Automatic sample injection structure and liquid chromatograph thereof

Abstract

The utility model belongs to the technical field of pharmacy, and discloses an automatic sample injection structure and a liquid chromatograph thereof, the automatic sample injection structure comprises a sampling needle arranged above the ground and a height adjusting structure arranged on one side of the sampling needle, the height adjusting structure comprises a fixed block, a first screw rod, a displacement block and a lantern ring, the two ends of the first screw rod are rotationally connected with the two ends of the fixed block respectively, the displacement block is in threaded connection with the first screw rod, the lantern ring is fixedly connected with the wall surface of the sampling needle, one side of the displacement block is fixedly connected with the lantern ring, and the displacement sampling structure comprises a moving block, a second screw rod and an adjusting block. One end of the moving block is in threaded connection with the second screw rod; the second servo motor drives the first screw rod to rotate; the displacement block drives the lantern ring and the sampling needle to move up and down; the needle head extends into the bottom of the medicine according to the depth of the medicine, so that the medicine can be completely sucked.

Description

Technical Field

[0001] This utility model belongs to the technical field of pharmaceutical manufacturing, specifically, it relates to an automatic sample injection structure and its liquid chromatograph. Background Technology

[0002] Liquid chromatography is a highly efficient, rapid, and sensitive separation and analysis instrument. It separates mixtures based on the difference in the distribution ratio between a liquid and a solid or between two immiscible liquids, and then analyzes and identifies the mixtures.

[0003] A sample injection device for a liquid chromatograph (CN202323633145.9) includes a tube body, a sampling needle, a piston, and an automatic control mechanism. The sampling needle is detachably screwed onto the bottom of the tube body. The piston is movably installed inside the tube body, and a core rod is installed above the piston. The automatic control mechanism is located inside the tube body and includes a gear and a motor. The gear is rotatably installed inside the tube body via a rotating shaft, and the output shaft of the motor is connected to the rotating shaft. A toothed structure is provided on the core rod in the vertical direction, and the gear meshes with the toothed structure.

[0004] During the sampling process of liquid chromatography, different bottles have different depths. It is necessary to insert the needle into the bottom of the bottle after the drug is completely aspirated. Current technology cannot automatically adjust the needle depth. Secondly, if the needle is not straight and precise enough when inserted into the bottle mouth or injection port, it is easy to bend the needle and wear it out.

[0005] In view of this, this utility model is proposed. Utility Model Content

[0006] To solve the aforementioned technical problems of the inability to automatically adjust the needle depth and the tendency for the needle tip to bend, the basic concept of the technical solution adopted by this utility model is: an automatic sample injection structure, including a sampling needle, which is set above the ground;

[0007] The height adjustment structure is located on one side of the sampling needle. The height adjustment structure includes a fixed block, a first lead screw, a displacement block, and a collar. The two ends of the first lead screw are rotatably connected to the two ends of the fixed block. The displacement block is threadedly connected to the first lead screw. The collar is fixedly connected to the wall of the sampling needle. One side of the displacement block is fixedly connected to the collar.

[0008] The displacement injection structure includes a moving block, a second lead screw, and an adjusting block. The two ends of the second lead screw are rotatably connected to the two ends of the adjusting block. One end of the moving block is threadedly connected to the second lead screw. The other end of the moving block is provided with a drug extraction plate. The bottom surface of one end of the drug extraction plate is fixedly connected to the top end of the sampling needle.

[0009] The needle auxiliary structure is located below the sampling needle; the needle auxiliary structure includes a bottle pressing block and springs, the bottom surface of the sampling needle is fixedly connected to one end of the two springs, and the other end of the two springs is fixedly connected to the top surface of the bottle pressing block.

[0010] In a preferred embodiment of the present invention, the height adjustment structure further includes a groove and a sliding block. A groove is formed on one side of the fixed block, and one side of the sliding block is fixedly connected to one side of the displacement block. The sliding block is slidably connected to the groove.

