Polypeptide medical intermediate raw material proportioning device

Abstract

The utility model relates to the technical field of medicine production, in particular to a polypeptide medicine intermediate raw material proportioning device, which is convenient for adding materials, can scrape and clean the materials adhered to the inner wall, reduces the waste of the raw materials and improves the proportioning efficiency. Comprising a batching barrel, a discharging pipe, a feeding assembly, a lifting assembly, a mixing assembly, a scraping assembly and a supporting assembly, the bottom of the batching barrel protrudes upwards, the right side of the bottom of the batching barrel is connected with the discharging pipe, the feeding assembly is installed on the top of the batching barrel, the lifting assembly is installed on the left side wall of the batching barrel, and the mixing assembly is installed in the batching barrel; a scraping assembly is installed at the bottom of the batching barrel and connected with the mixing assembly, and a supporting assembly is installed at the bottom of the batching barrel.

Description

Technical Field

[0001] This utility model relates to the technical field of drug production, and in particular to a device for proportioning raw materials of polypeptide pharmaceutical intermediates. Background Technology

[0002] Polypeptides are a class of compounds formed by multiple amino acids linked by peptide bonds. Polypeptides play a crucial role in various parts of the human body. Drugs produced from polypeptide raw materials have high safety and significant efficacy, and have broad development prospects. Pharmaceutical intermediates are chemical raw materials or chemical products used in the process of drug synthesis. These chemical products do not require a drug production license and can be produced in ordinary chemical plants. As long as they meet certain standards, they can be used in drug synthesis. The preparation of pharmaceutical intermediates requires mixing multiple solid raw materials together. Existing technology publication number CN21667876U discloses a mixing device for the production and preparation of pharmaceutical intermediates, which includes a rectangular box with a lid on top and a feeding port on top of the lid. The bottom inner wall of the rectangular box is inclined, a discharge pipe is located on the left side of the rectangular box, and a controller is located on the outside of the rectangular box. A strip-shaped hole is opened on the top of the lid, and a rectangular block is slidably installed in the strip-shaped hole. A dual-shaft motor is installed on the top of the rectangular block, and a rotating rod is installed on the bottom output shaft of the dual-shaft motor. Multiple stirring rods are installed at the bottom of the rotating rod. A through hole is opened on the rectangular block, and a bearing is installed in the through hole. The rotating rod is connected to the inner ring of the bearing. A sealing shell is installed at the bottom of the rectangular block. However, it cannot discharge the raw materials adhering to the inner wall of the mixing tank, causing the raw materials to agglomerate during mixing and resulting in waste of raw materials, affecting the proportioning efficiency. Utility Model Content

[0003] To solve the above-mentioned technical problems, this utility model provides a polypeptide pharmaceutical intermediate raw material proportioning device that facilitates the addition of materials, can scrape and clean the materials adhering to the inner wall, reduces raw material waste, and improves proportioning efficiency.

[0004] This utility model discloses a polypeptide pharmaceutical intermediate raw material proportioning device, comprising a mixing cylinder, a discharge pipe, a feeding component, a lifting component, a mixing component, a scraping component, and a support component. The bottom of the mixing cylinder protrudes upwards, and the discharge pipe is connected to the right side of the bottom of the mixing cylinder. The feeding component is installed at the top of the mixing cylinder, and the lifting component is installed on the left side wall of the mixing cylinder. The mixing component is installed inside the mixing cylinder, and the scraping component is installed at the bottom of the mixing cylinder. The mixing component is connected to the scraping component, and the support component is installed at the bottom of the mixing cylinder. The support component supports the equipment. The material is quantitatively input into the mixing cylinder through the feeding component. The lifting component can transport materials that are difficult to handle into the mixing cylinder. The mixing component can proportion and mix various materials inside the mixing cylinder. The scraping component can scrape and clean the material adhering to the inner wall, reducing the waste of raw materials. The proportioned material can be discharged through the discharge pipe.

