Reaction cup taking and conveying device for mass spectrum magnetic bead method

Abstract

The utility model relates to a reaction cup taking and delivering device for a mass spectrum magnetic bead method, which comprises a shell, a reaction cup taking and delivering device, a reaction cup taking and delivering device and a reaction cup taking and delivering device, and the shell is internally provided with a containing cavity and a reaction cup storage space, the lifting mechanism is arranged in the containing cavity, at least part of the lifting mechanism extends to the reaction cup storage space, and the lifting mechanism is provided with a lifting part used for carrying the reaction cup to ascend and descend; the pushing mechanism is provided with a first shifting rod, a cup outlet is formed in the shell, and the first shifting rod can push the reaction cup moving to the preset position to slide out of the cup outlet; the gliding mechanism is connected between the cup outlet and the rotary positioning mechanism; the rotary positioning mechanism is provided with a rotating body, the rotating body is provided with a containing groove, and the rotating body is used for carrying the reaction cups which sequentially pass through the cup outlet and the downward sliding mechanism to slide into the containing groove to rotate to a taking-out station. According to the utility model, the reaction cups are automatically discharged and the positions of the reaction cups are automatically adjusted, so that the working intensity of manually taking the cups is effectively reduced and the taking and conveying efficiency of the reaction cups is improved.

Description

Technical Field

[0001] This utility model relates to the field of medical devices, and in particular to a reaction cup delivery device for mass spectrometry magnetic bead method. Background Technology

[0002] The simple magnetic bead method is one of the main methods currently used for nucleic acid extraction. It involves adding lysis buffer to a reaction vessel containing the sample to release nucleic acids from the cell nucleus; then adding magnetic beads to adsorb the nucleic acids; and finally, using a magnet to concentrate the nucleic acid-laden beads on one side of the reaction vessel. After removing the waste liquid from the reaction vessel, washing buffer is added to wash the nucleic acids. Then, the washing waste liquid is removed, and elution buffer is added to separate the nucleic acids from the magnetic beads. Finally, the magnetic beads are removed to obtain purified nucleic acids. The entire process can be simplified to: lysis, washing, and elution.

[0003] In some scenarios, there is a need to process large quantities of nucleic acids. The removal and transfer of reaction cups are all done manually by staff, which is not only labor-intensive and tedious, but also prone to errors, leading to incorrect test results and serious consequences.

[0004] Currently, there is no effective solution to the problem that manually removing and transporting reaction cups in mass spectrometry magnetic bead methods is labor-intensive, cumbersome, and prone to errors.

[0005] Therefore, this utility model proposes a reaction cup handling device for mass spectrometry magnetic bead method to solve at least one of the above-mentioned technical problems. Utility Model Content

[0006] The purpose of this invention is to provide a reaction cup handling device for mass spectrometry magnetic bead method, which can automatically lift and remove the reaction cup and adjust its position, making it convenient to pick up and transfer to the next process. It is especially suitable for scenarios with large-scale processing of reaction cups, effectively reducing workload and improving the handling efficiency of reaction cups.

[0007] The objective of this utility model can be achieved by the following solutions:

[0008] This utility model provides a reaction cup handling device for mass spectrometry magnetic bead method, comprising:

[0009] The outer casing has a accommodating cavity and a reaction vessel storage space for storing reaction vessels, the reaction vessel storage space being located above the accommodating cavity;

[0010] A lifting mechanism is disposed within the accommodating cavity, and at least a portion of the lifting mechanism extends into the reaction cup storage space. The lifting mechanism has a lifting part that can be lifted and moved vertically, and the lifting part is used to carry the reaction cup in the reaction cup storage space to a preset position in the vertical direction.

[0011] A pushing mechanism is disposed on the top of the housing. The pushing mechanism has a movable and swingable first lever. The top or near the top of the housing has a cup outlet communicating with the reaction cup storage space. The cup outlet is close to the preset position. When the reaction cup is carried to the preset position by the lifting part, the first lever is moved to a position close to the cup outlet and the reaction cup is pushed out of the cup outlet by the swing of the first lever.

[0012] A sliding mechanism and a rotating positioning mechanism are provided. The sliding mechanism is connected between the cup outlet and the rotating positioning mechanism. The sliding mechanism is used to allow the reaction cup to slide from the cup outlet to the rotating positioning mechanism.

[0013] The rotary positioning mechanism has a rotating body with a receiving groove, and the rotating body is used to carry the reaction cup that has slid into the receiving groove to the removal station.

[0014] In a preferred embodiment of the present invention, the lifting mechanism includes a vertically arranged first slide rail, the lower part of which is disposed in the accommodating cavity, the top of which extends upward to the reaction cup storage space and is close to the outlet of the cup, and the lifting part is slidably disposed on the first slide rail.

[0015] In a preferred embodiment of the present invention, the lifting mechanism further includes a first motor, a slider, and a lead screw located within the accommodating cavity. The lead screw is arranged vertically and its bottom is rotatably connected to the bottom inner wall of the housing. The slider is slidably disposed on the first slide rail and connected to the lifting part. The slider is also screwed onto the lead screw. The first motor is fixed to the accommodating cavity by a bracket, and the output shaft of the first motor is connected to the lead screw by a first transmission belt.

