Blood perfusion device

Abstract

The utility model discloses a hemoperfusion device, relates to the technical field of blood purification, it includes the cylinder, be provided the inlet end cover and the outlet end cover of cylinder both ends respectively, and heating device, the heating device is used for raising the temperature in the cylinder and maintains at the specified temperature, the utility model provides a hemoperfusion device. When treatment is carried out, the heating device is turned on to heat the interior of the cylinder body and maintain the temperature at the specified temperature, so that the conditions of viscosity increase and fluidity reduction caused by temperature reduction of blood are avoided, the risk of blood coagulation is reduced, meanwhile, the conditions of hypothermia are reduced, and the problems that the viscosity increase of the blood is caused by temperature reduction and the fluidity of the blood is reduced are solved. The problem that the treatment effect is affected due to reduction of the adsorption surface area of resin microspheres caused by mutual adhesion of the resin microspheres after the resin microspheres in the perfusion device are in contact with the blood is solved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of blood purification, more particularly to a blood perfusion device. BACKGROUND

[0002] In the field of medical equipment, especially in the field of blood purification technology, the blood perfusion device is a commonly used medical equipment, the blood of the patient is drawn out of the body into the perfusion device, the blood circulating outside the body contacts the resin microspheres in the perfusion device, the resin microspheres have a large surface area and can adsorb the harmful toxins in the blood, reduce the harmful toxins in the blood of the patient, and the purified blood is returned to the patient's body, thereby achieving the therapeutic effect.

[0003] In the prior art, the perfusion device is usually composed of an end cover, a cylinder, a filter screen and resin microspheres, the blood of the patient is drawn out of the body into the perfusion device, the perfusion device is filled with resin microspheres, the resin microspheres have a large surface area and can adsorb the harmful toxins in the blood, the purified blood is returned to the patient's body, thereby achieving the therapeutic effect.

[0004] However, in high-altitude or low-temperature areas, when the patient needs blood perfusion treatment, the temperature of the blood drawn out of the body decreases, causing hypothermia (hypothermia, also known as hypothermia, is a disease in which the core temperature of the human body is lower than 35℃, which can directly or indirectly cause death, and the main cause of hypothermia is that the body is exposed to a low-temperature environment for a long time, causing excessive heat loss). Since blood is a viscous fluid, the viscosity of blood increases when the temperature decreases, and the flowability of blood decreases. After the resin microspheres in the perfusion device contact the blood, the resin microspheres adhere to each other, causing a decrease in adsorption performance and an increase in the risk of blood clotting.

[0005] In summary, how to avoid the occurrence of hypothermia in high-altitude or low-temperature areas and maintain the adsorption performance of the resin microspheres in the blood perfusion device to reduce the risk of blood clotting is a problem that needs to be solved by those skilled in the art. UTILITY MODEL CONTENT

[0006] Therefore, the utility model aims to provide a blood perfusion device that effectively avoids the occurrence of hypothermia and solves the problem of a decrease in the adsorption surface area of the resin microspheres caused by the adhesion of the resin microspheres to each other, thereby affecting the therapeutic effect.

[0007] To achieve the above-mentioned purpose, the utility model provides the following technical scheme:

[0008] A blood perfusion device, comprising a cylinder and an inlet end cover and an outlet end cover respectively arranged at both ends of the cylinder, further comprising a heating device for heating the cylinder and maintaining the temperature at a specified temperature.

[0009] Preferably, the heating device comprises:

[0010] a liquid storage bin, which is arranged around the outer circumferential surface of the cylinder body, and a cavity is formed in the liquid storage bin, and a heat transfer medium is arranged in the cavity;

[0011] a heater, which is arranged on the liquid storage bin and is used for heating the heat transfer medium in the cavity.

[0012] Preferably, the heater comprises:

[0013] a temperature controller, which is fixedly arranged on the outer surface of the liquid storage bin;

[0014] a heating rod, which is arranged in the cavity and is electrically connected with the temperature controller.

[0015] Preferably, a liquid injection port is formed on the surface of the liquid storage bin, and a sealing cover is arranged at the liquid injection port to prevent the heat transfer medium in the liquid storage bin from flowing out of the liquid injection port.

