On-line sample diluting and separating device

Abstract

The utility model discloses a sample on-line dilution and separation device, which comprises a sample mixing mechanism, a sample filling mechanism and a waste liquid separation mechanism, and the sample mixing mechanism comprises a mounting structure, a linear power source arranged on the mounting structure, a mixing power source driven by the linear power source to linearly move back and forth, and an eccentric mixing assembly. The sample mixing mechanism disclosed by the utility model is provided with at least two eccentric mixing assemblies, and the eccentric mixing assemblies can linearly move back and forth, so that the linear back and forth movement of the eccentric mixing assemblies can be realized; the at least two eccentric uniform mixing assemblies can alternately complete cup receiving, liquid injection, uniform mixing and the like, so that flexible dilution (single time, two times or multiple times) of each sample is realized, the detection requirements of high-concentration samples are met, continuous dilution of a plurality of samples is realized, the sample dilution efficiency is improved, and the detection efficiency is further ensured; residual liquid is pumped away by the waste liquid separation mechanism, so that empty reaction cups are discarded, and biological hazards caused by residual samples are reduced.

Description

Technical Field

[0001] This utility model relates to sample pretreatment technology in the field of in vitro diagnostics, and in particular to an online sample dilution and separation device. Background Technology

[0002] In immunoassay testing, because the concentration of analytes in the blood varies among different patients, blood samples often need to be diluted to a specific ratio before the immunoassay reaction can be performed. While existing sample dilution devices can also dilute samples, their structures are relatively complex and their functions are limited. They cannot flexibly dilute high-concentration samples, nor can they meet the increasingly stringent demands for low manufacturing costs and diversified functions in the market. Summary of the Invention

[0003] In view of this, the present invention proposes an online sample dilution and separation device, which can realize continuous dilution of samples by any multiple, improve detection efficiency, and also realize the disposal of empty cups, reducing biological hazards.

[0004] To achieve the above objectives, the present invention adopts the following technical solution:

[0005] The online sample dilution and separation device of this utility model includes a reaction cup supply gripper and a reaction cup waste gripper that move in the X direction, a sample mixing mechanism arranged in the Y direction and a sample dispensing mechanism arranged on one side of the sample mixing mechanism, and a waste liquid separation mechanism arranged at one end of the sample mixing mechanism. The waste liquid separation mechanism is arranged opposite to the sample dispensing mechanism.

[0006] The sample mixing mechanism includes an installation structure, a linear power source disposed on the installation structure, a moving seat driven linearly by the linear power source, a mixing power source, and at least two eccentric mixing components disposed at Y-axis intervals on the moving seat, wherein the mixing power source is connected to the eccentric mixing components in a transmission connection.

[0007] The beneficial effects are as follows: The sample mixing mechanism of this utility model has at least two eccentric mixing components, and the eccentric mixing components can move back and forth in a straight line, realizing the linear back and forth movement of the eccentric mixing components; during operation, at least two eccentric mixing components can alternately complete cup receiving, liquid injection and mixing (mixing while moving), thereby achieving high-ratio dilution of each sample, meeting the detection requirements of high-concentration samples, and also realizing continuous dilution of multiple samples, improving sample dilution efficiency, and thus ensuring detection efficiency; after detection, the reaction liquid can be extracted using the waste liquid separation mechanism, realizing the disposal of empty reaction cups, thereby reducing biological hazards.

[0008] Preferably, the mounting structure includes a first mounting plate and a second mounting plate vertically disposed on the first mounting plate. The linear power source is any one of a belt drive mechanism, a lead screw motor, and an electric cylinder disposed on the first mounting plate. In actual installation, a column and a fixing plate can also be installed at the bottom of the second mounting plate, and the fixing plate can be used to fix the present invention to the frame of a biochemical immunoassay analyzer or production line.

[0009] More preferably, the linear power source is a belt drive mechanism, the vertical mounting plate of the moving seat is fixedly connected to the first synchronous belt of the linear power source, and the vertical mounting plate is connected to the second mounting plate through a horizontal guide pair to ensure the moving accuracy and stability of the moving seat.

