Polypeptide medical intermediate extraction tower

Abstract

The utility model relates to the technical field of medicine production, in particular to a polypeptide medicine intermediate extraction tower, which not only utilizes water bath to conveniently heat medicine and improve the accurate control of temperature, but also accelerates the full mixing of extract liquor and medicine and improves the extraction efficiency by increasing the contact area and stirring. Comprising an extraction mechanism; the device further comprises a water bath mechanism, a feeding mechanism, a stirring mechanism and a waste heat utilization mechanism, the water bath mechanism is installed on the extraction mechanism and heats the medicine, the feeding mechanism is installed on the water bath mechanism and conveys the medicine into the extraction mechanism, and the stirring mechanism is installed on the extraction mechanism and accelerates mixing and contact of the medicine and the extraction agent. And the waste heat utilization mechanism is mounted on the extraction mechanism and is used for collecting and utilizing waste heat.

Description

Technical Field

[0001] This utility model relates to the technical field of pharmaceutical production, and in particular to an extraction tower for polypeptide pharmaceutical intermediates. Background Technology

[0002] Extraction towers are often used in the production of pharmaceutical intermediates for liquid-liquid separation. Liquid-liquid extraction utilizes the different distribution ratios between two complementary or partially miscible solvents to achieve the separation and purification of each component.

[0003] Existing pharmaceutical intermediate extraction towers, such as the oscillating extraction tower for pharmaceutical intermediate production disclosed in utility model patent application number 201920786253.4, mainly include a tower body comprising, from top to bottom, a raffinate settling section, an extraction section, and an extract phase settling section. The raffinate settling section has a raffinate discharge outlet at the top of its side wall, the extraction section has an extract liquid inlet on one side at the top and a raw material inlet on one side at the bottom, and the extract phase settling section has an extract phase outlet at the bottom. In use, the oscillating shaft in the extraction section not only drives the oscillating plate to move up and down, thus agitating the two phase media, but also drives the oscillating spring to oscillate irregularly, making the two phase media more fully contacted. The vertical ring plates of different heights on the annular extraction plate can also interfere with the mixing of the media, thereby improving the overall extraction efficiency.

[0004] However, most existing intermediate extraction towers do not regulate temperature. Inaccurate temperature control can easily lead to the inactivation of heat-sensitive peptides. Moreover, most existing extraction towers do not fully mix the extraction solution, resulting in low extraction efficiency. Utility Model Content

[0005] To solve the above-mentioned technical problems, this utility model provides a polypeptide pharmaceutical intermediate extraction tower that not only utilizes a water bath to conveniently heat the drug and improves the precise control of temperature, but also accelerates the full mixing of the extract and the drug by increasing the contact area and stirring, thereby improving the extraction efficiency.

[0006] This utility model discloses an extraction tower for polypeptide pharmaceutical intermediates, comprising an extraction mechanism; it also includes a water bath mechanism, a feeding mechanism, a stirring mechanism, and a waste heat utilization mechanism. The water bath mechanism is installed on the extraction mechanism to heat the drug; the feeding mechanism is installed on the water bath mechanism to transport the drug into the extraction mechanism; the stirring mechanism is installed on the extraction mechanism to accelerate the mixing and contact of the drug and the extractant; and the waste heat utilization mechanism is installed on the extraction mechanism to collect and utilize waste heat. Operators transport the extract into the extraction mechanism, while the feeding mechanism simultaneously transports the drug into the extraction mechanism. The water bath mechanism is activated to heat the drug in the extraction mechanism, and the stirring mechanism is activated to stir the extract to increase the extraction rate. When the temperature inside the extraction mechanism becomes too high, the waste heat utilization mechanism is activated to extract the waste heat to preheat the drug in the feeding mechanism. Then, the stirring mechanism is turned off, and the extract is allowed to separate and discharged.

