Filling device for isavuconazole sulfate for injection
By using multiple filling pump pipes and a filling device designed with special materials, the problems of inaccurate filling and corrosiveness in the production of injectable isaconazole sulfate have been solved, achieving stable outflow of the drug solution and efficient filling.
Patent Information
- Application Number
- CN202520285052.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-21
- Publication Date
- 2026-02-27
- Estimated Expiration
- 2035-02-21
AI Technical Summary
During the production of injectable isaconazole sulfate, the low pH of the intermediate product solution leads to strong corrosivity of the filling equipment, and the pressure difference between the inside and outside during filling prevents the solution from being completely discharged, resulting in waste and inaccurate filling.
The system employs a multi-pump design, including a first, second, and third filling pump tube, which are connected by a tee connector. Combined with the special structure and material design of the filling body, it uses silicone tubing with a Shore A hardness of 50, and works with a breather to balance the internal and external pressures, ensuring stable flow of the liquid and accurate filling.
It improved filling accuracy, reduced residual liquid, enhanced the corrosion resistance of the device, stabilized the filling process, avoided liquid waste, and ensured the consistency of liquid volume in each vial.
Smart Images
Figure CN223949425U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The application relates to an esconazole sulfate for injection filling device and belongs to the technical field of pharmacy. BACKGROUND
[0002] Esconazole sulfate for injection is an antifungal drug used for the treatment of severe fungal infections such as invasive aspergillosis and invasive mucormycosis.
[0003] In the production process of esconazole sulfate for injection, the pH of the intermediate product liquid medicine is low, and the liquid medicine has strong corrosiveness to the filling device, which affects industrial production. In addition, when filling is carried out using the filling device, as the liquid medicine continuously flows out of the filling device, an internal and external pressure difference is formed in the device, the liquid medicine cannot be completely discharged, and a certain amount of waste is caused. CONTENT OF THE UTILITY MODEL
[0004] According to one aspect of the application, an esconazole sulfate for injection filling device is provided, the second filling pump pipe comprises N filling pump sub-pipes connected with the first filling pump pipe and the third filling pump pipe, so that the liquid medicine flows out of the filling device more stably during filling, and the possible flow deviation phenomenon is eliminated. When there are multiple filling pump pipes, the liquid medicine in the vials under each filling pump pipe has the same amount, the filling precision is improved, production is facilitated, the flow rate is slowed down by increasing the path, and sufficient time is provided to balance the internal and external pressures.
[0005] The esconazole sulfate for injection filling device provided by the application comprises a filling main body (1), a filling pump pipe (2) and a filling needle (3).
[0006] The filling needle (3) is connected with the filling main body (1) through the filling pump pipe (2).
[0007] Optionally, the filling pump pipe (2) comprises a first filling pump pipe (201), a second filling pump pipe (202) and a third filling pump pipe (203) connected in sequence.
[0008] Optionally, the second filling pump pipe (202) comprises N filling pump sub-pipes, and N is greater than or equal to 2.
[0009] The N filling pump sub-pipes are connected with the first filling pump pipe (201) and the third filling pump pipe (203), respectively.
[0010] Optionally, N is equal to 2, and the two filling pump sub-pipes are connected with the first filling pump pipe (201) and the third filling pump pipe (203) through a three-way joint (8), respectively.
[0011] Optionally, the three-way joint (8) and the filling pump pipe (2) are tightly tied by a tie.
[0012] Optionally, the Shore A hardness of the filling pump pipe (2) is 50.
[0013] Optionally, the material of the filling pump pipe (2) is silica gel.
[0014] Optionally, the filling body (1) comprises a filling body upper end (101) and a filling body lower end (102).
[0015] The filling body upper end (101) and the filling body lower end (102) are integrally connected.
[0016] The connection between the filling body upper end (101) and the filling body lower end (102) is a rounded corner (103).
[0017] The design of the rounded corner in the present application improves the emptying rate and greatly reduces residual liquid.
[0018] Optionally, the included angle α between the side of the filling body lower end (102) and the horizontal line is 160-165°, which not only ensures the emptying rate of the liquid medicine, but also buffers the emptying of the liquid medicine in cooperation with the filling pump pipe, thereby maintaining the stability of the filling.
[0019] Optionally, the first filling pump pipe (201) comprises an upstream pump pipe (2011) and a downstream pump pipe (2012).
[0020] Optionally, the upstream pump pipe (2011) and the downstream pump pipe (2012) are connected through a straight-through joint.
[0021] Optionally, the inner diameter of the upstream pump pipe (2011) is 5-10 mm.
[0022] Optionally, the inner diameter of the upstream pump pipe (2011) is independently selected from any one value or a range value between any two of 5 mm, 6 mm, 6.5 mm, 7 mm, 8 mm, 9 mm, and 10 mm.
[0023] Optionally, the inner diameter of the downstream pump pipe (2012) is half of the inner diameter of the upstream pump pipe (2011).
[0024] Optionally, the inner diameters of the second filling pump pipe (202) and the third filling pump pipe (203) are each half of the inner diameter of the upstream pump pipe (2011).
