Reaction device for preparing fosfomycin tromethamine

Abstract

The utility model provides a reaction device for preparing fosfomycin tromethamine, and particularly relates to the technical field of pharmaceutical production, the reaction device comprises a tank body, a feed port and a discharge port are respectively arranged at the upper end and the lower end of the tank body, an interlayer is arranged outside the tank body, a plurality of partition plates are vertically arranged in the interlayer, and the partition plates divide the interlayer into a plurality of cavities; a first outlet and a second outlet are respectively formed in the lower sides of two adjacent cavities; a first inlet and a second inlet are respectively formed in the upper sides of the two cavities adjacent to the first outlet and the second outlet; in the anticlockwise direction of the first inlet, each cavity is provided with a plurality of first flow guide pipes at intervals, and every two spaced partition plates are connected through the corresponding first flow guide pipe; in the clockwise direction of the second inlet, each cavity is provided with a plurality of second flow guide pipes at intervals, and every two spaced partition plates are connected in a penetrating mode through the corresponding second flow guide pipes. According to the utility model, the heating efficiency can be improved, and the heating uniformity can be improved.

Description

Technical Field

[0001] This utility model belongs to the field of pharmaceutical production technology, specifically relating to a reaction apparatus for the preparation of fosfomycin tromethamine. Background Technology

[0002] The synthesis of fosfomycin tromethamine requires maintaining a certain reaction temperature. Existing reaction vessels are generally heated by setting up a jacket on the outside of the reaction vessel and passing a heating medium through the jacket. However, existing jackets are mostly single-inlet and single-outlet, resulting in slow heating efficiency and uneven heating.

[0003] To address the above shortcomings, a reaction apparatus for the preparation of fosfomycin tromethamine is needed to improve heating efficiency and heating uniformity. Utility Model Content

[0004] The purpose of this invention is to provide a reaction apparatus for the preparation of fosfomycin tromethamine, which can improve heating efficiency and heating uniformity.

[0005] This utility model provides the following technical solution:

[0006] A reaction apparatus for preparing fosfomycin tromethamine includes a tank, with an inlet at the top and an outlet at the bottom. The tank is provided with an outer jacket, and several partition plates are vertically arranged inside the jacket, dividing the jacket into several cavities.

[0007] The two adjacent cavities are respectively provided with a first outlet and a second outlet on their lower sides;

[0008] The upper sides of the two cavities adjacent to the first and second outlets are respectively provided with a first inlet and a second inlet;

[0009] From the first inlet counterclockwise, each cavity is provided with several first guide tubes at intervals, and the first guide tubes connect the partition plates of two intervals.

[0010] Starting from the second inlet and proceeding clockwise, each cavity is provided with several second guide tubes at intervals, which connect the two partition plates at intervals. Furthermore, each partition plate is provided with several second guide holes at intervals.

[0011] Preferably, each cavity is provided with two first guide tubes, the first guide tubes having an overall arc shape; both ends of the first guide tubes are connected to the partition plate.

[0012] Preferably, the first guide pipe has flanges at both ends, and the flanges are connected to the partition plate by welding or bolts.

[0013] Preferably, each cavity is provided with two second guide tubes, the second guide tubes having an overall arc shape; both ends of the second guide tubes are connected to the partition plate.

[0014] Preferably, the second guide pipe has flanges at both ends, and the flanges are connected to the partition plate by welding or bolts.

[0015] Preferably, a sealing gasket is provided between the flange face and the partition plate.

[0016] Preferably, the connection points of the first and second guide tubes are spaced apart from top to bottom.

[0017] Preferably, the outer layer is coated with a high-temperature resistant heat-insulating coating.

[0018] The beneficial effects of this utility model are:

[0019] 1. This device has two inlets and outlets, which can improve the efficiency of medium flow and thus improve the heating efficiency.

[0020] 2. This device uses two inlets and two outlets for countercurrent heating, and the two media can transfer heat to each other, ensuring the overall uniformity of the medium temperature, which in turn helps to improve the uniformity of heating. Attached Figure Description

[0021] The accompanying drawings are provided to further illustrate the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention, but do not constitute a limitation thereof. In the drawings:

[0022] Figure 1 This is a diagram of the overall structure.

[0023] Figure 2 Internal structure diagram;

[0024] Figure 3 This is a partial view;

[0025] The following are marked in the diagram: 1. First outlet; 2. Second outlet; 3. First inlet; 4. Second inlet; 5. First guide pipe; 6. Second guide pipe; 7. Flange face; 8. Jacket; 9. Partition plate; 10. Tank body; 11. Feed inlet; 12. Discharge outlet; 13. Cavity. Detailed Implementation

[0026] like Figures 1 to 3 A reaction apparatus for preparing fosfomycin tromethamine includes a tank 10, with an inlet 11 at the top and an outlet 12 at the bottom for feeding and discharging materials, respectively. The tank 10 is provided with an outer jacket 8, which can be a welded structure or a conventional structure. Several partition plates 9 are vertically welded inside the jacket 8, dividing the jacket 8 into several cavities 13. The number of partition plates 9 is determined according to actual needs.

