Lifting and rotating mechanism and cell culture equipment

Abstract

The utility model relates to a lifting rotating mechanism which comprises a lifting seat, a limiting seat, a first shaft sleeve, a second shaft sleeve and a shaft assembly, the limiting seat is fixed above the lifting seat, the first shaft sleeve is fixed on the limiting seat, and the second shaft sleeve is fixed on the first shaft sleeve; the shaft assembly comprises an upper fixing plate and a shaft extending downwards along the fixing plate, the shaft, the first shaft sleeve and the second shaft sleeve are coaxial, one or more limiting rods are arranged at the bottom of the shaft, and the limiting rods are eccentrically arranged relative to the central axis of the shaft; a containing groove is formed in the limiting base, the shaft penetrates through the second shaft sleeve and the first shaft sleeve, the limiting rod is contained in the containing groove, the inner wall of the containing groove is formed by an arc-shaped guide face and a stop face, and when the shaft rotates, the limiting rod makes contact with the arc-shaped guide face.

Description

TECHNICAL FIELD

[0001] The utility model relates to cell culture field especially is used for disposable cell culture bag lifting rotation mechanism and cell culture equipment. BACKGROUND

[0002] Bioreactor is the proper environment or engineering equipment that provides biochemical reaction, usually refers to the device that utilizes enzyme or organism (microorganism) to have the function of simulating biology, can carry out biochemical reaction outside cell, can carry out aerobic reaction and anaerobic reaction in the simulated process. On the source, can be divided into natural bioreactor and engineering bioreactor etc., bioreactor is usually cylindrical, its volume is from several liters to several cubic meters, is usually made of stainless steel or borosilicate glass.

[0003] At present, disposable bioreactor because the culture bag and the container of culture bag are separate structure design, need to install disposable cell culture bag in the container before use, and need to take disposable cell culture bag from the equipment after use, this requires that the installation and disassembly of disposable cell culture bag are very convenient and fast. Because the top of disposable cell culture bag needs to be connected with motor assembly, and at the same time disposable cell culture bag is placed in the container enclosed all around, this leads to that disposable cell culture bag does not have enough operation space when installing. In the industry, the conventional solution is to open a door window on the tank container, when installing or disassembling, open the door window, put disposable cell culture bag into the container from the door window, then the top is connected with motor, completes the installation and disassembly of culture bag. This method can complete the installation and disassembly of disposable cell culture bag, but the operation is inconvenient, the space of door window is still very limited, and because the door window is opened on the container, the heat transfer area of container is reduced, which has certain influence on the temperature control function of equipment, in addition, this installation method has very strict requirements on the processing size of equipment and disposable cell culture bag, and the material of disposable cell culture bag is flexible plastic material, so the size precision is difficult to guarantee, so the installation method is very bad and can affect the temperature control function of equipment. SUMMARY

[0004] The utility model provides a kind of lifting rotary mechanism, including lifting seat, limit seat, first shaft sleeve, second shaft sleeve, shaft assembly, the limit seat is fixed in the upper of lifting seat, the first shaft sleeve is fixed on limit seat, the second shaft sleeve is fixed on first shaft sleeve;The shaft assembly includes the fixed plate of upper portion, and shaft extending downward along fixed plate, the shaft, first shaft sleeve, second shaft sleeve coaxial line, the bottom of the shaft is provided with one or more limit rods, the limit rod is eccentric with respect to the central axis of shaft Setting;Limit seat is provided with accommodating groove, the shaft passes through the second shaft sleeve and first shaft sleeve, and the limit rod is contained in the accommodating groove, the inner wall of accommodating groove is formed by arc guide surface and stop surface, when shaft rotates, limit rod and arc guide surface contact.

[0005] Further, a ball bearing is provided in the middle of the shaft, the ball bearing is located between the shaft and the first shaft sleeve, embedded in the inner ring annular groove of the first shaft sleeve, the outer diameter of the ball bearing is greater than the inner diameter of the second shaft sleeve.

[0006] Further, the stop surface is an arc surface smoothly connected with the end of the arc guide surface, the inner diameter of the arc surface is less than the inner diameter of the arc guide surface.

