Platelet-rich plasma preparation device

Abstract

The utility model discloses a platelet-rich plasma preparation device, which belongs to the technical field of medical instruments and comprises an upper end jacket, one end of the upper end jacket is connected with an upper end cover, the other end of the upper end jacket is connected with a lower end jacket, the bottom of the lower end jacket is connected with a lower end cover capable of moving up and down, and the upper end jacket is provided with a first cavity. A second chamber, a third chamber and a connecting channel for communicating the second chamber with the third chamber are sleeved outside the lower end part, and the second chamber is communicated with the first chamber; the upper end cover is provided with an upper sealing rod for controlling the first cavity to be communicated with or disconnected from the second cavity, the lower end cover is provided with a lower sealing rod for controlling the second cavity to be communicated with or disconnected from the third cavity, the upper sealing rod is provided with a fourth cavity, and a limiting rod capable of moving up and down along the inner wall of the fourth cavity is arranged in the fourth cavity. The PRP preparation device is convenient to operate, high in preparation efficiency and capable of preparing PRP with different leukocyte contents according to requirements, and different treatment requirements are met.

Description

Technical Field

[0001] This utility model relates to a platelet-rich plasma preparation device, belonging to the field of medical device technology. Background Technology

[0002] Platelet-rich plasma (PRP), as a biotherapy material derived from the patient's own body, is rich in high concentrations of platelets and various growth factors (such as PDGF, TGF-β, and EGF), exhibiting excellent clinical effects in promoting cell proliferation, tissue repair, and regeneration. It has been widely applied in various fields, including medical aesthetics, orthopedics, and dentistry. Platelet concentration is the core factor determining the efficacy of PRP; therefore, how to efficiently and accurately extract high-purity, high-concentration platelets from whole blood has become a key objective of PRP preparation technology. Currently, PRP preparation mainly relies on centrifugation technology, achieving the stratified separation of blood components by controlling centrifugation speed and time.

[0003] However, existing PRP preparation devices still have many shortcomings in practical applications: traditional devices have cumbersome operation procedures, often requiring inverting the equipment during secondary centrifugation and manually extracting excess plasma to adjust the concentration, demanding high operator proficiency and being susceptible to human error affecting the results; at the same time, due to structural design limitations, some devices have low platelet enrichment efficiency and recovery rates, making it difficult to meet the high concentration requirements in clinical practice. In addition, existing technologies also face problems of poor adaptability and insufficient purity control: there are significant individual differences in blood components among different patients (such as platelet count, red blood cell ratio, etc.), but existing devices lack flexible volume adjustment mechanisms, making it difficult to stably adapt to individual needs.

[0004] Therefore, there is an urgent need to develop a new PRP preparation device to solve the above-mentioned technical pain points and achieve efficient and precise PRP preparation. Utility Model Content

[0005] The technical problem to be solved by this utility model is to overcome the shortcomings of the prior art and provide a platelet-rich plasma preparation device that is easy to operate, has high preparation efficiency, and can prepare PRP with different white blood cell contents according to clinical needs to meet different treatment requirements.

[0006] The technical solution adopted by this utility model to solve its existing problems is:

[0007] A platelet-rich plasma preparation device includes an upper end jacket, one end of which is fixedly connected to an upper end cover, and the other end of which is fixedly connected to a lower end jacket. The bottom of the lower end jacket is connected to a lower end cover that can move up and down. The upper end jacket has a first chamber, and the lower end jacket has a second chamber, a third chamber, and a connecting channel connecting the second chamber and the third chamber. The second chamber is connected to the first chamber.

[0008] The upper end cover is provided with an upper sealing rod that controls the connection or disconnection between the first chamber and the second chamber, and the lower end cover is provided with a lower sealing rod that controls the connection or disconnection between the second chamber and the third chamber. The upper sealing rod is provided with a fourth chamber, and a limiting rod that can move up and down along the inner wall of the fourth chamber is provided in the fourth chamber.

[0009] Preferably, the upper end cover is provided with an extension bushing, the upper part of the upper sealing rod is threadedly connected to the upper end cover, and the lower part of the upper sealing rod abuts against the inner wall of the extension bushing; the upper sealing rod can move up and down along the inner wall of the extension bushing by adjusting the thread.

