60-120 mW / cm 2 irradiates the cranial left side and the cranial right side with a spatiotemporal average light power density of 32-85 mW / cm 2 .

12. Light therapy device according to any of claims 1-4, characterized in that, The array of near-infrared irradiation units is specifically configured to emit near-infrared light with a duty cycle of 30%-70%, a wavelength of 650-1100 nm, and a frequency falling within the frequency range of Alpha waves, the frequency range of Gamma waves, or the neighborhood of both.

13. The light therapy device of claim 9, wherein, The near-infrared irradiation units are composed of a plurality of LED devices, and the average optical power of a single LED device is 90 mW or more.

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