[0005] Preferably, the feeding assembly includes two support blocks, a feeding box, a servo motor, a rotating shaft, and two spiral conveyor blades. The two support blocks are fixedly installed at the top left and right ends of the feeding cylinder. The feeding box is connected to the top of the support blocks, and a feeding groove is opened in the support blocks to connect the feeding box with the inside of the feeding cylinder. The rotating shaft is rotatably installed inside the feeding box, and the input end of the rotating shaft is connected to the output end of the servo motor. Spiral conveyor blades are symmetrically installed at the left and right ends of the rotating shaft. When material is added to the feeding box, the servo motor is started to drive the rotating shaft to rotate. The rotating shaft drives the two spiral conveyor blades to rotate, pushing the material to both sides and feeding it into the inside of the feeding cylinder through the feeding groove in the support block.

[0006] Preferably, the material lifting assembly includes a lifting cylinder, a second servo motor, a lifting shaft, and spiral lifting blades. The lifting cylinder is installed on the outer left wall of the batching cylinder, and the upper output end of the lifting cylinder is connected to the inside of the batching cylinder. The second servo motor is installed at the top of the lifting cylinder, and the lifting shaft is rotatably installed inside the lifting cylinder. Spiral lifting blades are installed on the outer wall of the lifting shaft and are rotatably connected to the inner wall of the lifting cylinder. A feed inlet is provided at the lower end of the lifting cylinder. The second servo motor is started to drive the lifting shaft to rotate, and the lifting shaft drives the spiral lifting blades to rotate, lifting and conveying the lower material upwards and inputting it into the batching cylinder for mixing and processing.

[0007] Preferably, it also includes a feeding hopper, a feed pipe, a storage hopper, a liquid adding ring pipe, and a liquid inlet pipe. The feeding hopper is connected to the middle of the top of the feeding box. The feed pipe is connected to the feed inlet of the lifting cylinder. The input end of the feed pipe is connected to the storage hopper. The liquid adding ring pipe is installed at the top inside the mixing cylinder. A liquid outlet is provided at the bottom of the liquid adding ring pipe. The input end of the liquid adding ring pipe is connected to the liquid inlet pipe, which is located outside the mixing cylinder. The input end of the liquid inlet pipe is connected to a liquid pipeline. Liquid is input into the liquid adding ring pipe through the liquid inlet pipe and output into the mixing cylinder through the liquid outlet, so that various materials are mixed in proportion. The feeding hopper can temporarily store the materials added to the feeding box for easy feeding. At the same time, the lower material is added to the storage hopper and introduced into the input end at the bottom of the lifting cylinder through the feed pipe for easy feeding.

[0008] Preferably, the mixing assembly includes a gearbox, a mixing motor, a main shaft, multiple stirring racks, multiple stirring rods, multiple sets of stirring support rods, and spiral blades. The gearbox is installed at the top center of the batching cylinder. The input end of the gearbox is connected to the output end of the mixing motor. The bottom output end of the gearbox passes through the top of the batching cylinder and is connected to the main shaft. Multiple stirring racks are axially connected to the outer wall of the main shaft. Spiral blades are installed on the stirring racks, and multiple stirring support rods are installed on the spiral blades. Spiral blades are also installed on the lower outer wall of the main shaft. When the mixing motor is started, it drives the main shaft to rotate through the gearbox. The main shaft drives the multiple stirring racks to rotate, and the stirring racks drive the multiple stirring rods and multiple sets of stirring support rods to rotate, mixing and batching various materials. At the same time, the main shaft drives the spiral blades to rotate, conveying the lower material upwards, ensuring the agitation of the lower sediment and improving the batching quality.

