Mesenchymal stem cell exosome ovarian injection device

Abstract

The utility model relates to a mesenchymal stem cell exosome ovary injection device which comprises a puncture needle, an elastic tube and an injector, a plurality of liquid outlet holes are formed in the side wall of the puncture needle, the needle tip of the puncture needle is a sharp solid needle tip, one end of the elastic tube is communicated with the puncture needle through a hollow connecting part, the other end of the elastic tube is provided with a silica gel plug, and the injector is connected with the puncture needle through a connecting part. One end, far away from the elastic tube, of the silica gel plug is provided with a guide hole which is sunken inwards, and the guide hole is used for guiding a needle head of the injector to pierce the silica gel plug. The needle tip is solid, sharp and high in rigidity, and can smoothly pierce into ovarian tissues; a plurality of liquid outlet holes are formed in the side surface of the puncture needle, so that exosomes can be more uniformly distributed in the ovary during puncture and injection, the puncture frequency is reduced, and the physical damage to the ovary of a patient is reduced; a silica gel plug is designed at one end of the elastic tube for plugging, so that liquid backflow in the process of switching different injection liquid medicine can be prevented, and the infection risk is reduced.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the medical instrument technical field, especially is related to a mesenchymal stem cell exosome ovary injection device. BACKGROUND

[0002] Premature ovarian insufficiency (POI) is the most common female reproductive aging disease, which not only makes the patient's fertility decline prematurely or even lose, but also threatens the patient's health. The main diagnostic criteria of POI is that a woman has oligomenorrhea or amenorrhea for more than 4 months before the age of 40, and the serum level of follicle-stimulating hormone (FSH) is more than 25 IU / L detected twice with an interval of more than 4 weeks. In China, about 4 million women of childbearing age suffer from POI.

[0003] At present, the treatment means for POI in clinic is very limited. In recent years, mesenchymal stem cells and their derived exosomes have been tried for POI treatment, and good clinical effects have been achieved. However, when stem cells or exosomes are used for POI treatment in clinic, the laparoscopic injection method is often used, which causes great trauma to the patient.

[0004] When taking ovum operation in clinic, the vaginal ultrasound method can be used for visual guidance, and the ovum needle is punctured into the ovary tissue through the genital tract, which causes less trauma. However, when the exosome injection is performed under the guidance of ultrasound using the ovum needle, there are several problems: first, the ovaries of POI patients are relatively compact, and the conventional ovum needle is difficult to pierce, and it is easy to block the outlet hole after piercing; second, multiple puncture and exit need to be performed on the ovary to achieve the effect of uniform distribution of exosomes throughout the ovary, which causes great damage to the patient's ovary; third, in order to avoid the residue of exosome liquid in the injection device, different liquids need to be switched for flushing during the injection process, which has the risk of backflow and contamination of the liquid. UTILITY MODEL CONTENTS

[0005] The utility model solves the technical problem to provide a mesenchymal stem cell exosome injection device, which enables medical staff to easily complete the ovary injection of exosomes under the guidance of ultrasound, shortens the operation time and reduces the surgical damage to the patient.

[0006] The utility model solves the technical problem by adopting the following technical scheme: a mesenchymal stem cell exosome ovary injection device is provided, which comprises a puncture needle, an elastic tube and a syringe, the side wall of the puncture needle is provided with a plurality of liquid outlet holes, the needle tip of the puncture needle is a sharp solid needle tip, one end of the elastic tube is communicated with the puncture needle through a hollow connecting part, the other end of the elastic tube is provided with a silica gel plug, the end of the silica gel plug away from the elastic tube is provided with an inwardly recessed guide hole, and the guide hole is used to guide the needle of the syringe to pierce the silica gel plug.

[0007] Preferably, the number of liquid outlet holes is 6, which are arranged in two columns on the two sides of the puncture needle.

[0008] Preferably, the distance between the two adjacent liquid outlet holes in the same column is 0.3-1.5 mm.

[0009] Preferably, the length of the needle body of the puncture needle is 20-50 mm.

[0010] Preferably, the outer diameter of the needle body of the puncture needle is 0.5-1.8 mm.

