Procoagulant hemostatic particle structure

By improving the powder connection structure and support plate connecting rod design of the hemostatic particles, the problem of blood coagulase separation in the snake spathula was solved, achieving the stability and continuous hemostatic effect of the hemostatic particles and promoting wound healing.

CN224126342UActive Publication Date: 2026-04-17SHENZHEN PEOPLES HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
SHENZHEN PEOPLES HOSPITAL
Filing Date
2025-04-12
Publication Date
2026-04-17

AI Technical Summary

Technical Problem

When the existing hemostatic particles expand and disintegrate, the coagulase from the snake-like snake easily separates from the shell, making it impossible to act precisely and continuously on the bleeding site. This interferes with the coagulation process, affects hemostasis efficiency, and increases the risk of bleeding.

Method used

The structure employs a combination of first powder, second powder, and third powder. The stability between the powders is enhanced by the interlocking connection of the first protrusion and the second groove, and the second protrusion and the third groove. Furthermore, the overall strength and resistance to deformation of the structure are improved by utilizing the synergistic effect of the support plate and the connecting rod.

Benefits of technology

This ensures that the hemostatic particles maintain stability and continuity in complex physiological environments, avoids unstable connections between powder particles, achieves continuous and reliable hemostatic function, and promotes wound healing.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model belongs to the technical field of hemostatic particles, and particularly relates to a procoagulant hemostatic particle structure which comprises first powder, second powder and third powder, a first groove is formed in the outer side wall of the first powder, three supporting plates are assembled in the first powder, a connecting rod is connected among the three supporting plates, and the connecting rod is connected with the second powder. A second groove is formed in the outer side wall of the supporting plate, and a first protruding block is connected to the inner side wall of the second powder body. According to the utility model, the first convex block is embedded with the second groove, and the first convex block is matched with the first groove, so that the first convex block, the second groove and the first convex block cooperate with each other, and the stability of connection between the first powder and the second powder can be effectively enhanced. And then, the second convex block is embedded and clamped into the third groove, so that firm connection between the second powder and the third powder is ensured. When the hemostasis particle structure is in contact with the blood of a patient to play a hemostasis role, the situation of unstable connection among powder can be avoided to a great extent, and the reliability of the hemostasis process is ensured.
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Description

Technical Field

[0001] This invention belongs to the field of hemostatic particle technology, specifically relating to a hemostatic particle structure that promotes blood coagulation. Background Technology

[0002] Hemostatic particles are materials with a specific shape used for hemostasis, appearing as particles. Specifically, they can be applied to various wound bleeding scenarios, especially for bleeding from puncture needle tracts, where their particle shape or particle-like structure allows them to exert a hemostatic effect. During the coagulation process, the outer shell of the hemostatic particles is designed to rapidly expand and disintegrate upon contact with blood, significantly increasing in volume. This compression and sealing of the puncture needle tract achieves hemostasis.

[0003] However, these hemostatic particles currently have significant drawbacks. When the outer shell expands and disintegrates, it easily separates from the hemocoagulase contained within. As a key hemostatic active ingredient, this hemocoagulase, once separated from the shell, cannot act precisely and continuously on the bleeding site, failing to effectively activate the coagulation mechanism. This severely interferes with the normal coagulation process, greatly affecting the actual effectiveness of the hemostatic particles, reducing hemostatic efficiency, and potentially even failing to achieve the intended hemostatic goal, delaying wound healing, and increasing the patient's bleeding risk. Utility Model Content

[0004] The purpose of this invention is to provide a hemostatic particle structure that promotes blood clotting, addressing the problem that existing technologies, when the outer shell expands and disintegrates, easily separate from the coagulant contained within, the *Porcini spathulatus*. As a key hemostatic active ingredient, *Porcini spathulatus* coagulant, once separated from the outer shell, cannot act precisely and continuously on the bleeding site, failing to effectively activate the coagulation mechanism, severely interfering with the normal coagulation process, and thus greatly affecting the actual effectiveness of the hemostatic particles. This results in reduced hemostatic efficiency, and may even prevent the achievement of the intended hemostatic goal, delaying wound healing and increasing the patient's bleeding risk.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a hemostatic particle structure that promotes blood clotting, comprising a first powder, a second powder, and a third powder. The outer side wall of the first powder has a first groove, and the interior of the first powder is equipped with three support plates. A connecting rod is connected between the three support plates. The outer side wall of the support plates has a second groove. The inner side wall of the second powder is connected to a first protrusion. The outer side wall of the second powder has a third groove, and the inner side wall of the third powder is connected to a second protrusion.

[0006] As a preferred embodiment of the hemostatic particle structure for promoting blood coagulation according to this utility model, the first powder is made of barium sulfate, the second powder is made of snake coagulase, and the third powder is made of regenerated oxidized cellulose.

[0007] As a preferred embodiment of the hemostatic particle structure for promoting blood clotting according to this utility model, the second groove matches the position of the first groove, and the second groove and the first groove have the same size.