[0010] More preferably, the horizontal guide pair is a guide pair consisting of a slide rail and a slider, or a guide pair consisting of a guide shaft and a linear bearing. In actual installation, the slide rail or guide shaft is fixed to the second mounting plate, and the slider or linear bearing is mounted on the vertical mounting plate.

[0011] Preferably, the movable seat also has a horizontal fixed base, and the eccentric mixing assembly includes a mixing seat, an eccentrically mounted mixing head, and a limiting unit for limiting the mixing head. The mixing seat has a stepped structure, and its middle part is rotatably connected to the fixed base through a first bearing. The upper part of the mixing seat has an inclined mounting hole, and the mounting part of the mixing head is mounted in the mounting hole through a second bearing.

[0012] Preferably, the mixing power source is a belt drive mechanism, and a drive pulley is fixedly connected to the mounting head at the bottom of each mixing seat. The second synchronous belt of the mixing power source is wound around the drive pulley. The bottom of the fixed base is provided with multiple tensioning pulleys to tension the second synchronous belt, and the tensioning pulleys and the drive pulleys are offset. In actual installation, the drive pulley is a synchronous pulley that cooperates with the second synchronous belt to avoid slippage. This invention utilizes a single mixing motor to achieve independent mixing of the two eccentric mixing components, reducing the power source. Multiple tensioning pulleys keep the synchronous belt taut, further preventing slippage.

[0013] Preferably, the moving seat or limiting unit is provided with a first position sensor for monitoring the position of the mixing head, and the mixing seat is provided with a third trigger plate that cooperates with the first position sensor.

[0014] Preferably, one end of the mounting structure is provided with a first sensor for determining the initial position of the movable seat, and the movable seat is provided with a first trigger piece that cooperates with the first sensor;

[0015] A second position sensor is fixedly connected to the movable base, and a sensing code tooth that cooperates with the second position sensor is installed on the mounting structure. The sensing code tooth is arranged along the length direction of the mounting structure.

[0016] Preferably, the waste liquid separation mechanism has a suction needle that is raised and lowered by a lifting power source, and the suction needle is connected to the waste liquid container of a biochemical immunoassay analyzer or laboratory automated line through a pipeline with a suction pump.

[0017] More preferably, the waste liquid separation mechanism further includes a lifting seat driven by the lifting power source, and the suction needle is fixedly connected to the lifting seat through a column; the waste liquid separation mechanism also includes a vertical guide pair to prevent the lifting seat from twisting; a second sensor for monitoring the position of the lifting seat is provided at one end of the second mounting plate, and a second trigger plate matching the second sensor is provided on the lifting seat.

[0018] Compared with the prior art, the advantages of this utility model are as follows: The sample mixing mechanism of this utility model has at least two eccentric mixing components, and the eccentric mixing components can move back and forth in a straight line, realizing the linear back and forth movement of the eccentric mixing components; during operation, at least two eccentric mixing components can alternately complete cup receiving, liquid injection and mixing (mixing while moving), thereby achieving high-ratio dilution of each sample, meeting the detection requirements of high-concentration samples, and also enabling online continuous multiple dilution of samples, improving sample dilution efficiency; after detection, the reaction liquid can be extracted using the waste liquid separation mechanism, realizing the disposal of empty reaction cups and reducing biological hazards. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the present invention.

[0020] Figure 2 This is a side view schematic diagram of the sample mixing mechanism and the waste liquid separation mechanism in this utility model.

[0021] Figure 3 yes Figure 2 Top view.

[0022] Figure 4 yes Figure 2 Axonometric drawing.

[0023] Figure 5 This is a schematic diagram of the sample mixing mechanism omitting the eccentric mixing component and the eccentric power source.

[0024] Figure 6 This is a schematic diagram of the installation of the eccentric mixing component and the fixed base.

[0025] Figure 7 yes Figure 6 A schematic diagram of direction AA.

[0026] Figure 8 It is a diagram showing the positional relationship between the transmission pulley, the tensioner, and the second synchronous belt. Detailed Implementation

[0027] The embodiments of this utility model will be described in detail below with reference to the accompanying drawings. These embodiments are implemented based on the technical solution of this utility model and provide detailed implementation methods and specific operation processes. However, the protection scope of this utility model is not limited to the following embodiments.

