Bionic pyloric structure, pyloric contraction structure and bionic system

Abstract

The utility model relates to the technical field of in-vitro digestive systems, and aims to solve the technical problem that a pylorus structure is not simulated. In order to solve the technical problem, the utility model provides a bionic pylorus structure, a pylorus contraction structure and a bionic system. The device comprises a flexible main body with a tubular structure, the plurality of pyloric sphincter bionic pieces are uniformly distributed on the inner wall of the flexible main body along the circumferential direction; the pyloric sphincter bionic part is formed by bulging from the inner wall of the flexible main body to the center; the hollow structure is enlarged and shrunk; in the axis direction of the flexible main body, the bulging size of the pyloric sphincter bionic piece is gradually increased and then reduced; a gap is formed between the free ends of every two adjacent pyloric sphincter bionic pieces, so that a multi-awn-star-shaped channel is formed in the center of the flexible main body to simulate the pyloric sphincter; the pylorus contraction structure drives the multiple pylorus sphincter bionic parts to relax and contract, and the diameter of the channel and the width and length of the gap are changed. The device can simulate the pylorus structure, and the test accuracy is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to in-vitro digestion system technical field especially is a kind of bionic pylorus structure, pyloric contraction structure and bionic system. BACKGROUND

[0002] In recent years, bionic technology has made significant progress in the application of medical and engineering fields. In-vitro bionic technology can help researchers to complete the research on the digestion function of food in the stomach. The existing dynamic in-vitro bionic digestion system can simulate the gastric digestion and gastric emptying process of the human body, but none of them is provided with a pylorus structure. However, it is found in the actual process that if there is no pylorus structure in the flexible stomach model, it is lack for us to study the role of the pylorus in the digestion process. As the root of the stomach and duodenum, the complex anatomical structure and physiological function of the pylorus have always been the focus of research. Although significant progress has been made in the simulation of the pylorus, many devices are presented separately and not as a system. How to further improve the physiological relevance and stability of the model, and how to better simulate the complex physiological function of the pylorus, are still the focus of current research. In the future, with the continuous innovation of technology and the deep cooperation of multi-disciplines, the simulation of the pylorus is expected to play a greater role in basic research and clinical application.

[0003] For example, Chinese patent CN108735060A discloses a bionic human esophagus and stomach digestion system; and for example, Chinese patent CN306513447S discloses a dynamic in-vitro bionic human stomach digestion system device. The flexible bionic technology mainly focuses on the digestion process of the sample in the stomach, and does not pay attention to the process of the sample passing through the pylorus. In fact, the study of the pylorus in the whole process has important clinical and scientific significance, involving gastric emptying, reflux prevention, digestive juice secretion, nutrient absorption and other aspects. Through in-depth study of the function and mechanism of the pylorus, important theoretical support and technical means can be provided for the diagnosis, treatment and prevention of digestive system diseases.

[0004] In the prior art, there is no flexible pylorus structure, or the flexible pylorus structure is not bionic enough, which affects the accuracy of drug testing. Therefore, it is necessary to design a more realistic bionic pylorus structure. UTILITY MODEL CONTENT

[0005] Therefore, the utility model solves the technical problems existing in the prior art.

[0006] To solve the above technical problems, the utility model provides a bionic pylorus structure, comprising:

[0007] Flexible main body, tubular structure;

[0008] A plurality of pyloric sphincter biomimetic elements are evenly arranged on the inner wall of the flexible main body in the circumferential direction, and the pyloric sphincter biomimetic element is flexible; the pyloric sphincter biomimetic element is formed by being bulged from the inner wall of the flexible main body to the center; the interior of the pyloric sphincter biomimetic element is a hollow structure, and the hollow structure can be enlarged and reduced; along the axis direction of the flexible main body, the size of the pyloric sphincter biomimetic element is gradually increased and then reduced; a gap is formed between the free ends of two adjacent pyloric sphincter biomimetic elements, so that the center of the flexible main body forms a multi-star-shaped channel for simulating the pyloric sphincter.

[0009] The plurality of pyloric sphincter biomimetic elements are dilated and contracted to change the diameter of the channel, the width and the length of the gap.

[0010] In an embodiment of the present application, the biomimetic pyloric structure further comprises an inflation component for inflating and deflating the hollow structure.

[0011] In an embodiment of the present application, the hollow structures of the plurality of pyloric sphincter biomimetic elements are connected to each other.