[0011] In a preferred embodiment of this utility model, the height adjustment structure further includes a second servo motor, which is disposed on the top surface of the fixed block, and the rotation shaft of the second servo motor is fixedly connected to one end of the first lead screw.

[0012] In a preferred embodiment of the present invention, the displacement injection structure further includes an L-groove, an L-groove is formed on one side of the adjusting block, a moving block is disposed inside the L-groove and is slidably connected to the L-groove, and one side of the moving block is fixedly connected to one side of the fixed block.

[0013] In a preferred embodiment of this utility model, the movable block is L-shaped and the shape of the movable block is adapted to the shape of the L-groove. A cylinder is fixedly provided on the top surface of one end of the movable block, and the output end of the cylinder is fixedly connected to the bottom surface of one end of the medicine extraction plate.

[0014] In a preferred embodiment of the present invention, the displacement injection structure further includes a first servo motor, which is fixedly mounted on one side of the adjustment block by a bracket, and the rotation shaft of the first servo motor is fixedly connected to one end of the second lead screw.

[0015] A liquid chromatograph includes all of the above-mentioned automatic injection structures, the liquid chromatograph is disposed on one side of the automatic injection structure, and the liquid chromatograph is fixedly connected to one side of the adjustment block.

[0016] Compared with the prior art, the present invention has the following advantages:

[0017] 1. The second servo motor drives the first lead screw to rotate, and the displacement block drives the collar and sampling needle to move up and down. According to the depth of the medicine, the needle is inserted into the bottom of the medicine to ensure that the medicine can be completely drawn up.

[0018] 2. The other ends of the two telescopic rods are fixedly connected to the top surface of the bottle-pressing block, so that the bottle-pressing block is aligned with the bottle mouth. During the descent of the sampling needle, the two springs are pressed, and the two telescopic rods extend and retract at the same time. The needle tip of the sampling needle can be inserted into the bottle mouth smoothly and accurately without tilting or bending.

[0019] The specific embodiments of this utility model will be described in further detail below with reference to the accompanying drawings. Attached Figure Description

[0020] In the attached diagram:

[0021] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0022] Figure 2 This is a schematic diagram of the height adjustment structure of this utility model;

[0023] Figure 3 This is a partial schematic diagram of the height adjustment structure of this utility model;

[0024] Figure 4 This is a schematic diagram of the displacement injection structure of this utility model;

[0025] Figure 5 This is a schematic diagram of the needle auxiliary structure of this utility model.

[0026] In the diagram: 1. Sampling needle; 2. Collar; 3. Drug extraction plate; 4. Fixing block; 5. First lead screw; 6. Slide groove; 7. Cylinder; 8. Adjusting block; 9. First servo motor; 10. Second lead screw; 11. Second servo motor; 12. Displacement block; 13. Sliding block; 14. Moving block; 15. L-groove; 16. Bottle pressing block; 17. Spring. Detailed Implementation

[0027] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions in the embodiments will be clearly and completely described below with reference to the accompanying drawings. The following embodiments are used to illustrate this utility model.

