Condensation reaction kettle for pharmacy and fine chemical engineering

Abstract

The utility model relates to the technical field of reaction kettles, and discloses a condensation reaction kettle for pharmacy and fine chemical engineering, which comprises a barrel body, a motor arranged above the barrel body and a stirring shaft connected with the motor, an outer coil pipe with a semi-ring cross section is spirally arranged outside the barrel body along the circumferential direction, and the outer coil pipe is combined with the outer wall of the barrel body through a C-shaped opening. An outer coil medium inlet is formed above the outer coil, and an outer coil medium outlet is formed below the outer coil; a jacket is arranged at the bottom of the barrel, a jacket medium outlet is formed below the jacket, a jacket medium inlet is formed above the jacket, and the outer coil medium outlet is communicated with the jacket medium inlet; an inner coil pipe is spirally arranged at the position, close to the inner wall face, in the barrel, and an inner coil pipe medium inlet is formed in the top of the barrel; an inner coil medium outlet is formed in the bottom of the barrel; and the inner coil pipe is fixed on the inner wall of the cylinder body through a fixing device. The temperature adjusting device is simple in structure, high in flexibility, capable of rapidly adjusting the temperature and beneficial to uniform distribution of the temperature.

Description

Technical Field

[0001] This utility model relates to the technical field of reaction vessels, specifically to a condensation reaction vessel for pharmaceuticals and fine chemicals. Background Technology

[0002] Condensation reactors are widely used in fields such as polymer synthesis, pharmaceuticals and fine chemicals, fragrances and dyes, and biomass conversion. They require heating the reactants at specific temperatures according to process requirements. Therefore, condensation reactors have heating structures.

[0003] In the pharmaceutical and fine chemical industries, the substances involved in condensation reactions are highly sensitive to temperature, which places high demands on the heating structure technology of condensation reaction vessels.

[0004] Currently, condensation reactors used in pharmaceuticals and fine chemicals typically employ jacketed or heating coil structures for heating. These heating structures are limited in type, making it difficult and inflexible to adjust the heating of the condensation reaction materials, which directly affects processing efficiency and quality.

[0005] A search revealed that a condensation reactor suitable for the production of pharmaceutical intermediates is disclosed in the prior art. Please refer to the Chinese patent document entitled "A Condensation Reactor," publication number CN219291370U, published on July 4, 2023. This technology achieves temperature control and reduces energy consumption by adjusting the supply of heating medium according to the amount of material. However, in actual production, when the amount of material is small, jacketed heating leads to uneven temperature distribution within the reactor, causing material fatigue and crack formation, thus shortening the reactor's service life and increasing maintenance costs. Furthermore, jacketed heating results in a slow temperature change rate, leading to low production efficiency.

[0006] The prior art also discloses a condensation reactor suitable for synthesizing 2-hydroxychalcone. Please refer to the Chinese patent document entitled "Condensation Reactor for Synthesizing 2-Hydroxychalcone," publication number CN208427038U, published on January 25, 2019. In this technology, by winding an upper and lower coil around the stirring shaft and connecting them to a jacket outside the reactor body, precise control and uniform distribution of the material temperature inside the reactor are achieved. However, in actual use, because the upper and lower coils are wound around the stirring shaft and connected to the jacket, this structure makes the disassembly and assembly process complex and time-consuming, increases the difficulty of maintenance and cleaning, and leads to low production efficiency.

[0007] Existing technology also discloses a reactor suitable for condensation reactions; please refer to the technology published in Chinese patent document entitled "A Continuously Feeding Condensation Reactor," publication number CN211586559U, publication date September 29, 2020. In this technology, a heating layer is set in the reactor, and a heating coil is installed in the heating layer. The material is heated by the heating coil, achieving effective temperature control within the reactor. However, in actual production processes, heating by the heating coil leads to uneven temperature distribution within the reactor, resulting in material fatigue and crack formation, thereby reducing the reactor's service life and increasing maintenance costs. Utility Model Content

[0008] The technical objective of this invention is to address the shortcomings of the prior art by providing a condensation reactor for pharmaceuticals and fine chemicals that is simple in structure, highly flexible, capable of rapid temperature adjustment, and facilitates uniform temperature distribution.

