Medical bioactive peptide low-temperature sterile mixing and dissolving system

Abstract

The utility model discloses a medical bioactive peptide low-temperature sterile mixing and dissolving system which comprises a driving frame and a material mixing barrel, a cooling mechanism for cooling the material mixing barrel is arranged on the driving frame, the material mixing barrel comprises a rotary drum and a barrel cover, the rotary drum is installed on a machine shell and rotationally connected with the machine shell, and the barrel cover is arranged on the machine shell. The driving frame comprises a machine shell, a control panel, a first motor, a second motor, a transmission shaft and a grinding cylinder, the first motor is installed in the machine shell to drive the mixing barrel, the transmission shaft is installed on the lower end face of the top of the machine shell and rotationally connected with the machine shell, and the bottom of the transmission shaft penetrates through the top of the rotating cylinder and rotationally connected with the rotating cylinder; the second motor is installed in the machine shell and drives the transmission shaft, and the rolling cylinder is fixedly installed at the lower end of the transmission shaft. The device disclosed by the utility model has the advantages of high-efficiency mixing, low-temperature control, sterile protection and automatic operation, and solves the problems of non-uniform mixing, material caking and temperature rise inactivation of traditional equipment.

Description

Technical Field

[0001] This utility model relates to the field of mixing equipment technology, specifically a low-temperature aseptic mixing system for medical bioactive peptides. Background Technology

[0002] With the continuous development of biomedical technology, bioactive peptides have been widely used in pharmaceuticals, health products, and cosmetics. Due to their small molecular weight, high bioactivity, and well-defined mechanisms of action, bioactive peptides place extremely high demands on the environmental conditions during their preparation and mixing processes, especially in terms of temperature control and aseptic operation. Traditional mixing equipment commonly suffers from the following problems when processing high-value-added bioactive peptides.

[0003] First, conventional mixing devices are prone to material agglomeration during the stirring process due to insufficient shear force or uneven mixing, especially for active peptide raw materials with hygroscopic or viscous properties, which easily lead to aggregation, seriously affecting the uniformity and stability of the final product. Second, the heat generated by mechanical stirring during the mixing process is difficult to control effectively, and bioactive peptides are heat-sensitive, easily causing structural denaturation or loss of activity due to temperature rise, affecting product quality and efficacy. Therefore, a medical bioactive peptide low-temperature aseptic mixing system is needed to solve the above problems. Utility Model Content

[0004] The purpose of this invention is to provide a low-temperature aseptic mixing system for medical bioactive peptides, which has the advantages of efficient mixing, low-temperature control, aseptic protection and automated operation, and solves the problems of uneven mixing, material clumping and temperature rise inactivation in traditional equipment.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a low-temperature aseptic mixing system for medical bioactive peptides, comprising a drive frame and a mixing tank, wherein the drive frame is provided with a cooling mechanism for cooling the mixing tank.

[0006] The mixing drum includes a rotating drum and a lid. The rotating drum is mounted on the machine housing and rotatably connected thereto. The drive frame includes the machine housing, a control panel, a first motor, a second motor, a drive shaft, and a compaction cylinder. The first motor is installed inside the machine housing to drive the mixing drum. The drive shaft is mounted on the lower top surface of the machine housing and rotatably connected thereto. The bottom of the drive shaft passes through the top of the rotating drum and rotatably connected thereto. The second motor is installed inside the machine housing to drive the drive shaft. The compaction cylinder is fixedly mounted on the lower end of the drive shaft.

[0007] In a preferred embodiment of the medical bioactive peptide low-temperature aseptic mixing system of this utility model, the outer end face of the crushing cylinder is in contact with the inner end face of the rotating cylinder, and the rotation direction of the crushing cylinder is opposite to that of the rotating cylinder.

[0008] As a preferred embodiment of the low-temperature aseptic mixing system for medical bioactive peptides of this utility model, the inner end face of the crushing cylinder is provided with spiral blades.

[0009] As a preferred embodiment of the medical bioactive peptide low-temperature aseptic mixing system of this utility model, the housing is provided with a vent pipe that runs through the top of the rotating drum, the bottom of the vent pipe is flush with the bottom upper surface of the rotating drum, and the inner end surface of the rotating drum is provided with an antibacterial coating.