[0016] Preferably, the heating device comprises:

[0017] a heating pipeline, two ends of which are respectively arranged through the inlet end cover and the outlet end cover, and the heating pipeline is arranged in the cylinder body;

[0018] a thermostat, a water tank of which stores constant temperature water, a water return port of the water tank is connected in communication with one end of the heating pipeline through a heat recovery pipeline, and a water outlet of the water tank is connected in communication with the other end of the heating pipeline through a heat supply pipeline;

[0019] a water pump, which is arranged on the heat supply pipeline and is used for providing power for the constant temperature water in the water tank.

[0020] Preferably, an anti-coagulation coating is arranged on the outer surface of the heating pipeline arranged in the cylinder body, and the anti-coagulation coating is used for inhibiting the adhesion of blood on the outer surface of the heating pipeline.

[0021] Preferably, the heat supply pipeline and the heat recovery pipeline are both medical PVC hoses.

[0022] Preferably, an inlet filter screen is arranged at one end of the cylinder body close to the inlet end cover, and an outlet filter screen is arranged at one end of the cylinder body close to the outlet end cover.

[0023] Preferably, at least one partition filter screen is arranged in the cylinder body, and the partition filter screen divides the cylinder body into a plurality of independent spaces, and uniform resin microspheres are arranged in each of the independent spaces.

[0024] Preferably, the inlet end cover is provided with a medicine injection opening communicated with the barrel, and a medical silica gel sheet is attached to the medicine injection opening.

[0025] The blood perfusion device provided by the utility model, when treating, the heating device is turned on to heat the barrel and maintain the temperature of the barrel at a specified temperature, so that the blood viscosity is prevented from increasing and the blood flowability is prevented from decreasing due to temperature reduction, the risk of blood clotting is reduced, the occurrence of hypothermia is reduced, the blood viscosity is prevented from increasing due to temperature reduction, the blood flowability is prevented from being poor, the adsorption surface area of the resin microspheres is prevented from decreasing due to mutual adhesion between the resin microspheres after the resin microspheres in the blood perfusion device contact the blood, and the treatment effect is prevented from being affected.

[0026] The blood perfusion device provided by the utility model, when treating, the heating device is turned on to heat the barrel and maintain the temperature of the barrel at a specified temperature, so that the blood viscosity is prevented from increasing and the blood flowability is prevented from decreasing due to temperature reduction, the risk of blood clotting is reduced, the occurrence of hypothermia is reduced, the blood viscosity is prevented from increasing due to temperature reduction, the blood flowability is prevented from being poor, the adsorption surface area of the resin microspheres is prevented from decreasing due to mutual adhesion between the resin microspheres after the resin microspheres in the blood perfusion device contact the blood, and the treatment effect is prevented from being affected. BRIEF DESCRIPTION OF DRAWINGS

[0027] In order to more clearly illustrate the technical scheme in the embodiments of the utility model or the prior art, the drawings needed to be used in the following embodiment or prior art description will be briefly introduced. Obviously, the drawings in the following description are only embodiments of the utility model, and other drawings can be obtained by the provided drawings without creative labor for the ordinary skilled in the art.

[0028] Figure 1 It is a structure schematic view of the blood perfusion device with the first heating device in the embodiment;

[0029] Figure 2 It is a sectional view of the blood perfusion device with the first heating device in the embodiment;

[0030] Figure 3 It is a structure schematic view of the first heating device in the embodiment;

[0031] Figure 4 It is a structure schematic view of the blood perfusion device with the second heating device in the embodiment;

[0032] Figure 5 It is a sectional view of the blood perfusion device with the second heating device in the embodiment;

[0033] Figure 6 It is a schematic view of the blood perfusion device with the second heating device connected with the thermostat in the embodiment;

[0034] Figure 7 It is a structure schematic view of the medicine injection opening in the embodiment.