[0007] Further, the inner diameter of the arc surface is slightly larger than the diameter of the limit rod.

[0008] Further, the arc surface is two, respectively located at both ends of the arc guide surface.

[0009] Further, the lifting rotary mechanism further includes a handle, the handle is arranged on the side of the second shaft sleeve, for locking the shaft in the second shaft sleeve.

[0010] Further, the lifting rotary mechanism further includes a motor, a motor mounting seat assembly, a rocker arm, one end of the rocker arm is fixedly connected with the fixed plate, the other end is connected with the motor mounting seat assembly, and the motor is fixed on the motor mounting seat assembly.

[0011] Further, the motor is located above the rocker arm, the motor mounting seat assembly is a sleeve structure, and the motor shaft of the motor passes through the motor mounting seat assembly and extends below the rocker arm.

[0012] The utility model also provides a kind of cell culture equipment, including equipment base, equipment frame, tank bracket, heating tank, further including the lifting rotary device of described, equipment frame is fixedly installed on the side of equipment base, tank bracket is located below equipment frame, heating tank is located on tank bracket, the lifting rotary device is installed on the upper side of equipment frame, and lifting seat can be moved up and down relative to equipment frame.

[0013] Further, the cell culture device further comprises an upper pipeline support for supporting and connecting the functional pipelines at the upper end of the cell culture bag, and a lower pipeline support for supporting and connecting the functional pipelines at the lower end of the cell culture bag.

[0014] The lifting and rotating mechanism of the present application does not need to move the heating tank or install doors and windows on the heating tank when the cell culture bag is installed or dismounted, thereby ensuring the integrity of the tank design. In addition, the rotating and lifting cooperation operation can quickly and conveniently realize the installation and dismounting of the cell culture bag. BRIEF DESCRIPTION OF DRAWINGS

[0015] Figure 1 is an overall appearance view of the device.

[0016] Figure 2 is a schematic view of the lifting and rotating mechanism;

[0017] Figure 3 is a schematic view of the local structure of the lifting and rotating device;

[0018] Figure 4 is a schematic view of the limiting seat structure;

[0019] Figure 5 is a sectional view of the lifting and rotating mechanism;

[0020] Figure 6 is Figure 5 a local enlarged view. DETAILED DESCRIPTION

[0021] Figure 1 is a disposable cell culture device, comprising a device base 1, a device frame 2, a lifting and rotating device 3, a tank body bracket 5, a heating tank 6, a cell culture bag 7, an upper pipeline support 8, and a lower pipeline support 9.

[0022] The device base 1 is located at the bottom as the chassis of the device, and various electrical control components and control circuits are installed inside. The device frame 2 is fixedly installed on one side of the device base 1, and the tank body bracket 5 is arranged below the device frame 2. The heating tank 6 is located on the tank body bracket 5, and the lifting and rotating device 3 is installed on the upper side of the device frame and can move up and down relative to the device frame 2 through a sliding module.

[0023] The cell culture bag 7 is used to hold cell liquid and can be placed in the heating tank 6 for heating and temperature maintenance of the cell culture bag 7, so as to accurately control the temperature of the culture liquid in the cell culture bag 7.

[0024] The upper pipeline support 8 is used to support and connect the functional pipelines at the upper end of the cell culture bag 7, and the lower pipeline support 9 is used to support and connect the functional pipelines at the lower end of the cell culture bag 7.

[0025] Referring to Figures 2-6 The lifting and rotating device 3 comprises a lifting seat 31, a limiting seat 32, a first shaft sleeve 33, a second shaft sleeve 34, a handle 35, a shaft assembly 36, a rocker arm 37, a motor 38, and a motor mounting seat assembly 39.

[0026] The lifting seat 31 is connected to the equipment frame 2 by a sliding rail mechanism, and is movable up and down relative to the equipment frame 2. The limiting seat 32 is fixed above the lifting seat 31. The first shaft sleeve 33 is fixed on the limiting seat 32. The second shaft sleeve 34 is fixed on the first shaft sleeve 33.