[0009] The technical solution adopted in this utility model is as follows:

[0010] A condensation reactor for pharmaceuticals and fine chemicals includes a cylindrical body, a motor disposed above the cylindrical body, and a stirring shaft connected to the motor. The stirring shaft is rotatably disposed inside the cylindrical body. The top of the cylindrical body is provided with a feed inlet, and the bottom of the cylindrical body is provided with a discharge outlet.

[0011] The outer side of the cylinder is provided with an outer coil with a semi-circular cross-section spirally along the outside. The outer coil is connected to the outer wall of the cylinder with a C-shaped opening. The outer coil has a medium inlet at the top and a medium outlet at the bottom.

[0012] The bottom of the cylinder is provided with a jacket, the jacket medium outlet is provided below the jacket, and the jacket medium inlet is provided above the jacket. The outer coil medium outlet is connected to the jacket medium inlet.

[0013] Inside the cylinder, an inner coil is spirally arranged near the inner wall. The top of the cylinder has an inner coil medium inlet, and the bottom of the cylinder has an inner coil medium outlet. The inner coil is fixed to the inner wall of the cylinder by a fixing device.

[0014] The aforementioned technical measures, through the synergistic effect of the inner coil, outer coil, and jacket, can rapidly regulate the temperature of the material, thereby improving reaction efficiency. The inner coil and jacket are independently configured, and both have separate medium inlets, resulting in a simple structure that allows for the use of different heat exchange media to meet varying needs, effectively enhancing flexibility. By placing the inner coil inside the cylinder and the jacket at the bottom, uniform temperature distribution is achieved during production, preventing localized overheating or undercooling of the reactor, thus extending its service life and enhancing its stability. The outer coil is located outside the cylinder, and its medium outlet is connected to the jacket's medium inlet. This allows for the transfer of the heat exchange medium to the jacket and effectively reduces the temperature difference between the inside and outside of the cylinder wall, minimizing damage caused by thermal stress and further extending its service life.

[0015] Furthermore, the fixing device includes multiple fixing brackets, which are evenly distributed on the inner wall of the cylinder.

[0016] The above-mentioned technical measures enhance the structural stability by fixing the inner coil with a fixing bracket, while preventing direct contact between the inner coil and the inner wall of the cylinder. This effectively reduces damage to the inner wall of the cylinder caused by excessively high or low temperatures of the inner coil, and helps to extend its service life.

[0017] Furthermore, multiple stirring blades are spaced apart along the axial direction of the stirring shaft.

[0018] The above-mentioned technical measures can improve the mixing efficiency of materials by setting multiple stirring blades, thereby improving the reaction efficiency.

[0019] Furthermore, a water inlet is provided at the upper end of the cylinder.

[0020] The above-mentioned technical measures, by setting up a separate water inlet, can ensure that water does not come into direct contact with other materials, avoiding the risk of cross-contamination, while also being able to meet different production needs.

[0021] Furthermore, the upper and lower ends of the cylinder are equipped with remote level gauges for detecting the height of the liquid inside the cylinder and sending the height data to the terminal; the lower end of the cylinder is equipped with a remote thermometer for detecting the temperature of the liquid inside the cylinder and sending the temperature data to the terminal.

[0022] The above-mentioned technical measures, by setting up remote level gauges and remote thermometers, can transmit the detected level and temperature data to terminal devices, facilitating remote monitoring by staff and improving convenience and safety.

[0023] Furthermore, a thermometer is provided on the outer coil to detect the temperature of the medium inside the outer coil; a thermometer is provided at the lower end of the cylinder to detect the temperature of the liquid inside the cylinder; and a level gauge is provided at the top of the cylinder to detect the height of the liquid inside the cylinder.

