Medium-pressure liquid chromatography preparative column nozzle

Abstract

The utility model discloses a medium-pressure liquid chromatography preparative column sprayer which comprises a sprayer body, a fixing pipe is fixedly connected to the middle of the upper surface of the sprayer body, a rubber sleeve is fixedly connected to the outer surface of the fixing pipe, and rubber barbs are fixedly connected to the outer surface of the rubber sleeve. According to the medium-pressure liquid chromatography preparative column nozzle, through the arrangement of the rubber sleeve, the rubber barbs, the threaded sleeve and the limiting ring, the rubber barbs can improve the sealing performance of connection between the rubber sleeve and the inner side face of a chromatographic instrument connecting column, the liquid leakage phenomenon is avoided, the threaded sleeve is divided into four sets of arc-shaped structures through the multiple through grooves, the chromatographic instrument connecting column is sleeved with the threaded sleeve, and the limiting ring is arranged on the threaded sleeve. The limiting ring is rotated downwards, so that the thread sleeve of an arc-shaped structure inclines towards the center of the spray head, the spray head is installed and fixed, the installation firmness is improved, meanwhile, the spray head can be suitable for installation of chromatographic instrument connecting columns with different sizes within a certain range, the use range is expanded, and the applicability is enhanced.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography preparation column technology, and in particular to a medium-pressure liquid chromatography preparation column nozzle. Background Technology

[0002] Medium-pressure liquid chromatography (LC) is an analytical instrument used in the fields of biology, materials science, and chemical engineering. LC is a liquid chromatography method with a column pressure of 5–20 MPa. Its system mainly consists of a pump, injection valve, detector, and fraction collector. It is widely used in laboratory and industrial-scale applications for biological products (such as animal organ extracts, concentrated solutions, body fluids, plant extracts, and biotechnology fermentation broths).

[0003] A search revealed Chinese Patent Publication No. CN215866545U, which discloses a medium-pressure liquid chromatography preparative column nozzle, comprising: a body; a column head located on the outer wall of the body; and a fixing mechanism including an adapter and a spring block. Pulling the body moves the fixing block towards the end of the fixing groove, at which point the spring block moves back to its initial position, the first spring rebounds, and the spring block contacts and holds against the fixing block, thereby achieving a quick connection between the body and the adapter.

[0004] While the preparation column nozzles of the aforementioned patents are easy to connect, they can only be connected to preparation columns of chromatographs of fixed sizes, limiting their applicability and reducing the suitability for installation. Therefore, it is necessary to design a medium-pressure liquid chromatography preparation column nozzle to solve the above problems. Utility Model Content

[0005] The main objective of this invention is to provide a medium-pressure liquid chromatography preparative column nozzle that can effectively solve the problems in the background art.

[0006] To achieve the above objectives, the technical solution adopted by this utility model is as follows:

[0007] A medium-pressure liquid chromatography preparative column nozzle includes a nozzle, a fixing tube fixedly connected to the middle of the upper surface of the nozzle, a rubber sleeve fixedly connected to the outer surface of the fixing tube, and rubber barbs fixedly connected to the outer surface of the rubber sleeve; a chromatograph connecting column is movably connected to the outer surface of the rubber barbs; a threaded sleeve is fixedly connected to the edge of the upper surface of the nozzle, a through groove is formed on the outer surface of the threaded sleeve, and a limit ring is threadedly connected to the outer surface of the threaded sleeve.

[0008] To enhance the anti-slip effect, the outer surface of the limiting ring of the medium-pressure liquid chromatography preparation column nozzle of this utility model is provided with an anti-slip groove.

[0009] In order to enhance the sealing effect, a sealing gasket is fixedly connected to the upper surface of the nozzle of the medium-pressure liquid chromatography preparation column of this utility model, which is close to the side of the chromatograph connecting column.

[0010] To facilitate the rotation of the nozzle, the nozzle of this medium-pressure liquid chromatography preparation column is provided with a number of raised strips fixedly connected to its outer surface. These raised strips are uniformly fixedly connected to the outer surface of the nozzle in a circumferential array.

[0011] To facilitate flow control, the nozzle of this medium-pressure liquid chromatography preparative column is provided with a guide rod fixedly connected to the middle of the inner bottom wall of the nozzle, a stop block slidably connected to the outer surface of the guide rod, and a flow-limiting block fixedly connected to the top of the inner side of the nozzle.

[0012] In order to facilitate the support of the stop block, as a medium-pressure liquid chromatography preparative column nozzle of this utility model, the lower surface of the stop block is fixedly connected with a spring.

[0013] In order to prevent the stop block from detaching from the guide rod, as a medium-pressure liquid chromatography preparative column nozzle of this utility model, one end of the guide rod is fixedly connected to a limiting block.