[0027] The shaft assembly 36 comprises a fixed plate 361 at the upper portion, and a shaft 362 extending downward from the fixed plate 361. The bottom of the shaft 362 is provided with one or more limiting rods 3621, which are eccentrically arranged relative to the central axis of the shaft 362.

[0028] The limiting seat 32 is provided with a receiving groove 321. The fixed plate 361 is fixedly connected to one end of the rocker arm 37. The shaft 362 passes through the second shaft sleeve 34 and the first shaft sleeve 33, and the limiting rods 3621 are accommodated in the receiving groove 321. The shaft 362, the first shaft sleeve 33, and the second shaft sleeve 34 are coaxial.

[0029] The inner wall of the receiving groove 321 is formed by an arc-shaped guide surface 322 and a stop surface 323. When the rocker arm 37 drives the shaft 362 to rotate, the limiting rods 3621 come into contact with the arc-shaped guide surface 322. When the limiting rods 3621 move to the stop surface 323, they are blocked by the stop surface 323, thereby forming a rotational limit. Preferably, the stop surface 323 is an arc-shaped surface 324 that is smoothly connected to the end of the arc-shaped guide surface 322. The inner diameter of the arc-shaped surface 324 is smaller than the inner diameter of the arc-shaped guide surface 322, and is preferably slightly larger than the diameter of the limiting rods 3621. Further, the arc-shaped surface 324 is two, one at each end of the arc-shaped guide surface 322.

[0030] The handle 35 is arranged on the side of the second shaft sleeve 34. When the handle 35 rotates, the internal locking member moves towards or away from the shaft 362. When it comes into contact with the shaft 362, the internal locking member blocks the rotation of the shaft 362, thereby completing the locking. This structure is a common method for locking a rotating shaft in the art.

[0031] The other end of the rocker arm 37 is fixed with the motor mounting seat assembly 39. The motor 38 is located above the rocker arm 37 and is fixedly connected with the motor mounting seat assembly 39. The motor mounting seat assembly 39 is a sleeve structure. The motor shaft of the motor 38 passes through the motor mounting seat assembly and extends below the rocker arm 37.

[0032] The limiting seat 32 limits the rotation angle of the shaft 362 (or the rocker arm), preferably, the rotation angle of the rocker arm 37 is limited to ±90°, which is achieved by changing the arc of the arc surface 324. The handle locks the rotation of the shaft 362 (or the rocker arm).

[0033] Referring to Figures 5-6 In order to limit the movement of the shaft 362 in the axial direction, a ball bearing 363 is arranged in the middle of the shaft 362, which is located between the shaft 362 and the first shaft sleeve 33, embedded in the inner ring annular groove of the first shaft sleeve 33, and the outer diameter of the ball bearing 363 is greater than the inner diameter of the second shaft sleeve 34.

[0034] Figures 5-6 In the middle, the shaft 362 includes an upper shaft 3623 and a lower shaft 3624, the fixed plate 361 is fixedly connected with the top of the upper shaft 3623, preferably integrally formed, the lower shaft 3624 is fixedly connected with the upper shaft 3623 through screws, and the limiting rod 3621 is located at the bottom of the lower shaft 3624. The lower end of the upper shaft 3623 has an extension, the diameter of the extension is smaller than the diameter of the upper part of the upper shaft 3623, forming a stepped structure, and the ball bearing 363 is sleeved on the extension of the upper shaft 3623.

[0035] The working process of the utility model is as follows: the lifting and rotating device 3 is used for controlling the height and position of the motor 38 relative to the tank body, for example, when it is needed to place or take out the cell culture bag 7, the rocker arm 37 is driven by the lifting and rotating device 3 and moves upwards, and then is manually rotated to one side of the tank body. Due to the action of the limiting seat 32, the rocker arm 37 will not rotate too large an angle, generally 90° at most, since the rocker arm 37 has left the position directly above the heating tank 6, at this time, it is convenient to put the cell culture bag 7 into the heating tank 6 or take the cell culture bag 7 out of the heating tank 6. The front end of the motor 4 is used for being connected with the stirring paddle (not shown) in the cell culture bag 7.