[0010] Preferably, the fourth chamber is located at the lower part of the upper sealing rod, and the outer circular surface of the lower part of the upper sealing rod is adapted to the inner wall of the first chamber side located at the connection between the first chamber and the second chamber;

[0011] The upper part of the limiting rod is threadedly connected to the upper sealing rod, and the lower end of the limiting rod is provided with a sliding plug, which abuts against the inner wall of the fourth chamber; the limiting rod can move up and down along the inner wall of the fourth chamber by adjusting the thread.

[0012] Preferably, the slide plug is provided with multiple venting grooves, and a venting water-blocking membrane is provided on the top of the slide plug, which covers the top opening of the venting groove.

[0013] Preferably, the lower sealing rod is threadedly connected to the lower end cover. By adjusting the thread, the lower sealing rod can move up and down along the axial direction of the lower end cover. The end of the lower sealing rod is provided with a plug that is adapted to the connection channel.

[0014] Preferably, the upper end cover is provided with an exhaust device and an injection part, and the lower end cover is provided with an extraction part located in the second chamber.

[0015] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0016] 1. Improved preparation efficiency and ease of operation, simplified process and reduced human error: The device achieves secondary centrifugation without inverting the equipment through the threaded adjustment structure of the upper sealing rod, limiting rod and lower sealing rod, eliminating the cumbersome steps of inverted centrifugation in traditional devices. At the same time, by rotating the limiting rod to adjust the position of the sliding plug and rotating the upper sealing rod to precisely control the volume of the cavity, it can automatically adapt to the required amount of plasma according to the needs, without the need to manually extract excess plasma, which greatly simplifies the operation process, reduces the dependence on the operator's skill level, reduces the impact of human operation error on the preparation effect, and significantly improves the efficiency and stability of PRP preparation.

[0017] 2. Improve platelet purity and concentration, and reduce contamination risk: The device effectively solves the problem of red blood cell contamination in traditional devices through a multi-seal design (first to seventh seals) and a precise chamber isolation structure. The blockage of the lower sealing rod can be completely sealed by the fifth seal to isolate the red blood cell layer in the third chamber, preventing it from contaminating the white membrane layer and plasma layer. The fourth seal at the bottom of the upper sealing rod ensures reliable disconnection between the first and second chambers, so that only the white membrane layer and the required plasma remain in the target cavity, which significantly improves the purity of PRP. At the same time, through precise adjustment of the cavity volume, platelets can be concentrated in a targeted manner to further increase the platelet concentration and meet the needs of clinical treatment.

[0018] 3. Enhance individual adaptability and achieve personalized preparation: The device can flexibly adjust the volume of the fourth chamber according to the differences in blood components of different patients (such as the initial number of platelets, plasma ratio, etc.) through the cooperation structure of the limiting rod and the sliding plug. Combined with the movement of the upper sealing rod to control the total volume of the chamber, it can achieve precise control of PRP concentration and usage, and can stably adapt to the personalized needs of different patients, solving the problem that traditional devices are difficult to adapt to individual differences due to the lack of adjustment mechanism.

[0019] 4. Optimize structural stability and sealing reliability, reduce costs and improve equipment practicality: The device guides and stabilizes the upper sealing rod through the extended bushing, ensuring that the sealing rod accurately aligns with the inner wall of the cavity when it moves, avoiding misalignment that affects the sealing effect. The synergistic effect of multiple sealing components comprehensively prevents liquid leakage and the intrusion of external impurities, ensuring the overall working reliability of the device. In addition, the device has a compact structure, requires no additional auxiliary tools, reduces the size of the equipment and lowers production and usage costs, making it more conducive to clinical promotion and application. Attached Figure Description

[0020] Figure 1 This is a structural diagram of a platelet-rich plasma preparation device according to the present invention;

[0021] Figure 2 This is a full sectional front view of a platelet-rich plasma preparation device according to the present invention;

[0022] Figure 3 This is a partial enlarged view of point A in the full sectional view of the platelet-rich plasma preparation device of this utility model.