[0012] In an embodiment of the present application, the pyloric sphincter biomimetic element comprises a root connected with the flexible main body and a wrinkle part connected with the other end of the root; the roots of the plurality of pyloric sphincter biomimetic elements are connected with each other, and a gap is formed between the wrinkle parts of two adjacent pyloric sphincter biomimetic elements.

[0013] In an embodiment of the present application, a round corner transition is adopted at the tip of the wrinkle part.

[0014] In an embodiment of the present application, the wrinkle part comprises two simulation curved surfaces symmetrically arranged along the longitudinal section thereof; and the two simulation curved surfaces are connected at the tip of the wrinkle part.

[0015] In an embodiment of the present application, the flexible main body is made of flexible silica gel; and the pyloric sphincter biomimetic element is made of flexible silica gel.

[0016] The present application also provides a pyloric contraction structure, comprising:

[0017] A contraction main body is sleeved at the middle position of the biomimetic pyloric structure of any of the above embodiments; a circular hole is arranged in the contraction main body, and the diameter of the circular hole is adjustable;

[0018] A plurality of blades are evenly arranged on the inner wall of the contraction main body in the circumferential direction;

[0019] A power part is connected with the contraction main body, and is used for continuously changing the diameter of the circular hole to drive the dilation and contraction of the biomimetic pyloric structure.

[0020] The present application also provides a biomimetic system, comprising:

[0021] An extracorporeal biomimetic stomach model;

[0022] The bionic pylorus structure of any of the above embodiments;

[0023] The pyloric contraction structure of any of the above embodiments;

[0024] The bionic pylorus structure is installed at the antrum end of the in-vitro bionic stomach model, and the pyloric contraction structure is sleeved on the bionic pylorus structure.

[0025] The above technical solution of the utility model has the following advantages compared with the prior art:

[0026] The bionic pylorus structure, the pyloric contraction structure and the bionic system, the pyloric sphincter bionic piece of the application is bulged, and the size of the bulge gradually increases and then decreases. The original model is only a simple structure of a pipeline, which can more realistically simulate the structure of the pylorus (i.e. the pyloric sphincter at the middle position). In addition, there is a gap between the free ends of the two adjacent pyloric sphincter bionic pieces, so that the center of the flexible body forms a multi-star-shaped channel. In the process of contraction and relaxation, the channel is a hole structure (not a slit), which is closer to the real state of the human body, so that the structure of the pyloric sphincter can be more realistically simulated. The bionic pylorus structure of the application is a flexible structure, and the pyloric contraction structure drives the ring-shaped relaxation or contraction of the pyloric sphincter bionic piece, so as to promote the controllable continuous change of the pore size of the channels of the multiple pyloric sphincter bionic pieces. This makes the deformation of the channel more capable of simulating the working process of the pyloric sphincter. In the process of relaxation and contraction, the hollow structure needs to be deflated and inflated, so as to facilitate the repeated process and improve the smoothness of the contraction and relaxation of the pyloric sphincter bionic piece. Therefore, the application can more simulate the pylorus structure and improve the test accuracy. BRIEF DESCRIPTION OF DRAWINGS

[0027] In order to make the content of the utility model more easily understood clearly, the utility model will be further described in detail below according to the specific embodiments of the utility model and in combination with the drawings, in which:

[0028] Figure 1 is a structure schematic view of a bionic system in the preferred embodiment of the utility model;

[0029] Figure 2 is Figure 1 a connection schematic view of a bionic pylorus structure and a pyloric contraction structure in a bionic system of

[0030] Figure 3 is Figure 2 a top view of

[0031] Figure 4 is a structure schematic view of a pyloric contraction structure in the preferred embodiment of the utility model;

[0032] Figure 5 is a schematic view of diameter change of a circular hole in a pyloric contraction structure in the preferred embodiment of the utility model;

[0033] Figure 6 is a structure schematic of a bionic pyloric structure in the preferred embodiment of the utility model Figure 1 ;

[0034] Figure 7 is a structure schematic of a bionic pyloric structure in the preferred embodiment of the utility model Figure 2 ;

[0035] Figure 8 is a plan view of Figure 6 ;

[0036] Figure 9 is a sectional view of Figure 6 ;

[0037] Figure 10 is a schematic view of passage change in a bionic pyloric structure in the preferred embodiment of the utility model;

[0038] The description of the drawing mark of the utility model is as follows: 1000, in-vitro bionic stomach model; 2000, bionic pyloric structure; 3000, pyloric contraction structure;

[0039] 100, flexible main body;

[0040] 200, pyloric sphincter bionic piece; 210, hollow structure; 220, gap; 230, passage; 240, root; 250, wrinkle part; 260, round corner transition; 270, simulation curved surface;

[0041] 300, contraction main body; 310, circular hole;

[0042] 400, blade. DETAILED DESCRIPTION

[0043] The utility model is further explained in combination with the drawings and specific embodiments, so that the person skilled in the art can better understand the utility model and can be implemented, but the embodiment is not as the limitation of the utility model.