[0028] It should be noted that in the description of this utility model, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.

[0029] In the description of this utility model, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0030] like Figure 1-4 As shown, the online sample dilution and separation device of this utility model includes a sample mixing mechanism 1, a sample dispensing mechanism 2 (which can inject samples and diluents into the reaction cup) and a waste liquid separation mechanism 3 disposed on one side of the sample mixing mechanism 1, and also includes a reaction cup feeding mechanism 6 and a reaction cup feeding gripper 4 and a reaction cup waste gripper 5 disposed in the X direction (the reaction cup feeding gripper and the reaction cup waste gripper are both existing conventional reaction cup grippers).

[0031] The sample mixing mechanism 1 includes an installation structure 1.1, a linear power source 1.2 mounted on the installation structure 1.1, a mixing power source 1.3 driven by the linear power source 1.2 to move back and forth in a straight line, and two eccentric mixing components 1.4. The two eccentric mixing components 1.4 are spaced apart along the length of the first installation plate (described later) to ensure that each eccentric mixing component can pass through each station (such as the sample addition station for adding samples and diluents, the receiving station for receiving reaction cups, the aspiration station for solid-liquid separation, and the waste cup station).

[0032] The sample mixing mechanism 1 also includes a movable base driven by a linear power source 1.2. The movable base has a horizontally set fixed base 1.5a and a vertical mounting plate 1.5b. The fixed base 1.5a is fixed on the vertical mounting plate 1.5b, and two eccentric mixing components 1.4 are spaced apart on the fixed base 1.5a. The linear power source 1.2 drives the eccentric mixing components 1.4 to move horizontally back and forth through the movable base, realizing alternating cup receiving, liquid injection and mixing (mixing while moving), etc., to achieve high-ratio dilution of each sample, meet the detection requirements of high-concentration samples, and can also realize continuous dilution of multiple samples, improve sample dilution efficiency, and thus ensure detection efficiency.

[0033] The waste liquid separation mechanism 3 has a suction needle 3.1 that is lifted and lowered by a lifting power source. The suction needle 3.1 is connected to the waste liquid container of the biochemical immunoassay instrument or laboratory assembly line through a pipeline with a suction pump. It can draw the biological waste liquid after testing into the waste liquid container, realize the disposal of the empty reaction cup, and reduce biological hazards.

[0034] In a preferred embodiment of this utility model, combined with Figure 4 As can be seen, the mounting structure 1.1 includes a first mounting plate 1.1a and a second mounting plate 1.1b vertically arranged on the first mounting plate 1.1a. The first mounting plate 1.1a and the second mounting plate 1.1b can be an integral structure or a separate structure. In actual installation, a column 1.1c is installed at the bottom of the first mounting plate 1.1a, and a fixing plate 1.1d is installed at the bottom of the column 1.1c. The fixing plate 1.1d is fixed to the frame of the biochemical immunoassay analyzer or laboratory production line using bolts or screws to achieve fixation.

[0035] In a preferred embodiment of this utility model, combined with Figure 2-4 It can be seen that the linear power source 1.2 is a belt drive mechanism set on the first mounting plate 1.1a (of course, the linear power source can also be a power source that can achieve linear output, such as a screw motor, cylinder, electric cylinder or hydraulic cylinder set on the first mounting plate 1.1a). It includes a moving motor 1.2a, a first synchronous belt 1.2b, a first driving pulley 1.2c and a first driven pulley 1.2d. The first driving pulley 1.2c and the first driven pulley 1.2d are located at both ends of the first mounting plate 1.1a. The moving motor 1.2a is fixed to the bottom of the first mounting plate 1.1a. A clamping plate 1.5c is fixedly connected to the lower part of the vertical mounting plate 1.5b. The clamping plate 1.5c is fixedly connected to the first synchronous belt 1.2b by clamping pieces. The clamping plate 1.5c and the clamping pieces are fixed with bolts. After the mobile motor 1.2a starts, it can drive the vertical mounting plate 1.5b to move horizontally back and forth through the first synchronous belt 1.2b, thereby realizing the horizontal back and forth of the two eccentric mixing components 1.4 and enabling them to move back and forth between different workstations.