[0023] In the diagram: 1. Upper end cap; 101. Exhaust vent; 102. Injection section; 103. Extending bushing; 2. Upper end sleeve; 201. First chamber; 3. Lower end sleeve; 301. Extraction section; 302. Second chamber; 303. Connecting channel; 304. Third chamber; 4. Lower end cap; 5. Lower sealing rod; 501. Plug; 6. Upper sealing rod; 601. Fourth chamber; 7. Limiting rod; 701. Exhaust water-blocking membrane; 702. Sliding plug; 703. Exhaust groove; 8. First seal; 9. Second seal; 10. Third seal; 11. Fourth seal; 12. Fifth seal; 13. Sixth seal; 14. Seventh seal. Detailed Implementation

[0024] The present invention will be further described below with reference to specific embodiments.

[0025] like Figures 1-3 The illustrated platelet-rich plasma (PRP) preparation device includes an upper outer sleeve 2, one end of which is fixedly connected to an upper cover 1, and the other end of which is fixedly connected to a lower outer sleeve 3. A lower cover 4, movable vertically, is connected to the bottom of the lower outer sleeve 3. The upper outer sleeve 2 has a first chamber 201, and the lower outer sleeve 3 has a second chamber 302, a third chamber 304, and a connecting channel 303 connecting the second chamber 302 and the third chamber 304. The second chamber 302 connects to the first chamber 201. The upper cover 1 is provided with an upper sealing rod 6 for controlling the connection or disconnection between the first chamber 201 and the second chamber 302. The lower cover 4 is provided with a lower sealing rod 5 for controlling the connection or disconnection between the second chamber 302 and the third chamber 304. The upper sealing rod 6 provides a fourth chamber 601, and a limiting rod 7, movable vertically along the inner wall of the fourth chamber 601, is provided within the fourth chamber 601.

[0026] A first sealing element 8 is provided at the connection between the upper end cover 1 and the upper end sleeve 2 to seal the connection between the two parts, preventing liquid leakage from the gap between them, and preventing the intrusion of external impurities, dust, etc., ensuring the sealing of the connection between the two parts and the operational reliability of the overall structure. The upper end cover 1 is provided with an extension sleeve 103. The upper part of the upper sealing rod 6 is threadedly connected to the upper end cover 1, and the lower part of the upper sealing rod 6 abuts against the inner wall of the extension sleeve 103. By rotating the upper sealing rod 6 and adjusting it through the thread, the upper sealing rod 6 can move up and down along the inner wall of the extension sleeve 103. A second sealing element 9 is provided on the upper sealing rod 6. The second sealing element 9 plays a sealing role when the upper sealing rod 6 moves up and down along the inner wall of the extension sleeve 103, preventing liquid leakage from the gap between the second sealing element 9 and the extension sleeve 103.

[0027] The fourth chamber 601 is located at the lower part of the upper sealing rod 6. The lower outer circular surface of the upper sealing rod 6 is adapted to the inner wall of the first chamber 201 located at the connection between the first chamber 201 and the second chamber 302. The diameter of the fourth chamber 601 is equal to the diameter of the second chamber 302. A fourth sealing element 11 is provided on the lower outer circular surface of the upper sealing rod 6. When the upper sealing rod 6 moves downward and the lower outer circular surface of the upper sealing rod 6 abuts against the inner wall of the first chamber 201, the communication between the first chamber 201 and the second chamber 302 can be disconnected, so that the upper part of the second chamber 302 is only connected to the fourth chamber 601. At this time, the fourth sealing element 11 is used to seal the gap between the upper sealing rod 6 and the first chamber 201 to prevent liquid leakage. The protruding bushing 103 serves as a guide and structural stabilizer when the upper sealing rod 6 moves up and down. When the upper sealing rod 6 moves downward, the protruding bushing 103 ensures that its lower end precisely abuts against the inner wall of the first chamber 201 at the connection between the first chamber 201 and the second chamber 302, thereby preventing misalignment of the upper sealing rod 6. The upper part of the limiting rod 7 is threadedly connected to the upper sealing rod 6, and the lower end of the limiting rod 7 is provided with a sliding plug 702, which abuts against the inner wall of the fourth chamber 601. By rotating the limiting rod 7 and adjusting it through the thread, the sliding plug 702 can move up and down along the inner wall of the fourth chamber 601, and the volume of the fourth chamber 601 can be adjusted by the up and down movement of the sliding plug 702. A third sealing element 10 is provided on the outer circumference of the sliding plug 702. The third sealing element 10 plays a sealing role when the sliding plug 702 moves up and down along the inner wall of the fourth chamber 601, preventing liquid from leaking from the gap between the sliding plug 702 and the fourth chamber 601.