[0044] The bionic digestive system is closer to the actual, which has important role for us to study the sample in-vitro bionic digestion. The existing flexible pyloric model is tubular structure, and the contraction mechanism of the flexible pyloric model is external air bag device, which can simulate the contraction of the pylorus, but its contraction range is limited; in addition, it is a slit after contraction, and cannot simulate the pyloric sphincter structure. How can better simulate the pyloric structure, make it closer to the actual, which has important role for us to study the sample in-vitro bionic digestion.

[0045] Reference Figures 1-10 As shown, this embodiment of the invention provides a biomimetic system, including an in vitro biomimetic stomach model 1000, a biomimetic pyloric structure 2000, and a pyloric contraction structure 3000. The biomimetic pyloric structure 2000 is installed at the antral end of the in vitro biomimetic stomach model 1000; the pyloric contraction structure 3000 is sleeved on the biomimetic pyloric structure 2000.

[0046] The biomimetic pyloric structure 2000 includes a flexible tubular body 100 and multiple pyloric sphincter biomimetic components 200. The flexible body 100 is flexible. The multiple pyloric sphincter biomimetic components 200 are evenly distributed circumferentially on the inner wall of the flexible body 100, and the pyloric sphincter biomimetic components 200 are flexible. The pyloric sphincter biomimetic components 200 bulge from the inner wall of the flexible body 100 towards the center; the interior of the pyloric sphincter biomimetic component 200 is a hollow structure 210, which can be enlarged or reduced; along the axial direction of the flexible body 100, the size of the bulge of the pyloric sphincter biomimetic component 200 gradually increases and then decreases; there is a gap 220 between the free ends of two adjacent pyloric sphincter biomimetic components 200, so that a multi-pointed star-shaped channel 230 is formed in the center of the flexible body 100, which is used to simulate the folded structure of the pyloric sphincter. The flexible main body 100 relaxes and contracts, causing multiple pyloric sphincter bionic components 200 to relax and contract, thereby changing the diameter of the channel 230 and the width and length of the gap 220.

[0047] The pyloric contraction structure 3000 includes a contraction body 300, a power unit, and multiple blades 400.

[0048] The contraction body 300 is fitted at the middle position of the biomimetic pyloric structure 2000 (i.e., at the position where the pyloric sphincter biomimetic component 200 has the largest bulge). The contraction body 300 has a circular hole 310 inside, and the diameter of the circular hole 310 is adjustable; in some embodiments, the contraction body 300 is a ring structure;

[0049] Multiple blades 400 are evenly distributed circumferentially on the inner wall of the contraction body 300;

[0050] A power unit is connected to the contraction body 300 and drives multiple blades 400 to move, thereby forming a circular hole 310 at the free end of the blades 400. The diameter of the circular hole 310 continuously changes to drive the biomimetic pyloric structure 2000 to expand and contract. In some embodiments, the power unit is a motor. In some embodiments, the power unit is slidably connected to the blades 400, and the motor drives the blades 400 to move, thereby changing the size of the circular hole 310. In other embodiments, the motor drives multiple blades 400 to rotate around a central axis, thereby opening and closing the blades 400 and changing the size of the circular hole 310. For example, the pyloric contraction structure 3000 is an aperture module variable aperture.

[0051] The method of simulation by the above-mentioned bionic system includes a contraction process and a relaxation process.

[0052] The contraction process: the pyloric contraction structure 3000 of the bionic system drives the bionic pyloric structure 2000 to contract, while the hollow structure 210 is enlarged (for example, the hollow structure 210 is inflated), so that the diameter of the channel 230 is reduced, and the length of the gap 220 is increased and the width is reduced.

[0053] The relaxation process: the pyloric contraction structure 3000 of the bionic system drives the bionic pyloric structure 2000 to open, while the hollow structure 210 is reduced (for example, the hollow structure 210 is deflated), so that the diameter of the channel 230 is increased, and the length of the gap 220 is reduced and the width is increased.

[0054] Drug test using the present application: two metformin pills with different diameters (5mm and 7mm) are selected. The pill emptying test is carried out at an inclination angle of 30 degrees, and the squeezing contraction and relaxation of the pylorus are simulated to obtain the following discharge time.