[0010] As a preferred embodiment of the medical bioactive peptide low-temperature aseptic mixing system of this utility model, the cooling mechanism includes a cooling jacket and a heat insulation layer. The cooling jacket is fixedly installed on the housing and rotatably connected to the heat exchange plate. The side end face of the cooling jacket is provided with a refrigerant inlet and a refrigerant outlet.

[0011] As a preferred embodiment of the low-temperature aseptic mixing system for medical bioactive peptides of this utility model, heat exchange plates are uniformly arranged on the outer end face of the rotating cylinder.

[0012] In a preferred embodiment of the medical bioactive peptide low-temperature aseptic mixing system of this utility model, a barrel cover is provided on the upper end face of the rotating drum, and a connecting rod that is rotatably connected to the machine housing is fixedly installed on the upper end face of the barrel cover. A third motor that drives the connecting rod is provided inside the machine housing.

[0013] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0014] 1. This utility model, through the design of a counter-rotating compaction cylinder and a rotating drum structure, combined with the tight fit between the outer wall of the compaction cylinder and the inner wall of the rotating drum, generates shear force and a vortex effect, effectively crushing lumps in the material and accelerating the mixing process. The spiral blades inside the compaction cylinder cause the material to tumble up and down during rotation, solving the problem of uneven mixing caused by stratification or agglomeration in traditional mixing devices, and significantly improving the uniformity and dispersion efficiency of the material. This structural design not only enhances the mixing effect but also avoids the risk of deformation of the compaction cylinder during high-speed operation through the reinforcement effect of the spiral blades.

[0015] 2. This invention achieves continuous low-temperature control of the mixing tank through the synergistic effect of the cooling jacket, the refrigerant circulation system, and the heat exchange fins on the outer wall of the rotating drum. As the refrigerant flows within the jacket, the heat exchange fins increase the contact area and agitate the refrigerant, ensuring uniform temperature transfer and preventing the denaturation and inactivation of active peptides caused by heat generated during agitation. Furthermore, the nano-silver ion antibacterial coating on the inner wall of the rotating drum, combined with the sterile air supplied through the vent pipe, inhibits microbial growth and promotes material exchange between layers through bubble agitation, further enhancing mixing efficiency. This design maintains a low-temperature environment while completely isolating external contaminants, ensuring the sterile stability of the bioactive peptides. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0017] Figure 2 This is a top view of the present invention;

[0018] Figure 3 For the present utility model Figure 2 Sectional view of AA;

[0019] Figure 4 For the present utility model Figure 3 Enlarged view of section B in the middle.

[0020] In the diagram: 1. Drive frame; 101. Casing; 102. Control panel; 103. First motor; 104. Second motor; 105. Drive shaft; 106. Compactor; 1061. Spiral blades; 107. Vent pipe; 2. Mixing tank; 201. Rotary drum; 2011. Heat exchange plate; 202. Tank lid; 203. Connecting rod; 204. Third motor; 3. Cooling mechanism; 301. Cooling jacket; 3011. Refrigerant inlet; 3012. Refrigerant outlet; 302. Insulation layer. Detailed Implementation

[0021] Please see Figures 1-4 A medical bioactive peptide low-temperature aseptic mixing system includes a drive frame 1 and a mixing tank 2. The drive frame 1 is equipped with a cooling mechanism 3 to cool down the mixing tank 2.

[0022] The mixing drum 2 includes a rotating drum 201 and a lid 202. The rotating drum 201 is mounted on the housing 101 and rotatably connected thereto. The drive frame 1 includes the housing 101, a control panel 102, a first motor 103, a second motor 104, a drive shaft 105, and a crushing cylinder 106. The first motor 103 is mounted inside the housing 101 to drive the mixing drum 2. The drive shaft 105 is mounted on the lower top surface of the housing 101 and rotatably connected thereto. The bottom of the drive shaft 105 passes through the top of the rotating drum 201 and is rotatably connected thereto. The second motor 104 is mounted inside the housing 101 to drive the drive shaft 105. The crushing cylinder 106 is fixedly mounted on the lower end of the drive shaft 105.