[0035] Figures 1-7 In the drawings, reference numerals include:

[0036] 1, import end cover; 2, import luer joint; 3, medicine injection port; 4, medical silica gel sheet; 5, barrel; 6, import filter screen; 7, separation filter screen; 8, independent space; 9, resin microspheres; 10, export filter screen; 11, export end cover; 12, export luer joint; 13, liquid storage bin; 14, liquid injection port; 15, sealing cover; 16, heater; 17, heating rod; 18, temperature controller; 19, heating pipeline; 20, heat supply pipe; 21, water pump; 22, thermostat; 23, heat recovery pipe. DETAILED DESCRIPTION

[0037] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of the present application.

[0038] Unless otherwise defined, technical or scientific terms used in the present application should be understood as having the common meaning in the field of the present application to which the present application pertains. The terms "first", "second", and similar terms used in the present application do not denote any order, quantity, or importance. The terms "connected" or "coupled" or similar terms do not necessarily mean physical or mechanical connections, but can include electrical connections, whether direct or indirect. The terms "upper", "lower", "left", "right", and the like are used only to indicate relative positions, and when the absolute positions of the described objects are changed, the relative positions can also be changed accordingly. The embodiments of the present application disclose a blood perfusion device.

[0039] The core of the present application is to provide a blood perfusion device.

[0040] Please refer to Figures 1-7 .

[0041] The blood perfusion device provided by the present application comprises a barrel 5, an import end cover 1 and an export end cover 11 respectively arranged at two ends of the barrel 5, and a heating device. The heating device is used for heating the barrel 5 and maintaining the barrel 5 at a specified temperature.

[0042] Specifically, by installing a heating device in the blood perfusion device, the blood flowing in the barrel 5 is heated and kept at a constant temperature by the heating device, thereby ensuring the maintenance of the temperature of the extracorporeal circulation blood, thereby reducing the occurrence of hypothermia. At the same time, it also avoids the increase of blood viscosity and the decrease of blood flow, and avoids the problem that the resin microspheres in the perfusion device are adhered to each other after contacting with the blood, which leads to the decrease of adsorption performance and the increase of the risk of blood coagulation.

[0043] The blood perfusion device effectively avoids the increase of blood viscosity and the decrease of blood flow caused by temperature reduction, reduces the risk of blood coagulation, and reduces the occurrence of hypothermia. It solves the problem that the increase of blood viscosity and the decrease of blood flow caused by temperature reduction, the decrease of adsorption surface area of resin microspheres caused by the mutual adhesion between resin microspheres after contacting with blood, thereby affecting the treatment effect.

[0044] The blood perfusion device provided by the present application will be described in more detail below in combination with the drawings and specific embodiments.

[0045] In a specific embodiment, referring to Figures 1-3 The heating device includes a liquid storage bin 13 and a heater 16. The liquid storage bin 13 is arranged around the outer periphery of the barrel 5, and a cavity is formed in the liquid storage bin 13. The cavity is provided with a heat transfer medium, and the heater 16 is arranged on the liquid storage bin 13. The heater 16 is used to heat the heat transfer medium in the cavity.

[0046] Specifically, the liquid storage bin 13 is arranged around the outer periphery of the barrel 5 and cooperates with the inlet end cover 1 and the outlet end cover 11 to surround the barrel 5. The liquid storage bin 13 is a hollow structure, and the inside of the liquid storage bin 13 stores a heat transfer medium. The side of the liquid storage bin 13 close to the barrel 5 is attached to the outer wall of the barrel 5. The heater 16 is arranged on the liquid storage bin 13, and the heater 16 is used to heat the heat transfer medium in the cavity of the liquid storage bin 13 to a specified temperature. The heat transfer medium is heated by heat transfer, and the temperature in the barrel 5 is controlled at a specified temperature (usually 37℃) and kept unchanged, thereby avoiding the increase of blood viscosity and the decrease of blood flow caused by temperature reduction, reducing the risk of blood coagulation, and reducing the occurrence of hypothermia.

[0047] Further, the heater 16 includes a heating rod 17 and a temperature controller 18. The temperature controller 18 is fixedly arranged on the outer surface of the liquid storage bin 13, and the heating rod 17 is arranged in the cavity. The heating rod 17 is electrically connected to the temperature controller 18.