[0014] In order to facilitate fluid outflow, the nozzle of the medium-pressure liquid chromatography preparative column of this utility model has through holes on its lower surface, and the number of through holes is several.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] 1. In this utility model, the rubber sleeve, rubber barbs, threaded sleeve, and limiting ring are designed to enhance the sealing between the rubber sleeve and the inner side of the chromatograph connecting column, preventing leakage. Multiple through grooves divide the threaded sleeve into four arc-shaped structures. The threaded sleeve is fitted onto the chromatograph connecting column. Rotating the limiting ring downwards causes the arc-shaped threaded sleeve to tilt towards the center of the nozzle, thus securing it in place and increasing the installation's stability. Furthermore, this design is applicable to the installation of chromatograph connecting columns of different sizes within a certain range, expanding its scope of use and enhancing its applicability.

[0017] 2. In this utility model, the sealing gasket, the stop block, and the spring enhance the sealing performance at the port where the chromatograph connecting column is connected to the nozzle, thereby improving the sealing effect. Under the action of the flow restrictor, the liquid entering the nozzle can be turbulent, reducing the flow rate and alleviating the pressure on the nozzle. At the same time, the flow rate of the liquid entering the nozzle can be controlled according to the position of the stop block on the guide rod surface, preventing excessive flow from damaging the nozzle and making it more reliable. The spring supports and resets the stop block, facilitating future use and increasing ease of use. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the main structure of an embodiment of the present utility model;

[0019] Figure 2 This is a cross-sectional planar structural diagram of an embodiment of the present utility model;

[0020] Figure 3 This is a cross-sectional structural diagram of an embodiment of the present utility model;

[0021] Figure 4 This is a cross-sectional view of the rubber sleeve according to an embodiment of the present utility model;

[0022] Figure 5 This is a schematic diagram of the internal structure of the nozzle in an embodiment of the present utility model.

[0023] In the diagram: 1. Nozzle; 2. Fixing tube; 3. Rubber sleeve; 4. Rubber barbs; 5. Chromatograph connecting column; 6. Screw sleeve; 7. Through groove; 8. Limiting ring; 9. Anti-slip groove; 10. Sealing gasket; 11. Raised strip; 12. Guide rod; 13. Stop block; 14. Flow limiting block; 15. Spring; 16. Limiting block; 17. Through hole. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] Example

[0026] like Figure 1-5As shown, a medium-pressure liquid chromatography preparative column nozzle includes a nozzle 1, a fixed tube 2 fixedly connected to the middle of the upper surface of the nozzle 1, a rubber sleeve 3 fixedly connected to the outer surface of the fixed tube 2, and rubber barbs 4 fixedly connected to the outer surface of the rubber sleeve 3; a chromatograph connecting column 5 is movably connected to the outer surface of the rubber barbs 4; a threaded sleeve 6 is fixedly connected to the edge of the upper surface of the nozzle 1, a through groove 7 is opened on the outer surface of the threaded sleeve 6, and a limit ring 8 is threadedly connected to the outer surface of the threaded sleeve 6.

[0027] In practical use, the rubber sleeve 3, rubber barbs 4, threaded sleeve 6, through groove 7, and limiting ring 8 are used. The rubber sleeve 3 is fixed to the outer surface of the fixing tube 2, and multiple rubber barbs 4 are fixed to the outer surface of the rubber sleeve 3. The fixing tube 2 is then inserted into the interior of the chromatograph connecting column 5. The rubber barbs 4 can increase the sealing between the rubber sleeve 3 and the inner surface of the chromatograph connecting column 5, preventing leakage. Multiple through grooves 7 divide the threaded sleeve 6 into four sets of arc-shaped structures. When installing the chromatograph connecting column 5, the threaded sleeve 6 is fitted onto the chromatograph connecting column 5, and then the limiting ring 8 is rotated downwards, causing the arc-shaped threaded sleeve 6 to tilt towards the center of the nozzle 1, thereby installing and fixing it. This achieves the effect of convenient installation, increases the firmness of the installation, and enhances the stability. At the same time, it can be used for the installation of chromatograph connecting columns 5 of different sizes within a certain range, expanding the scope of use, enhancing applicability, and meeting installation requirements.

[0028] In this embodiment, the outer surface of the limiting ring 8 is provided with an anti-slip groove 9.

[0029] In practical use, the anti-slip groove 9 is set on the outer surface of the limiting ring 8, which can increase the friction between the hand and the limiting ring 8, making it easier for the hand to exert force and increasing the convenience of use.

[0030] In this embodiment, a sealing gasket 10 is fixedly connected to the upper surface of the nozzle 1 on the side near the chromatograph connecting column 5.

[0031] In practical use, by setting the sealing gasket 10, the sealing gasket 10 is fixed on the upper surface of the nozzle 1, which can enhance the sealing at the port when the chromatograph connecting column 5 is connected to the nozzle 1, and the sealing effect is enhanced.

[0032] In this embodiment, a number of protrusions 11 are fixedly connected to the outer surface of the nozzle 1. The number of protrusions 11 is several, and the several protrusions 11 are evenly fixedly connected to the outer surface of the nozzle 1 in a circumferential array.