[0028] The slide plug 702 is provided with multiple venting grooves 703, which provide gas flow channels and prevent gas from accumulating in the cavity and forming gas resistance during the movement of the slide plug 702, thereby ensuring the smooth movement of the slide plug 702 or the balance of internal pressure of the equipment. A venting and water-blocking membrane 701 is provided at the top of the slide plug 702, covering the top opening of the venting grooves 703. The venting and water-blocking membrane 701 achieves selective blocking of "venting without draining," allowing the gas guided by the venting grooves 703 to be smoothly discharged through the membrane while preventing liquid from leaking back through the venting grooves 703. The venting and water-blocking membrane 701 is generally made of medical-grade materials, such as polytetrafluoroethylene (PTFE), polyethylene (PE), or composite materials, all of which are mature existing technologies.

[0029] The lower sealing rod 5 is threadedly connected to the lower end cover 4. By rotating the lower sealing rod 5 and adjusting it via the thread, the lower sealing rod 5 can move up and down along the axial direction of the lower end cover 4. The end of the lower sealing rod 5 is provided with a plug 501 adapted to the connecting channel 303. When the lower sealing rod 5 moves upward, the plug 501 can enter the connecting channel 303 to disconnect the connection between the second chamber 302 and the third chamber 304. A fifth sealing element 12 is provided on the outer circumference of the plug 501. The fifth sealing element 12 plays a sealing role when the plug 501 enters the connecting channel 303, preventing liquid from leaking from the gap between the plug 501 and the connecting channel 303.

[0030] The upper end cover 1 is provided with an exhaust vent 101 and an injection section 102. The exhaust vent 101 is used to expel air from the device when liquid is injected into the device through the injection section 102, and the injection section 102 is used for liquid injection. The lower end cover 3 is provided with an extraction section 301 located in the second chamber 302 for liquid extraction.

[0031] A sixth seal 13 is provided at the connection between the lower end jacket 3 and the lower end cover 4, and a seventh seal 14 is provided at the connection between the lower end cover 4 and the lower sealing rod 5. Both the sixth seal 13 and the seventh seal 14 are used to prevent liquid leakage at the connection.

[0032] The preparation method of a platelet-rich plasma preparation device is as follows:

[0033] 1. Blood Injection: First, the collected blood is injected into the device through the injection part 102 on the upper end cover 1. At this time, the blood will fill the third chamber 304, the connecting channel 303, the second chamber 302 and the lower part of the first chamber 201 of the entire device.

[0034] 2. Initial centrifugation: Place the device in a centrifuge for the first centrifugation process. After centrifugation, the blood will be divided into three layers: the bottom layer is the red blood cell layer, the top layer is the plasma layer, and the middle layer is the white blood membrane layer rich in white blood cells and platelets.

[0035] 3. Red blood cell separation: Rotate and adjust the position of the lower end cap 4 so that it moves axially closer to the connecting channel 303. As the volume of the third chamber 304 decreases, the blood will gradually flow to the lower part of the connecting channel 303, the second chamber 302 and the first chamber 201. When the white membrane layer completely enters the connecting channel 303, stop adjusting the position of the lower end cap 4.

[0036] 4. Seal the red blood cell layer: Rotate the lower sealing rod 5 until the blockage 501 is completely inserted into the connecting channel 303, ensuring that the red blood cell layer is isolated in the third chamber 304, while the white membrane layer and plasma layer are located in the second chamber 302 and the first chamber 201.

[0037] 5. Second centrifugation: The white membrane layer has entered the second chamber 302, and a second centrifugation can be performed without inverting the device. In order to further concentrate the platelets in the white membrane layer, the device is placed in the centrifuge again for a second centrifugation operation.