[0048] Specifically, the temperature controller 18 is arranged on one side of the outer surface of the liquid storage bin 13, and can be arranged on the upper part of the liquid storage bin 13 for convenient operation. The heating rod 17 is arranged in the cavity of the liquid storage bin 13 and is in full contact with the heat transfer medium in the cavity. The heating rod 17 can be a high-resistance coil, and the specific shape of the heating rod 17 can be adjusted to increase the contact area with the heat transfer medium. The heating rod 17 is electrically connected with the temperature controller 18 to convert electrical energy into heat energy. The temperature controller 18 has the function of adjusting and maintaining the temperature. When blood perfusion treatment is performed in a low-temperature environment, the heating rod 17 is connected to the power supply to heat the liquid in the liquid storage bin 13, so that the temperature of the blood in the blood perfusion device is maintained at about 37°C, preventing hypothermia caused by hypothermia and improving the safety of treatment.

[0049] On the basis of any one of the above embodiments, with reference to Figures 1-3 The liquid storage bin 13 is provided with a liquid injection port 14, and the liquid injection port 14 is provided with a sealing cover 15 to prevent the heat transfer medium in the liquid storage bin 13 from flowing out of the liquid injection port 14.

[0050] Specifically, the liquid injection port 14 is in communication with the cavity in the liquid storage bin 13, and the sealing cover 15 is arranged at the liquid injection port 14 to seal the liquid injection port 14. The heat transfer medium is injected into the liquid storage cavity 13 through the liquid injection port 14, and the sealing cover 15 is installed on the liquid injection port 14 to seal the liquid injection port 14 and prevent the heat transfer medium in the liquid storage cavity 13 from flowing out.

[0051] In one specific embodiment, with reference to Figures 4-6 The heating device includes a heating pipe 19, a thermostat 22, and a water pump 21. The two ends of the heating pipe 19 are respectively arranged through the inlet end cover 1 and the outlet end cover 11, and the heating pipe 19 is arranged in the barrel 5. The water tank of the thermostat 22 stores constant-temperature water. The backwater port of the water tank is connected with one end of the heating pipe 19 through a heat recovery pipe 23, and the water outlet of the water tank is connected with the other end of the heating pipe 19 through a heat supply pipe 20. The water pump 21 is arranged on the heat supply pipe 20, and the water pump 21 is used to provide power for the constant-temperature water in the water tank.

[0052] Specifically, the inlet end cover 1, the cylinder body 5 and the outlet end cover 11 are all provided with through holes, and the heating pipes 19 are sequentially inserted into the through holes. The connection between the heating pipes 19 and the through holes can be fixed by using cyclohexanone bonding. The heating pipes 19 and the filter screen in the cylinder body 5 can also be fixed by using clamping. The water tank of the thermostat 22 stores constant temperature water. The constant temperature water is connected with both ends of the heating pipes 19 through the heating pipes 20 and the heat return pipes 23. The water pump 21 is used to guide the constant temperature water in the water tank into the heating pipes 19 through the heating pipes 20, so as to heat and keep the constant temperature of the blood in the cylinder body 5. The constant temperature water flowing through the heating pipes 19 is returned to the water tank of the thermostat 22 through the heat return pipes 23 to be heated again to the constant temperature. The blood in the cylinder body 5 can keep the specified temperature, so as to prevent the hypothermia caused by the temperature loss and improve the safety of the treatment.

[0053] On the basis of any one of the above embodiments, the outer surface of the heating pipe 19 placed in the cylinder body 5 is provided with an anticoagulant coating for inhibiting the adhesion of blood on the outer surface of the heating pipe 19.

[0054] Specifically, the anticoagulant coating is arranged on the outer surface of the heating pipe 19, which can effectively inhibit the adhesion of blood on the outer surface of the heating pipe 19, prevent the aggregation of platelets at this position, and further inhibit the occurrence of blood coagulation at the outer surface of the heating pipe 19. The anticoagulant coating can be a heparin coating made of a medical polymer material or other coatings that can inhibit the adhesion of blood on the outer surface of the heating pipe 19.

[0055] Optionally, the heating pipes 20 and the heat return pipes 23 are medical PVC hoses.