[0008] As a preferred embodiment of the hemostatic particle structure for promoting blood clotting according to this utility model, the first protrusion is connected to the second groove and the first groove, and the cross-section of the first protrusion, the second groove and the first groove are in the shape of a "T".

[0009] As a preferred embodiment of the hemostatic particle structure for promoting blood clotting according to this utility model, the second protrusion and the third groove have the same size, and the cross-sections of the second protrusion and the third groove are T-shaped.

[0010] In a preferred embodiment of the hemostatic particle structure for promoting blood clotting according to this invention, the support plate and connecting rod are made of inorganic materials.

[0011] As a preferred embodiment of the hemostatic particle structure for promoting blood clotting according to this utility model, the height of the first powder, the second powder, and the third powder is 4.5 mm, and the diameter at which the first powder, the second powder, and the third powder are connected is 0.8 mm.

[0012] Compared with the prior art, the beneficial effects of this utility model are:

[0013] The first protrusion engages with the second groove, and the first protrusion fits into the first groove; the three elements work synergistically to effectively enhance the stability of the connection between the first and second powder particles. Subsequently, the second protrusion engages with the third groove, ensuring a firm connection between the second and third powder particles. When the hemostatic particle structure comes into contact with the patient's blood to exert its hemostatic effect, it can greatly avoid unstable connections between the powder particles, ensuring the reliability of the hemostatic process.

[0014] The interplay between the support plate and the connecting rod plays a crucial role in enhancing the overall strength of the hemostatic particle structure. The support plate, with its inherent rigidity, provides extensive support for the structure, while the connecting rod reinforces it from within, strengthening its resistance to deformation. In complex physiological environments, such as those involving blood flow impact and tissue compression, this structure not only prevents deformation due to external forces but also effectively maintains the integrity of the blood particles, ensuring the hemostatic particle structure can continuously and stably perform its hemostatic function, creating favorable conditions for wound healing. Attached Figure Description

[0015] The accompanying drawings are provided to further illustrate the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention, but do not constitute a limitation thereof. In the drawings:

[0016] Figure 1This is a schematic diagram of the main structure of the present utility model;

[0017] Figure 2 This is a schematic diagram of the disassembled structure of this utility model;

[0018] Figure 3 This is a schematic diagram of the structure of the first and second powders of this utility model;

[0019] Figure 4 This utility model Figure 1 A magnified structural diagram at point A in the diagram.

[0020] In the figure: 1. First powder; 2. Second powder; 3. Third powder; 4. Support plate; 5. Connecting rod; 6. Second groove; 7. First protrusion; 8. Third groove; 9. Second protrusion; 10. First groove. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0022] Please see Figures 1-4 The present invention provides the following technical solution: a hemostatic particle structure for promoting blood clotting, comprising a first powder 1, a second powder 2 and a third powder 3. The outer side wall of the first powder 1 is provided with a first groove 10. The interior of the first powder 1 is equipped with three support plates 4. The three support plates 4 are connected by a connecting rod 5. The outer side wall of the support plate 4 is provided with a second groove 6. The inner side wall of the second powder 2 is connected with a first protrusion 7. The outer side wall of the second powder 2 is provided with a third groove 8. The inner side wall of the third powder 3 is connected with a second protrusion 9.

[0023] Preferably, the first powder 1 is made of barium sulfate, the second powder 2 is made of snake coagulase, and the third powder 3 is made of regenerated oxidized cellulose.

[0024] In practical use, the first powder 1 is barium sulfate, which is opaque under X-ray fluoroscopy or CT scan. The second powder 2 is krait hemocoagulase, which can rapidly coagulate blood upon contact. The third powder 3 is regenerated oxidized cellulose, which can swell and disintegrate upon contact with blood, increasing in volume and compressing and sealing the puncture needle path.

[0025] Preferably, the second groove 6 is positioned to match the first groove 10, and the second groove 6 and the first groove 10 have the same dimensions.

[0026] In practical use, the first protrusion 7 can pass through the first groove 10 and connect with the second groove 6. At the same time, the first protrusion 7 is also fitted and connected with the first groove 10, which makes it convenient to fix the support plate 4.

[0027] Preferably, the first protrusion 7 is connected to the second groove 6 and the first groove 10, and the cross-sections of the first protrusion 7, the second groove 6 and the first groove 10 are "T" shaped.

[0028] In practical use, the first protrusion 7 and the second groove 6 are fitted together, and the first protrusion 7 is adapted to the first groove 10. The three work together to effectively enhance the stability of the connection between the first powder 1 and the second powder 2.

[0029] Preferably, the second protrusion 9 and the third groove 8 have the same size, and the cross-sections of the second protrusion 9 and the third groove 8 are T-shaped.

[0030] In practical use, the second protrusion 9 fits into the third groove 8, ensuring a firm connection between the second powder 2 and the third powder 3.

[0031] Preferably, the support plate 4 and the connecting rod 5 are made of inorganic materials.