[0025] Optionally, the inner diameter of the upstream pump pipe (2011) is 6.35 mm.
[0026] Optionally, the inner diameter of the downstream pump pipe (2012) is 3.175 mm.
[0027] Optionally, the inner diameter of the second filling pump pipe (202) is 3.175 mm.
[0028] Optionally, the third filling pump pipe (203) has an inner diameter of 3.175 mm.
[0029] Optionally, the filling main body (1) is provided with a breather (4) for balancing internal and external pressure.
[0030] Optionally, the breather (4) is connected to the filling main body (1) through a pipeline (5).
[0031] Optionally, the pipeline (5) is provided with a liquid stopper (6).
[0032] The breather of the present application balances the internal and external pressure, and improves the filling stability.
[0033] Optionally, the filling main body (1) is provided with an upstream pipeline (7) for connecting an upstream liquid storage bag.
[0034] Optionally, the upstream pipeline (7) is provided with a liquid stopper.
[0035] Optionally, the filling main body (1) is composed of a filling main body film, which comprises a liquid contact layer, a first adhesive layer, a gas barrier layer, a second adhesive layer, and a protective layer connected in sequence.
[0036] Optionally, the liquid contact layer is made of ultra-low density polyethylene.
[0037] Optionally, the gas barrier layer is made of ethylene-vinyl alcohol copolymer.
[0038] Optionally, the protective layer is made of high-density polyethylene.
[0039] Optionally, the filling main body is provided with a through hole at the upper end.
[0040] The number and shape of the through hole are not particularly limited, and can be routinely selected by those skilled in the art.
[0041] The through hole is used for carrying or hanging.
[0042] The beneficial effects of the present application include:
[0043] 1. The second filling pump pipe in the present application comprises N filling pump sub-pipes, which are respectively connected to the first filling pump pipe and the third filling pump pipe, so that the drug solution flows out more stably during filling, eliminating the possible flow deviation phenomenon. When there are multiple filling pump pipes, the drug solution in each vial under each filling pump pipe has the same amount, improving the filling precision, facilitating production, and at the same time increasing the path to slow down the flow rate and provide sufficient time to balance the internal and external pressure.
[0044] 2. The first filling pump tube of the application comprises an upstream pump tube and a downstream pump tube, and the inner diameters of the upstream pump tube, the downstream pump tube and the second filling pump tube and the third filling pump tube are controlled, so that the filling is stable and the liquid medicine does not splash during the filling process.
[0045] 3. In the production process of esconazole sulfate for injection, the pH of the intermediate product liquid medicine is 1.3-1.9, which has extremely strong corrosiveness. The filling main body film of the application comprises a liquid contact layer, a first adhesive layer, a gas barrier layer, a second adhesive layer and a protective layer. The material of the liquid contact layer is ultra-low density polyethylene, the material of the gas barrier layer is ethylene-vinyl alcohol copolymer, and the material of the protective layer is high-density polyethylene. Not only can it withstand the corrosiveness of the esconazole sulfate intermediate product liquid medicine, but also the liquid medicine has low adhesion on the surface of the contact layer during filling, less residual liquid, high strength and good flexibility.
[0046] 4. The application uses a silica gel tube with a Shore hardness A of 50 as a filling pump tube, which can adapt to the bending requirement or be used in a small space.
[0047] 5. The included angle α between the side of the lower end of the filling main body and the horizontal line is 160-165°, which not only ensures the emptying rate of the liquid medicine, but also buffers the emptying of the liquid medicine in cooperation with the filling pump tube, thereby maintaining the stability of the filling. BRIEF DESCRIPTION OF DRAWINGS
[0048] Figure 1 It is a schematic diagram of an esconazole sulfate for injection filling device;
[0049] Figure 2 It is a schematic diagram of a second filling pump tube;
[0050] Figure 3 It is a schematic diagram of a filling main body film.
[0051] 1-filling main body 2-filling pump tube
[0052] 3-filling needle 4-breathing apparatus
[0053] 5-pipeline 6-liquid stop clamp
[0054] 7-upstream pipeline 8-three-way joint
[0055] 9-liquid contact layer 10-first adhesive layer
[0056] 11-gas barrier layer 12-second adhesive layer
[0057] 13-protective layer
[0058] 101-upper end of filling main body 102-lower end of filling main body
[0059] 103-round corner
[0060] 201 - first filling pump tube 202 - second filling pump tube
[0061] 203 - third filling pump tube
[0062] 2011 - upstream pump tube 2012 - downstream pump tube DETAILED DESCRIPTION
[0063] The present application will be described in detail below with reference to examples, but the present application is not limited to these examples.
[0064] The raw materials in the examples of the present application are all purchased through commercial channels unless otherwise specified.
[0065] Example 1
[0066] As Figure 1 , the injection esoxiconazole sulfate filling device comprises a filling main body 1, a filling pump tube 2 and a filling needle 3; the filling needle 3 is connected with the filling main body 1 through the filling pump tube 2.
