Double-optical-path slide scanner

Abstract

The utility model provides a double-light-path slide scanner which comprises a base, a movable first moving table is arranged on the base, a movable second moving table is arranged on the first moving table, the second moving table is used for placing a slide clamp, the moving direction of the first moving table is perpendicular to the moving direction of the second moving table, a vertical frame is arranged at one end of the base, and a light source is arranged at the other end of the base. The vertical frame is provided with the scanning mirror, the scanning mirror is provided with the first light splitting path and the second light splitting path which are different in amplification factor, the tail end of the first light splitting path is provided with the first camera, the tail end of the second light splitting path is provided with the second camera, and the problem that a traditional single-light-path scanning mirror is difficult to achieve image scanning of various different amplification factors is solved.

Description

Technical Field

[0001] This utility model relates to the field of cell and tissue detection, and in particular to a dual-light-path slide scanner. Background Technology

[0002] Cell and tissue analysis typically requires a slide scanner, which incorporates a microscope with image scanning capabilities. After preparing cell and tissue slides, the slides are inserted into the microscope objective for observation and scanning. Small, stand-alone slide scanners usually have the main scanning structure encapsulated internally, making it difficult to manually switch objectives and change the magnification. Generally, they can only perform fixed-magnification imaging, making them unsuitable for analyzing various tissues or cells. Utility Model Content

[0003] This invention provides a dual-light-path slide scanner, which solves the problem that traditional single-light-path scanning mirrors cannot achieve image scanning at various magnifications.

[0004] To solve the above-mentioned technical problems, the technical solution adopted by this utility model is: a dual-light-path slide scanner, including a base, a movable first moving stage on the base, a movable second moving stage on the first moving stage, the second moving stage being used to place slide holders, the moving direction of the first moving stage being perpendicular to the moving direction of the second moving stage, a stand at one end of the base, a scanning mirror on the stand, the scanning mirror having a first beam splitter and a second beam splitter with different magnifications, a first camera at the end of the first beam splitter, and a second camera at the end of the second beam splitter.

[0005] In a preferred embodiment, the scanning mirror includes an objective lens, a first magnifying lens, a second magnifying lens, and a beam splitter. The scanning mirror has a main optical path, in which the objective lens is located. Light passes through the objective lens and reaches the beam splitter, where it is split into a first beam splitter and a second beam splitter. The first beam splitter has a first magnifying lens, and the second beam splitter has a second magnifying lens. The magnification of the first magnifying lens and the second magnifying lens are different.

[0006] In the preferred embodiment, a reflector is provided in the second beam splitter path.

[0007] In the preferred embodiment, the beam splitter is a semi-transparent, semi-reflective mirror.

[0008] In a preferred embodiment, a first drive motor is provided on the base, a first lead screw is connected to the shaft end of the first drive motor, a first lead screw nut is provided on the first moving platform, and the first lead screw nut is sleeved with the first lead screw.

[0009] In a preferred embodiment, a second drive motor is provided on the first moving platform, a second lead screw is connected to the shaft end of the second drive motor, and a second lead screw nut is provided on the second moving platform, with the second lead screw nut sleeved with the second lead screw.

[0010] In the preferred embodiment, a third drive motor is provided on the upright frame, a third lead screw is connected to the shaft end of the connecting frame, and a connecting frame is also provided. The connecting frame is provided with a third lead screw seat, which is sleeved with the third lead screw. The other end of the connecting frame is connected to the scanning mirror.

[0011] In a preferred embodiment, the scanning device is further provided with an outer casing, the front of which is provided with a clip slot and an HMI, and the upper end of the outer casing is provided with a handle structure.

[0012] In a preferred embodiment, a preview camera facing the slide holder is mounted on the stand.

[0013] The beneficial effects of this utility model are as follows: a beam splitting device is used to split two branch beam paths from the main beam path. The branch beam paths are equipped with mirror groups with different magnifications and use their own independent cameras to receive images. Image scanning with two different magnifications can be achieved without manual operation. The position of the glass slide is adjusted by a two-dimensional moving stage and the scanning mirror is automatically focused, so that sample images can be continuously and automatically captured. The two beam splitting mirror tubes and cameras are arranged vertically and crosswise, making the design more compact. Attached Figure Description

[0014] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0015] Figure 1 This is a schematic diagram of the scanner's exterior.

[0016] Figure 2 This is a diagram showing the location of the scanning device within the casing.

[0017] Figure 3 This is a structural diagram of the front side of the scanning device.

[0018] Figure 4 This is a structural diagram of the rear side of the scanning device.

[0019] Figure 5 This is a diagram of the bottom structure of the scanning device.

[0020] Figure 6 This is a schematic diagram of the up-and-down drive mechanism for the scanning mirror.

