Plasma sample derivatization treatment device

Abstract

The utility model relates to the technical field of biological medicine, and discloses a plasma sample derivatization treatment device which comprises a treatment tank, an extension sleeve disc is fixedly connected to the outer surface of the treatment tank, a supporting block is jacked through a hydraulic rod, a connecting shaft and a fishing disc are driven to move upwards from the bottom of the treatment tank, and the treatment tank is driven to rotate. When the fishing disc reaches the position where the adsorption pipe is located, due to the fact that the notch groove in the surface of the fishing disc is matched with the adsorption pipe and the notch groove and the adsorption pipe are combined, the air pump is started, and the air pump adsorbs the non-polar biological matrix in the fishing disc through the adsorption pipe; then the adsorbed non-polar biological matrix is conveyed into the impurity box, so that the problems of incomplete cleaning, low efficiency and the like possibly existing in a traditional manual cleaning mode are avoided, and meanwhile, the adverse effect on subsequent detection work caused by matrix residues is also effectively avoided; and the conditions of inaccurate detection result, damage to detection equipment and the like which are possibly caused by matrix residue are solved.

Description

Technical Field

[0001] This utility model relates to the field of biomedical technology, and in particular to a plasma sample derivatization processing device. Background Technology

[0002] In the field of biomedical technology, derivatization of plasma samples is an important workflow. Plasma samples contain many components closely related to disease diagnosis, drug development, and biomarker detection. Derivatization can alter the chemical structure of biomolecules, thereby facilitating subsequent analysis and detection.

[0003] Plasma sample derivatization requires the removal or reduction of non-polar biological matrix in the plasma. Traditionally, this process relies on manual cleaning, which has several drawbacks. First, manual cleaning is difficult to ensure complete removal of non-polar biological matrix from the plasma. Due to the subjectivity and limitations of human operation, some matrix may be missed, leading to incomplete cleaning. Second, manual cleaning is inefficient, especially when processing large quantities of plasma samples. This inefficiency can severely affect the progress of the entire derivatization process. Utility Model Content

[0004] To solve the above-mentioned technical problems, this utility model provides a plasma sample derivatization processing device.

[0005] This utility model is achieved using the following technical solution: a plasma sample derivatization processing device, comprising a processing tank, an extension sleeve fixedly connected to the outer surface of the processing tank, an adjustment frame fixedly connected to the upper surface of the extension sleeve, a sliding groove formed on the surface of the adjustment frame, a support block slidably connected inside the sliding groove, a connecting shaft fixedly connected to the lower surface of the support block, a retrieval plate fixedly connected to the surface of the connecting shaft, a hydraulic rod fixedly connected to the surface of the support block, an impurity box fixedly connected to the outer surface of the processing tank, an air pump fixedly connected to the surface of the impurity box, an adsorption tube fixedly connected to the input end of the air pump, and a notch formed on the surface of the retrieval plate.

[0006] The above technical solution eliminates the need for manual cleaning of the non-polar biological matrix, significantly reducing workload. It also enables rapid cleaning and reduction of the non-polar biological matrix, effectively preventing residues that could reduce extraction efficiency and hinder the effective separation of target compounds from the matrix, thus avoiding impacts on subsequent analytical results.

[0007] As a further improvement to the above solution, the adsorption tube is disposed inside the treatment tank.

[0008] The above technical solutions ensure the accuracy and effectiveness of the adsorption operation, enabling the non-polar biological matrix to be smoothly transferred from the retrieval tray in the processing tank to the impurity box, which contributes to the efficient operation of the entire plasma sample derivatization processing device.

[0009] As a further improvement to the above solution, the hydraulic rod is fixedly connected to the inner wall of the adjusting frame.

[0010] As a further improvement to the above solution, the notched groove is adapted to the adsorption tube.

[0011] As a further improvement to the above solution, the output end of the air pump is fixedly connected to a delivery pipe, which is fixedly connected to the inside of the impurity box.

[0012] The above technical solution enables the adsorbed non-polar biological matrix to be properly collected into the impurity box, ensuring the integrity of the entire device in cleaning and collecting the non-polar biological matrix.

[0013] As a further improvement to the above solution, sealing covers are provided on both sides of the upper surface of the processing tank.

[0014] The above technical solution ensures the stability and purity of the reaction environment inside the treatment tank, which helps the plasma sample react normally with the chemical reagents and facilitates the smooth operation of subsequent operations such as cleaning the non-polar biological matrix with the retrieval tray.

[0015] As a further improvement to the above solution, the surface of the sealing cover is provided with an injection port.