[0011] Preferably, the length of the needle tip of the puncture needle is 1-5 mm.

[0012] Preferably, the inner diameter of the liquid outlet hole is 0.1-0.3 mm.

[0013] Preferably, the needle tip part of the puncture needle is a solid conical structure, and the included angle between the generatrix and the height is ≤30° and >0°.

[0014] Preferably, the length of the elastic tube is 10-50 cm, and the inner diameter is 0.6-1.2 mm.

[0015] Preferably, the specification of the syringe is 1-10 mL.

[0016] The beneficial effects are that: the needle tip position of the utility model is a solid structure, which is high in rigidity, facilitates the preparation of a sharper needle tip, and can be more smoothly pierced into the ovarian tissue; the utility model is designed with multiple liquid outlet holes on the side surface of the puncture needle, which can make the exosomes more evenly distributed in the ovary during puncture and injection, reduce the puncture frequency, and thus reduce the physical damage to the patient's ovary; the liquid outlet hole is perpendicular to the needle insertion direction, which can better prevent blockage; the inner diameter of the elastic tube is small and the length is short, which can reduce the residual liquid in the injection device; the utility model is designed with a silica gel plug at one end of the elastic tube, which can prevent liquid backflow during switching of different injection liquids and reduce the risk of infection. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 It is a mesenchymal stem cell exosome ovarian injection device structure schematic view.

[0018] Figure 2 It is Figure 1 It is a puncture needle enlarged schematic view.

[0019] Among them, 1-puncture needle; 101-needle tip; 102-liquid outlet hole; 2-elastic tube; 3-syringe; 301-injection port; 302-needle; 4-hollow connecting part; 5-rubber plug; 501-guide hole.

[0020] The same reference signs are used in all the figures to designate the same components. DETAILED DESCRIPTION

[0021] The utility model is further explained below in combination with specific embodiments. It should be understood that these embodiments are only used for illustrating the utility model and are not used for limiting the scope of the utility model. In addition, it should be understood that after reading the content taught by the utility model, those skilled in the art can make various changes or modifications to the utility model, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0022] As shown in Figure 1 The utility model provides a mesenchymal stem cell exosome ovarian injection device, including puncture needle 1, elastic tube 2 and syringe 3, the lateral wall of puncture needle 1 is equipped with a plurality of liquid outlet holes 102, the needle tip 101 of puncture needle 1 is sharp solid needle tip, one end of elastic tube 2 is communicated with hollow connecting part 4 of puncture needle 1, the other end is equipped with silica gel plug 5, the end of silica gel plug 5 away from elastic tube 2 is equipped with the guide hole 501 recessed inwards.

[0023] The guide hole 501 is used for guiding the needle 302 of syringe 3 to puncture silica gel plug 5 so that the solution in syringe 3 can flow into elastic tube 2. Because the material of silica gel plug 5 is silica gel, it can be automatically closed after the needle 302 exits silica gel plug 5, preventing backflow of drugs or solution and avoiding contamination.

[0024] Syringe 3 is a conventional medical syringe, including a syringe barrel, a piston, a needle 302 and a protective cap. One of the characteristics of syringe 3 is high accuracy, which can accurately control the dose of the drug. The specific structure is not described here.

[0025] Elastic tube 2 is a hollow tube that can send therapeutic drugs from syringe 3 into hollow connecting part 4. At the same time, elastic tube 2 is soft and foldable, so that the position of syringe 3 is not limited during injection and can be placed at will, reducing the work pressure of the physician. At the same time, the small inner diameter and short length of elastic tube 3 can reduce the residue of the drug solution in the injection device.

[0026] The front end of elastic tube 2 is connected to the end of hollow connecting part 4, and a joint can be provided at the connection to prevent liquid leakage. The end of elastic tube 2 is connected to the injection port 301 of syringe 3, and the needle 302 is inserted into elastic tube 2.

[0027] In one specific embodiment as shown in Figure 2 The number of liquid outlet holes 102 is six, arranged in two columns on both sides of puncture needle 1, with three in each column. The multi-hole design can improve the uniformity of the distribution of therapeutic drug injection.