[0021] Figure 7 This is a schematic diagram of a dual-optical-path system.

[0022] In the figure: outer shell 1; slide holder 101; handle structure 102; HMI 103; scanning device 2; scanning mirror 3; first camera 301; second camera 302; objective lens 303; first magnifying glass 304; second magnifying glass 305; beam splitter 306; reflector 307; base 4; stand 401; preview camera 402; first moving stage 5; first drive motor 501; first lead screw 502; first lead screw socket 503; first guide rail assembly 504; second moving stage 6; second drive motor 601; second lead screw 602; second lead screw socket 603; second guide rail assembly 604; slide holder 7; connecting frame 8; third drive motor 801; third lead screw 802; third lead screw socket 803; third guide rail assembly 804; supplementary light 9; main optical path 10; first beam splitter 11; second beam splitter 12. Detailed Implementation

[0023] like Figure 1-7 A dual-path slide scanner includes a base 4, a movable first stage 5 on the base 4, and a movable second stage 6 on the first stage 5. The second stage 6 is used to place slide holders 7. The movement direction of the first stage 5 is perpendicular to the movement direction of the second stage 6. A stand 401 is provided at one end of the base 4, and a scanning mirror 3 is provided on the stand 401. The scanning mirror 3 is provided with a first beam splitter 11 and a second beam splitter 12 with different magnifications. A first camera 301 is provided at the end of the first beam splitter 11, and a second camera 302 is provided at the end of the second beam splitter 12.

[0024] In a preferred embodiment, the scanning mirror 3 includes an objective lens 303, a first magnifying lens 304, a second magnifying lens 305, and a beam splitter 306. The scanning mirror 3 has a main optical path 10, in which the objective lens 303 is provided. The light passes through the objective lens 303 and reaches the beam splitter 306, where it is split into a first beam splitter 11 and a second beam splitter 12. The first beam splitter 11 has a first magnifying lens 304, and the second beam splitter 12 has a second magnifying lens 305. The magnification of the first magnifying lens 304 and the second magnifying lens 305 are different.

[0025] The first magnifying glass 304 and the second magnifying glass 305 have different magnifications. Since magnification is inversely proportional to the imaging field of view, the scanner can obtain two images at the same time: one with a large field of view and low magnification, and the other with a small field of view and high magnification. After image stitching, with the same image size, the image stitched together from a large number of high-magnification images has a higher resolution.

[0026] For applications requiring high resolution, such as intracellular imaging, use a camera on a high-magnification optical path to scan the image. For applications requiring low resolution, such as tissue imaging, use a camera on a low-magnification optical path to scan the image. Low-magnification images have a large field of view per frame, which greatly reduces the workload when stitching images together.

[0027] In the preferred embodiment, the second beam splitter 12 is equipped with a reflector 307.

[0028] The main lens tube containing the main optical path 10 is arranged vertically. The branch lens tubes containing the first beam splitter 11 and the second beam splitter 12 are both perpendicular to the main optical path 10, and the branch lens tubes containing the first beam splitter 11 and the second beam splitter 12 are also perpendicular to each other.

[0029] In the preferred embodiment, the beam splitter 306 is a semi-transparent and semi-reflective mirror.

[0030] In the preferred embodiment, the base 4 has a supplementary light 9 facing the glass slide clip 7 in the center.

[0031] The first moving stage 5, the second moving stage 6, and the glass slide holder 7 have a central cutout to prevent light from being blocked.

[0032] In a preferred embodiment, a first drive motor 501 is provided on the base 4, a first lead screw 502 is connected to the shaft end of the first drive motor 501, and a first lead screw nut 503 is provided on the first moving table 5, with the first lead screw nut 503 sleeved with the first lead screw 502.

[0033] The base 4 is provided with a first guide rail assembly 504, and the first moving stage 5 is provided with a slider and is slidably connected to the first guide rail assembly 504.

[0034] In a preferred embodiment, the first moving stage 5 is provided with a second drive motor 601, the shaft end of the second drive motor 601 is connected to a second lead screw 602, the second moving stage 6 is provided with a second lead screw nut 603, and the second lead screw nut 603 is sleeved with the second lead screw 602.

[0035] The first moving stage 5 is provided with a second guide rail assembly 604, and the second moving stage 6 is provided with a slider and is slidably connected to the second guide rail assembly 604.

[0036] In the preferred embodiment, the support frame 401 is provided with a third drive motor 801, the shaft end of the connecting frame 8 is connected to a third lead screw 802, and the connecting frame 8 is also provided with a third lead screw nut 803, which is sleeved with the third lead screw 802, and the other end of the connecting frame 8 is connected to the scanning mirror 3.

[0037] A vertical third guide rail assembly 804 is installed on the support frame 401, and the connecting frame 8 is provided with a slider and is slidably connected to the third guide rail assembly 804.