[0024] The above-mentioned technical measures ensure that the reaction takes place at the optimal temperature by setting a thermometer to detect the temperature of the medium and liquid, and can be adjusted in real time as needed; by setting a level gauge to detect the liquid level inside the cylinder, it can prevent excessive liquid from overflowing and also avoid insufficient liquid from affecting the production process, thus improving convenience.

[0025] Furthermore, a manhole is provided at the top of the cylinder, and a viewing mirror is installed on the manhole.

[0026] The above-mentioned technical measures improve convenience by providing manholes, allowing operators to enter the cylinder for easy maintenance and cleaning; and by installing sight glasses on the manholes, the condition inside the cylinder can be directly observed from the outside.

[0027] Furthermore, a sampling port is provided at the lower end of the cylinder.

[0028] The above-mentioned technical measures, by setting up sampling ports, facilitate sampling by staff, enable timely judgment of the degree and status of the reaction, and improve convenience.

[0029] Furthermore, the cylinder body is externally connected to an ear-type support, and the ear-type support is provided with a grounding plate.

[0030] The above-mentioned technical measures improve stability by placing the grounding plate on the lug support, and can effectively prevent the grounding plate from deforming during transportation, which would affect the grounding effect.

[0031] Furthermore, a gas outlet is provided at the top of the cylinder.

[0032] The above-mentioned technical measures, by setting up independent gas outlets, can effectively manage gas emissions, facilitate the collection and treatment of specific gases, and reduce environmental pollution and harm to human health; the gases generated during the production process can be discharged from the gas outlets, which helps to improve production efficiency and avoid safety hazards caused by gas accumulation.

[0033] One or more technical solutions provided by this utility model have at least the following technical effects or advantages:

[0034] This invention utilizes the synergistic effect of the inner coil, outer coil, and jacket to rapidly regulate the material temperature, thereby improving reaction efficiency. The inner coil and jacket are independently configured, each with its own media inlet, resulting in a simple structure that allows for the use of different heat exchange media to meet varying needs, significantly enhancing flexibility. By placing the inner coil inside the cylinder and the jacket at the bottom, uniform temperature distribution is achieved during production, preventing localized overheating or undercooling of the reactor, thus extending its service life and enhancing its stability. The outer coil is located outside the cylinder, with its media outlet connected to the jacket's media inlet. This facilitates the transfer of the heat exchange media to the jacket and effectively reduces the temperature difference between the inside and outside of the cylinder, minimizing damage caused by thermal stress and further extending its service life. Attached Figure Description

[0035] The accompanying drawings, which are provided to further illustrate the embodiments of the present invention and constitute a part of the present invention, do not constitute a limitation thereof.

[0036] Figure 1 This is a schematic diagram of the structure of this utility model;

[0037] Figure 2 This is a top view of the present invention;

[0038] The components are as follows: 1-Cylinder; 2-Motor; 3-Agitator shaft; 4-Feed inlet; 401-Condensate inlet; 402-Carboxyacetonitrile inlet; 403-Aniline inlet; 404-Nitrogen inlet; 5-Discharge outlet; 6-Outer coil; 601-Outer coil medium inlet; 602-Outer coil medium outlet; 7-Jacket; 701-Jacket medium inlet; 702-Jacket medium outlet; 8-Inner coil; 801-Inner coil medium inlet; 802-Inner coil medium outlet; 9-Fixed frame; 10-Agitator blades; 11-Water inlet; 12-Manhole; 13-Sampling port; 14-Plate; 15-Ear support; 16-Ground plate; 17-Connecting pipe; 18-Sight glass; 19-Gas outlet; 20-Spare port. Detailed Implementation

[0039] To better understand the above-mentioned objectives, features, and advantages of this utility model, the present utility model will be further described in detail below with reference to the accompanying drawings and specific embodiments. It should be noted that, where there is no conflict, the embodiments of this utility model and the features within them can be combined with each other.

[0040] Many specific details are set forth in the following description in order to provide a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Therefore, the scope of protection of the present invention is not limited to the specific embodiments disclosed below.