[0023] Furthermore, the outer end face of the compaction cylinder 106 is in contact with the inner end face of the rotating cylinder 201, and the rotation direction of the compaction cylinder 106 is opposite to the rotation direction of the rotating cylinder 201.

[0024] The first motor 103 drives the rotating drum 201 to rotate clockwise through the reducer to generate eddy currents. The second motor 104 drives the transmission shaft 105 to rotate through the synchronous belt and synchronous pulley, thereby driving the crushing drum 106 to rotate. The crushing drum 106 and the rotating drum 201 crush the lumpy materials and improve the mixing effect.

[0025] Furthermore, the inner end face of the rolling cylinder 106 is provided with a spiral blade 1061.

[0026] When the rolling cylinder 106 rotates, the internal spiral blades 1061 drive the material to surge upward, thereby promoting the mixing of the upper and lower layers of material. The spiral blades 1061 also increase the structural strength of the rolling cylinder 106, preventing it from deforming.

[0027] Furthermore, the housing 101 is provided with a vent pipe 107 that runs through the top of the rotating drum 201. The bottom of the vent pipe 107 is flush with the bottom upper surface of the rotating drum 201, and the inner end surface of the rotating drum 201 is provided with an antibacterial coating.

[0028] The antibacterial coating is a nano-silver ion coating, which can effectively inhibit the growth of microorganisms. At the same time, sterile air is introduced into the rotating drum 201 through the air pipe 107. The air bubbles carry the bottom material to the upper layer, accelerating the mixing of the upper and lower layers.

[0029] Furthermore, the cooling mechanism 3 includes a cooling jacket 301 and an insulation layer 302. The cooling jacket 301 is fixedly installed on the housing 101 and rotatably connected to the heat exchange plate 2011. The side end face of the cooling jacket 301 is provided with a refrigerant inlet 3011 and a refrigerant outlet 3012.

[0030] Refrigerant is introduced through refrigerant inlet 3011 and flows out through refrigerant outlet 3012, thereby cooling the rotating drum 201 and preventing the heat generated by stirring from causing the active peptides to become inactive and denatured. The heat insulation layer 302 covers the outer end face of the cooling jacket 301, which can prevent the refrigerant from absorbing heat from the surrounding air and improve the cooling effect.

[0031] Furthermore, heat exchange plates 2011 are evenly arranged on the outer end face of the rotating cylinder 201.

[0032] The heat exchange area between the rotating drum 201 and the refrigerant is increased by the heat exchange fins 2011, thereby improving the cooling effect. When the rotating drum 201 rotates, the heat exchange fins can stir the refrigerant in the cooling jacket 301, promote refrigerant mixing, and avoid uneven refrigerant temperature in the jacket.

[0033] Furthermore, a bucket cover 202 is provided on the upper end face of the rotating drum 201, and a connecting rod 203 that is rotatably connected to the housing 101 is fixedly installed on the upper end face of the bucket cover 202. A third motor 204 that drives the connecting rod 203 is provided inside the housing 101.

[0034] The third motor 204 drives the connecting rod 203 to move, thereby opening and closing the lid 202 without manual operation, further improving the automation level of the equipment.