[0007] Preferably, the extraction mechanism includes an extraction cylinder, a controller, a liquid addition hopper, a sealing cap, and a discharge pipe. The bottom end of the extraction cylinder is connected to the ground, and the inside of the extraction cylinder has a cavity. The controller is installed on the extraction cylinder. The bottom end of the liquid addition hopper is connected to the inside of the top end of the extraction cylinder. The sealing cap is rotatably installed on the liquid addition hopper. The top end of the discharge pipe is connected to the inside of the bottom end of the extraction cylinder. A first valve is installed on the discharge pipe. The operator opens the sealing cap and adds the extract into the cavity of the extraction cylinder through the liquid addition hopper. Then, the operator closes the sealing cap and uses the controller to control the water bath mechanism to heat the extract. After the extraction and stratification are completed, the operator opens the first valve and discharges the drug and extract separately through the discharge pipe.

[0008] Preferably, the water bath mechanism includes an insulation layer, six sets of heating rods, two sets of water inlet pipes, and two sets of second valves. The insulation layer is installed on the extraction cylinder and forms a sandwich between the extraction cylinder and the extraction cylinder. All six sets of heating rods are installed inside the sandwich, and both sets of water inlet pipes are connected to the interior of the sandwich. The two sets of second valves are installed on the two sets of water inlet pipes respectively. The operator opens the upper second valve to deliver clean water into the sandwich through the upper water inlet pipe. The six sets of heating rods heat the clean water to increase the temperature of the extractant in the cavity of the extraction cylinder. After extraction is completed, the lower second valve is opened, and hot water is discharged through the lower water inlet pipe.

[0009] Preferably, the feeding mechanism includes a flange, a feed pipe, a third valve, two sets of branch pipes, and two sets of packing layers. The flange is installed on the reactor, the feed pipe is installed on the flange, the third valve is installed on the feed pipe, both sets of branch pipes are installed on the extraction cylinder and communicate with the inside of the feed pipe, and both sets of packing layers are installed in the cavity of the extraction cylinder. The operator uses bolts to seal the flange to the discharge port of the reactor. The polypeptide pharmaceutical intermediate generated in the reactor is transported to the two sets of packing layers through the feed pipe and the two sets of branch pipes. The two sets of packing layers increase the contact area with the extract by folding, thereby increasing the contact area between the drug and the extract.

[0010] Preferably, the stirring mechanism includes a motor, a reducer, a drive shaft, and two sets of stirring blades. The bottom end of the motor is connected to the top end of the extraction cylinder, and the bottom end of the reducer is connected to the top end of the extraction cylinder. The drive shaft is rotatably installed in the cavity of the extraction cylinder and longitudinally connected to the reducer. Both sets of stirring blades are installed on the drive shaft and are located below the two sets of packing layers respectively. When the motor is started, the motor drives the drive shaft to rotate through the reducer. The drive shaft drives the two sets of stirring blades to rotate. The rotation of the two sets of stirring blades stirs the extract, thereby improving the extraction efficiency of the extract.

[0011] Preferably, the waste heat utilization mechanism includes a heat pump, an extraction pipe, a thermometer, a gas delivery pipe, and a preheating box. The bottom end of the heat pump is connected to the top end of the extraction cylinder. The extraction pipe is installed on the heat pump and communicates with the inside of the top end of the extraction cylinder. The thermometer is installed on the extraction pipe, the gas delivery pipe is installed on the heat pump, and the preheating box is installed on the extraction cylinder and communicates with the inside of the gas delivery pipe. When the thermometer detects that the temperature inside the cavity of the extraction cylinder is too high, the heat pump is started. The heat pump extracts the waste heat from the cavity through the extraction pipe and delivers the heat to the preheating box through the gas delivery pipe. The waste heat is used to preheat the drugs in the feed pipe and the two sets of branch pipes.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows: the staff delivers the extract to the extraction mechanism, and at the same time the feeding mechanism delivers the drug to the extraction mechanism. The water bath mechanism is started to heat the drug in the extraction mechanism, and the stirring mechanism is started to stir the extract to improve the extraction rate. When the temperature in the extraction mechanism is too high, the waste heat utilization mechanism is started to extract the waste heat to preheat the drug in the feeding mechanism. Then the stirring mechanism is turned off and the extract is discharged in layers. Attached Figure Description

[0013] Figure 1 This is a cross-sectional axonometric structural schematic diagram of this utility model;

[0014] Figure 2 This is a front view schematic diagram of the extraction mechanism of this utility model;

[0015] Figure 3 This is a cross-sectional isometric structural diagram of the water bath mechanism of this utility model;

[0016] Figure 4 This is a cross-sectional isometric structural diagram of the feeding mechanism and the stirring mechanism of this utility model;

[0017] Figure 5 This is a partially enlarged isometric structural diagram of the waste heat utilization mechanism of this utility model.