[0016] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0017] This invention uses a hydraulic rod to lift the support block, which drives the connecting shaft and the retrieval plate to move upward from the bottom of the processing tank. This retrieves the non-polar biological matrix from the plasma inside the processing tank. When the retrieval plate reaches the position of the adsorption tube, the notch groove on the surface of the retrieval plate matches the adsorption tube, and the two combine. At this time, by activating the air pump, the air pump adsorbs the non-polar biological matrix in the retrieval plate through the adsorption tube, and then sends the adsorbed non-polar biological matrix into the impurity box. This avoids the problems of incomplete cleaning and low efficiency that may exist in traditional manual cleaning methods. At the same time, it also effectively avoids the adverse effects of matrix residue on subsequent testing work, such as inaccurate test results or damage to testing equipment that may be caused by matrix residue. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0019] Figure 2 This is a schematic diagram of the structure of the retrieval tray of this utility model;

[0020] Figure 3 This is a schematic diagram of the notch groove of this utility model;

[0021] Figure 4 This is a schematic diagram of the structure of the air pump of this utility model.

[0022] Explanation of key symbols:

[0023] 1. Processing tank; 2. Extension sleeve; 3. Adjustment frame; 4. Slipform trough; 5. Support block; 6. Connecting shaft; 7. Retrieval tray; 8. Impurity box; 9. Air pump; 10. Adsorption pipe; 11. Notch groove; 12. Hydraulic rod; 13. Conveying pipe; 14. Sealing cover plate; 15. Filling port. Detailed Implementation

[0024] The present invention will be further described below with reference to the accompanying drawings and specific embodiments. It should be noted that, without conflict, the various embodiments or technical features described below can be arbitrarily combined to form new embodiments.

[0025] Example:

[0026] Please combine Figure 1-4 This embodiment of a plasma sample derivatization processing device includes a processing tank 1. An extension sleeve 2 is fixedly connected to the outer surface of the processing tank 1. An adjusting frame 3 is fixedly connected to the upper surface of the extension sleeve 2. A sliding groove 4 is formed on the surface of the adjusting frame 3. A support block 5 is slidably connected inside the sliding groove 4. A connecting shaft 6 is fixedly connected to the lower surface of the support block 5. A retrieval plate 7 is fixedly connected to the surface of the connecting shaft 6. A hydraulic rod 12 is fixedly connected to the surface of the support block 5. An impurity box 8 is fixedly connected to the outer surface of the processing tank 1. An air pump 9 is fixedly connected to the surface of the impurity box 8. An adsorption tube 10 is fixedly connected to the input end of the air pump 9. A notch 11 is formed on the surface of the retrieval plate 7. When a plasma sample... After the plasma is mixed and reacted with chemical reagents in the treatment tank 1, it is necessary to remove the non-polar biological matrix from the plasma. At this time, the personnel use hydraulic rod 12 to lift the support block 5. Since the support block 5 is located in the sliding groove 4 of the adjusting frame 3, the support block 5 can rise steadily along the sliding groove 4. The rise of the support block 5 drives the connecting shaft 6 and the retrieval plate 7 to move upward from the bottom of the treatment tank 1. When the retrieval plate 7 reaches the position of the adsorption tube 10, because the notch 11 on the surface of the retrieval plate 7 is adapted to the adsorption tube 10, the air pump 9 is started. The input end of the air pump 9 adsorbs the non-polar biological matrix in the retrieval plate 7 through the adsorption tube 10, and then sends the adsorbed non-polar biological matrix into the impurity box 8.

[0027] The adsorption tube 10 is installed inside the treatment tank 1. When the retrieval plate 7 rises to a suitable position inside the treatment tank 1, the adsorption tube 10 can accurately connect with the notch 11 on the retrieval plate 7, thereby enabling the air pump 9 to adsorb the non-polar biological matrix in the retrieval plate 7 through the adsorption tube 10.

[0028] The hydraulic rod 12 is fixedly connected to the inner wall of the adjusting frame 3.

[0029] The notch 11 is adapted to the adsorption tube 10. When the retrieval plate 7 rises to the position of the adsorption tube 10, the adsorption tube 10 can be tightly connected with the notch 11. In this way, when the air pump 9 is started, air can effectively enter the interior of the retrieval plate 7 through the adsorption tube 10 and adsorb the non-polar biological matrix.

[0030] The output end of the air pump 9 is fixedly connected to the delivery pipe 13, which is fixedly connected to the inside of the impurity box 8. When the air pump 9 draws in the non-polar biological matrix adsorbed from the retrieval plate 7 through the adsorption pipe 10, it will deliver the non-polar biological matrix to the inside of the impurity box 8 for storage through the delivery pipe 13 at the output end.

