Liquid nitrogen quick-frozen microsphere screening device
By designing a liquid nitrogen quick-freezing microsphere sieving device, efficient sieving and packaging of microspheres were achieved using a sieve and a counting device, solving the problems of microsphere filtration and counting packaging in existing technologies, and improving microsphere quality and production efficiency.
Patent Information
- Application Number
- CN202423157866.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-20
- Publication Date
- 2026-02-27
- Estimated Expiration
- 2034-12-20
AI Technical Summary
Existing technologies cannot filter and sieve microspheres that have been flash-frozen in liquid nitrogen, nor can they count and repackage the flash-frozen microspheres.
A liquid nitrogen quick-freezing microsphere sieving device was designed, including a main cylinder, an inner liner, a microsphere sieving device, and a counting device. The device uses first and second screens to filter microspheres of different diameters, and the counting device enables rapid dispensing.
It achieves efficient screening and counting of microspheres, reduces defect rate, improves packaging efficiency, and is suitable for pilot testing and small-batch production.
Smart Images
Figure CN223946208U_ABST
Abstract
Description
Technical Field
[0001] This utility model belongs to the field of quick-freezing microsphere production technology, specifically relating to a liquid nitrogen quick-freezing microsphere sieving device. Background Technology
[0002] With the development of cryogenic freezing technology, microsphere technology has been widely applied in many fields, including pharmaceuticals, cosmetics manufacturing, and food. Microsphere technology can maximize the preservation of enzyme / protein activity, and freeze-dried microspheres have a loose network structure, rapid reconstitution, and can be transported at room temperature and stored at room temperature for a long time. The preparation of microspheres mainly involves three steps: first, freezing liquid substances into a solid state; second, directly sublimating ice crystals into a gaseous state through vacuum drying; and finally, forming high-quality, stable microspheres.
[0003] Currently, the mainstream method for freezing microspheres is liquid nitrogen flash freezing, where liquid is dropped into liquid nitrogen and rapidly frozen into solid microspheres. The microspheres are then transferred to a freeze dryer for drying and sublimation. Existing technology cannot filter or sieve microspheres flash-frozen in liquid nitrogen, nor can it count and package the flash-frozen microspheres. Utility Model Content
[0004] In view of this, the purpose of this utility model is to provide a liquid nitrogen quick-freezing microsphere sieving device to solve the problem that the existing technology cannot filter and sieve microspheres quick-frozen in liquid nitrogen, nor can it count and package the quick-frozen microspheres.
[0005] To achieve the above objectives, this utility model provides the following technical solution:
[0006] This utility model discloses a liquid nitrogen quick-freezing microsphere sieving device, comprising a main cylinder, an inner liner for storing liquid nitrogen connected inside the main cylinder, and a microsphere sieving device connected inside the inner liner. The microsphere sieving device includes a first screen and a second screen, which are arranged sequentially and evenly inside the inner liner. Multiple locking blocks are connected inside the inner liner and located below the first screen and the second screen respectively. A discharge port is opened on one side of the inner liner, and a counting device is connected to the discharge port.
[0007] Furthermore, the main body is in the shape of an open cylinder, and an outer insulation layer is connected to the outside of the main body, the outer insulation layer being made of metal.
[0008] Furthermore, the first screen is located on the upper side of the inner liner, and the first screen is used to filter filters with a diameter greater than [missing information]. The microspheres are formed by a first screen having multiple holes. The diameter of the microspheres is d, and the depth of the holes in the first screen is H = 1 / 2d. The hole diameter is a fraction of the diameter of the microspheres. The first screen has circular holes and is made of stainless steel or other metal.
[0009] Further, the second screen is located at the lower side of the inner container, the second screen is used for filtering microspheres with a diameter less than , the second screen is provided with a plurality of holes, the hole depth H of the second screen is 1 / 2d, the hole diameter is a circular hole of the microspheres , and the second screen is made of stainless steel or other metal materials.
[0010] Further, the second screen is inclined, and handles are arranged above both ends of the second screen.
[0011] Further, the counting device is made of a transparent plastic pipe, the length of the counting device is L, and the width is d
[0012] Further, the counting device is connected with two valves.
[0013] The beneficial effects of the present application are as follows:
[0014] The liquid nitrogen quick-freezing microsphere screening device effectively reduces the defective rate of the microspheres by screening the microspheres through the microsphere screening device; after the microspheres are screened through the microsphere screening device, the microspheres are counted through the counting device, and then the valves are opened to achieve the effect of quick packaging; the device has a small overall size, a compact structure, and a small floor area, is convenient for use in the research and development of small test stages or small batch production, and is convenient for moving and storing.