[0036] In a preferred embodiment of this utility model, combined with Figure 4 It can be seen that the vertical mounting plate 1.5b is connected to the second mounting plate 1.1b through a horizontal guide pair, ensuring the moving accuracy and stability of the movable seat, and further ensuring the smooth movement of the eccentric mixing component 1.4. The horizontal guide pair includes a slide rail 1.1e (horizontally arranged along the length of the second mounting plate 1.1b) fixedly connected to the second mounting plate 1.1b and a slider slidably mounted on the slide rail 1.1e. The slider is fixedly connected to the vertical mounting plate 1.5a, limiting the movement of the vertical mounting plate 1.5a.

[0037] Of course, in actual installation, the slide rail can be replaced with a guide shaft, and the slider can be replaced with a linear bearing. The high-precision linear reciprocating movement of the moving seat can be achieved through the linear bearing and the guide shaft.

[0038] In a preferred embodiment of this utility model, combined with Figure 3 It can be seen that the movable seat also has a horizontal fixed base 1.5a, and two eccentric mixing components 1.4 are spaced apart on the fixed base 1.5a. Combined with... Figure 5-6 It can be seen that the eccentric mixing assembly 1.4 includes a mixing seat 1.4a, a mixing head 1.4b, and a limiting unit for limiting the mixing head 1.4b. The mixing seat 1.4a has a stepped structure. The middle part of the mixing seat 1.4a is rotatably connected to the fixed base 1.5a through the first bearing 1.4c. The mounting head 1.4e at the lower part is connected to the mixing power source 1.3. The middle part of the mixing seat 1.4a and the mounting head 1.4e are coaxial (vertical central axis). An inclined mounting hole is opened at the upper part of the mixing seat 1.4a. The mounting part of the mixing head 1.4b is rotatably set in the mounting hole through the second bearing 1.4d. The mixing head 1.4b and the mounting hole are coaxially arranged, so that the mixing head 1.4b is eccentrically arranged relative to the mounting head 1.4e.

[0039] The limiting unit includes a limiting baffle 1.4f and a limiting rod 1.4g vertically mounted on the fixed base 1.5a. One end of the limiting rod 1.4g is fixedly connected to the mixing head 1.4b, and the other end of the limiting rod 1.4g is in rolling engagement with the guide hole on the upper part of the limiting baffle 1.4f through a rolling bearing 1.4h. During operation, due to the eccentric design of the mixing head 1.4b relative to the mixing seat 1.4a, when the mixing seat 1.4a rotates, it will drive the mixing head 1.4b to move in a conical motion. The limiting rod 1.4g can pull and limit the mixing head 1.4b, and the rolling bearing 1.4h can move up and down within the guide hole.

[0040] In a preferred embodiment of this utility model, combined with Figure 3 , 6As can be seen from 8, the preferred mixing power source 1.3 is a belt drive mechanism, that is, using one motor to simultaneously achieve the eccentric rotation of the reaction cups inside the two eccentric mixing components 1.4, thus reducing the number of motors. Combined with... Figure 1 It can be seen that the mixing power source 1.3 includes a mixing motor 1.3a, a second synchronous belt 1.3b, a second driving pulley 1.3c, and two second driven pulleys 1.3d. The mixing motor 1.3a is fixed to the bottom of the first mounting plate 1.1a, and the two second driven pulleys 1.3d are located at both ends of the first mounting plate 1.1a. A transmission pulley 1.3e (the transmission pulley 1.3e is a synchronous pulley) is fixedly connected to the mounting head 1.4e of each eccentric mixing component 1.4. The second synchronous belt 1.3b of the mixing power source 1.3 passes around the two transmission pulleys 1.3e.

[0041] Three tensioning pulleys 1.3f are arranged side by side on the fixed base 1.5a to tension the second synchronous belt 1.3b. The tensioning pulleys 1.3f and the transmission pulley 1.3e are staggered to keep the second synchronous belt 1.3b in a taut state and prevent slippage.