[0018] The attached diagram is labeled as follows: 01, extraction mechanism; 11, extraction cylinder; 12, controller; 13, liquid addition hopper; 14, sealing cover; 15, discharge pipe; 16, first valve; 02, water bath mechanism; 21, insulation layer; 22, heating rod; 23, water inlet pipe; 24, second valve; 03, feeding mechanism; 31, flange; 32, feeding pipe; 33, third valve; 34, branch pipe; 35, packing layer; 04, stirring mechanism; 41, electric motor; 42, reducer; 43, drive shaft; 44, stirring blade; 05, waste heat utilization mechanism; 51, heat pump; 52, exhaust pipe; 53, thermometer; 54, gas transmission pipe; 55, preheating box. Detailed Implementation

[0019] To facilitate understanding of this utility model, a more complete description will be given below with reference to the accompanying drawings. This utility model can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to make the disclosure of this utility model more thorough and complete.

[0020] Example 1

[0021] This utility model discloses an extraction tower for polypeptide pharmaceutical intermediates, comprising an extraction mechanism 01; it also includes a water bath mechanism 02, a feeding mechanism 03, a stirring mechanism 04, and a waste heat utilization mechanism 05. The water bath mechanism 02 is installed on the extraction mechanism 01 to heat the drug; the feeding mechanism 03 is installed on the water bath mechanism 02 to transport the drug into the extraction mechanism 01; the stirring mechanism 04 is installed on the extraction mechanism 01 to accelerate the mixing and contact of the drug and the extractant; and the waste heat utilization mechanism 05 is installed on the extraction mechanism 01 to collect and utilize waste heat. The system includes an extraction cylinder 11, a controller 12, a liquid addition hopper 13, a sealing cap 14, and a discharge pipe 15. The bottom end of the extraction cylinder 11 is connected to the ground, and the interior of the extraction cylinder 11 has a cavity. The controller 12 is mounted on the extraction cylinder 11. The bottom end of the liquid addition hopper 13 is connected to the interior of the top end of the extraction cylinder 11. The sealing cap 14 is rotatably mounted on the liquid addition hopper 13. The top end of the discharge pipe 15 is connected to the interior of the bottom end of the extraction cylinder 11. A first valve 16 is mounted on the discharge pipe 15. The water bath mechanism 02 includes an insulation layer 21, six sets of heating rods 22, two sets of water inlet pipes 23, and... Two sets of second valves 24, an insulation layer 21 installed on the extraction cylinder 11 and forming a jacket between the two cylinders, six sets of heating rods 22 all installed in the jacket, two sets of water inlet pipes 23 all communicating with the interior of the jacket, and two sets of second valves 24 respectively installed on the two sets of water inlet pipes 23; the feeding mechanism 03 includes a flange 31, a feed pipe 32, a third valve 33, two sets of branch pipes 34 and two sets of packing layers 35, the flange 31 is installed on the reactor, the feed pipe 32 is installed on the flange 31, the third valve 33 is installed on the feed pipe 32, and the two sets of branch pipes 34 Both are installed on the extraction cylinder 11 and communicate with the inside of the feed pipe 32. Both sets of packing layers 35 are installed in the cavity of the extraction cylinder 11. The stirring mechanism 04 includes a motor 41, a reducer 42, a drive shaft 43 and two sets of stirring blades 44. The bottom end of the motor 41 is connected to the top end of the extraction cylinder 11, the bottom end of the reducer 42 is connected to the top end of the extraction cylinder 11, the drive shaft 43 is rotatably installed in the cavity of the extraction cylinder 11 and is longitudinally connected to the reducer 42, and both sets of stirring blades 44 are installed on the drive shaft 43 and are respectively located below the two sets of packing layers 35.During operation, the operator first opens the sealing cap 14 and adds the extractant into the cavity of the extraction cylinder 11 through the addition hopper 13. Then, the sealing cap 14 is closed, and the operator uses bolts to seal the flange 31 to the discharge port of the reactor. The polypeptide pharmaceutical intermediate generated in the reactor is transported to the two packing layers 35 through the feed pipe 32 and two sets of branch pipes 34. The two sets of packing layers 35 increase the contact area with the extractant by folding, thereby increasing the contact area between the drug and the extractant. The operator then opens the second valve 24 located at the top and supplies clean water through the water inlet pipe 23 located at the top to the clamp. Inside the chamber, six sets of heating rods 22 heat the water, raising the temperature of the extractant in the cavity of the extraction cylinder 11. The motor 41 is started, and through the reducer 42, the motor drives the drive shaft 43 to rotate. The drive shaft 43 drives two sets of stirring blades 44 to rotate, stirring the extractant and improving its extraction efficiency. Then, the motor 41 is turned off, and the solution is allowed to separate. Once the extraction and separation are complete, the operator opens the first valve 16, discharging the drug and extractant separately through the discharge pipe 15. The second valve 24 is then opened, allowing hot water to drain through the inlet pipe 23 located below.