[0015] Other advantages, objects and features of the present application will be described in the following specification, and will be apparent to those skilled in the art to some extent, or can be taught by those skilled in the art from the practice of the present application. The objects and other advantages of the present application can be achieved and obtained by the following specification. BRIEF DESCRIPTION OF DRAWINGS
[0016] In order to make the objects, technical solutions and beneficial effects of the present application more clear, the present application provides the following drawings for description:
[0017] Figure 1 It is a schematic view of the overall structure of the present application;
[0018] Figure 2 It is a partial view of the microsphere screening device and other components of the present application;
[0019] Figure 3 It is an enlarged view of A in the present application. Figure 2
[0020] The marks in the drawings are as follows: 1, main body cylinder; 2, inner container; 3, microsphere screening device; 31, first screen; 32, second screen; 4, discharge port; 5, counting device; 6, valve; 7, clamping block; 8, handle; 9, hole; 10, outer shell heat preservation layer. DETAILED DESCRIPTION
[0021] As Figures 1 to 3 shown, the utility model discloses a liquid nitrogen quick-freezing microsphere screening device, including main body cylinder 1, and the main body cylinder 1 is open barrel shape. The main body cylinder 1 outside is connected with the outer shell heat preservation layer 10, and the outer shell heat preservation layer 10 is metal material. The main body cylinder 1 is connected with the inner container 2 for storing liquid nitrogen in, and the inner container 2 is connected with the microsphere screening device 3 for screening microspheres in, and the microsphere screening device 3 includes: first screen 31 and second screen 32. The first screen 31 and second screen 32 are evenly arranged vertically inside the inner container 2. The inner container 2 is connected with a plurality of clamping blocks 7 respectively located the lower side of first screen 31 and second screen 32, so that the first screen 31 and second can be disassembled. The inner container 2 one side is provided with discharge port 4, and the discharge port 4 is connected with counting device 5.
[0022] The first screen 31 is located on the upper side of the inner container 2, and the first screen 31 is used for filtering microspheres with a diameter greater than X+2sd (sd: standard deviation, X: average diameter of microspheres). The first screen 31 is provided with a plurality of holes 9, and the diameter of the microspheres is d (d: diameter of microspheres). The depth H of the hole 9 of the first screen 31 is 1 / 2d (H: depth of hole 9), and the diameter of the hole 9 is X+2sd of the microspheres. The diameter of the hole 9 can also be set according to the size of the material, and the material of the first screen 31 is stainless steel or other metal material.
[0023] The second screen 32 is located on the lower side of the inner container 2, and the second screen 32 is inclined, and the inclination angle is 15°-30°. The second screen 32 is provided with handles 8 above both ends, which is convenient for installation and disassembly. The second screen 32 is used for filtering microspheres with a diameter less than X-2sd, and the second screen 32 is provided with a plurality of holes 9. The depth H of the hole 9 of the second screen 32 is 1 / 2d, and the diameter of the hole 9 is X-2sd of the microspheres. The diameter of the hole 9 can also be set according to the size of the material, and the material of the second screen 32 is stainless steel or other metal material.
[0024] The counting device 5 is made of transparent plastic pipe, the length of the counting device 5 is L and the width is d < W < 1.5d (d: diameter of the microspheres). The principle of the counting device 5 is that the number of microspheres is equal to the length of the pipe L divided by the diameter of the microspheres d. The number of counting sub-packages can be set according to the actual sub-packaging quantity, the material of the counting device 5 is low-temperature resistant plastic, and the plastic material is any one of polyethylene, polypropylene, polyethylene terephthalate and polyvinyl chloride. The inclination angle of the counting device 5 is 30-45°, one end of the counting device 5 is connected with the discharge port 4, the other end of the counting device 5 is connected with the valve 6, the valve 6 has two functions of counting and sub-packaging microspheres, and after the valve 6 is opened, the microspheres are stored in a vial. The valve 6 is a straight-through valve.