[0009] Preferably, the scraping assembly includes a drive base, a turntable, a support ring, a gear, multiple connecting arms, multiple scrapers, and a guide ring. The drive base is mounted on the bottom of the main shaft, and a gear groove is provided on the bottom of the drive base. A support groove is provided at the bottom of the inner part of the dispensing cylinder, and the support ring is rotatably mounted in the support groove. A turntable is mounted on the top of the support ring, and a gear is mounted on the top of the turntable, located in a gear groove. Multiple connecting arms are axially and evenly connected to the outer wall of the turntable, and scrapers are connected to the connecting arms. Multiple sets of circular holes are provided on the scrapers, and the scrapers are slidably connected to the inner wall of the dispensing cylinder for dispensing. A guide groove is provided at the top of the inner part of the cylinder, and a guide ring is rotatably installed in the guide groove. The top of the scraper is connected to the bottom of the guide ring. When the main shaft rotates, it drives the turntable to rotate through the drive seat and gears. The turntable drives the support ring to rotate in the support groove. The turntable drives the scraper to rotate through multiple connecting arms to scrape and clean the material on the inner wall of the batching cylinder, reducing material waste. At the same time, the round holes on the scraper can improve the material mixing effect. When the scraper rotates, it drives the guide ring to rotate in the guide groove, which guides and limits the scraper, improves structural strength, and ensures stability.

[0010] Preferably, the support assembly includes multiple legs and a base plate. The multiple legs are evenly installed at the bottom of the feeding cylinder, and the bottom of the legs is connected to the base plate. The bottom of the lifting cylinder is connected to the top of the base plate. The legs and the base plate support the bottom of the equipment, ensuring stability and increasing the stability of the lifting cylinder installation.

[0011] Compared with the prior art, the beneficial effects of this utility model are as follows: the equipment is supported by the support component, the material is quantitatively input into the batching cylinder through the feeding component, the lifting component can transport materials that are difficult to handle into the batching cylinder, the mixing component can mix various materials in the batching cylinder in proportion, the scraping component can scrape and clean the material adhering to the inner wall, reducing the waste of raw materials, and the mixed material can be discharged through the discharge pipe. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the structure of this utility model;

[0013] Figure 2 This is a schematic diagram of the isometric structure of this utility model;

[0014] Figure 3 This is a partial cross-sectional structural schematic diagram of the present invention;

[0015] Figure 4 This is a front cross-sectional structural diagram of the present invention;

[0016] Figure 5 This is a schematic diagram of the internal structure of this utility model;

[0017] Figure 6 This is a schematic diagram of the structure of this utility model;

[0018] The following components are labeled in the attached diagram: 1. Batching cylinder; 2. Support block; 3. Feed box; 4. Feed hopper; 5. Servo motor; 6. Rotary shaft; 7. Spiral conveyor blade; 8. Lifting cylinder; 9. Second servo motor; 10. Lifting shaft; 11. Spiral lifting blade; 12. Feed pipe; 13. Storage hopper; 14. Liquid addition ring pipe; 15. Liquid inlet pipe; 16. Gearbox; 17. Mixing motor; 18. Main shaft; 19. Stirring frame; 20. Stirring rod; 21. Stirring support rod; 22. Spiral blade; 23. Drive seat; 24. Turntable; 25. Support ring; 26. Gear; 27. Connecting arm; 28. Scraper; 29. ​​Guide ring; 30. Support leg; 31. Base plate; 32. Discharge pipe. Detailed Implementation

[0019] To facilitate understanding of this utility model, a more complete description will be given below with reference to the accompanying drawings. This utility model can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to make the disclosure of this utility model more thorough and complete.

[0020] Example 1

[0021] like Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 6As shown, the bottom of the mixing cylinder 1 protrudes upwards. A discharge pipe 32 is connected to the right side of the bottom of the mixing cylinder 1. Two support blocks 2 are fixedly installed at the top left and right ends of the mixing cylinder 1. A feed box 3 is connected to the top of the support blocks 2, and a feed groove is opened inside the support blocks 2 to connect the feed box 3 with the inside of the mixing cylinder 1. A rotating shaft 6 is rotatably installed inside the feed box 3. The input end of the rotating shaft 6 is connected to the output end of the servo motor 5. Spiral conveying blades 7 are symmetrically installed at the left and right ends of the rotating shaft 6. An elevator cylinder 8 is installed on the left outer wall of the mixing cylinder 1. The upper output end of the elevator cylinder 8 is connected to the inside of the mixing cylinder 1. A second servo motor 9 is installed on the top of the elevator cylinder 8. An elevator shaft 10 is rotatably installed inside the elevator cylinder 8. The upper part is equipped with a spiral lifting blade 11, which is rotatably connected to the inner wall of the lifting cylinder 8. The gearbox 16 is installed at the middle of the top of the mixing cylinder 1. The input end of the gearbox 16 is connected to the output end of the mixing motor 17. The bottom output end of the gearbox 16 passes through the top of the mixing cylinder 1 and is connected to the main shaft 18. Multiple stirring racks 19 are axially connected to the outer wall of the main shaft 18. Spiral blades 22 are installed on the stirring racks 19. Multiple stirring support rods 21 are installed on the spiral blades 22. Spiral blades 22 are installed on the lower outer wall of the main shaft 18. Multiple support legs 30 are evenly installed at the bottom of the mixing cylinder 1. The bottom of the support legs 30 is connected to the bottom plate 31. The bottom of the lifting cylinder 8 is connected to the top of the bottom plate 31.

