Medium-pressure chromatograph with multi-sector automatic collection function

Abstract

The utility model discloses a multi-sector automatic collection medium-pressure chromatographic instrument which comprises a machine shell, a medium-pressure preparation system is arranged in the machine shell, a chromatographic column outflow end of the medium-pressure preparation system is connected with a liquid conveying pipe, a liquid outlet end of the liquid conveying pipe is provided with a flow divider, a test tube placing cavity is arranged on the machine shell, a test tube assembly is arranged in the test tube placing cavity, and the flow divider is connected with the flow divider. The test tube assembly comprises a rotary carrying table, a test tube rack is arranged on the rotary carrying table, a plurality of groups of test tubes are arranged on the test tube rack in a circumferential array mode, the flow divider is located over one group of test tubes, one end of the flow divider is connected with the liquid outlet end of the infusion tube, and the other end of the flow divider is provided with a plurality of injection ports matched with the test tubes in the group one by one. The liquid injection device can inject liquid into a plurality of test tubes at a time, the liquid injection efficiency is improved, the position of the injection head is fixed, liquid can be injected into all the test tubes on the test tube rack without moving, the possibility that the infusion hose is bent in the moving process of the injection head is reduced, smooth infusion is guaranteed, and liquid leakage is reduced.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of medium pressure chromatograph, concretely relates to a medium pressure chromatograph of multi-sector automatic collection. BACKGROUND

[0002] The medium pressure fast preparation system is mainly applied in the extraction, detection and purification of products in the fields of phytochemistry, organic synthesis, medicinal chemistry, fine chemical industry, biological engineering and life science. The system is based on the chemical principle that different components have different residence times in the stationary phase under the action of the same driving force (because the properties and structures of the components are different, the strengths of the action with the stationary phase are different), thereby flowing out from the stationary phase in different orders, so that different components are separated.

[0003] In the existing medium pressure chromatograph, the components separated by the chromatographic column of the medium pressure preparation system are connected to an injection head capable of moving horizontally and longitudinally through a liquid delivery hose. The injection head performs liquid injection operation on the multiple test tubes on the test tube rack one by one. Since the injection head can only inject a single test tube at a time, the liquid injection efficiency is low, increasing the experimental time. In addition, in order for the injection head to reach the position of each test tube, a driving mechanism is needed to drive the injection head to move frequently. During the movement of the injection head, the liquid delivery hose will be bent. After the liquid delivery hose is bent and deformed, it may cause flow path obstruction, affecting normal liquid transmission. Moreover, after the liquid delivery hose is bent frequently, liquid leakage may occur at the connection between the two ends, affecting the safety of the experiment. SUMMARY

[0004] The utility model aims at providing a medium pressure chromatograph of multi-sector automatic collection, which can inject multiple test tubes at a time, improve the liquid injection efficiency, and fix the position of the injection head, so that liquid injection can be performed on all the test tubes on the test tube rack without moving, reducing the possibility of bending the liquid delivery hose during the movement of the injection head, ensuring smooth liquid delivery, and reducing the occurrence of liquid leakage.

[0005] To achieve the above-mentioned purpose, the utility model adopts the technical scheme of a medium pressure chromatograph of multi-sector automatic collection, which comprises a cabinet. A medium pressure preparation system is arranged in the cabinet. A liquid delivery tube is connected to the outflow end of the chromatographic column of the medium pressure preparation system. A flow divider is arranged at the liquid outlet end of the liquid delivery tube. A test tube placement cavity is arranged on the cabinet. A test tube assembly is arranged in the test tube placement cavity. The test tube assembly comprises a rotary table. A test tube rack is arranged on the rotary table. A plurality of test tube groups are arranged in a circumferential array on the test tube rack. The flow divider is located directly above one of the test tube groups. One end of the flow divider is connected to the liquid outlet end of the liquid delivery tube. The other end of the flow divider is provided with a plurality of injection ports matched with each test tube in the test tube group. Each test tube group can be rotated to the lower side of the flow divider by the rotary table and liquid injection can be performed on all the test tubes in the test tube group.

[0006] The utility model discloses further improve scheme is, the upper end surface of test -tube rack is circular, and is even divided into several same sectors with circumference, and a group of test tubes is placed in each sector, and the distribution position of several test tubes in each group is consistent in respective sector.

[0007] The utility model discloses further improve scheme is, the lower extreme of shunt is equipped with with every sector in several test tubes distribution position corresponding injection port.