[0028] An automated sample introduction structure and its liquid chromatograph, such as Figure 1 , Figure 2 , Figure 3 and Figure 4As shown, the height adjustment structure is located on one side of the sampling needle 1. The height adjustment structure includes a fixed block 4, a first lead screw 5, a displacement block 12, and a collar 2. Both ends of the first lead screw 5 are rotatably connected to both ends of the fixed block 4. The displacement block 12 is threadedly connected to the first lead screw 5. The collar 2 is fixedly connected to the wall of the sampling needle 1. One side of the displacement block 12 is fixedly connected to the collar 2. The displacement injection structure includes a moving block 14, a second lead screw 10, and an adjusting block 8. Both ends of the second lead screw 10 are rotatably connected to both ends of the adjusting block 8. One end of the moving block 14 is threadedly connected to the second lead screw 10. The other end of the moving block 14 is provided with a drug extraction plate 3. The bottom surface of one end of the drug extraction plate 3 is fixedly connected to the top end of the sampling needle 1. The height adjustment structure also includes a groove 6 and a sliding block 13. A groove 6 is opened on one side of the fixed block 4. One side of the sliding block 13 is fixedly connected to one side of the displacement block 12. The sliding block 13 is slidably connected to the slide groove 6. The height adjustment structure also includes a second servo motor 11, which is set on the top surface of the fixed block 4. The rotating shaft of the second servo motor 11 is fixedly connected to one end of the first lead screw 5. The displacement injection structure also includes an L-groove 15. An L-groove 15 is opened on one side of the adjusting block 8. The moving block 14 is set inside the L-groove 15 and is slidably connected to the L-groove 15. One side of the moving block 14 is fixedly connected to one side of the fixed block 4. The moving block 14 is L-shaped and its shape matches that of the L-groove 15. A cylinder 7 is fixedly mounted on the top surface of one end of the moving block 14. The output end of the cylinder 7 is fixedly connected to the bottom surface of one end of the extraction plate 3. The displacement injection structure also includes a first servo motor 9, which is fixedly mounted on one side of the adjusting block 8 by a bracket. The rotating shaft of the first servo motor 9 is fixedly connected to one end of the second lead screw 10.

[0029] Both the second servo motor 11 and the first servo motor 9 are forward and reverse servo motors. When the power to the first servo motor 9 is turned on, the rotating shaft of the first servo motor 9 drives the second lead screw 10 to rotate. The moving block 14 drives the height adjustment structure to move left and right, and the displacement is adjusted according to the position of the injection port. When the power to the second servo motor 11 is turned on, the second servo motor 11 drives the first lead screw 5 to rotate. The displacement block 12 drives the collar 2 and the sampling needle 1 to move up and down. According to the depth of the drug, the needle is inserted into the bottom of the drug to ensure that the drug can be completely drawn up.

[0030] An automated sample introduction structure and its liquid chromatograph, such as Figure 1 and Figure 4 As shown, there is an anti-reverse structure and a needle auxiliary structure. The needle auxiliary structure is located below the sampling needle 1. The needle auxiliary structure includes a bottle pressing block 16 and springs 17. The bottom surface of the sampling needle 1 is fixedly connected to one end of the two springs 17, and the other end of the two springs 17 is fixedly connected to the top surface of the bottle pressing block 16.

[0031] Each of the two springs 17 has a telescopic rod inside. One end of the two telescopic rods is fixedly connected to the ground of the sampling needle 1, and the other end of the two telescopic rods is fixedly connected to the top surface of the bottle pressing block 16, so that the bottle pressing block 16 is aligned with the bottle mouth. When the sampling needle 1 descends, it presses the two springs 17, and at the same time the two telescopic rods extend and retract. The needle tip of the sampling needle 1 can be inserted into the bottle mouth smoothly and accurately without tilting or bending.

[0032] A liquid chromatograph is provided, wherein the liquid chromatograph is mounted on one side of an automatic injection structure and is fixedly connected to one side of an adjusting block 8. By setting up the aforementioned automatic injection structure, the liquid chromatograph has the characteristics of adjusting the needle depth and preventing the needle tip from bending.

[0033] The working principle of this utility model is as follows: Both the second servo motor 11 and the first servo motor 9 are forward and reverse servo motors. When the power of the first servo motor 9 is turned on, the rotating shaft of the first servo motor 9 drives the second lead screw 10 to rotate. The moving block 14 drives the height adjustment structure to move left and right, and the displacement is adjusted according to the position of the sample inlet. When the power of the second servo motor 11 is turned on, the second servo motor 11 drives the first lead screw 5 to rotate. The displacement block 12 drives the collar 2 and the sampling needle 1 to move up and down. According to the depth of the medicine, the needle tip is inserted into the bottom of the medicine to ensure that the medicine can be completely absorbed. Each of the two springs 17 has a telescopic rod inside. One end of the two telescopic rods is fixedly connected to the ground of the sampling needle 1, and the other end of the two telescopic rods is fixedly connected to the top surface of the bottle pressing block 16, so that the bottle pressing block 16 is aligned with the bottle mouth. During the descent of the sampling needle 1, the two springs 17 are pressed, and the two telescopic rods extend and retract at the same time. The needle tip of the sampling needle 1 can be inserted into the bottle mouth smoothly and accurately without tilting or bending.