[0056] On the basis of any one of the above embodiments, with reference to Figure 2 , the cylinder body 5 is provided with an inlet filter screen 6 near one end of the inlet end cover 1, and is provided with an outlet filter screen 10 near one end of the outlet end cover 11.

[0057] Specifically, the inlet filter screen 6 is arranged at one end of the cylinder body 5 near the inlet end cover 1. The inlet filter screen 6 has countless tiny holes. The blood enters the cylinder body 5 through the inlet filter screen 6 and prevents the resin microspheres 9 from flowing out of the cylinder body 5 into the extracorporeal circulation blood circuit, thereby providing protection for the life safety of the patient. The outlet filter screen 10 is arranged at one end of the cylinder body 5 near the outlet end cover 11. The blood purified by the resin microspheres 9 flows out through the outlet filter screen 10. The outlet filter screen 10 can prevent the resin microspheres 9 from falling off, thereby providing safety protection for the blood perfusion treatment.

[0058] On the basis of any one of the above embodiments, with reference to Figure 2At least one separator filter 7 is provided inside the cylinder 5. The separator filter 7 divides the inside of the cylinder 5 into multiple independent spaces 8. Each independent space 8 is provided with uniform resin microspheres 9.

[0059] Specifically, with Figure 2 For example, two spaced-apart filter screens 7 are set inside the cylinder 5, dividing the cylinder 5 into three independent spaces 8. Resin microspheres 9 are evenly filled in the three independent spaces 8, which can effectively reduce the crowding and accumulation of resin microspheres 9 inside the perfusion device, reduce the phenomenon of reduced effective adsorption surface area caused by accumulation, improve blood flow inside the perfusion device, reduce the probability of blood clotting, and increase the ability to remove toxins.

[0060] Based on any of the above embodiments, refer to Figure 7 The inlet end cap 1 has an injection port 3 that communicates with the cylinder 5, and a medical silicone sheet 4 is attached to the injection port 3.

[0061] Specifically, the injection port 3 is located on the upper part of the inlet end cap 1 and is connected to the cylinder 5. A medical silicone sheet 4 is adhered to the injection port 3. During hemoperfusion therapy, anticoagulants (such as low molecular weight heparin, sodium citrate, etc.) need to be added to prevent thrombus formation within the perfusion device. This allows the anticoagulant to act directly on the site of thrombus formation, which is more efficient and timely than the existing method of injecting anticoagulants through the venous infusion chamber, and reduces the occurrence of coagulation. When additional anticoagulant is needed, the needle of a syringe containing anticoagulant is inserted through the medical silicone sheet 4 on the injection port 3 to inject the anticoagulant into the perfusion device, allowing the anticoagulant to act directly on the site of thrombus formation.

[0062] Based on any of the above embodiments, an inlet Luer connector 2 is provided at the upper end of the inlet end cap 1. The inlet Luer connector 2 is used to connect with the arterial end of the extracorporeal circulation blood circuit. Blood drawn out of the patient's body enters the inlet end cap 1 through the inlet Luer connector 2. An outlet Luer connector 12 is provided at the lower end of the outlet end cap 11. The outlet Luer connector 12 is used to connect with the extracorporeal circulation venous blood circuit. Blood flowing out of the hemoperfusion device enters the extracorporeal circulation venous blood circuit through the outlet Luer connector 12 and then returns to the patient's body.

[0063] Table 1 Temperature change data in the simulation test

[0064]