[0041] Reference Figures 1-2 This embodiment provides a condensation reactor for pharmaceuticals and fine chemicals, including a cylinder 1, a motor 2 located above the cylinder 1, and a stirring shaft 3 connected to the motor 2. The stirring shaft 3 is rotatably disposed inside the cylinder 1. The top of the cylinder 1 is provided with a feed inlet 4, and the bottom of the cylinder 1 is provided with a discharge outlet 5.

[0042] Among them, the feed inlet 4 includes a condensate inlet 401, a carboxyacetonitrile inlet 402, an aniline inlet 403, and a nitrogen inlet 404; it can avoid mixing materials before they are added, reduce cross-contamination between different materials, improve safety, allow the addition of multiple materials at the same time, and help improve production efficiency.

[0043] The top of the cylinder 1 is equipped with two spare ports 20 to adapt to different needs and changes during the production process, which helps to improve flexibility.

[0044] The outer wall of the cylinder 1 is provided with an outer coil 6 with a semi-circular cross-section spiral around the outside. The outer coil 6 is connected to the outer wall of the cylinder 1 with a C-shaped opening. The outer coil 6 has an outer coil medium inlet 601 above it and an outer coil medium outlet 602 below it.

[0045] The bottom of the cylinder 1 is provided with a jacket 7, the jacket medium outlet 702 is provided below the jacket 7, and the jacket medium inlet 701 is provided above the jacket 7. The outer coil medium outlet 602 is connected to the jacket medium inlet 701.

[0046] The external coil medium outlet 602 is connected to the jacket medium inlet 701 via the connecting pipe 17.

[0047] Inside the cylinder 1, an inner coil 8 is spirally arranged near the inner wall. The top of the cylinder 1 has an inner coil medium inlet 801, and the bottom of the cylinder 1 has an inner coil medium outlet 802. The inner coil 8 is fixed to the inner wall of the cylinder 1 by a fixing device.

[0048] The fixing device includes multiple fixing frames 9, which are evenly distributed on the inner wall of the cylinder 1.

[0049] The specific number of fixing brackets 9 depends on actual needs, and this embodiment does not impose a specific limit.

[0050] The mounting bracket 9 has multiple ring structures, which are used to fix the inner coil 8 to the mounting bracket 9.

[0051] Multiple stirring blades 10 are spaced apart along the axial direction of the stirring shaft 3.

[0052] The specific number of stirring blades 10 depends on actual needs, and this embodiment does not impose a specific limit.

[0053] The upper end of the cylinder 1 is provided with a water inlet 11.

[0054] The upper and lower ends of the cylinder 1 are equipped with remote level gauges to detect the height of the liquid inside the cylinder 1 and send the height data to the terminal; the lower end of the cylinder 1 is equipped with a remote thermometer to detect the temperature of the liquid inside the cylinder 1 and send the temperature data to the terminal.

[0055] A thermometer is installed on the outer coil 6 to detect the temperature of the medium inside the outer coil 6; a thermometer is installed at the lower end of the cylinder 1 to detect the temperature of the liquid inside the cylinder 1; a level gauge is installed at the top of the cylinder 1 to detect the height of the liquid inside the cylinder 1.

[0056] The top of the cylinder 1 is provided with a manhole 12, and a sight glass 18 is installed on the manhole 12.

[0057] A sampling port 13 is provided at the lower end of the cylinder 1.

[0058] The cylinder 1 is externally connected to an ear-type support 15, and a grounding plate 16 is provided on the ear-type support 15.

[0059] Among them, a pad 14 is installed between the ear-type support 15 and the cylinder 1 to strengthen the connection.

[0060] The top of the cylinder 1 is provided with a gas outlet 19.