[0038] The first drive motor 501, the second drive motor 601, and the third drive motor 801 are stepper motors or servo motors.

[0039] In a preferred embodiment, the scanning device 2 is further provided with an outer shell 1, the front side of which is provided with a clip slot 101 and an HMI 103, and the upper end of the outer shell 1 is provided with a handle structure 102.

[0040] The first camera 301 and the second camera 302 are oriented perpendicularly, forming a right-angled concave area when viewed from above. The handle structure 102 is located in this position to prevent interference and make the outer shell 1 structure more compact.

[0041] In a preferred embodiment, a preview camera 402 facing the slide holder 7 is mounted on the stand 401.

[0042] The first drive motor 501 and the second drive motor 601 drive the slide holder 7 to move in the X and Y directions, moving the slide on the slide holder 7 below the preview camera 402, so that the preview camera 402 is aligned with the sample area, takes a picture of the label code on the slide, and determines the accurate position of the sample on the slide, which is convenient for setting the scanning start point.

[0043] Subsequently, the glass slide is moved to the starting scanning area by the first drive motor 501 and the second drive motor 601, and the scanning mirror 3 is moved up and down by the third drive motor 801 so that the sample area is located on the focal plane.

[0044] The first drive motor 501 and the second drive motor 601 drive the glass slide to move intermittently in small steps on the plane and scan the image.

[0045] The above embodiments are merely preferred technical solutions of this utility model and should not be considered as limitations on this utility model. The protection scope of this utility model should be the technical solution described in the claims, including equivalent substitutions of the technical features described in the claims. That is, equivalent substitutions and improvements within this scope are also within the protection scope of this utility model.

Claims

1. A dual-path slide scanner, characterized in that: Includes a base (4), on which a movable first moving stage (5) is provided, and on which a movable second moving stage (6) is provided, the second moving stage (6) is used to place a slide holder (7), the moving direction of the first moving stage (5) is perpendicular to the moving direction of the second moving stage (6), one end of the base (4) is provided with a stand (401), on which a scanning mirror (3) is provided, the scanning mirror (3) is provided with a first beam splitter (11) and a second beam splitter (12) with different magnifications, the first beam splitter (11) is provided with a first camera (301) at the end, and the second beam splitter (12) is provided with a second camera (302) at the end.

2. The dual-path slide scanner according to claim 1, characterized in that: The scanning mirror (3) includes an objective lens (303), a first magnifying lens (304), a second magnifying lens (305), and a beam splitter (306). The scanning mirror (3) is provided with a main optical path (10). An objective lens (303) is provided in the main optical path (10). The light passes through the objective lens (303) and is split into a first beam splitter (11) and a second beam splitter (12) at the beam splitter (306). A first magnifying lens (304) is provided in the first beam splitter (11), and a second magnifying lens (305) is provided in the second beam splitter (12). The magnification of the first magnifying lens (304) and the second magnifying lens (305) is different.

3. The dual-path slide scanner according to claim 2, characterized in that: The second beam splitter (12) is equipped with a reflector (307).

4. The dual-path slide scanner according to claim 2, characterized in that: The beam splitter (306) is a semi-transparent and semi-reflective mirror.

5. The dual-path slide scanner according to claim 1, characterized in that: The base (4) has a supplementary light (9) facing the slide holder (7) in the center.

6. The dual-path slide scanner according to claim 1, characterized in that: The base (4) is provided with a first drive motor (501), the shaft end of the first drive motor (501) is connected to a first lead screw (502), the first moving table (5) is provided with a first lead screw seat (503), and the first lead screw seat (503) is sleeved with the first lead screw (502).

7. The dual-path slide scanner according to claim 1, characterized in that: The first moving stage (5) is provided with a second drive motor (601), the shaft end of the second drive motor (601) is connected to a second lead screw (602), the second moving stage (6) is provided with a second lead screw seat (603), and the second lead screw seat (603) is sleeved with the second lead screw (602).

8. The dual-path slide scanner according to claim 1, characterized in that: The support frame (401) is equipped with a third drive motor (801), the shaft end of the connecting frame (8) is connected to a third lead screw (802), and the connecting frame (8) is also equipped with a third lead screw seat (803). The third lead screw seat (803) is sleeved with the third lead screw (802), and the other end of the connecting frame (8) is connected to the scanning mirror (3).

9. The dual-path slide scanner according to claim 1, characterized in that: The scanning device (2) is also provided with an outer shell (1), and the front side of the outer shell (1) is provided with a clip slot (101) and an HMI (103). The upper end of the outer shell (1) is provided with a handle structure (102).

10. The dual-path slide scanner according to claim 1, characterized in that: A preview camera (402) facing the slide holder (7) is mounted on the stand (401).

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