[0042] During operation, the mixing motor 1.3a rotates, and the mixing motor 1.3a causes each transmission pulley 1.3e to rotate via the second synchronous belt 1.3b. The transmission pulley 1.3e transmits power to the mixing seat 1.4a, which rotates synchronously with the transmission pulley 1.3e. Due to the eccentric arrangement of the mixing head 1.4b, it performs a conical motion with its bottom as the center, thereby achieving the mixing of the sample and diluent in the reaction cup.

[0043] In a preferred embodiment of this utility model, combined with Figure 5 , 7 It can be seen that the vertical mounting plate 1.5b of the moving seat is provided with first position sensors F1 that cooperate with the eccentric mixing components 1.4 at intervals, and each mixing seat 1.4a is provided with a third trigger piece F2 that cooperates with the first position sensor F1, which can initialize the position of the mixing seat 1.4a; combined with Figure 4-5 The second mounting plate 1.1b has a first sensor F3 at one end for determining the initial position of the movable seat, and the movable seat has a first trigger piece F4 that cooperates with the first sensor F3; the back of the vertical mounting plate 1.5b is fixedly connected to a second position sensor F5, and the second mounting plate 1.1b has a sensing code tooth F6 that cooperates with the second position sensor F5, and the sensing code tooth F6 is arranged along the length direction of the mounting structure 1.1.

[0044] The first sensor F3, the first position sensor F1, and the second position sensor F3 mentioned above are all photoelectric switches, and their signal output terminals are all connected to the control system of the biochemical immunoassay analyzer (or production line).

[0045] In a preferred embodiment of this utility model, combined with Figure 4 It is known that the lifting power source is preferably a lead screw motor 3.2 fixedly mounted on the first mounting plate 1.1a. The lead screw of the lead screw motor 3.2 has a lifting seat 3.3, and a needle seat is mounted on the lifting seat 3.3 via a vertical mounting column 3.4. The suction needle 3.1 is fixedly mounted on the needle seat. The waste liquid separation mechanism 3 also includes a vertical guide pair to prevent the lifting seat 3.3 from twisting, preferably a guide rod 3.5 and a linear bearing 3.6. One end of the second mounting plate 1.1b is provided with a second sensor 3.7 (selected as a photoelectric switch) for monitoring the position of the lifting seat 3.3. The lifting seat 3.3 is provided with a second trigger piece 3.8 matching the second sensor 3.7. The second sensor 3.7 can be used to monitor the height of the lifting seat 3.3, and the height of the suction needle 3.1 is determined by the height of the lifting seat 3.3 to meet the lifting and suction requirements of the suction needle 3.1.

[0046] This invention features two eccentric mixing components 1.4, enabling flexible sample dilution through alternating cup collection and dilution mixing to meet practical testing needs. For easy differentiation, the mixing heads 1.4b of the two eccentric mixing components 1.4 are respectively marked as 1. # Mixing head and 2 # The mixing head performs the following single-stage sample dilution:

[0047] The linear power source 1.2 drives the eccentric mixing component 1.4 to move to the receiving cup position, and the reaction cup feeder 4 grabs the reaction cup and places it on 1. # Inside the mixing head, after receiving the reaction cup, the linear power source 1.2 drives the eccentric mixing component 1.4 to move to the sample dispensing position; the sample needle of the sample dispensing mechanism 2 first draws a certain volume of diluent and then draws a certain volume of sample, then rotates to the sample dispensing position to inject the diluent and sample into the sample dispensing head. # Inside the reaction vessel of the mixing head;

[0048] After injection, the sample needle is cleaned inside and out, and the mixing motor 1.3a is started. The mixing motor 1.3a drives the eccentric mixing component 1.4 to rotate, mixing the sample and diluent. After mixing, a certain volume of the mixture is drawn using the sample needle and injected into the designated reaction cup. After sampling, the eccentric mixing component 1.4 is moved to the suction position below the waste liquid separation mechanism 3, and the suction needle 3.1 is used to transfer the sample to the appropriate position. # Excess sample diluent is extracted from the mixing head, and then the eccentric mixing assembly 1.4 is moved to the waste cup position. The waste cup gripper 5 is used to move the 1... # Simply move the reaction cup inside the mixing head to the designated recovery position; during the detection process, repeat the above operation to achieve continuous single dilution of the sample.