[0022] Material is added to the feed box 3. The servo motor 5 is started to drive the rotating shaft 6 to rotate. The rotating shaft 6 drives the two spiral conveyor blades 7 to rotate, pushing the material to both sides and feeding it into the mixing cylinder 1 through the feed trough in the support block 2. The second servo motor 9 is started to drive the lifting shaft 10 to rotate. The lifting shaft 10 drives the spiral lifting blades 11 to rotate, lifting and conveying the lower material upwards into the mixing cylinder 1 for mixing. The mixing motor 17 is started to drive the main shaft 18 to rotate through the gearbox 16. The main shaft 18 drives multiple mixing racks 19 to rotate. The mixing racks 19 drive multiple mixing rods 20 and multiple sets of mixing support rods 21 to rotate, mixing and batching various materials. At the same time, the main shaft 18 drives the spiral blades 22 to rotate, conveying the lower material upwards, ensuring the agitation of the lower sediment and improving the mixing quality. The bottom of the equipment is supported by the support legs 30 and the base plate 31 to ensure stability and increase the stability of the lifting cylinder 8 installation.

[0023] Example 2

[0024] like Figures 3 to 5As shown, based on Embodiment 1, it further includes a feed inlet at the lower end of the lifting cylinder 8, a feeding hopper 4 connected to the middle of the top of the feeding box 3, a feeding pipe 12 connected to the feed inlet of the lifting cylinder 8, a storage hopper 13 connected to the input end of the feeding pipe 12, a liquid adding ring pipe 14 installed at the top inside the mixing cylinder 1, a liquid adding head provided at the lower part of the liquid adding ring pipe 14, an input end of the liquid adding ring pipe 14 connected to the liquid inlet pipe 15, the liquid inlet pipe 15 located outside the mixing cylinder 1, a drive seat 23 installed at the bottom of the main shaft 18, a gear groove opened at the bottom of the drive seat 23, and the bottom inside the mixing cylinder 1... The end is provided with a support rotating groove, and the support rotating ring 25 is rotatably installed in the support rotating groove. The top of the support rotating ring 25 is installed with a turntable 24, and the top of the turntable 24 is installed with a gear 26. The gear 26 is located in a gear groove. Multiple connecting arms 27 are axially and evenly connected on the outer wall of the turntable 24. Scrapers 28 are connected to the connecting arms 27. Multiple sets of round holes are opened on the scrapers 28. The scrapers 28 are slidably connected to the inner wall of the dispensing cylinder 1. The top of the dispensing cylinder 1 is provided with a guide rotating groove, and the guide rotating ring 29 is rotatably installed in the guide rotating groove. The top of the scraper 28 is connected to the bottom of the guide rotating ring 29.

[0025] The inlet pipe 15 is connected to the liquid pipeline, and the liquid is fed into the liquid ring pipe 14 through the inlet pipe 15 and output into the mixing cylinder 1 through the outlet head, so that various materials are mixed in proportion. The material added to the feed box 3 can be temporarily stored through the feed hopper 4 for easy feeding. At the same time, the lower material is added to the storage hopper 13 and introduced into the input end of the bottom of the lifting cylinder 8 through the feed pipe 12 for easy feeding. When the main shaft 18 rotates, it drives the turntable 24 to rotate through the drive seat 23 and the gear 26. The turntable 24 drives the support ring 25 to rotate in the support groove. The turntable 24 drives the scraper 28 to rotate through multiple connecting arms 27 to scrape and clean the material on the inner wall of the mixing cylinder 1, reducing material waste. At the same time, the round hole on the scraper 28 can improve the material mixing effect. When the scraper 28 rotates, it drives the guide ring 29 to rotate in the guide groove, which guides and limits the scraper 28, improves the structural strength, and ensures stability.