[0055]

[0056] It has been verified that the squeezing time is qualified for the two different diameter drug tests using the present application. In addition, the present application can repeatedly relax and contract the pylorus stably, and the minimum aperture of the channel 230 after contraction can be controlled to be 1-2mm, which is more consistent with the actual movement of the pyloric sphincter.

[0057] The present application is inflated along the axis direction of the flexible main body 100, and the size of the inflation gradually increases and then decreases; the change of the original model is only the simple structure of the pipeline, which can more realistically simulate the structure of the pylorus (i.e. the pyloric sphincter at the middle position). In addition, the present application has a gap 220 between the free ends of the two adjacent pyloric sphincter bionic pieces 200, so that the center of the flexible main body 100 forms a multi-star-shaped channel 230, which is a hole structure (not a slit) in the process of contraction and relaxation, which is more close to the real state of the human body, so as to more realistically simulate the structure of the pyloric sphincter. The bionic pyloric structure 2000 of the present application is a flexible structure, the pyloric contraction structure 3000 drives the pyloric sphincter bionic piece 200 to relax or contract in a ring shape, so as to promote the controllable continuous change of the aperture of the channel 230 of the multiple pyloric sphincter bionic pieces 200, so that the deformation of the channel 230 more realistically simulates the working process of the pyloric sphincter; and in the process of relaxation and contraction, the hollow structure 210 is deflated and inflated, so as to facilitate the repeated process and improve the smoothness of the contraction and relaxation of the pyloric sphincter bionic piece 200.

[0058] The application is matched with the original in-vitro bionic device, so that the adaptability is high, the rest of the device does not need to be replaced, and the cost is reduced.

[0059] The application is combined with the flexible bionic device and applied to the test process of the medicine.

[0060] In order to better simulate the actual movement process of the sample through the pyloric structure, the bionic pyloric structure 2000 is driven by the pyloric contraction structure 3000 to realize the driving, so that the cost of the device is reduced, and the complexity of the device is reduced.

[0061] Further, the bionic pyloric structure 2000 further comprises an inflation component (not shown in the figure) for inflating and deflating the hollow structure 210. Specifically, the inflation component inflates and deflates the hollow structure 210, so that the expansion and contraction of the hollow structure 210 are realized, the structure is simple, the operation is reliable and stable, and the manufacturing cost is low.

[0062] Further, the hollow structures 210 of the plurality of pyloric sphincter bionic pieces 200 are communicated with each other. Specifically, inflation and deflation of the plurality of pyloric sphincter bionic pieces 200 can be realized by one inflation component, the structure is simpler, and the cost is reduced; in addition, it is more convenient to control the same pressure of inflation and deflation of the plurality of pyloric sphincter bionic pieces 200, and the consistency of inflation and deflation of the plurality of pyloric sphincter bionic pieces 200 is ensured.

[0063] Further, the pyloric sphincter bionic piece 200 comprises a root 240 connected with the flexible main body 100 and a wrinkle part 250 connected at the other end of the root 240; the roots 240 of the plurality of pyloric sphincter bionic pieces 200 are connected with each other, and the gap 220 is formed between the wrinkle parts 250 of the adjacent two pyloric sphincter bionic pieces 200. Specifically, the pyloric sphincter bionic piece 200 of the embodiment is connected with the flexible main body 100 through the root 240, so as to ensure the stability and reliability of the connection, and then the wrinkle part 250 simulates the pyloric sphincter.

[0064] Further, a round corner transition 260 is adopted at the tip of the wrinkle part 250. Specifically, the structure of the tip is smoother, so that the application is more realistic.

[0065] Further, the wrinkle part 250 comprises two simulation curved surfaces 270 symmetrically arranged along the longitudinal section thereof; and the two simulation curved surfaces 270 are connected at the tip of the wrinkle part 250. Specifically, the side wall of the gap 220 is curved, so that the internal structure of the pylorus can be more realistically simulated.

[0066] Further, the flexible main body 100 is made of flexible silica gel. For example, the pyloric sphincter bionic piece 200 is made of flexible silica gel. For example, the flexible main body 100 is made of flexible silica gel; and the pyloric sphincter bionic piece 200 is made of flexible silica gel.

[0067] Specifically, the flexible silica gel can resist multiple chemicals, so it is more suitable for drug testing, research, etc. in the present application; and can be repeatedly deformed elastically. Secondly, it has good processability and various processing methods, which is more convenient for processing the wrinkle part 250 of the bionic pylorus structure 2000. In addition, it has excellent toughness and elasticity, low cost, high practicality, no color and no toxicity, high temperature resistance and oxidation resistance.