[0036] The above embodiments are only used to illustrate the technical solutions of the utility model, and not to limit them; although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that the technical solutions recorded in the foregoing embodiments can still be modified, or some technical features can be replaced equivalently; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the utility model.

Claims

1. A lifting and rotating mechanism, characterized by, The lifting seat (31), the limiting seat (32), the first shaft sleeve (33), the second shaft sleeve (34), the shaft assembly (36), The limiting seat (32) is fixed above the lifting seat (31), the first shaft sleeve (33) is fixed on the limiting seat (32), and the second shaft sleeve (34) is fixed on the first shaft sleeve (33); The shaft assembly (36) comprises a fixed plate (361) at the upper portion and a shaft (362) extending downward along the fixed plate (361), the shaft (362), the first shaft sleeve (33) and the second shaft sleeve (34) are coaxial, and the bottom of the shaft (362) is provided with one or more limiting rods (3621) which are eccentrically arranged relative to the central axis of the shaft (362); The limiting seat (32) is provided with a containing groove (321), the shaft (362) passes through the second shaft sleeve (34) and the first shaft sleeve (33), and the limiting rod (3621) is contained in the containing groove (321), and the inner wall of the containing groove (321) is formed by an arc-shaped guide surface (322) and a stop surface (323), and when the shaft (362) rotates, the limiting rod (3621) is in contact with the arc-shaped guide surface (322).

2. The lift-and-rotate mechanism of claim 1, wherein A ball bearing (363) is arranged at the middle portion of the shaft (362), the ball bearing (363) is located between the shaft (362) and the first shaft sleeve (33), is embedded in the inner ring annular groove of the first shaft sleeve (33), and the outer diameter of the ball bearing (363) is greater than the inner diameter of the second shaft sleeve (34).

3. The lift-and-rotate mechanism of claim 2, wherein, The stop surface (323) is an arc-shaped surface (324) which is smoothly connected with the end of the arc-shaped guide surface (322), and the inner diameter of the arc-shaped surface (324) is smaller than the inner diameter of the arc-shaped guide surface (322).

4. The lift-and-rotate mechanism of claim 3, wherein The inner diameter of the arc-shaped surface (324) is greater than the diameter of the limiting rod (3621).

5. The lift-and-rotate mechanism of claim 3, wherein The arc-shaped surface (324) is two, and is located at the two ends of the arc-shaped guide surface (322) respectively.

6. The lift-and-rotate mechanism of claim 1 or 2, wherein The lifting and rotating mechanism further comprises a handle (35) which is arranged at the side of the second shaft sleeve (34) and is used for locking the shaft (362) in the second shaft sleeve (34).

7. The lift-and-rotate mechanism of claim 1 or 2, wherein The lifting and rotating mechanism further comprises a motor (38), a motor mounting seat assembly (39) and a rocker arm (37), one end of the rocker arm (37) is fixedly connected with the fixed plate (361), the other end is connected with the motor mounting seat assembly (39), and the motor (38) is fixed on the motor mounting seat assembly (39).

8. The lift-and-rotate mechanism of claim 7, wherein, The motor (38) is located above the rocker arm (37), the motor mounting seat assembly (39) is a sleeve structure, the motor shaft of the motor (38) passes through the motor mounting seat assembly and extends below the rocker arm (37).

9. A cell culture apparatus comprising an apparatus base (1), an apparatus frame (2), a tank body carrier (5), a heating tank (6), characterized in that, The lifting and rotating mechanism of any one of claims 1-8, wherein the device frame (2) is fixedly installed on one side of the device base (1), the tank bracket (5) is located below the device frame (2), the heating tank (6) is located on the tank bracket (5), the lifting and rotating mechanism is installed on the upper side of the device frame (2), and the lifting seat (31) is movable up and down relative to the device frame (2).

10. The cell culture apparatus of claim 9, wherein, The cell culture device further comprises an upper pipeline support (8) for supporting and connecting the functional pipelines at the upper end of the cell culture bag (7), and a lower pipeline support (9) for supporting and connecting the functional pipelines at the lower end of the cell culture bag (7).

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