[0026] like Figures 1 to 6As shown, this utility model discloses a polypeptide pharmaceutical intermediate raw material proportioning device. During operation, materials are added to the feed hopper 3. A servo motor 5 is started, driving the rotating shaft 6 to rotate. The rotating shaft 6 drives two spiral conveying blades 7 to rotate, pushing the materials to both sides and feeding them into the mixing cylinder 1 through the feed trough in the support block 2. A second servo motor 9 is started, driving the lifting shaft 10 to rotate. The lifting shaft 10 drives the spiral lifting blades 11 to rotate, lifting and conveying the lower material upwards into the mixing cylinder 1 for mixing. The input end of the liquid inlet pipe 15 is connected to a liquid pipeline, and liquid is fed into the liquid addition ring pipe 14 through the liquid inlet pipe 15, and then output into the mixing cylinder 1 through the liquid outlet head, thus mixing various materials in a proportionate manner. The feeding hopper 4 can temporarily store the materials added to the feed hopper 3 for easy feeding, while simultaneously discharging the lower material... The material is added to the storage hopper 13 and introduced into the input end of the bottom of the lifting cylinder 8 through the feed pipe 12. The mixing motor 17 is started and drives the main shaft 18 to rotate through the gearbox 16. The main shaft 18 drives multiple stirring racks 19 to rotate. The stirring racks 19 drive multiple stirring rods 20 and multiple sets of stirring support rods 21 to rotate to mix and batch various materials. At the same time, the main shaft 18 drives the spiral blades 22 to rotate and convey the lower material upward to ensure the agitation of the lower sediment. When the main shaft 18 rotates, it drives the turntable 24 to rotate through the drive seat 23 and gear 26. The turntable 24 drives the support ring 25 to rotate in the support groove. The turntable 24 drives the scraper 28 to rotate through multiple connecting arms 27 to scrape and clean the material on the inner wall of the batching cylinder 1, reducing material waste. At the same time, the round holes on the scraper 28 can improve the mixing effect of the material.

[0027] The servo motor 5, second servo motor 9, liquid addition ring pipe 14, gearbox 16 and mixing motor 17 of the polypeptide pharmaceutical intermediate raw material proportioning device of this utility model are commercially available. Technical personnel in this industry only need to install and operate them according to the accompanying instruction manual, without requiring any creative work from those skilled in the art.

[0028] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of the present utility model, and these improvements and modifications should also be considered within the protection scope of the present utility model.

Claims

1. A device for proportioning raw materials of polypeptide pharmaceutical intermediates, characterized in that, It includes a batching cylinder (1), a discharge pipe (32), a feeding component, a lifting component, a mixing component, a scraping component, and a support component. The bottom of the batching cylinder (1) protrudes upward. The discharge pipe (32) is connected to the right side of the bottom of the batching cylinder (1). The feeding component is installed on the top of the batching cylinder (1). The lifting component is installed on the left side wall of the batching cylinder (1). The mixing component is installed inside the batching cylinder (1). The scraping component is installed at the bottom of the batching cylinder (1). The mixing component is connected to the scraping component. The support component is installed at the bottom of the batching cylinder (1).

2. The polypeptide pharmaceutical intermediate raw material proportioning device as described in claim 1, characterized in that, The feeding assembly includes two support blocks (2), a feeding box (3), a servo motor (5), a rotating shaft (6), and two spiral conveyor blades (7). The two support blocks (2) are fixedly installed on the top left and right ends of the feeding cylinder (1). The top of the support block (2) is connected to the feeding box (3). A feeding groove is opened in the support block (2) so that the feeding box (3) is connected to the inside of the feeding cylinder (1). The rotating shaft (6) is rotatably installed inside the feeding box (3). The input end of the rotating shaft (6) is connected to the output end of the servo motor (5). Spiral conveyor blades (7) are symmetrically installed on the left and right ends of the rotating shaft (6).