[0033] In practical use, the protrusions 11 are set on the outer surface of the nozzle 1. This makes it easier to apply force with your hand when installing the structure, increases the friction of your hand, and strengthens the structural strength of the nozzle 1, thus extending its service life.

[0034] In this embodiment, a guide rod 12 is fixedly connected to the middle of the inner bottom wall of the nozzle 1, a stop block 13 is slidably connected to the outer surface of the guide rod 12, and a flow limiting block 14 is fixedly connected to the top of the inner side of the nozzle 1.

[0035] In practical use, the baffle 13, under the action of the flow limiting block 14, can turbulently flow the liquid entering the nozzle 1, reduce the flow rate, and reduce the pressure of the nozzle 1. At the same time, according to the position of the baffle 13 on the surface of the guide rod 12, the flow rate of the liquid entering the nozzle 1 can be regulated to avoid excessive flow rate from damaging the nozzle 1, making the use more reliable.

[0036] In this embodiment, a spring 15 is fixedly connected to the lower surface of the stop 13.

[0037] In practical use, the spring 15 is fixed to the lower surface of the stop block 13, which can support and reset the stop block 13 for easy use next time and increase the convenience of use.

[0038] In this embodiment, one end of the guide rod 12 is fixedly connected to the limit block 16.

[0039] In practical use, the limiting block 16 is fixed to the top of the guide rod 12 to limit the stop block 13 and prevent the stop block 13 from sliding too far upward and detaching from the guide rod 12.

[0040] In this embodiment, the lower surface of the nozzle 1 is provided with through holes 17, and the number of through holes 17 is several.

[0041] In practical use, through the setting of through holes 17, multiple horn-shaped through holes 17 are opened in a circumferential array on the lower surface of the nozzle 1, making the liquid discharge more uniform.

[0042] Working principle: In use, the fixing tube 2 is inserted into the inside of the chromatograph connecting column 5. The rubber barbs 4 increase the sealing between the rubber sleeve 3 and the inner side of the chromatograph connecting column 5. The screw sleeve 6 is fitted onto the outer surface of the chromatograph connecting column 5. Then, the limiting ring 8 is rotated downwards, so that the screw sleeve 6 is tilted towards the center of the nozzle 1 for installation and fixation. The sealing gasket 10 strengthens the sealing at the port when the chromatograph connecting column 5 is connected to the nozzle 1. In use, the chromatograph connecting column 5 delivers liquid into the inside of the nozzle 1. Under the action of the flow limiting block 14, the liquid entering the inside of the nozzle 1 is turbulent. At the same time, according to the position of the baffle 13 on the surface of the guide rod 12, the flow rate of the liquid entering the inside of the nozzle 1 is regulated to avoid excessive flow and damage to the nozzle 1. The spring 15 supports and resets the baffle 13. Multiple horn-shaped through holes 17 make the structure more uniform when dispensing liquid.

[0043] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A medium pressure liquid chromatography preparative column frit comprising a frit (1) characterised in that: The upper surface of the spray head (1) is fixedly connected with a fixed pipe (2), the outer surface of the fixed pipe (2) is fixedly connected with a rubber sleeve (3), and the outer surface of the rubber sleeve (3) is fixedly connected with a rubber barb (4); the outer surface of the rubber barb (4) is movably connected with a chromatograph connecting column (5), the edge of the upper surface of the spray head (1) is fixedly connected with a screw sleeve (6), the outer surface of the screw sleeve (6) is provided with a through groove (7), and the outer surface of the screw sleeve (6) is threadedly connected with a limiting ring (8).

2. A medium pressure liquid chromatography preparative column frit according to claim 1, characterized in that: The outer surface of the limiting ring (8) is provided with an anti-skid groove (9).

3. A medium pressure liquid chromatography preparative column frit according to claim 1, wherein: The upper surface of the spray head (1) is fixedly connected with a sealing gasket (10) on one side close to the chromatograph connecting column (5).

4. A medium pressure liquid chromatography preparative column frit according to claim 1, wherein: The outer surface of the spray head (1) is fixedly connected with convex strips (11), the number of the convex strips (11) is several, and the several convex strips (11) are uniformly fixedly connected in a circumferential array on the outer surface of the spray head (1).

5. A medium pressure liquid chromatography preparative column frit according to claim 1, wherein: The middle part of the inner bottom wall of the spray head (1) is fixedly connected with a guide rod (12), the outer surface of the guide rod (12) is slidably connected with a stop block (13), and the top of the inner side of the spray head (1) is fixedly connected with a flow limiting block (14).

6. A medium pressure liquid chromatography preparative column frit according to claim 5, wherein: The lower surface of the stop block (13) is fixedly connected with a spring (15).

7. A medium pressure liquid chromatography preparative column frit according to claim 5, wherein: One end of the guide rod (12) is fixedly connected with a limiting block (16).

8. A medium pressure liquid chromatography preparative column frit according to claim 1, wherein: The lower surface of the spray head (1) is provided with through holes (17), and the number of the through holes (17) is several.

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