Britinib reaction kettle

Abstract

The utility model relates to the technical field of pharmacy, in particular to a boritinib reaction kettle, which ensures that materials are kept in a balanced state in the whole reaction process and reduces potential safety hazards possibly generated at high temperature. Comprising a reaction kettle, a cooling component and a feeding component, a stirring motor is arranged at the top of the reaction kettle, a stirring rod is arranged in the reaction kettle and connected with the stirring motor, a discharging port is formed in the lower end of the reaction kettle, a feeding port is formed in one side of the top of the reaction kettle, the output end of the feeding component is communicated with the feeding port, and an air outlet is formed in the other end of the top of the reaction kettle; the output end of the air outlet is connected with the cooling component.

Description

Technical Field

[0001] This utility model relates to the technical field of pharmaceutical manufacturing, and in particular to a beritinib reaction vessel. Background Technology

[0002] Beritinib is a small molecule kinase inhibitor targeting C-MET, which inhibits tumor cell development. In the pharmaceutical industry, the manufacturing process of beritinib is a precise and complex chemical process. To obtain high-quality drugs, the temperature and pressure conditions at each step must be strictly controlled. Cyclopropyl bromide is a key raw material in the production process, with a relatively low boiling point, approximately between 67-69°C. All raw materials cannot react fully below 190°C. This necessitates the use of an autoclave for pressurized processing during the reaction. For example, the prior art announcement CN219922846U proposes a highly targeted tumor drug reaction vessel, which includes a vessel body and a feeding assembly. A stirring motor is located above the vessel body and is fixedly connected to the vessel body. A discharge end is located on one side of the vessel body, and a feed end is located at the top of the vessel body. A mixing assembly is located at the output end of the stirring motor. The feeding assembly is located on one side of the feed end, and a feed inlet is located on the side of the feeding assembly near the vessel body. The feed inlet is connected to the feed end. Ultimately, workers no longer need to climb to the feed inlet of the reaction vessel to feed the material; the feeding can be completed through the feeding assembly.

[0003] High temperatures can cause cyclopropyl bromide to deteriorate or degrade, thus affecting the overall product quality. To address this issue, a thorough study of its exothermic operation at high temperatures is needed. How to adjust the reaction conditions to be more moderate under the intense pressure of the autoclave, while ensuring production safety, is a pressing problem that requires our attention. Utility Model Content

[0004] To solve the above-mentioned technical problems, this utility model provides a beritinib reactor that ensures the materials remain in a balanced state throughout the reaction process and also reduces potential safety hazards at high temperatures.

[0005] This utility model discloses a beritinib reaction vessel, comprising a reaction vessel, a cooling component, and a feeding component. A stirring motor is installed at the top of the reaction vessel, and a stirring rod is installed inside the reaction vessel, connected to the stirring motor. A discharge port is located at the bottom of the reaction vessel, and a feed port is opened on one side of the top of the reaction vessel. The output end of the feeding component is connected to the feed port, and a gas outlet is opened at the other end of the top of the reaction vessel, connected to the cooling component. The feeding component feeds the material into the reaction vessel for reaction. During the high-temperature reaction, the release of heat generates a large amount of gas, which is sent to the cooling component through the gas outlet for cooling, thereby bringing the gas to a certain temperature. The cooled liquid substance is then directly fed into the reaction vessel, while the generated gas flows into the feeding component, achieving equilibrium between the reactants. This ensures that the material remains in a balanced state throughout the reaction process and reduces potential safety hazards at high temperatures. Precise temperature control technology not only improves production speed and efficiency but also significantly increases the purity of the reaction liquid, thus enabling high-quality product control.

[0006] Preferably, the feeding component includes a conveying pump, a mobile hopper, a feeder, and a feed pipe. The output end of the feeder is connected to the feed pipe, and the output end of the feed pipe is connected to the inlet of the reactor. The input end of the feeder is connected to a pipe, and the input end of the pipe is equipped with a conveying pump, which is connected to the mobile hopper. The material is added to the mobile hopper and then sent to the feeder by the conveying pump. The material in the feeder is then sent to the inlet through the feed pipe and fed into the reactor for reaction.

[0007] Preferably, the cooling components include a condenser and a gas delivery pipe. The inlet of the gas delivery pipe is connected to the outlet of the reactor, the outlet of the gas delivery pipe is connected to the inlet of the condenser, and the outlet of the condenser is connected to the feed pipe. During the high-temperature reaction, the release of heat will generate a large amount of gas. This gas can be sent to the condenser through the gas delivery pipe for cooling, so that the gas reaches a certain temperature requirement. Then, the cooled liquid substance is directly sent into the reactor.

[0008] Preferably, it also includes a balance pipe, and the output end of the condenser is connected to the feeder through the balance pipe; the gas generated in the condenser flows into the feeder through the balance pipe to achieve equilibrium between the material reactions.