3. The polypeptide pharmaceutical intermediate raw material proportioning device as described in claim 1, characterized in that, The material lifting assembly includes a lifting cylinder (8), a second servo motor (9), a lifting shaft (10), and a spiral lifting blade (11). The lifting cylinder (8) is installed on the outer left side of the feeding cylinder (1). The upper output end of the lifting cylinder (8) is connected to the inside of the feeding cylinder (1). The second servo motor (9) is installed on the top of the lifting cylinder (8). The lifting shaft (10) is rotatably installed inside the lifting cylinder (8). The spiral lifting blade (11) is installed on the outer wall of the lifting shaft (10). The spiral lifting blade (11) is rotatably connected to the inner wall of the lifting cylinder (8). The lower end of the lifting cylinder (8) is provided with a feed port.

4. The polypeptide pharmaceutical intermediate raw material proportioning device as described in claim 3, characterized in that, It also includes a feeding hopper (4), a feed pipe (12), a storage hopper (13), a liquid adding ring pipe (14), and a liquid inlet pipe (15). The feeding hopper (4) is connected to the middle of the top of the feeding box (3). The feed pipe (12) is connected to the feed inlet of the lifting cylinder (8). The input end of the feed pipe (12) is connected to the storage hopper (13). The liquid adding ring pipe (14) is installed inside the top of the mixing cylinder (1). The liquid adding ring pipe (14) is provided with a liquid outlet at the bottom. The input end of the liquid adding ring pipe (14) is connected to the liquid inlet pipe (15). The liquid inlet pipe (15) is located outside the mixing cylinder (1).

5. The polypeptide pharmaceutical intermediate raw material proportioning device as described in claim 1, characterized in that, The mixing assembly includes a gearbox (16), a mixing motor (17), a main shaft (18), multiple mixing racks (19), multiple mixing rods (20), multiple sets of mixing support rods (21), and spiral blades (22). The gearbox (16) is installed at the top center of the mixing cylinder (1). The input end of the gearbox (16) is connected to the output end of the mixing motor (17). The bottom output end of the gearbox (16) passes through the top of the mixing cylinder (1) and is connected to the main shaft (18). Multiple mixing racks (19) are axially connected to the outer wall of the main shaft (18). Spiral blades (22) are installed on the mixing racks (19). Multiple mixing support rods (21) are installed on the spiral blades (22). Spiral blades (22) are installed on the lower outer wall of the main shaft (18).

6. The polypeptide pharmaceutical intermediate raw material proportioning device as described in claim 5, characterized in that, The scraping assembly includes a drive base (23), a turntable (24), a support ring (25), a gear (26), multiple connecting arms (27), multiple scrapers (28), and a guide ring (29). The drive base (23) is installed at the bottom of the main shaft (18), and a gear groove is provided at the bottom of the drive base (23). A support groove is provided at the bottom of the inner part of the feeding cylinder (1). The support ring (25) is rotatably installed in the support groove. The turntable (24) is installed on the top of the support ring (25). A gear (26) is installed on the top, and the gear (26) is located in the gear groove. Multiple connecting arms (27) are axially and evenly connected on the outer wall of the turntable (24). A scraper (28) is connected to the connecting arm (27). Multiple sets of round holes are opened on the scraper (28). The scraper (28) is slidably connected to the inner wall of the feeding cylinder (1). A guide groove is opened at the top of the inner part of the feeding cylinder (1). A guide ring (29) is rotatably installed in the guide groove. The top of the scraper (28) is connected to the bottom of the guide ring (29).

7. The polypeptide pharmaceutical intermediate raw material proportioning device as described in claim 3, characterized in that, The support assembly includes multiple legs (30) and a base plate (31). The multiple legs (30) are evenly installed at the bottom of the feeding cylinder (1). The bottom of the legs (30) is connected to the base plate (31). The bottom of the lifting cylinder (8) is connected to the top of the base plate (31).

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