Multifunctional living animal and molecule imaging device

Abstract

The utility model discloses a multifunctional living animal and molecule imaging device, and relates to the technical field of living body imaging. After the driving machine is started, the driving wheel can be driven to perform circular motion, so that the bearing seat can move along the horizontal direction, the fluorescence excitation equipment and the fixed column above can move, and the aim of imaging living animals at different positions can be fulfilled; the movement stability of the bearing seat can be ensured under the cooperation of a limiting plate and a limiting shaft, and when the bearing seat moves, a counterweight seat and a side plate are driven to move, so that the use stability of the left side of the bearing seat can be ensured; when the output shaft of the air cylinder on one side extends out, the output shaft of the air cylinder on the other side shrinks, and the included angle between the supporting frame and the air cylinders can be changed under the action of the connecting shaft, so that the use angle of the fluorescence excitation equipment and the fixing column can be changed, the applicability can be effectively improved, and the practicability is high.

Description

Technical Field

[0001] This utility model relates to the field of in vivo imaging technology, specifically to a multifunctional animal in vivo and molecular imaging device. Background Technology

[0002] In vivo imaging primarily employs two techniques: bioluminescence and fluorescence. Bioluminescence uses luciferase genes to label cells or DNA, while fluorescence uses fluorescent reporter groups (GFP, RFP, Cyt, and dyes, etc.) for labeling. In vivo imaging utilizes a highly sensitive optical detection system, allowing researchers to directly monitor cellular activity and gene behavior within living organisms. This system enables the observation of biological processes such as tumor growth and metastasis, the development of infectious diseases, and the expression of specific genes in living animals. Traditional animal experimental methods require the sacrifice of experimental animals at different time points to obtain data, resulting in multiple time-point experimental results. In contrast, visible light in vivo imaging records the same group of experimental subjects at different time points, tracking the movement and changes of the same observation target (labeled cells and genes), yielding more accurate and reliable data. Furthermore, this technique has extremely high sensitivity for detecting micrometastases and does not involve radioactive materials or methods, making it very safe. Due to its extremely simple operation, intuitive results, and high sensitivity, it has been widely used in life sciences, medical research, and drug development in just a few years since its development.

[0003] In existing technologies, the energy of a xenon lamp source is directed onto a live animal by an optical fiber bundle emitted from a fluorescence excitation device, and then multi-point transmission excitation scanning is performed on the live animal. This concentrates the excitation energy while reducing the generation of spontaneous background fluorescence, thereby achieving deep fluorescence imaging of the live animal. However, most existing fluorescence excitation devices are fixedly installed in small animal live imaging instruments. Since the positions of the fluorescence excitation device and the fixed live animal are not adjustable, fluorescence excitation scanning imaging can only be performed on local areas of the live animal, resulting in insufficient comprehensive fluorescence excitation scanning imaging of the live animal. Therefore, we propose a multifunctional animal live and molecular imaging device. Utility Model Content

[0004] The purpose of this invention is to provide a multifunctional animal in vivo and molecular imaging device to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model specifically adopts the following technical solution:

[0006] A multifunctional animal in vivo and molecular imaging device, comprising:

[0007] A fluorescence excitation device, wherein a fixing column is installed on the left side of the fluorescence excitation device;

[0008] An adjustment mechanism is installed below the fluorescence excitation device and the fixed column. The adjustment mechanism includes a support base, a limiting shaft is movably installed inside the support base, and limiting plates are detachably connected to the front and back of the support base through the limiting shaft. A support plate is detachably installed at the lower part between the two limiting plates. A drive motor is installed at the upper end of the support plate, and drive wheels are sleeved on the circumferential surface of the drive shaft of the drive motor. A counterweight is installed on the left side of the support base, and a support frame is installed at the lower end of both the support plate and the counterweight. A cylinder is movably connected inside the support frame through a connecting shaft.

[0009] An imaging mechanism is installed on the left side of the adjustment mechanism. The imaging mechanism includes a support plate, a protective frame is installed on the upper end of the support plate, and a display screen is installed inside the protective frame.