[0008] The utility model discloses further improve scheme is, the inside of shunt is equipped with shunt flow channel, and one end of shunt flow channel is connected with the liquid outlet of infusion pipe, and the other end is connected to several injection ports.

[0009] The utility model discloses further improve scheme is, the rotating platform includes the loading plate, and the loading plate is rotationally connected with the inner bottom surface of test -tube placing cavity through the pivot, and one side of pivot is equipped with power source and drives it to rotate.

[0010] The utility model discloses further improve scheme is, one side of pivot is equipped with motor, and the output shaft of motor is vertically upwards, and both are equipped with pulley and are connected through synchronous belt transmission on pivot and the output shaft of motor.

[0011] The utility model discloses further improve scheme is, and at least two positioning protrusions are equipped on the loading plate, and the lower extreme of test -tube rack is equipped with with positioning protrusion one one cooperation's positioning groove.

[0012] The utility model discloses further improve scheme is, and at least two positioning protrusions are equipped on the loading plate, and the lower extreme of test -tube rack is equipped with with positioning protrusion one one cooperation's positioning groove.

[0013] The utility model discloses further improve scheme is, and at least two positioning protrusions are equipped on the loading plate, and the lower extreme of test -tube rack is equipped with with positioning protrusion one one cooperation's positioning groove.

[0014] The utility model discloses further improve scheme is, and at least two positioning protrusions are equipped on the loading plate, and the lower extreme of test -tube rack is equipped with with positioning protrusion one one cooperation's positioning groove.

[0015] The utility model discloses further improve scheme is, and at least two positioning protrusions are equipped on the loading plate, and the lower extreme of test -tube rack is equipped with with positioning protrusion one one cooperation's positioning groove. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 It is the main view structural schematic drawing of the utility model (the test tube is not shown in the drawing).

[0017] Figure 2 It is the test tube rack plan view structural schematic drawing of the utility model.

[0018] Figure 3 It is the injection head bottom view structural schematic drawing of the utility model.

[0019] Figure 4 It is the main view cross section structural schematic drawing of the utility model.

[0020] In the drawing, 1 - casing, 2 - medium pressure preparation system, 3 - chromatographic column, 4 - infusion tube, 5 - injection head, 6 - test tube placement cavity, 7 - test tube rack, 8 - test tube, 9 - injection port, 10 - carrier plate, 11 - rotating shaft, 12 - motor, 13 - pulley, 14 - synchronous belt, 15 - positioning protrusion, 16 - positioning groove. DETAILED DESCRIPTION

[0021] The utility model is further illustrated below in combination with the drawings and specific embodiments. EMBODIMENT

[0022] In combination with the drawings, Figures 1-4 It can be known that a multi-sector automatic collection medium pressure chromatograph includes a casing 1, a medium pressure preparation system 2 is arranged in the casing, an infusion tube 4 is connected to the outflow end of a chromatographic column 3 of the medium pressure preparation system 2, a flow divider 5 is arranged at the liquid outlet end of the infusion tube 4, a test tube placement cavity 6 is arranged on the casing 1, a test tube assembly is arranged in the test tube placement cavity 6, the test tube assembly includes a rotating carrier, a test tube rack 7 is arranged on the rotating carrier, a plurality of groups of test tubes are arranged in a circumferential array on the test tube rack 7, the flow divider 5 is located directly above one group of test tubes 8, one end of the flow divider 5 is connected to the liquid outlet end of the infusion tube 4, and the other end of the flow divider 5 is provided with a plurality of injection ports 9 matched with each test tube 8 in the group. Each group of test tubes can be rotated to the lower side of the flow divider 5 by the rotating carrier and liquid injection can be performed on all test tubes 8 in the group. The injection head of the utility model includes the flow divider 5 and the injection ports 9 arranged at the lower end of the flow divider 5.

[0023] The upper end surface of the test tube rack 7 is circular and is evenly divided into a plurality of identical sectors, one group of test tubes is arranged in each sector, and the distribution positions of the plurality of test tubes 8 in each group of test tubes are consistent in the respective sectors. The lower end of the flow divider 5 is provided with the injection ports 9 corresponding to the distribution positions of the plurality of test tubes 8 in each sector.

[0024] Preferably, the upper end surface of the test tube rack 7 is evenly divided into six identical sectors, and six test tube sockets are arranged in each sector for placing six test tubes 8.

[0025] The shunt 5 is internally provided with a shunt flow channel, one end of which is connected to the liquid outlet end of the infusion tube 4, and the other end is connected to a plurality of injection ports 9.