[0035] When using this mixing system, firstly, the third motor 204 is turned on, which drives the connecting rod 203 to open the barrel lid 202, allowing the medical bioactive peptide material to be mixed to be placed into the rotating drum 201. Then, the third motor 204 is turned on again to close the barrel lid 202. Next, the first motor 103 and the second motor 104 are turned on via the control panel 102. The first motor 103 drives the rotating drum 201 to rotate clockwise via a reducer, generating eddies. The second motor 104 drives the transmission shaft 105 and the crushing cylinder 106 fixed at its lower end to rotate via a synchronous belt and synchronous pulley. Since the outer end face of the crushing cylinder 106 is in contact with the inner end face of the rotating drum 201 and rotates in opposite directions, they can crush the lumpy material. At the same time, the spiral blades 1061 on the inner end face of the crushing cylinder 106 cause the material to surge upward as it rotates, promoting the mixing of the upper and lower layers of material. During the mixing process, refrigerant is introduced into the cooling jacket 301 through the refrigerant inlet 3011. The refrigerant passes through the cooling jacket... The heat exchange fins 2011 on the outer end face of the rotating drum 201 are in full contact with the drum 201, increasing the heat exchange area and improving the cooling effect. When the drum 201 rotates, the heat exchange fins 2011 agitate the refrigerant to avoid uneven temperature inside the jacket. The insulation layer 302 covers the outer end face of the cooling jacket 301 to prevent the refrigerant from absorbing external heat, thereby maintaining a low-temperature environment and preventing the active peptides from being deactivated or denatured due to heat generated by agitation. In addition, sterile air is introduced into the rotating drum 201 through the vent pipe 107 on the casing 101. The bottom of the vent pipe 107 is flush with the upper end face of the bottom of the rotating drum 201. The bubbles formed by the sterile air carry the bottom material to the upper layer, accelerating the mixing of the material. The nano silver ion antibacterial coating on the inner end face of the rotating drum 201 can effectively inhibit the growth of microorganisms and ensure a sterile environment during the mixing process. After the material is fully mixed, the first motor 103, the second motor 104 and the third motor 204 are turned off, and the bucket lid 202 is opened to take out the mixed medical bioactive peptide material.

[0036] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A medical bioactive peptide low-temperature sterile mixing system comprising a driving frame (1) and a mixing barrel (2), characterized in that: The driving frame (1) is provided with a cooling mechanism (3) for cooling the mixing barrel (2). The mixing barrel (2) comprises a rotating drum (201) and a barrel cover (202), the rotating drum (201) is rotatably connected to the shell (101), the driving frame (1) comprises a shell (101), a control panel (102), a first motor (103), a second motor (104), a transmission shaft (105) and a rolling cylinder (106), the first motor (103) is installed in the shell (101) to drive the mixing barrel (2), the transmission shaft (105) is rotatably connected to the top lower end surface of the shell (101), the bottom of the transmission shaft (105) is rotatably connected to the top of the rotating drum (201), the second motor (104) is installed in the shell (101) to drive the transmission shaft (105), and the rolling cylinder (106) is fixedly installed at the lower end of the transmission shaft (105).

2. A medical bioactive peptide low temperature aseptic miscible system as claimed in claim 1, characterized in that: The outer end surface of the rolling cylinder (106) is in contact with the inner end surface of the rotating drum (201), and the rotating direction of the rolling cylinder (106) is opposite to the rotating direction of the rotating drum (201).

3. A medical bioactive peptide low temperature aseptic miscible system as defined in claim 1, wherein: The inner end surface of the rolling cylinder (106) is provided with a spiral blade (1061).

4. A medical bioactive peptide low temperature aseptic miscible system as defined in claim 1, wherein: The shell (101) is provided with a ventilation pipe (107) penetrating through the top of the rotating drum (201), the bottom of the ventilation pipe (107) is flush with the upper end surface of the bottom of the rotating drum (201), and the inner end surface of the rotating drum (201) is provided with a bacteriostatic coating.

5. A medical bioactive peptide low temperature aseptic miscible system as defined in claim 1, wherein: The cooling mechanism (3) comprises a cooling jacket (301) and a heat preservation layer (302), the cooling jacket (301) is rotatably connected to the heat exchange fin (2011) and is fixedly installed on the shell (101), and the side end surface of the cooling jacket (301) is provided with a refrigerant inlet (3011) and a refrigerant outlet (3012).

6. A medical bioactive peptide low temperature aseptic miscible system as defined in claim 1, wherein: The outer end surface of the rotating drum (201) is uniformly provided with a heat exchange fin (2011).

7. A medical bioactive peptide low temperature aseptic miscible system as defined in claim 1, wherein: The upper end surface of the rotating drum (201) is provided with a barrel cover (202), the upper end surface of the barrel cover (202) is fixedly installed with a connecting rod (203) rotatably connected to the shell (101), and the shell (101) is provided with a third motor (204) for driving the connecting rod (203).

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