[0010] Furthermore, the upper end of the support is provided with a recessed groove, the fixing column is located in the recessed groove, and the interior of the support is provided with a through groove, through which the limiting shaft is movably connected to the support.

[0011] Furthermore, couplings are installed on the lower part of the opposite sides of the two limiting plates, and through holes are opened inside the support plate, into which the couplings are inserted.

[0012] Furthermore, a fixed base is installed at the upper end of the support plate, and the drive motor is installed inside the fixed base.

[0013] Furthermore, each of the drive wheels has drive teeth on its circumferential surface, and the lower end of the support is uniformly provided with multiple transmission teeth in the horizontal direction, with the drive teeth meshing with the transmission teeth.

[0014] Furthermore, the front and back of the counterweight base are movably connected to side plates via mounting shafts, and a base plate is installed at the lower end of the side plates.

[0015] Furthermore, a ball bearing is installed at the upper end of the cylinder output shaft, and a through groove is opened at the lower end of the support frame, with the ball bearing installed in the through groove.

[0016] The beneficial effects of this utility model are as follows:

[0017] 1. After the drive motor of this utility model is started, it can drive the drive wheel to perform circular motion, thereby enabling the support to move in the horizontal direction, thus enabling the fluorescence excitation device and the fixed column above to move, that is, to achieve the imaging purpose of live animals in different positions. With the cooperation of the limiting plate and the limiting shaft, the movement stability of the support can be guaranteed. When the support moves, it will drive the counterweight and the side plate to move, thus ensuring the stability of the left side of the support.

[0018] 2. When the output shaft of one cylinder extends, the output shaft of the other cylinder retracts. Under the action of the connecting shaft, the angle between the support frame and the cylinder will change, which can change the usage angle of the fluorescence excitation device and the fixing column, thereby effectively improving applicability and practicality. Attached Figure Description

[0019] Figure 1 This is a three-dimensional schematic diagram of the present invention;

[0020] Figure 2 This is a front sectional view of the present invention;

[0021] Figure 3 This is a three-dimensional schematic diagram of the adjustment mechanism in this utility model.

[0022] Reference numerals: 100, fluorescence excitation device; 200, fixed column; 300, adjustment mechanism; 301, support seat; 302, limiting shaft; 303, limiting plate; 304, support plate; 305, drive motor; 306, drive wheel; 307, counterweight seat; 308, support frame; 309, connecting shaft; 310, cylinder; 400, side plate; 500, base plate; 600, imaging mechanism; 601, support plate; 602, protective frame; 603, display screen. Detailed Implementation

[0023] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings.

[0024] Please see Figure 1 - Figure 3 This utility model provides a multifunctional animal in vivo and molecular imaging device, comprising:

[0025] A fluorescence excitation device 100 is provided, and a fixing column 200 is installed on the left side of the fluorescence excitation device 100.

[0026] The principle of the fluorescence excitation device 100 is to direct the energy of the xenon lamp source onto the live animal through an optical fiber bundle, and then perform multi-point transmission excitation scanning on the live animal. While concentrating the excitation energy, it reduces the generation of spontaneous background fluorescence and performs deep fluorescence imaging on the live animal. Since the operating principle of the fluorescence excitation device 100 is a conventional technical means in the existing technical field, it will not be described in detail. The installation stability of the fluorescence excitation device 100 can be guaranteed by the fixed column 200.

[0027] An adjustment mechanism 300 is installed below the fluorescence excitation device 100 and the fixed column 200. The adjustment mechanism 300 includes a support 301. A limiting shaft 302 is movably installed inside the support 301. A limiting plate 303 is detachably connected to the front and back of the support 301 through the limiting shaft 302. A support plate 304 is detachably installed at the lower part between the two limiting plates 303. A drive motor 305 is installed at the upper end of the support plate 304. Drive wheels 306 are sleeved on the circumferential surface of the drive shaft of the drive motor 305. A counterweight 307 is installed on the left side of the support 301. A support frame 308 is installed at the lower end of both the support plate 304 and the counterweight 307. A cylinder 310 is movably connected inside the support frame 308 through a connecting shaft 309.