[0022] Example 2

[0023] like Figures 1 to 5As shown, this utility model discloses a polypeptide pharmaceutical intermediate extraction tower based on Example 1. The waste heat utilization mechanism 05 includes a heat pump 51, an extraction pipe 52, a thermometer 53, a gas delivery pipe 54, and a preheating box 55. The bottom end of the heat pump 51 is connected to the top end of the extraction cylinder 11. The extraction pipe 52 is installed on the heat pump 51 and communicates with the inside of the top end of the extraction cylinder 11. The thermometer 53 is installed on the extraction pipe 52. The gas delivery pipe 54 is installed on the heat pump 51. The preheating box 55 is installed on the extraction cylinder 11 and communicates with the inside of the gas delivery pipe 54. 4. Internal Connection; During operation, firstly, the operator opens the sealing cover 14 and adds the extractant into the cavity of the extraction cylinder 11 through the addition hopper 13. Then, the sealing cover 14 is closed, and the operator uses bolts to seal the flange 31 to the discharge port of the reactor. The polypeptide pharmaceutical intermediate generated in the reactor is transported to the two packing layers 35 through the feed pipe 32 and two sets of branch pipes 34. The two sets of packing layers 35 increase the contact area with the extractant by folding, thereby increasing the contact area between the drug and the extractant. The operator opens the second valve 24 located at the top and sends clean water into the jacket through the water inlet pipe 23 located at the top. Six sets of heating rods 22 heat the clean water to increase the temperature of the extractant in the cavity of the extraction cylinder 11. The motor 41 is started, and the motor 41 drives the drive shaft 43 to rotate through the reducer 42. The drive shaft 43 drives the two sets of stirring blades 44 to rotate. The two sets of stirring blades 44 rotate to stir the extractant and improve the extraction efficiency. When the thermometer 53 detects the temperature of the extraction cylinder 11, the temperature rises. When the temperature inside the cavity becomes too high, the heat pump 51 is activated. The heat pump 51 extracts the residual heat from the cavity through the air extraction pipe 52 and transfers the heat to the preheating box 55 through the air delivery pipe 54. The residual heat is used to preheat the drugs in the feed pipe 32 and the two sets of branch pipes 34. Then the motor 41 is turned off and the solution is allowed to separate. When the extraction and separation are completed, the operator opens the first valve 16 and discharges the drugs and extract through the discharge pipe 15. The second valve 24 below is opened and hot water is discharged through the water inlet pipe 23 located below.

[0024] The electric motor 41, reducer 42, and heat pump 51 of this utility model are commercially available. Technical personnel in this industry only need to install and operate them according to the accompanying instruction manual, without requiring any creative work from those skilled in the art.