[0061] During application, the materials to be reacted are placed into the cylinder 1 through its dedicated feed port 4. The motor 2 is started to drive the stirring shaft 3, thereby driving the stirring blades 10 to stir inside the cylinder 1. At the same time, heating or cooling media are introduced into the outer coil 6, inner coil 8 and jacket 7 through the outer coil medium inlet 601 and the inner coil medium inlet 801 to ensure that the temperature inside the cylinder 1 meets the temperature conditions required for the reaction. When water needs to be added, it is added through the water inlet 11. During the reaction process, the reaction inside the cylinder 1 is monitored through a remote level gauge, a remote thermometer, a thermometer and a level gauge. At the same time, the operator can check the reaction inside the cylinder 1 through the sight glass 18. Under specified conditions, the operator takes a sample of the reaction liquid through the sampling port 13 to detect and evaluate the progress and status of the reaction. Gases generated during production can be discharged through gas outlet 19. Heating or cooling media can be discharged through inner coil media outlet 802 and jacket media outlet 702. After the reaction is completed, the reaction products are discharged through discharge port 5 at the bottom of cylinder 1. If maintenance and cleaning are required, operators can enter the inside of cylinder 1 through manhole 12 for maintenance and cleaning.

[0062] Although preferred embodiments of the present invention have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments as well as all changes and modifications falling within the scope of the present invention.

[0063] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.

Claims

1. A condensation reactor for pharmaceutical and fine chemical industries, comprising a cylindrical body (1), a motor (2) disposed above the cylindrical body (1), and a stirring shaft (3) connected to the motor (2), wherein the stirring shaft (3) is rotatably disposed inside the cylindrical body (1), the top of the cylindrical body (1) is provided with a feed inlet (4), and the bottom of the cylindrical body (1) is provided with a discharge outlet (5). Its features are: The outer wall of the cylinder (1) is provided with an outer coil (6) with a semi-circular cross-section spirally arranged around the outside. The outer coil (6) is connected to the outer wall of the cylinder (1) with a C-shaped opening. The outer coil (6) has an outer coil medium inlet (601) above it and an outer coil medium outlet (602) below it. The bottom of the cylinder (1) is provided with a jacket (7), the jacket (7) is provided with a jacket medium outlet (702) below the jacket (7) and a jacket medium inlet (701) above the jacket, and the outer coil medium outlet (602) is connected to the jacket medium inlet (701); Inside the cylinder (1), an inner coil (8) is spirally arranged near the inner wall. The top of the cylinder (1) is provided with an inner coil medium inlet (801); the bottom of the cylinder (1) is provided with an inner coil medium outlet (802); the inner coil (8) is fixed to the inner wall of the cylinder (1) by a fixing device.

2. The condensation reaction kettle according to claim 1, characterized in that, The fixing device includes multiple fixing frames (9), which are evenly distributed on the inner wall of the cylinder (1).

3. The condensation reaction kettle according to claim 1, wherein Multiple stirring blades (10) are spaced apart along the axial direction of the stirring shaft (3).

4. The condensation reaction kettle according to claim 1, wherein The upper end of the cylinder (1) is provided with a water inlet (11).

5. The condensation reaction kettle according to claim 1, wherein The upper and lower ends of the cylinder (1) are equipped with remote liquid level gauges for detecting the height of the liquid inside the cylinder (1) and sending the height data to the terminal; the lower end of the cylinder (1) is equipped with a remote thermometer for detecting the temperature of the liquid inside the cylinder (1) and sending the temperature data to the terminal.

6. The condensation reaction kettle according to claim 1, wherein A thermometer is provided on the outer coil (6) to detect the temperature of the medium inside the outer coil (6); a thermometer is provided at the lower end of the cylinder (1) to detect the temperature of the liquid inside the cylinder (1); a level gauge is provided at the top of the cylinder (1) to detect the height of the liquid inside the cylinder (1).

7. The condensation reaction kettle according to claim 1, wherein The top of the cylinder (1) is provided with a manhole (12), and a viewing mirror (18) is installed on the manhole (12).

8. The condensation reaction kettle according to claim 1, characterized in that, The lower end of the cylinder (1) is provided with a sampling port (13).

9. The condensation reaction kettle according to claim 1, wherein The cylinder (1) is externally connected to an ear-type support (15), and a grounding plate (16) is provided on the ear-type support (15).

10. The condensation reaction kettle according to claim 1, wherein The top of the cylinder (1) is provided with a gas outlet (19).

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