[0016] In a preferred embodiment of this utility model, the bottom surface of the reaction cup storage space is an inclined surface that gradually slopes downward from away from the first slide rail to near the first slide rail. A guide cylinder is provided in the reaction cup storage space and around the outer periphery of the first slide rail. The lifting part is movably and vertically disposed in the guide cylinder. The guide cylinder has at least one inlet near the bottom surface of the reaction cup storage space, so that the reaction cup can slide sequentially along the bottom surface of the reaction cup storage space and the inlet into the guide cylinder and fall to the top of the lifting part.

[0017] In a preferred embodiment of the present invention, the top of the outer shell has an outwardly protruding platform, and the pushing mechanism is disposed on the outwardly protruding platform;

[0018] The pushing mechanism includes a second slide rail arranged in a horizontal direction, a slide block that can slide along the second slide rail, a first lever that is rotatably mounted on the slide block, and the first lever is connected to the output shaft of a second motor to drive the first lever to swing.

[0019] In a preferred embodiment of the present invention, the pushing mechanism further includes a driving wheel, a first driven wheel, a second driven wheel, and a second transmission belt. The first driven wheel and the second driven wheel are respectively disposed at both ends of the second slide rail. The driving wheel is located on one side of the second slide rail. The second transmission belt is arranged around the driving wheel, the first driven wheel, and the second driven wheel. The second transmission belt located between the first driven wheel and the second driven wheel is parallel to the extending direction of the second slide rail. The second transmission belt is connected to the slide block to drive the slide block to slide along the second slide rail.

[0020] A third motor is provided on the protruding platform, and the output shaft of the third motor is connected to the drive wheel.

[0021] In a preferred embodiment of the present invention, a second photoelectric sensor and / or an infrared detector are provided on the convex platform, and the second photoelectric sensor and / or the infrared detector are used to collect the position signal of the first lever.

[0022] In a preferred embodiment of the present invention, the sliding mechanism includes a connecting block that is inclined downward from the cup outlet to the rotary positioning mechanism. The connecting block has a groove extending from the cup outlet to the rotary positioning mechanism, and the groove is used for the reaction cup to slide from the cup outlet to the rotary positioning mechanism.

[0023] In a preferred embodiment of the present invention, the rotary positioning mechanism includes a base and a fourth motor. The base has a mounting recess, and the rotating body is rotatably disposed in the mounting recess. The fourth motor is disposed below the base and the output shaft of the fourth motor is connected to the rotating body. The fourth motor is used to drive the rotating body to rotate in the mounting recess.

[0024] The base has a notch communicating with the slide groove, and a plurality of receiving grooves are provided on the base at intervals along the circumference of the base near its edge. The sidewalls of the plurality of receiving grooves are open so that the receiving grooves that rotate with the rotating body to a position relative to the sliding mechanism communicate with the slide groove through the openings.

[0025] In a preferred embodiment of this utility model, the base has a take-out groove communicating with the mounting recess, and the location of the take-out groove is the take-out station. A rotatable second lever is provided on the base near the take-out groove. The second lever is connected to the output shaft of a fifth motor. When the receiving groove containing the reaction cup rotates to the position communicating with the take-out groove, the fifth motor drives the second lever to swing, so as to push the reaction cup located in the receiving groove into the take-out groove through the second lever.

[0026] As described above, the features and advantages of this utility model for handling reaction cups in mass spectrometry magnetic bead method are:

[0027] The outer casing contains a accommodating cavity and a reaction cup storage space. A cup outlet is located at or near the top of the outer casing. A lifting mechanism is installed within the accommodating cavity and extends into the reaction cup storage space. The lifting mechanism has a movable lifting section. By controlling the lifting section, the reaction cups in the storage space can be moved vertically to a preset position (located near the cup outlet). During operation, when the reaction cup is carried to the preset position by the lifting section, a first lever can be moved to a position near the cup outlet. By controlling the swing of the first lever, the reaction cup located at the preset position is pushed out of the cup outlet. The reaction cup sliding out of the cup outlet slides down to the rotary positioning mechanism under the sliding guide of the sliding mechanism and is received by the accommodating groove on the rotating body of the rotary positioning mechanism. Then, by controlling the rotation of the rotating body, the reaction cup located therein is rotated to the removal station. At the removal station, the operator can directly remove the reaction cup and transfer it to the next process. The entire process enables the storage, automatic dispensing, and automatic movement of reaction cups to the dispensing position, making it easier to pick up and transfer reaction cups. The degree of automation is greatly improved, making it particularly suitable for scenarios involving large-scale processing of reaction cups. It can effectively reduce workload and improve the efficiency of picking up and delivering reaction cups. Attached Figure Description

[0028] The following figures are intended only to illustrate and explain the present invention and do not limit the scope of the present invention. Wherein:

[0029] Figure 1 This is a perspective view of a reaction cup handling device for mass spectrometry magnetic bead method according to the present invention;

[0030] Figure 2 This is a schematic diagram of the internal structure of a reaction cup handling device for mass spectrometry magnetic bead method according to the present invention;

[0031] Figure 3 This is a schematic diagram of the pushing device in a reaction cup handling device for mass spectrometry magnetic bead method according to the present invention;

[0032] Figure 4 This is a schematic diagram of the sliding mechanism and the rotary positioning mechanism in a reaction cup handling device for mass spectrometry magnetic bead method according to the present invention.