[0065] Referring to Table 1, by comparing the in vitro test of two blood perfusion devices on the market and the blood perfusion device of the present application, the perfusion treatment is simulated in a low temperature laboratory, fresh bovine blood is used as simulated blood, a dialysis machine is used as a power device, and a thermocouple temperature tester is used to monitor the temperature of the outer surface of the perfusion device in real time. The test results are shown in Table 1. The outer surface temperature of the first and second perfusion devices both decreased, and when the temperature was lower than 35℃ at 80 min, the risk of hypothermia (hypothermia refers to a disease in which the core temperature of the human body is lower than 35℃, which can directly or indirectly cause death, and the main cause of hypothermia is that the body is exposed to a low temperature environment for a long time, resulting in excessive heat dissipation) increased. The temperature of the perfusion device of the present application did not change, the perfusion device of the present application can effectively maintain the temperature of the blood, and reduce the occurrence of hypothermia caused by hypothermia. In a low temperature environment, platelets in the blood are prone to aggregation, increasing the risk of blood clotting. The three tested perfusion devices were disassembled to observe the internal blood clotting. The first and second perfusion devices both had thrombosis, and the blood clotting level was I level. The perfusion device of the present application had no blood clotting, and the blood clotting level was 0 level. The perfusion device of the present application can effectively reduce the occurrence of blood clotting.

[0066] Each embodiment in the specification is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between each embodiment can be referred to each other.

[0067] The blood perfusion device provided by the present application has been described in detail. The principles and implementation methods of the present application are described by applying specific examples. The above description of the embodiments is only used to help understand the method and core idea of the present application. It should be pointed out that for ordinary skilled persons in the technical field, without departing from the principles of the present application, the present application can be improved and modified in several ways. These improvements and modifications also fall within the scope of protection of the present application.

Claims

1. A blood perfusion device comprising a cartridge (5) and an inlet end cap (1) and an outlet end cap (11) provided at both ends of the cartridge (5) respectively, characterized in that, The heating device is used for heating and maintaining the specified temperature in the barrel (5).

2. A cartridge according to claim 1, wherein The heating device comprises: A liquid storage bin (13) is arranged around the outer circumferential surface of the barrel (5), and a cavity is formed in the liquid storage bin (13), and a heat transfer medium is arranged in the cavity; A heater (16) is arranged on the liquid storage bin (13), and the heater (16) is used for heating the heat transfer medium in the cavity.

3. A cartridge according to claim 2, wherein The heater (16) comprises: A temperature controller (18) is fixedly arranged on the outer surface of the liquid storage bin (13); A heating rod (17) is arranged in the cavity, and the heating rod (17) is electrically connected with the temperature controller (18).

4. A cartridge according to claim 2, wherein A liquid injection port (14) is formed on the surface of the liquid storage bin (13), and a sealing cover (15) is arranged at the liquid injection port (14) to prevent the heat transfer medium in the liquid storage bin (13) from flowing out of the liquid injection port (14).

5. A cartridge according to claim 1, wherein The heating device comprises: A heating pipeline (19) is arranged through the inlet end cover (1) and the outlet end cover (11) at both ends, and the heating pipeline (19) is arranged in the barrel (5); A water tank of a thermostat (22) stores constant temperature water, a backwater outlet of the water tank is connected with one end of the heating pipeline (19) through a heat recovery pipeline (23), and a water outlet of the water tank is connected with the other end of the heating pipeline (19) through a heat supply pipeline (20); A water pump (21) is arranged on the heat supply pipeline (20), and the water pump (21) is used for providing power for the constant temperature water in the water tank.

6. A cartridge according to claim 5, wherein An anticoagulant coating is arranged on the outer surface of the heating pipeline (19) arranged in the barrel (5), and the anticoagulant coating is used for inhibiting the adhesion of blood on the outer surface of the heating pipeline (19).

7. A cartridge according to claim 5, wherein The heat supply pipeline (20) and the heat recovery pipeline (23) are medical PVC hoses.

8. A cartridge according to any one of claims 1 to 7, wherein An inlet filter screen (6) is arranged at one end of the barrel (5) close to the inlet end cover (1), and an outlet filter screen (10) is arranged at one end of the barrel (5) close to the outlet end cover (11).

9. A cartridge according to any one of claims 1 to 7, wherein At least one separation filter screen (7) is arranged in the barrel (5), the separation filter screen (7) separates the barrel (5) into a plurality of independent spaces (8), and uniform resin microspheres (9) are arranged in each independent space (8).

10. A cartridge according to any one of claims 1 to 7, wherein A medicine injection port (3) is formed in the inlet end cover (1) and communicates with the barrel (5), and a medical silica gel sheet (4) is bonded to the medicine injection port (3).

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