[0034] It is understood that this utility model has been described through some embodiments, and those skilled in the art will recognize that various changes or equivalent substitutions can be made to these features and embodiments without departing from the spirit and scope of this utility model. Furthermore, under the teachings of this utility model, these features and embodiments can be modified to adapt to specific situations and materials without departing from the spirit and scope of this utility model. Therefore, this utility model is not limited to the specific embodiments disclosed herein, and all embodiments falling within the scope of the claims of this application are within the protection scope of this utility model.

Claims

1. An autosampler structure, characterized by, include Sampling needle (1), the sampling needle (1) is set above the ground; The height adjustment structure is set on one side of the sampling needle (1). The height adjustment structure includes a fixed block (4), a first lead screw (5), a displacement block (12) and a collar (2). The two ends of the first lead screw (5) are rotatably connected to the two ends of the fixed block (4). The displacement block (12) is threadedly connected to the first lead screw (5). The collar (2) is fixedly connected to the wall of the sampling needle (1). One side of the displacement block (12) is fixedly connected to the collar (2). The displacement injection structure includes a moving block (14), a second lead screw (10), and an adjusting block (8). The two ends of the second lead screw (10) are rotatably connected to the two ends of the adjusting block (8). One end of the moving block (14) is threadedly connected to the second lead screw (10). The other end of the moving block (14) is provided with a drug extraction plate (3). The bottom surface of one end of the drug extraction plate (3) is fixedly connected to the top end of the sampling needle (1). The needle auxiliary structure is located below the sampling needle (1). The needle auxiliary structure includes a bottle pressing block (16) and a spring (17). The bottom surface of the sampling needle (1) is fixedly connected to one end of the two springs (17), and the other end of the two springs (17) is fixedly connected to the top surface of the bottle pressing block (16).

2. The automatic sampling structure according to claim 1, characterized in that, The height adjustment structure also includes a groove (6) and a sliding block (13). A groove (6) is opened on one side of the fixed block (4). One side of the sliding block (13) is fixedly connected to one side of the displacement block (12). The sliding block (13) is slidably connected to the groove (6).

3. An autosampler according to claim 2, wherein, The height adjustment structure also includes a second servo motor (11), which is set on the top surface of the fixed block (4). The rotation shaft of the second servo motor (11) is fixedly connected to one end of the first lead screw (5).

4. The automatic sampling structure according to claim 1, characterized in that, The displacement injection structure also includes an L-groove (15). An L-groove (15) is opened on one side of the adjustment block (8). A moving block (14) is set inside the L-groove (15) and is slidably connected to the L-groove (15). One side of the moving block (14) is fixedly connected to one side of the fixed block (4).

5. An autosampler according to claim 4, wherein, The movable block (14) is L-shaped and is adapted to the shape of the L-groove (15). A cylinder (7) is fixedly installed on the top surface of one end of the movable block (14), and the output end of the cylinder (7) is fixedly connected to the bottom surface of one end of the medicine extraction plate (3).

6. The automatic sample introduction structure according to claim 5, characterized in that, The displacement injection structure also includes a first servo motor (9), which is fixed on one side of the adjustment block (8) by a bracket, and the rotation shaft of the first servo motor (9) is fixedly connected to one end of the second lead screw (10).

7. A liquid chromatograph characterized by, The liquid chromatograph is provided with an automatic injection structure as described in any one of claims 1-6, the liquid chromatograph is disposed on one side of the automatic injection structure, and the liquid chromatograph is fixedly connected to one side of the adjustment block (8).

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