[0038] 6. Concentration Adjustment: According to the required platelet concentration and dosage, first rotate the limiting rod 7 to adjust the sliding plug 702 to the corresponding volume position; then rotate the upper sealing rod 6 to move it downward until the lower end of the upper sealing rod 6 abuts against the inner wall of the first chamber 201 at the connection between the first chamber 201 and the second chamber 302, and its lower end face is in contact with the upper end face of the second chamber 302. At this time, the upper sealing rod 6 can no longer move. At this time, the cavity formed by the fourth chamber 601 and the second chamber 302 is filled with the required amount of plasma.

[0039] 7. PRP extraction: Finally, the well-mixed white membrane layer and the remaining plasma are collected through the extraction unit 301 to obtain platelet-rich plasma of the required concentration.

[0040] This device, without inverting, eliminates the need for manual extraction of excess plasma. By adjusting the upper sealing rod 6 and the limiting rod 7, the required amount of platelet-rich plasma can be extracted. This device optimizes the centrifugation process, simplifies the operation, reduces the number of tools required, and avoids inverting the device during secondary centrifugation, thus reducing the size of the equipment and lowering costs. It can efficiently increase platelet concentration and help meet the personalized treatment needs of different patients.

[0041] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present invention.

Claims

1. A platelet-rich plasma preparation device, comprising an upper end jacket (2), one end of which is fixedly connected to an upper end cap (1), the other end of which is fixedly connected to a lower end jacket (3), and a lower end cap (4) movable up and down connected to the bottom of the lower end jacket (3), characterized in that: The upper end jacket (2) is provided with a first chamber (201), and the lower end jacket (3) is provided with a second chamber (302), a third chamber (304) and a connecting channel (303) connecting the second chamber (302) and the third chamber (304). The second chamber (302) is connected to the first chamber (201). The upper end cover (1) is provided with an upper sealing rod (6) for controlling the connection or disconnection between the first chamber (201) and the second chamber (302). The lower end cover (4) is provided with a lower sealing rod (5) for controlling the connection or disconnection between the second chamber (302) and the third chamber (304). The upper sealing rod (6) is provided with a fourth chamber (601). A limiting rod (7) that can move up and down along the inner wall of the fourth chamber (601) is provided in the fourth chamber (601).

2. The platelet-rich plasma preparation apparatus according to claim 1, characterized in that: The upper end cover (1) is provided with an extension sleeve (103), the upper part of the upper sealing rod (6) is threadedly connected to the upper end cover (1), and the lower part of the upper sealing rod (6) abuts against the inner wall of the extension sleeve (103); by adjusting the thread, the upper sealing rod (6) can move up and down along the inner wall of the extension sleeve (103).

3. The platelet-rich plasma preparation apparatus according to claim 2, characterized in that: The fourth chamber (601) is located at the lower part of the upper sealing rod (6), and the lower outer circular surface of the upper sealing rod (6) is adapted to the inner wall of the first chamber (201) located at the connection between the first chamber (201) and the second chamber (302); The upper part of the limiting rod (7) is threadedly connected to the upper sealing rod (6), and the lower end of the limiting rod (7) is provided with a sliding plug (702), which abuts against the inner wall of the fourth chamber (601). Through thread adjustment, the limiting rod (7) can move up and down along the inner wall of the fourth chamber (601).

4. The platelet-rich plasma preparation apparatus according to claim 3, characterized in that: The slide (702) is provided with multiple venting grooves (703), and the top of the slide (702) is provided with a venting water-blocking membrane (701), which covers the top opening of the venting groove (703).

5. The platelet-rich plasma preparation apparatus according to claim 4, characterized in that: The lower sealing rod (5) is threadedly connected to the lower end cover (4). By adjusting the thread, the lower sealing rod (5) can move up and down along the axial direction of the lower end cover (4). The end of the lower sealing rod (5) is provided with a plug (501) that is compatible with the connecting channel (303).

6. The platelet-rich plasma preparation apparatus according to claim 1, characterized in that: The upper end cap (1) is provided with an exhaust device (101) and an injection part (102), and the lower end cover (3) is provided with an extraction part (301) located in the second chamber (302).

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