[0026] The rotating platform includes a carrier plate 10, which is rotatably connected to the inner bottom surface of the test tube placement cavity 6 through a rotating shaft 11. One side of the rotating shaft 11 is provided with a power source for driving rotation.

[0027] The rotating shaft 11 is provided with a motor 12 on one side, and the output shaft of the motor 12 is vertically upward. A belt pulley 13 is arranged on the rotating shaft 11 and the output shaft of the motor 12, and the two are drivingly connected through a synchronous belt 14. The power source for rotating the rotating shaft 11 is the motor 12.

[0028] The carrier plate 10 is provided with at least two positioning protrusions 15, and the lower end of the test tube rack 7 is provided with a positioning groove 16 matched with the positioning protrusions 15 one by one. The positioning protrusions 15 and the positioning grooves 16 are inserted and matched.

[0029] The working principle of the multi-sector automatic collection medium pressure chromatograph provided by the utility model is as follows: in use, the medium pressure preparation system 2 is started, the components flow out from the stationary phase, the components are connected to the shunt 5 through the infusion tube 4 at one end of the chromatographic column 3, the shunt 5 is started to inject a group of test tubes below, and each test tube 8 of the group of test tubes can be injected through the plurality of injection ports 9 on the shunt 5. When the group of test tubes is full, the shunt 5 stops injection, the motor 12 is started, the motor 12 drives the carrier plate 10 to rotate, so that the next group of test tubes moves to the lower side of the shunt 5, then the injection head continues to inject, and the above steps are repeated until all the test tubes 8 on the test tube rack 7 are full.

[0030] In the description of this utility model, it should be understood that the terms "upper," "lower," "front," "rear," "left," "right," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. Any equivalent structural or procedural transformations made using the content of this utility model specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. A multi-sector automatic collection medium-pressure chromatograph, comprising a housing (1), wherein a medium-pressure preparation system (2) is provided inside the housing, and an infusion tube (4) is connected to the outflow end of the chromatographic column (3) of the medium-pressure preparation system (2), and a flow splitter (5) is provided at the outflow end of the infusion tube (4), characterized in that: The housing (1) is provided with a test tube placement cavity (6), and a test tube assembly is provided in the test tube placement cavity (6). The test tube assembly includes a rotating platform, and a test tube rack (7) is provided on the rotating platform. Several groups of test tubes are arranged in a circular array on the test tube rack (7). The diverter (5) is located directly above one of the groups of test tubes (8). One end of the diverter is connected to the liquid outlet of the infusion tube (4), and the other end is provided with several injection ports (9) that correspond one-to-one with each test tube (8) in the group. Each group of test tubes can be rotated to the bottom of the diverter (5) through the rotating platform and injected into all the test tubes (8) in the group.

2. The multi-sector automatic collection medium-pressure chromatograph according to claim 1, characterized in that: The upper surface of the test tube rack (7) is circular and is evenly divided into several identical sectors. Each sector contains a set of test tubes, and the distribution of several test tubes (8) in each sector is consistent.

3. A medium-pressure chromatograph with multi-sector automatic collection according to claim 2, characterized in that: The lower end of the distributor (5) is provided with an injection port (9) corresponding to the distribution position of several test tubes (8) in each sector.

4. A medium-pressure chromatograph with automatic multi-sector collection according to claim 1, characterized in that: The diverter (5) has a diverting channel inside. One end of the diverting channel is connected to the outlet end of the infusion tube (4), and the other end is connected to several injection ports (9).

5. A medium-pressure chromatograph with multi-sector automatic collection according to claim 1, characterized in that: The rotating stage includes a carrier plate (10), which is rotatably connected to the inner bottom surface of the test tube placement cavity (6) via a rotating shaft (11). A power source for driving the rotating shaft (11) is provided on one side.

6. A medium-pressure chromatograph with automatic multi-sector collection according to claim 5, characterized in that: A motor (12) is provided on one side of the rotating shaft (11). The output shaft of the motor (12) is vertically upward. Both the rotating shaft (11) and the output shaft of the motor (12) are provided with pulleys (13) and are connected by a synchronous belt (14).

7. A multi-sector automatic collection medium-pressure chromatograph according to claim 5 or 6, characterized in that: The carrier plate (10) is provided with at least two positioning protrusions (15), and the lower end of the test tube rack (7) is provided with positioning grooves (16) that cooperate with the positioning protrusions (15) one by one.

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