[0027] The two adjacent cavities 13 are respectively provided with a first outlet 1 and a second outlet 2 on their lower sides for the outflow of heating medium;

[0028] The upper sides of the two cavities 13 adjacent to the first outlet 1 and the second outlet 2 are respectively provided with a first inlet 3 and a second inlet 4 for the inflow of heating medium;

[0029] See appendix Figure 2 and 3 From the first inlet 1 counterclockwise, each cavity 13 is provided with several first guide pipes 5 at intervals, and the first guide pipes 5 connect two spaced partition plates 9 through each other; it should be noted that the first guide pipes 5 are set from the next cavity 13 adjacent to the first inlet 1.

[0030] From the second inlet 2 in a clockwise direction, each cavity 13 is provided with several second guide pipes 6 at intervals, and the second guide pipes 6 connect two spaced partition plates 9 through each other; it should be noted that the second guide pipes 6 are set from the next cavity 13 adjacent to the second inlet 2;

[0031] To facilitate understanding by technicians, this embodiment first divides the interlayer 8 into four cavities 13; simultaneously, the two cavities containing the first outlet 1, the second outlet 2, the first inlet 3, and the second inlet 4 are further divided into four smaller cavities 13, thus forming a structure as follows: Figure 2 and Figure 3 The structure is such that the first guide pipe 5 and the second guide pipe 6 pass through the partition plate 9 before the medium flows out; in order to ensure sealing, the connection of the partition plate 9 can be welded and sealed.

[0032] This allows the heating medium to flow in through the first outlet 1 and then through the first guide pipe 5, intermittently flowing into two adjacent cavities 13; simultaneously, the heating medium flows in through the second outlet 2 and then through the second guide pipe 6, intermittently flowing into two adjacent cavities 13; thus achieving countercurrent heating between the two inlets and outlets, and enabling heat transfer between the two media, ensuring overall uniformity of medium temperature, thereby improving heating uniformity;

[0033] To further improve heating efficiency, each cavity 13 is equipped with two first guide pipes 5. The first guide pipes 5 are arc-shaped to conform to the external shape of the tank 10 and increase the flow time of the heating medium. Both ends of the first guide pipes 5 are connected to the partition plate. Similarly, two second guide pipes 6 are provided, which are also arc-shaped. To improve the airtightness of the connection, the first guide pipes 5 and the second guide pipes 6 are provided with flanges 7 at both ends. The flanges 7 are connected to the partition plate 9 by welding or bolts, and a sealing gasket is provided between the flanges 7 and the partition plate 9. To improve heating uniformity, the joints of the first guide pipes 5 and the second guide pipes 6 are spaced apart from top to bottom to ensure balanced heat transfer. At the same time, the outer layer 8 is coated with a high-temperature resistant heat-insulating coating to prevent heat loss and further improve heating efficiency.

[0034] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A reaction apparatus for the preparation of fosfomycin tromethamine, characterized in that: It includes a tank body, with a feed inlet and a discharge outlet at the top and bottom of the tank body, respectively. The tank body is equipped with an outer layer, and several partition plates are vertically installed inside the layer, dividing the layer into several cavities. The two adjacent cavities are respectively provided with a first outlet and a second outlet on their lower sides; The upper sides of the two cavities adjacent to the first and second outlets are respectively provided with a first inlet and a second inlet; From the first inlet counterclockwise, each cavity is provided with several first guide tubes at intervals, and the first guide tubes connect the partition plates of two intervals. Starting from the second inlet and moving clockwise, each cavity is provided with several second guide tubes at intervals, which connect the partition plates of the two intervals.

2. The reaction apparatus for preparing fosfomycin tromethamine according to claim 1, characterized in that: Each cavity is equipped with two first guide tubes, which are arc-shaped in shape; both ends of the first guide tubes are connected to the partition plate.

3. The reaction apparatus for preparing fosfomycin tromethamine according to claim 2, characterized in that: The first guide pipe has flanges at both ends, and the flanges are connected to the partition plate by welding or bolts.

4. The reaction apparatus for preparing fosfomycin tromethamine according to claim 3, characterized in that: Each cavity is equipped with two second guide tubes, which are arc-shaped in shape; both ends of the second guide tubes are connected to the partition plate.

5. The reaction apparatus for preparing fosfomycin tromethamine according to claim 4, characterized in that: The second guide pipe has flanges at both ends, which are connected to the partition plate by welding or bolts.

6. The reaction apparatus for preparing fosfomycin tromethamine according to claim 5, characterized in that: A sealing gasket is provided between the flange face and the partition plate.

7. The reaction apparatus for preparing fosfomycin tromethamine according to claim 6, characterized in that: The connection points of the first and second guide tubes are spaced apart from top to bottom.

8. The reaction apparatus for preparing fosfomycin tromethamine according to claim 7, characterized in that: The outer layer is coated with a high-temperature resistant heat-insulating coating.

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