[0028] In one embodiment, the distance between two adjacent liquid outlet holes 102 in the same column is 0.3-1.5 mm (e.g. 0.3, 0.5, 0.8, 1.2 mm); the length of the needle body of the puncture needle 1 is 20-50 mm, preferably 30-40 cm; the outer diameter of the needle body of the puncture needle 1 is 0.5-1.8 mm (e.g. 0.8, 1.2, 1.6 mm); the length of the needle tip 101 of the puncture needle 1 is 1-5 mm (e.g. 1.5, 3, 4.5 mm); the inner diameter of the liquid outlet hole 102 is 0.1-0.3 mm, preferably 0.2 mm. The needle tip of the puncture needle is a solid conical structure, the included angle between the generatrix and the height is ≤30° and >0° (e.g. 30°, 20°, 15°); the length of the elastic tube 2 is 10-50 cm, preferably 15 cm; the inner diameter of the elastic tube 2 is 0.6-1.2 mm, preferably 0.6-0.8 mm; the size of the syringe 3 is 1-10 mL.

[0029] In use, the mesenchymal stem cell exosome solution for treating POI is injected into the syringe 3 of the present application, then the needle 302 is inserted into the elastic tube 2 through the needle guide hole 501 on the silicone plug 5, the plunger of the syringe 3 is pushed to fill the entire device with liquid and expel the gas in the device, the physician holds the hollow connecting part 4 and performs ovarian puncture under the guidance of ultrasound, so that the puncture needle 1 is inserted into the ovary of the POI patient, then the therapeutic drug is injected into the ovary of the patient by pushing the plunger of the syringe 3. While keeping the puncture needle 1 in the ovary of the patient, the syringe 3 is pulled out of the silicone plug 5, then physiological saline is sucked into the syringe 3 and re-inserted into the silicone plug 5, then the therapeutic drug remaining in the device is injected into the ovary of the patient by pushing the plunger of the syringe 3. Finally, the puncture needle 1 is pulled out of the ovary of the patient, and the treatment process is completed.

Claims

1. A mesenchymal stem cell exosome ovarian injection device, comprising a puncture needle, an elastic tube, and a syringe, characterized in that, The puncture needle has several fluid outlet holes on its side wall, and the needle tip of the puncture needle is a sharp solid needle tip. One end of the elastic tube is connected to the puncture needle through a hollow connecting component, and the other end is provided with a silicone plug. The end of the silicone plug away from the elastic tube is provided with an inwardly recessed guide hole, which is used to guide the needle of the syringe to puncture the silicone plug.

2. The mesenchymal stem cell exosome ovarian injection device according to claim 1, characterized in that, There are a total of 6 outlet holes, arranged in two rows on both sides of the puncture needle.

3. The mesenchymal stem cell exosome ovarian injection device according to claim 2, characterized in that, In the same column, the distance between two adjacent liquid outlet holes is 0.3 to 1.5 mm.

4. The mesenchymal stem cell exosome ovarian injection device according to claim 1, characterized in that, The length of the puncture needle is 20-50 mm.

5. The mesenchymal stem cell exosome ovarian injection device according to claim 1, characterized in that, The outer diameter of the puncture needle is 0.5–1.8 mm.

6. The mesenchymal stem cell exosome ovarian injection device according to claim 1, characterized in that, The tip length of the puncture needle is 1–5 mm.

7. The mesenchymal stem cell exosome ovarian injection device according to claim 1, characterized in that, The inner diameter of the liquid outlet is 0.1–0.3 mm.

8. The mesenchymal stem cell exosome ovarian injection device according to claim 1, characterized in that, The tip of the puncture needle is a solid conical structure, and the angle between its generatrix and its height is ≤30° and >0°.

9. The mesenchymal stem cell exosome ovarian injection device according to claim 1, characterized in that, The elastic tube has a length of 10–50 cm and an inner diameter of 0.6–1.2 mm.

10. The mesenchymal stem cell exosome ovarian injection device according to claim 1, characterized in that, The syringe has a capacity of 1 to 10 mL.

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