[0028] The support 301 provides support for the fluorescence excitation device 100 and the fixed column 200. The limiting shaft 302 ensures the connection stability between the limiting plate 303 and the support 301. The support plate 304 ensures the connection stability of the lower end of the limiting plate 303. The support plate 304 supports the drive motor 305. The drive motor 305 rotates the drive wheel 306. The drive wheel 306 moves the support 301. The support 301 ensures the installation stability of the counterweight 307. The cylinder 310 and the connecting shaft 309 provide support for the support frame 308. The support frame 308 supports both the support 301 and the counterweight 307. The drive motor 305 is then started. Then, the drive wheel 306 can be driven to perform a circular motion, thereby enabling the support 301 to move horizontally, thus enabling the fluorescence excitation device 100 and the fixed column 200 above to move, that is, to achieve the imaging purpose of live animals in different positions. With the cooperation of the limiting plate 303 and the limiting shaft 302, the movement stability of the support 301 can be guaranteed. When the support 301 moves, it will drive the counterweight 307 and the side plate 400 to move, that is, to ensure the stability of the left side of the support 301. When the output shaft of the cylinder 310 on one side extends, the output shaft of the cylinder 310 on the other side retracts. Under the action of the connecting shaft 309, the angle between the support frame 308 and the cylinder 310 will change, that is, to change the usage angle of the fluorescence excitation device 100 and the fixed column 200, thereby effectively improving applicability and practicality.

[0029] Imaging mechanism 600 is installed on the left side of adjustment mechanism 300. Imaging mechanism 600 includes support plate 601. A protective frame 602 is installed on the upper end of support plate 601. A display screen 603 is installed inside the protective frame 602.

[0030] The support plate 601 supports the protective frame 602, and the protective frame 602 protects the display screen 603. The display screen 603 is connected to the fluorescence excitation device 100 via a network. The display screen 603 displays the results of the fluorescence excitation device 100, thus achieving the purpose of imaging.

[0031] In this embodiment, preferably, the upper end of the support 301 is provided with a recessed groove, the fixing column 200 is located in the recessed groove, and the interior of the support 301 is provided with a through groove, through which the limiting shaft 302 is movably connected to the support 301; the recessed groove can ensure the installation stability of the fixing column 200, and the through groove can provide space for the movement of the limiting shaft 302, while also having a limiting effect.

[0032] In this embodiment, preferably, couplings are installed on the lower part of the opposite surfaces of the two limiting plates 303, and the support plate 304 has through holes inside, into which the couplings are inserted; the through holes ensure the installation stability of the couplings, and the couplings ensure the connection stability between the limiting plates 303 and the support plate 304.

[0033] In this embodiment, preferably, a fixed seat is installed on the upper end of the support plate 304, and the drive motor 305 is installed inside the fixed seat; the support plate 304 can ensure the installation stability of the fixed seat, and the fixed seat can ensure the installation stability of the drive motor 305, thereby ensuring the performance of the drive motor 305.

[0034] In this embodiment, preferably, each drive wheel 306 has drive teeth on its circumferential surface, and the lower end of the support 301 is uniformly provided with multiple transmission teeth in the horizontal direction. The drive teeth and transmission teeth mesh with each other. The cooperation between the drive teeth and transmission teeth can ensure the movement stability of the support 301.

[0035] In this embodiment, preferably, the front and back of the counterweight 307 are movably connected to the side plates 400 via mounting shafts, and the lower end of the side plates 400 is equipped with a base plate 500; the base plate 500 can achieve the installation stability of the cylinder 310 and the side plates 400, and the side plates 400 can ensure the movement stability of the counterweight 307.

[0036] In this embodiment, preferably, a ball bearing is installed at the upper end of the output shaft of the cylinder 310, and a through groove is opened at the lower end of the support frame 308, in which the ball bearing is installed; the rotational stability of the ball bearing can be ensured by the cooperation of the through groove and the connecting shaft 309.