[0068] Test the present application:

[0069] 1. Fix the in-vitro bionic stomach model 1000 on the in-vitro bionic device.

[0070] 2. Install the bionic pylorus structure 2000 on the in-vitro bionic stomach model 1000 to test whether the in-vitro bionic device can be normally opened; if it can be normally opened, proceed to the next step, if it cannot be normally opened, check and repair the device until it can be normally opened.

[0071] 3. Start the in-vitro bionic device, and as the bionic device runs, the rollers on both sides of the in-vitro bionic device extrude the stomach wall of the in-vitro bionic stomach model 1000. At this time, the pyloric contraction structure 3000 of the present application cooperates with the bionic pylorus structure 2000 to perform annular contraction movement, so that the pyloric contraction structure 3000 contracts. When the rollers of the in-vitro bionic device move to the pyloric region, the bionic pylorus structure 2000 contracts to the smallest. Then form a small hole structure as shown in Figure 7 , thereby simulating the sphincter.

[0072] After repeated tests, the contraction and diastolic operation of the present application is smooth and stable; and can be repeatedly used.

[0073] Obviously, the above embodiments are only examples for clear illustration, and are not limited to the embodiments. For those skilled in the art, other different forms of changes or variations can be made on the basis of the above description. Here, it is not necessary and impossible to exhaust all the embodiments. The obvious changes or variations derived therefrom are still within the protection scope of the present application.

Claims

1. A bionic pyloric structure, characterized in that: The application relates to a flexible main body, a plurality of pyloric sphincter imitations arranged on the inner wall of the flexible main body in a circumferential direction, and a plurality of pyloric sphincter imitations. The pyloric sphincter imitations are arranged on the inner wall of the flexible main body in a circumferential direction, and the pyloric sphincter imitations are flexible and are formed by bulging from the inner wall of the flexible main body to the center; the pyloric sphincter imitations are hollow structures, the hollow structures can be enlarged and reduced; along the axis of the flexible main body, the size of the pyloric sphincter imitations gradually increases and then decreases; the free ends of two adjacent pyloric sphincter imitations have a gap, so that the center of the flexible main body forms a multi-star-shaped channel for simulating the pyloric sphincter. The pyloric sphincter imitations are relaxed and contracted to change the diameter of the channel and the width and length of the gap. The application further comprises an inflation component for inflating and deflating the hollow structures.

2. The bionic pylorus structure according to claim 1, characterized in that: The hollow structures of the pyloric sphincter imitations are connected with each other.

3. The bionic pylorus structure according to claim 2, characterized in that: The pyloric sphincter imitation comprises a root connected with the flexible main body and a wrinkle part connected with the other end of the root; the roots of the pyloric sphincter imitations are connected with each other, and the gap is formed between the wrinkle parts of two adjacent pyloric sphincter imitations.

4. The bionic pylorus structure according to claim 1, characterized in that: The sharp part of the wrinkle part is rounded.

5. The bionic pylorus structure according to claim 4, characterized in that: The wrinkle part comprises two simulation curved surfaces arranged symmetrically along the longitudinal section, and the two simulation curved surfaces are connected at the sharp part of the wrinkle part.

6. The bionic pylorus structure according to claim 4, characterized in that: The flexible main body is made of flexible silica gel.

7. The bionic pylorus structure according to claim 1, characterized in that: The pyloric sphincter imitation is made of flexible silica gel. The application relates to a flexible main body, a plurality of pyloric sphincter imitations arranged on the inner wall of the flexible main body in a circumferential direction, and a plurality of pyloric sphincter imitations.

8. A pyloric constriction device, characterized by: The application relates to a flexible main body, a plurality of pyloric sphincter imitations arranged on the inner wall of the flexible main body in a circumferential direction, and a plurality of pyloric sphincter imitations. The application relates to a flexible main body, a plurality of pyloric sphincter imitations arranged on the inner wall of the flexible main body in a circumferential direction, and a plurality of pyloric sphincter imitations. The application relates to a flexible main body, a plurality of pyloric sphincter imitations arranged on the inner wall of the flexible main body in a circumferential direction, and a plurality of pyloric sphincter imitations. The application relates to a flexible main body, a plurality of pyloric sphincter imitations arranged on the inner wall of the flexible main body in a circumferential direction, and a plurality of pyloric sphincter imitations.

9. A biomimetic system characterized by: ​ ​ ​ ​ ​

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