[0031] Both sides of the upper surface of the treatment tank 1 are equipped with sealing covers 14. During the reaction of plasma samples with chemical reagents, the sealing covers 14 can prevent the leakage of substances during the reaction process, and at the same time prevent external impurities from entering the treatment tank 1 and affecting the reaction and subsequent processing operations.

[0032] The surface of the sealing cover 14 is provided with a filling port 15. When the plasma sample is mixed and reacted with the chemical reagent, the plasma sample or chemical reagent can be added into the processing tank 1 through the filling port 15, which is convenient for operation.

[0033] The implementation principle of the plasma sample derivatization processing device in this embodiment is as follows: Personnel add a plasma sample to the processing tank 1 through the filling port 15 on the sealing cover 14. According to the processing requirements, an appropriate amount of chemical reagent is then added to the processing tank 1 through the filling port 15. The plasma sample and chemical reagent begin to mix and react within the processing tank 1. At this time, the sealing cover 14 prevents leakage of reactants and the entry of external impurities. Subsequently, personnel prepare to clean the non-polar biological matrix. First, the hydraulic rod 12 is operated. Because the hydraulic rod 12 is fixedly connected to the inner wall of the adjusting frame 3, starting the hydraulic rod 12 causes it to lift the support block 5. Since the support block 5 is located inside the sliding groove 4 of the adjusting frame 3, it rises steadily along the sliding groove 4. The rise of the support block 5 drives the connecting shaft 6 and the retrieval plate. 7 moves upward from the bottom of the processing tank 1. When the retrieval plate 7 rises to the position of the adsorption tube 10, since the notch 11 on the surface of the retrieval plate 7 is compatible with the adsorption tube 10, and the adsorption tube 10 is located inside the processing tank 1, the personnel start the air pump 9. The input end of the air pump 9 adsorbs the non-polar biological matrix in the retrieval plate 7 through the adsorption tube 10. Because the notch 11 is tightly connected to the adsorption tube 10, air can effectively enter the interior of the retrieval plate 7 to adsorb the non-polar biological matrix. After the air pump 9 sucks in the adsorbed non-polar biological matrix through the adsorption tube 10, since the output end of the air pump 9 is fixedly connected to the delivery pipe 13, which is fixedly connected to the interior of the impurity box 8, the air pump 9 will transport the non-polar biological matrix into the impurity box 8 for storage through the delivery pipe 13 at the output end.

[0034] The above embodiments are merely preferred embodiments of this utility model and should not be construed as limiting the scope of protection of this utility model. Any non-substantial changes and substitutions made by those skilled in the art based on this utility model shall fall within the scope of protection claimed by this utility model.

Claims

1. A plasma sample derivatization device, comprising: Including processing jar (1), the outer surface of processing jar (1) is fixedly connected with extension sleeve disc (2), the upper surface of extension sleeve disc (2) is fixedly connected with adjusting frame (3), the surface of adjusting frame (3) is equipped with sliding slot (4), the inside of sliding slot (4) is slidably connected with support block (5), the lower surface of support block (5) is fixedly connected with link shaft (6), the surface of link shaft (6) is fixedly connected with fishing disc (7), the surface of support block (5) is fixedly connected with hydraulic rod (12), the outer surface of processing jar (1) is fixedly connected with impurity box (8), the surface of impurity box (8) is fixedly connected with air pump (9), the input end of air pump (9) is fixedly connected with adsorption pipe (10), the surface of fishing disc (7) is equipped with notch groove (11).

2. A plasma sample derivatization apparatus as defined in claim 1, wherein: The adsorption pipe (10) is arranged in the processing jar (1).

3. A plasma sample derivatization apparatus as defined in claim 1, wherein: The hydraulic rod (12) is fixedly connected to the inner wall of the adjusting frame (3).

4. A plasma sample derivatization apparatus as defined in claim 1, wherein: The notch groove (11) is matched with the adsorption pipe (10).

5. A plasma sample derivatization apparatus as defined in claim 1, wherein: The output end of the air pump (9) is fixedly connected with the delivery pipe (13), and the delivery pipe (13) is fixedly connected to the inside of the impurity box (8).

6. A plasma sample derivatization apparatus as defined in claim 1, wherein: The both sides of the upper surface of the processing jar (1) are provided with sealing cover plates (14).

7. A plasma sample derivatization apparatus as defined in claim 6, wherein: The surface of the sealing cover plate (14) is provided with a filling port (15).

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