[0025] The working process of the above scheme is as follows: the main cylinder 1 is filled with liquid nitrogen, 15 microliters of liquid microspheres are added into the main cylinder 1, and the liquid enters the liquid nitrogen and is quickly frozen into solid microspheres. The average diameter of the microspheres is 2.65mm, and the microspheres will enter the first screen 31 under the action of gravity. The first screen 31 has a mesh size of 46 meshes. The first screen 31 filters the microspheres larger than 2.85mm and temporarily stores them in the first screen, and the microspheres smaller than 2.88mm pass through the first screen 31 and enter the second screen 32. The second screen 32 has a mesh size of 40 meshes. After the microspheres enter the second screen 32, the microspheres smaller than 2.50mm are filtered to the bottom of the main cylinder 1, and only the microspheres in the range of 2.50mm-2.88mm are left. Because the second screen 32 is inclined, the microspheres move towards the discharge port 4, so that the microspheres enter the counting device 5. The microspheres enter the counting device 5 together with the liquid nitrogen, and the number of sub-packaged microspheres can be adjusted according to the actual sub-packaging quantity. For example, if one vial contains 15 microspheres, the length of the pipe is 39.3mm. When the counting device 5 is filled with microspheres, the rotating valve 6 is closed to close the counting device 5, the vial is placed below the counting device 5, the valve 6 is opened, and the microspheres are packed into the vial. Then the valve 6 is closed, and the valve 6 near the discharge port 4 is opened. In this way, the screening, counting and sub-packaging are completed. The whole process does not need to wait for all the microspheres to be frozen before sub-packaging, and the microspheres can be sub-packaged while being dripped, which reduces the damage to the microspheres caused by manual sub-packaging, improves the quality of the frozen microspheres, and improves the sub-packaging efficiency.
[0026] The above scheme has the beneficial effects that the microspheres are screened by the microsphere screening device 3, which effectively reduces the defective rate of the microspheres; after the microspheres are screened by the microsphere screening device 3, the microspheres are counted by the counting device 5, and then the valve 6 is opened to achieve the effect of rapid sub-packaging; the whole device has a small size, a compact structure and a small occupation area, which is convenient for use in small test stage or small batch production, and is convenient for moving and storing.
[0027] Finally, it is explained that the above preferred embodiments are only used to illustrate the technical solutions of the present application and are not limited, although the present application has been described in detail through the above preferred embodiments, those skilled in the art should understand that various changes can be made in form and details without departing from the scope defined by the claims of the present application.
Claims
1. A liquid nitrogen quick-freezing microsphere sieving device, characterized in that: It includes a main body cylinder (1), an inner container (2) for storing liquid nitrogen is connected inside the main body cylinder (1), a microsphere screening device (3) is connected inside the inner container (2), and the microsphere screening device (3) includes: a first sieve (31) and a second sieve (32). The first sieve (31) and the second sieve (32) are arranged in sequence and evenly inside the inner container (2). A plurality of clamping blocks (7) are connected inside the inner container (2) and are respectively located below the first sieve (31) and the second sieve (32). An outlet (4) is provided on one side of the inner container (2), and the outlet (4) is connected to a counting device (5).
2. The liquid nitrogen quick-freezing microsphere sieving device according to claim 1, characterized in that: The main body cylinder (1) is in the shape of an open round barrel, and an outer shell insulation layer (10) is connected to the outside of the main body cylinder (1), and the outer shell insulation layer (10) is made of metal material.
3. The liquid nitrogen quick-freezing microsphere sieving device according to claim 1, characterized in that: The first sieve (31) is located above the inner container (2). The first sieve (31) is used to filter microspheres with a diameter greater than X + 2sd. The first sieve (31) is provided with a plurality of holes (9). The diameter of the microspheres is d. The depth H of the holes (9) in the first sieve (31) is 1 / 2d. The diameter of the holes (9) is a circular hole of X + 2sd of the microspheres. The material of the first sieve (31) is stainless steel.
4. The liquid nitrogen quick-freezing microsphere sieving device according to claim 3, characterized in that: The second sieve (32) is located below the inner container (2). The second sieve (32) is used to filter microspheres with a diameter less than X - 2sd. The second sieve (32) is provided with a plurality of the holes (9). The depth H of the holes (9) in the second sieve (32) is 1 / 2d. The diameter of the holes (9) is a circular hole of X - 2sd of the microspheres. The material of the second sieve (32) is stainless steel.
5. The liquid nitrogen quick-freezing microsphere sieving device according to claim 1, characterized in that: The second sieve (32) is inclined, and handles (8) are provided above both ends of the second sieve (32).
6. The liquid nitrogen quick-freezing microsphere sieving device according to claim 1, characterized in that: The counting device (5) is made of transparent plastic pipe material. The length of the counting device (5) is L and the width is d < W < 1.5d. The principle of the counting device (5) is the known length of the pipe and the diameter of the microspheres.
7. The liquid nitrogen quick-freezing microsphere sieving device according to claim 1, characterized in that: Two valves (6) are connected to the counting device (5).