[0032] In practical applications, inorganic materials, such as hydroxyapatite, possess excellent biocompatibility. Their chemical composition is similar to that of human tissues, reducing the body's immune response and increasing the receptivity of blood particles, thus enhancing hemostasis. Furthermore, the inorganic material framework can serve as a carrier, loading bioactive molecules such as growth factors to further promote tissue repair and regeneration, thereby improving practicality. Simultaneously, the first protrusion 7 and the second protrusion 9 are also made of inorganic materials.

[0033] Preferably, the height of the first powder 1, the second powder 2 and the third powder 3 is 4.5 mm, and the diameter at which the first powder 1, the second powder 2 and the third powder 3 are connected is 0.8 mm.

[0034] In practical use, medical staff use tweezers to gently pick up the hemostatic particle structure, which is composed of the first powder 1, the second powder 2, and the third powder 3. Because its height is uniformly 4.5mm, the placement of the hemostatic particles at the wound site can be accurately predicted during operation, facilitating precise placement. The 0.8mm diameter of the connecting parts makes the overall hemostatic particle structure relatively slender, which is beneficial for insertion into narrow wounds such as puncture needle tracts.

[0035] Working principle: Medical staff, using strictly sterilized forceps, gently grasp the hemostatic particle structure composed of three connected powders: powder 1, powder 2, and powder 3. Then, they precisely and slowly insert it into the puncture needle tract. Once the hemostatic particle structure comes into contact with the patient's blood, each powder quickly takes effect. Powder 2, containing *Polygonum avianus* hemocoagulase, is the first to come into contact with the blood, rapidly initiating the coagulation mechanism and accelerating the blood clotting process due to its highly efficient coagulation properties. Simultaneously, the regenerated oxidized cellulose in powder 3 immediately expands and disintegrates upon contact with the blood, significantly increasing its volume and thus exerting strong pressure on the puncture needle tract, tightly sealing it and further preventing blood leakage.

[0036] During the action of the second powder 2 and the third powder 3, the internal connection mechanism of the structure operates synchronously to ensure overall stability. The connection between the first protrusion 7 and the second groove 6, and its perfect fit with the first groove 10, work together to greatly enhance the stability of the connection between the first powder 1 and the second powder 2. Subsequently, the connection between the second protrusion 9 and the third groove 8 ensures an equally strong connection between the second powder 2 and the third powder 3. In this way, when the hemostatic particle structure exerts its full hemostatic effect, it can minimize the possibility of unstable connections between the powders, effectively guaranteeing the reliability and continuity of the hemostatic process.

[0037] Furthermore, the support plate 4 and connecting rod 5 play a crucial role in maintaining the overall performance of the hemostatic particle structure. The support plate 4, with its excellent rigidity, provides a large area of ​​solid support for the entire structure, effectively dispersing external pressure. The connecting rod 5 reinforces the structure from within, enhancing its resistance to deformation. In complex and variable physiological environments, such as when subjected to strong blood flow impacts or compression from surrounding tissues, this hemostatic particle structure, through the synergistic effect of the support plate 4 and connecting rod 5, effectively prevents deformation caused by external forces. It also reliably maintains the integrity of the blood particles, ensuring the hemostatic particle structure can continuously and stably perform its hemostatic function, creating favorable conditions for the smooth healing of the patient's wound and aiding in the patient's rapid recovery.

[0038] Finally, it should be noted that the above are merely preferred embodiments of this utility model and are not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A procoagulant hemostatic particle structure comprising a first powder (1), a second powder (2) and a third powder (3), characterized in that: The outer side wall of the first powder (1) is provided with a first groove (10), and the interior of the first powder (1) is equipped with three support plates (4), and a connecting rod (5) is connected between the three support plates (4). The outer side wall of the support plate (4) is provided with a second groove (6), the inner side wall of the second powder (2) is connected with a first protrusion (7), the outer side wall of the second powder (2) is provided with a third groove (8), and the inner side wall of the third powder (3) is connected with a second protrusion (9).

2. A procoagulant hemostatic particle structure according to claim 1, wherein: The first powder (1) is made of barium sulfate, the second powder (2) is made of snake coagulase, and the third powder (3) is made of regenerated oxidized cellulose.

3. A procoagulant hemostatic particle structure according to claim 1, wherein: The second groove (6) is in the same position as the first groove (10), and the second groove (6) and the first groove (10) are the same size.

4. The procoagulant hemostatic particle structure according to claim 1, wherein: The first protrusion (7) is connected to the second groove (6) and the first groove (10), and the cross-sections of the first protrusion (7), the second groove (6) and the first groove (10) are in the shape of a "T".

5. A procoagulant hemostatic particle structure according to claim 1, wherein: The second protrusion (9) and the third groove (8) are the same size, and the cross-sections of the second protrusion (9) and the third groove (8) are "T" shaped.

6. A procoagulant hemostatic particle structure according to claim 1, wherein: The support plate (4) and the connecting rod (5) are made of inorganic materials.

7. A procoagulant hemostatic particle structure according to claim 1, wherein: The height of the first powder (1), the second powder (2) and the third powder (3) is 4.5 mm, and the diameter of the connection between the first powder (1), the second powder (2) and the third powder (3) is 0.8 mm.