[0049] When a sample needs to be diluted twice, first dilute it once using the #2 mixing head container, then dilute it again using the #1 container. #The mixing head is used for secondary dilution in a collection cup. The specific dilution process is as follows:

[0050] The linear power source 1.2 drives the eccentric mixing component 1.4 to move to the receiving position. The reaction cup feeder 4 grabs the reaction cup and places it inside the #2 mixing head. After receiving the reaction cup, the linear power source 1.2 drives the eccentric mixing component 1.4 to move to the sample dispensing position (located within the sample dispensing range of the sample dispensing mechanism 2). The sample needle of the sample dispensing mechanism 2 successively draws a certain volume of diluent and sample, and rotates to the top of the #2 mixing head for dispensing.

[0051] After injection, start the mixing motor 1.3a. The mixing motor 1.3a drives the eccentric mixing component 1.4 to rotate, so that the sample and diluent are mixed. After mixing, the sample needle draws a certain volume of the initial mixture.

[0052] Move the eccentric mixing component 1.4 to the receiving cup position, and the reaction cup feeder 4 grabs the reaction cup and places it on 1. # In the mixing head, add 1 # The mixing head is moved to the sample loading position; after the sample needle aspirates a certain amount of the mixture, it aspirates a certain volume of the diluent and injects it into the reaction cup inside the mixing head #1. The mixing motor 1.3a drives the eccentric mixing component 1.4 to rotate for secondary mixing; the sample needle is cleaned during the secondary mixing process. After mixing, a certain volume of the secondary mixture is aspirated by the sample needle and injected into the reaction cup to be tested (the sample needle is cleaned after injection) to achieve secondary dilution of the sample.

[0053] The eccentric mixing component 1.4 is moved sequentially to below the suction needle 3.1, and the suction needle 3.1 is used to mix the mixture. # Excess liquid is extracted from the reaction cups on the mixing head and the No. 2 mixing head; then the two eccentric mixing components 1.4 are moved to the waste cup position one after the other, and the two reaction cups are grabbed to the designated recycling position using the reaction cup waste gripper 5.

[0054] When a sample needs to be diluted three times, the dilution is carried out on the basis of the second dilution. That is, after the second dilution, a certain volume of the secondary mixture is drawn with a sample needle and the sample needle is cleaned externally.

[0055] Then 2 # Move the mixing head directly below the aspiration needle 3.1, use the aspiration needle 3.1 to extract excess liquid, then... # The mixing head is moved to the waste cup position, and the reaction cup is moved to the designated position using the waste cup gripper; then 2 # The mixing head moves to the receiving position, and the reaction cup feeder 4 places the retrieved reaction cup back into position 2. # Mixing head;

[0056] 2 containing the new reaction vessel# Move the mixing head to the sample dispensing position, and simultaneously draw a certain volume of diluent from the externally cleaned sample needle. Rotate the sample needle to 2... # Directly above the mixing head and inject the secondary mixture and diluent into 2... # The sample is mixed three times in the reaction cup on the mixing head; the sample needle is cleaned during the three mixing processes; after mixing, a certain volume of the three-times mixed solution is drawn using the sample needle and placed in the reaction cup to be tested, thus achieving three dilutions of the sample; the sample needle is cleaned inside and out after each injection.

[0057] The eccentric mixing component 1.4 is moved sequentially to below the suction needle 3.1, and the suction needle 3.1 is used to mix the mixture. # Mixing head and 2 # Excess liquid is extracted from the reaction cup on the mixing head; then the two eccentric mixing components 1.4 are moved to the waste cup position one after the other, and the reaction cup waste gripper 5 moves the 2... # Mixing head and 1 # The reaction cup inside the mixing head is delivered to the designated position.

[0058] During the dilution process described above, the sample needle must be cleaned both internally and externally after each injection to avoid cross-contamination between samples. If the sample needle needs to draw diluent after drawing the mixed solution, it must first be cleaned externally before drawing the diluent to avoid contaminating the diluent with the sample.

[0059] This invention features two movable eccentric mixing components 1.4, which allow for multiple dilutions of samples during operation by alternating cups, enabling dilution at any ratio to meet the needs of different testing projects. This invention can be used not only in biochemical and immunoassay analyzers but also in laboratory automated testing lines, making it applicable to a wide range of applications.