[0009] Compared with existing technologies, the advantages of this invention are as follows: Materials are fed into the reaction vessel via a feeding component for reaction. During the high-temperature reaction, the release of heat generates a large amount of gas. This gas is sent to the cooling component through the outlet for cooling, thereby reaching a certain temperature requirement. The cooled liquid substance is then directly fed into the reaction vessel, while the generated gas flows into the feeding component, achieving equilibrium between the reactants. This ensures that the materials remain in a balanced state throughout the reaction process and reduces potential safety hazards at high temperatures. Precise temperature control technology not only improves production speed and efficiency but also significantly increases the purity of the reaction liquid, thus enabling high-quality product control. Attached Figure Description

[0010] Figure 1 This is a schematic diagram of the structure of this utility model;

[0011] Figure 2 This is a structural schematic diagram of the feeding component of this utility model;

[0012] Figure 3 This is a schematic diagram of the cooling component of this utility model;

[0013] The following are labels in the attached diagram: 1. Reactor; 2. Transfer pump; 3. Moving silo; 4. Condenser; 5. Feeder; 6. Gas pipeline; 7. Balance pipe; 8. Feed pipe. Detailed Implementation

[0014] To facilitate understanding of this utility model, a more complete description will be given below with reference to the accompanying drawings. This utility model can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to make the disclosure of this utility model more thorough and complete.

[0015] like Figures 1 to 3 As shown, a stirring motor is installed at the top of the reactor 1, and a stirring rod is installed inside the reactor 1. The stirring rod is connected to the stirring motor. A discharge port is installed at the bottom of the reactor 1, and a feed port is opened on one side of the top of the reactor 1. The output end of the feeder 5 is connected to the feed pipe 8, and the output end of the feed pipe 8 is connected to the feed port of the reactor 1. The input end of the feeder 5 is connected to a pipeline, and a conveying pump 2 is installed at the input end of the pipeline. The input end of the conveying pump 2 is connected to the mobile hopper 3. The input end of the gas pipeline 6 is connected to the gas outlet of the reactor 1, and the output end of the gas pipeline 6 is connected to the input end of the condenser 4. The output end of the condenser 4 is connected to the feed pipe 8, and the output end of the condenser 4 is connected to the feeder 5 through the balance pipe 7.

[0016] The material is added to the mobile hopper 3 and then sent to the feeder 5 via the conveying pump 2. The material in the feeder 5 is sent to the feed inlet through the feed pipe 8 and then fed into the reactor 1 for reaction. During the high-temperature reaction, the release of heat will generate a large amount of gas. This gas can be sent to the condenser 4 through the gas transmission pipe 6 to cool it, so that the gas reaches a certain temperature requirement. Then, the cooled liquid substance is directly sent into the reactor. The gas generated in the condenser 4 flows into the feeder 5 through the balance pipe 7 to achieve the balance between the material reactions.

[0017] like Figures 1 to 3 As shown, this utility model discloses a beritinib reaction vessel. During operation, the material is fed into a mobile hopper 3, then pumped to the inlet by a conveying pump 2, and finally fed into the reaction vessel 1 for reaction. During the high-temperature reaction, the release of heat generates a large amount of gas. This gas can be sent to a condenser 4 through a gas pipeline 6 for cooling, thereby bringing the gas to a certain temperature. The cooled liquid substance is then directly fed into the reaction vessel, and the generated gas flows into a feeder 5 through a balance pipe 7, thus achieving equilibrium between the reactants.

[0018] The delivery pump 2, mobile silo 3, condenser 4, and feeder 5 of the berberine reactor of this utility model are commercially available. Technical personnel in this industry only need to install and operate them according to the accompanying instruction manual, without requiring any creative work from those skilled in the art.

[0019] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of the present utility model, and these improvements and modifications should also be considered within the protection scope of the present utility model.

Claims

1. A birinapant reaction vessel, characterized in that, Including the reaction kettle (1), cooling parts and loading parts, the reaction kettle (1) top is provided with stirring motor, the reaction kettle (1) inside is provided with stirring rod, and the stirring rod is connected with stirring motor, and the reaction kettle (1) lower end is provided with discharge gate, and the reaction kettle (1) top side is provided with feeding port, and the output of loading parts is communicated with feeding port, and the reaction kettle (1) top other end is provided with gas outlet, and the output of gas outlet is connected with cooling parts.

2. The brigatinib reaction vessel of claim 1, wherein, The loading parts includes conveying pump (2), mobile bin (3), material supplementing machine (5) and feeding pipe (8), the output of material supplementing machine (5) is connected with feeding pipe (8), the output of feeding pipe (8) is connected with the feeding port of reaction kettle (1), the input of material supplementing machine (5) is connected with pipeline, the input of pipeline is installed with conveying pump (2), and the input of conveying pump (2) is connected with mobile bin (3).

3. The brigatinib reaction vessel of claim 2, wherein, The cooling parts includes condenser (4) and gas pipeline (6), the input of gas pipeline (6) is connected with the gas outlet of reaction kettle (1), the output of gas pipeline (6) is connected with the input of condenser (4), and the output of condenser (4) is connected with feeding pipe (8).

4. The brigatinib reaction vessel of claim 3, wherein, It also includes balance pipe (7), and the output of condenser (4) is connected with material supplementing machine (5) through balance pipe (7).

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