[0067] Among them, the material of the filling pump tube 2 is silica gel, the Shore hardness A is 50, and it comprises a first filling pump tube 201, a second filling pump tube 202 and a third filling pump tube 203 connected in sequence.
[0068] Among them, the filling main body 1 comprises a filling main body upper end 101 and a filling main body lower end 102; the filling main body upper end 101 and the filling main body lower end 102 are integrally connected; the connecting place of the filling main body upper end 101 and the filling main body lower end 102 is a round corner 103. A respirator 4 is arranged on the filling main body 1 and connected with the filling main body 1 through a pipeline 5, which is used to balance the internal and external pressure, a liquid stop clamp 6 is arranged on the pipeline 5, and an upstream pipeline 7 is also arranged on the filling main body 1 for connecting an upstream liquid storage bag.
[0069] As Figure 2 , it is a local enlarged view of the second filling pump tube 202, which comprises two filling pump sub-tubes, connected with the first filling pump tube 201 and the third filling pump tube 203 through three-way joints 8 respectively, and the three-way joints 8 and the filling pump tube 2 are tightly tied with a tie, which makes the drug solution more stable when filling, eliminates the possible flow deviation phenomenon, and when there are multiple filling pump tubes, makes the drug solution in each vial under the filling pump tube the same, which is convenient for production, and at the same time increases the path to slow down the flow rate and provides sufficient time to balance the internal and external pressure.
[0070] The filling main body 1 is composed of a filling main body film, such as Figure 3The diagram shows a filling body film, which includes a liquid contact layer 9, a first adhesive layer 10, a gas barrier layer 11, a second adhesive layer 12, and a protective layer 13 connected in sequence. The liquid contact layer 9 is made of ultra-low density polyethylene, the gas barrier layer 11 is made of ethylene-vinyl alcohol copolymer, and the protective layer 13 is made of high density polyethylene.
[0071] Example 2
[0072] The injectable isoconazole sulfate filling device is the same as in Example 1, except that the angle α between the side of the lower end 102 of the filling body and the horizontal line is 165°, which ensures the emptying rate of the drug solution and, together with the filling pump tube, buffers the emptying of the drug solution and maintains the stability of the filling.
[0073] Example 3
[0074] The injectable isoconazole sulfate filling device is the same as in Embodiment 1, except that the first filling pump tube 201 includes an upstream pump tube 2011 and a downstream pump tube 2012. The inner diameter of the upstream pump tube 2011 is 6.35 mm, the inner diameter of the downstream pump tube 2012 is 3.175 mm, the inner diameter of the second filling pump tube 202 is 3.175 mm, and the inner diameter of the third filling pump tube 203 is 3.175 mm.
[0075] The above description is merely a few embodiments of this application and is not intended to limit this application in any way. Although this application discloses preferred embodiments as described above, it is not intended to limit this application. Any changes or modifications made by those skilled in the art without departing from the scope of the technical solution of this application using the disclosed technical content are equivalent to equivalent implementation cases and fall within the scope of the technical solution.
Claims
1. An isavuconazonium sulfate for injection filling device characterized by, The filling device comprises a filling body, a filling pump pipe and a filling needle; the filling needle is connected with the filling body through the filling pump pipe; The filling pump pipe comprises a first filling pump pipe, a second filling pump pipe and a third filling pipe connected in sequence; The second filling pump pipe comprises N filling pump sub-pipes, N≥2; The N filling pump sub-pipes are connected with the first filling pump pipe and the third filling pump pipe respectively.
2. The esoxiconazole sulfate for injection filling device according to claim 1, characterized by, The Shore A hardness of the filling pump pipe is 50.
3. The eslicarbazepine acetate filling device for injection according to claim 1, wherein The filling body comprises a filling body upper end and a filling body lower end; The filling body upper end and the filling body lower end are connected in an integral structure; The connecting part of the filling body upper end and the filling body lower end is provided with a round corner.
4. The esoxicanide sulfate for injection filling device according to claim 1, characterized by, The included angle α between the side of the filling body lower end and the horizontal line is 160°-165°.
5. The eslicarbazepine acetate filling device for injection according to claim 1, wherein A respirator is arranged on the filling body.
6. The isavuconazonium sulfate for injection filling device according to claim 5, wherein The respirator is communicated with the filling body through a pipeline; a liquid stopping clamp is arranged on the pipeline.
7. The eslicarbazepine acetate filling device for injection according to claim 1, wherein An upstream pipeline is arranged on the filling body, and the upstream pipeline is used for connecting an upstream liquid storage bag.
8. The eslicarbazepine acetate filling device for injection according to claim 1, wherein The filling body is made of a filling body film; the filling body film comprises, from inside to outside, a liquid contact layer, a first adhesive layer, a gas barrier layer, a second adhesive layer and a protective layer.
9. The eslicarbazepine acetate filling device for injection according to claim 8, wherein The material of the liquid contact layer is ultra-low density polyethylene; The material of the gas barrier layer is ethylene-vinyl alcohol copolymer; The material of the protective layer is high-density polyethylene.
10. The eslicarbazepine acetate filling device for injection according to claim 1, wherein A through hole is arranged on the filling body upper end.