[0060] Finally, it should be emphasized that the above description is merely a preferred embodiment of this utility model and is not intended to limit this utility model. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still make modifications to the technical solutions described in the foregoing embodiments without creative effort, or make equivalent substitutions for some of the technical features. Therefore, any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A sample online dilution and separation device, comprising a reaction cup feeder and a reaction cup waste gripper moving in the X direction, a sample mixing mechanism arranged in the Y direction, and a sample dispensing mechanism disposed on one side of the sample mixing mechanism, characterized in that: It also includes a waste liquid separation mechanism disposed at one end of the sample mixing mechanism, wherein the waste liquid separation mechanism is arranged opposite to the sample dispensing mechanism; The sample mixing mechanism includes an installation structure, a linear power source disposed on the installation structure, a moving seat driven linearly by the linear power source, a mixing power source, and at least two eccentric mixing components disposed at Y-axis intervals on the moving seat, wherein the mixing power source is connected to the eccentric mixing components in a transmission connection.

2. The online sample dilution and separation device according to claim 1, characterized in that: The mounting structure includes a first mounting plate and a second mounting plate vertically disposed on the first mounting plate. The linear power source is any one of a belt drive mechanism, a lead screw motor, and an electric cylinder disposed on the first mounting plate.

3. The online sample dilution and separation device according to claim 2, characterized in that: The linear power source is a belt drive mechanism. The vertical mounting plate of the moving seat is fixedly connected to the first synchronous belt of the linear power source. The vertical mounting plate is connected to the second mounting plate through a horizontal guide pair.

4. The online sample dilution and separation device according to claim 3, characterized in that: The horizontal guide pair is either a guide pair consisting of a slide rail and a slider, or a guide pair consisting of a guide shaft and a linear bearing.

5. The online sample dilution and separation device according to claim 2, characterized in that: The movable seat also has a horizontal fixed base. The eccentric mixing assembly includes a mixing seat, an eccentrically mounted mixing head, and a limiting unit for limiting the mixing head. The mixing seat has a stepped structure, and its middle part is rotatably connected to the fixed base through a first bearing. The upper part of the mixing seat has an inclined mounting hole, and the mounting part of the mixing head is mounted in the mounting hole through a second bearing.

6. The online sample dilution and separation device according to claim 5, characterized in that: The mixing power source is a belt drive mechanism. Each mixing seat has a drive pulley fixedly connected to the mounting head at the bottom. The second synchronous belt of the mixing power source is wound around the drive pulley. The bottom of the fixed base is provided with a plurality of tensioning pulleys to tension the second synchronous belt. The tensioning pulleys and the drive pulleys are staggered.

7. The online sample dilution and separation device according to claim 5, characterized in that: The moving seat or limiting unit is provided with a first position sensor for monitoring the position of the mixing head, and the mixing seat is provided with a third trigger plate that cooperates with the first position sensor.

8. The online sample dilution and separation device according to claim 2, characterized in that: One end of the mounting structure is provided with a first sensor for determining the initial position of the movable seat, and the movable seat is provided with a first trigger piece that cooperates with the first sensor. A second position sensor is fixedly connected to the movable base, and a sensing code tooth that cooperates with the second position sensor is installed on the mounting structure. The sensing code tooth is arranged along the length direction of the mounting structure.

9. The online sample dilution and separation device according to claim 2, characterized in that: The waste liquid separation mechanism has a suction needle that is raised and lowered by a lifting power source. The suction needle is connected to the waste liquid container of a biochemical immunoassay analyzer or laboratory assembly line through a pipeline with a liquid pump.

10. The online sample dilution and separation device according to claim 9, characterized in that: The waste liquid separation mechanism also includes a lifting seat driven to rise and fall by the lifting power source, and the suction needle is fixedly connected to the lifting seat through a column; the waste liquid separation mechanism also includes a vertical guide pair to prevent the lifting seat from twisting. One end of the second mounting plate is provided with a second sensor for monitoring the position of the lifting seat, and the lifting seat is provided with a second trigger piece that matches the second sensor.

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