[0025] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of the present utility model, and these improvements and modifications should also be considered within the protection scope of the present utility model.

Claims

1. An extraction tower for polypeptide pharmaceutical intermediates, comprising an extraction mechanism (01); characterized in that, It also includes a water bath mechanism (02), a feeding mechanism (03), a stirring mechanism (04), and a waste heat utilization mechanism (05). The water bath mechanism (02) is installed on the extraction mechanism (01) to heat the drug. The feeding mechanism (03) is installed on the water bath mechanism (02) to transport the drug into the extraction mechanism (01). The stirring mechanism (04) is installed on the extraction mechanism (01) to accelerate the mixing and contact of the drug with the extractant. The waste heat utilization mechanism (05) is installed on the extraction mechanism (01) to collect and utilize the waste heat.

2. The polypeptide pharmaceutical intermediate extraction tower as described in claim 1, characterized in that, The extraction mechanism (01) includes an extraction cylinder (11), a controller (12), a liquid addition hopper (13), a sealing cap (14), and a discharge pipe (15). The bottom end of the extraction cylinder (11) is connected to the ground. The extraction cylinder (11) has a cavity inside. The controller (12) is installed on the extraction cylinder (11). The bottom end of the liquid addition hopper (13) is connected to the inside of the top end of the extraction cylinder (11). The sealing cap (14) is rotatably installed on the liquid addition hopper (13). The top end of the discharge pipe (15) is connected to the inside of the bottom end of the extraction cylinder (11). The first valve (16) is installed on the discharge pipe (15).

3. The polypeptide pharmaceutical intermediate extraction tower as described in claim 2, characterized in that, The water bath mechanism (02) includes an insulation layer (21), six sets of heating rods (22), two sets of water inlet pipes (23) and two sets of second valves (24). The insulation layer (21) is installed on the extraction cylinder (11) and forms a sandwich between the extraction cylinder (11). All six sets of heating rods (22) are installed in the sandwich. Both sets of water inlet pipes (23) are connected to the interior of the sandwich. The two sets of second valves (24) are installed on the two sets of water inlet pipes (23) respectively.

4. The polypeptide pharmaceutical intermediate extraction tower as described in claim 2, characterized in that, The feeding mechanism (03) includes a flange (31), a feed pipe (32), a third valve (33), two sets of branch pipes (34) and two sets of packing layers (35). The flange (31) is installed on the reactor, the feed pipe (32) is installed on the flange (31), the third valve (33) is installed on the feed pipe (32), the two sets of branch pipes (34) are both installed on the extraction cylinder (11) and communicate with the inside of the feed pipe (32), and the two sets of packing layers (35) are both installed in the cavity of the extraction cylinder (11).

5. The polypeptide pharmaceutical intermediate extraction tower as described in claim 4, characterized in that, The stirring mechanism (04) includes a motor (41), a reducer (42), a drive shaft (43), and two sets of stirring blades (44). The bottom end of the motor (41) is connected to the top end of the extraction cylinder (11), the bottom end of the reducer (42) is connected to the top end of the extraction cylinder (11), the drive shaft (43) is rotatably installed in the cavity of the extraction cylinder (11) and longitudinally connected to the reducer (42), and the two sets of stirring blades (44) are installed on the drive shaft (43) and located below the two sets of packing layers (35).

6. The polypeptide pharmaceutical intermediate extraction tower as described in claim 2, characterized in that, The waste heat utilization mechanism (05) includes a heat pump (51), an extraction pipe (52), a thermometer (53), a gas delivery pipe (54), and a preheating box (55). The bottom end of the heat pump (51) is connected to the top end of the extraction cylinder (11). The extraction pipe (52) is installed on the heat pump (51) and communicates with the inside of the top end of the extraction cylinder (11). The thermometer (53) is installed on the extraction pipe (52). The gas delivery pipe (54) is installed on the heat pump (51). The preheating box (55) is installed on the extraction cylinder (11) and communicates with the inside of the gas delivery pipe (54).

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