[0037] The working principle and usage process of this utility model are as follows: When the drive motor 305 is started, it drives the drive wheel 306 to perform circular motion, thereby enabling the support 301 to move horizontally. This allows the fluorescence excitation device 100 and the fixed column 200 above to move, thus achieving the imaging purpose of live animals in different positions. The cooperation of the limiting plate 303 and the limiting shaft 302 ensures the stability of the support 301's movement. When the support 301 moves, it drives the counterweight 307 and the side plate 400 to move, thus ensuring the stability of the left side of the support 301. When the cylinder 310 on one side... When the output shaft extends, the output shaft of the cylinder 310 on the other side retracts. Under the action of the connecting shaft 309, the angle between the support frame 308 and the cylinder 310 changes, which can change the usage angle of the fluorescence excitation device 100 and the fixed column 200, thereby effectively improving applicability and practicality. Under the action of the support plate 601, the protective frame 602 can be supported. Under the action of the protective frame 602, the display screen 603 can be protected. The display screen 603 is connected to the fluorescence excitation device 100 through a network. Under the action of the display screen 603, the results of the fluorescence excitation device 100 can be displayed, that is, the imaging purpose can be achieved.

[0038] The above description of the disclosed embodiments enables those skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A multifunctional animal in vivo and molecular imaging device, characterized in that, include: A fluorescence excitation device (100), wherein a fixing column (200) is installed on the left side of the fluorescence excitation device (100); An adjustment mechanism (300) is installed below the fluorescence excitation device (100) and the fixed column (200). The adjustment mechanism (300) includes a support (301), a limiting shaft (302) is movably installed inside the support (301), and limiting plates (303) are detachably connected to the front and back of the support (301) via the limiting shaft (302). A support plate is detachably installed at the lower part between the two limiting plates (303). (304), a drive machine (305) is installed on the upper end of the support plate (304), and drive wheels (306) are sleeved on the circumferential surface of the drive shaft of the drive machine (305). A counterweight seat (307) is installed on the left side of the support seat (301). A support frame (308) is installed on the lower end of the support plate (304) and the counterweight seat (307), and a cylinder (310) is movably connected inside the support frame (308) through a connecting shaft (309). An imaging mechanism (600) is installed on the left side of the adjustment mechanism (300). The imaging mechanism (600) includes a support plate (601), a protective frame (602) is installed on the upper end of the support plate (601), and a display screen (603) is installed inside the protective frame (602).

2. The multifunctional animal in vivo and molecular imaging device according to claim 1, characterized in that: The upper end of the support (301) is provided with a recessed groove, the fixing column (200) is located in the recessed groove, and the inside of the support (301) is provided with a through groove, and the limiting shaft (302) is movably connected to the support (301) through the through groove.

3. The multifunctional animal in vivo and molecular imaging device according to claim 1, characterized in that: The lower part of the opposite surfaces of the two limiting plates (303) is equipped with a coupling, and the support plate (304) has a through hole inside, into which the coupling is inserted.

4. The multifunctional animal in vivo and molecular imaging device according to claim 1, characterized in that: The upper end of the support plate (304) is equipped with a fixed seat, and the drive motor (305) is installed inside the fixed seat.

5. The multifunctional animal in vivo and molecular imaging device according to claim 1, characterized in that: Each of the drive wheels (306) has drive teeth on its circumferential surface, and the lower end of the support (301) is provided with a plurality of transmission teeth evenly arranged in the horizontal direction, and the drive teeth are meshed with the transmission teeth.

6. The multifunctional animal in vivo and molecular imaging device according to claim 1, characterized in that: The front and back of the counterweight base (307) are movably connected to side plates (400) via mounting shafts, and a base plate (500) is installed at the lower end of the side plates (400).

7. The multifunctional animal in vivo and molecular imaging device according to claim 1, characterized in that: A ball bearing is installed at the upper end of the output shaft of the cylinder (310), and a through groove is provided at the lower end of the support frame (308), in which the ball bearing is installed.

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