[0033] The reference numerals in the accompanying drawings of this utility model are:

[0034] 1. Outer shell; 101. Receiving cavity;

[0035] 102. Reaction cup storage space; 103. Guide tube;

[0036] 1031. Imported; 104. Protruding platform;

[0037] 105. Connecting rod; 106. Top cover;

[0038] 107. Cup outlet;

[0039] 2. Reaction cup;

[0040] 3. Lifting mechanism;

[0041] 301. First slide rail; 302. Lifting unit;

[0042] 303. First motor; 304. Slider;

[0043] 305. Lead screw;

[0044] 4. Push notification providers;

[0045] 401. Second slide rail; 402. Drive wheel;

[0046] 403. First driven gear; 404. Second driven gear;

[0047] 405. Second transmission belt; 406. First lever;

[0048] 407. Slide;

[0049] 5. Sliding mechanism; 501. Slide groove;

[0050] 6. Rotary positioning mechanism; 601. Base;

[0051] 602, Rotating body; 6021, Receiving groove;

[0052] 603. Fourth motor; 604. Second lever;

[0053] 605. Positioning plate; 6051. Positioning notch;

[0054] 606. Fiber optic sensor; 607. Third photoelectric sensor;

[0055] 7. First photoelectric sensor;

[0056] 8. Second photoelectric sensor;

[0057] 9. Infrared detector. Detailed Implementation

[0058] The technical solution of this utility model will be described in detail below with reference to the accompanying drawings and specific embodiments. It should be understood that these embodiments are only used to illustrate this utility model and are not intended to limit the scope of this utility model. After reading this utility model, any modifications of this utility model in various equivalent forms by those skilled in the art will fall within the scope defined by the appended claims.

[0059] It should be noted that when an element is referred to as being "set on" another element, it can be directly on the other element or there may be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or there may be an intervening element. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only possible implementation.

[0060] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0061] like Figures 1 to 4As shown, this utility model provides a reaction cup handling device for mass spectrometry magnetic bead method. The device includes a housing 1, a lifting mechanism 3, a pushing mechanism 4, a sliding mechanism 5, and a rotation positioning mechanism 6. The housing 1 is generally a vertically arranged cuboid shape. The housing 1 has a receiving cavity 101 and a reaction cup storage space 102. The reaction cup storage space 102 is used to store the reaction cup 2 to be processed. The receiving cavity 101 is used to accommodate the lifting mechanism 3, and the reaction cup storage space 102 is located above the receiving cavity 101. The lifting mechanism 3 is disposed within the receiving cavity 101, and at least a portion of the lifting mechanism 3 extends upward into the reaction cup storage space 102. The lifting mechanism 3 has a lifting part 302 that can be lifted and moved vertically, used to carry the reaction cup 2 in the reaction cup storage space 102 to a preset position. The pushing mechanism 4 is disposed at the top of the housing 1. The housing 1 has a movable and swingable first lever 406. The top or near the top of the housing 1 has a cup outlet 107 that communicates with the reaction cup storage space 102. The cup outlet 107 is close to a preset position. When the reaction cup 2 is carried to the preset position by the lifting part 302, the first lever 406 is used to move to a position close to the cup outlet 107 and push the reaction cup 2 out of the cup outlet 107 by swinging the first lever 406. The sliding mechanism 5 is connected between the cup outlet 107 and the rotary positioning mechanism 6. The sliding mechanism 5 is used to allow the reaction cup 2 to slide from the cup outlet 107 to the rotary positioning mechanism 6. The rotary positioning mechanism 6 has a rotating body 602. The rotating body 602 has a receiving groove 6021. The reaction cup 2 can slide along the sliding mechanism 5 into the receiving groove 6021 of the rotating body 602. The rotating body 602 is used to carry the reaction cup 2 that has slid into the receiving groove 6021 to the removal position.

[0062] In this invention, the preset position to which the lifting part 302 moves vertically can be set by the user. The preset position is preferably located near the cup outlet 107, so that the first lever 406 can push the reaction cup 2 located at the preset position to the cup outlet 107 in the swing state, so that the reaction cup 2 can slide out from the cup outlet 107.

[0063] In this invention, a receiving cavity 101 and a reaction cup storage space 102 for storing a reaction cup 2 are formed inside the outer shell 1. A cup outlet 107 is located at or near the top of the outer shell 1. A lifting mechanism 3 is provided within the receiving cavity 101, extending upwards into the reaction cup storage space 102. The lifting mechanism 3 has a movable lifting section 302, on which the reaction cup 2 can be positioned. By controlling the lifting movement of the lifting section 302, the reaction cup 2 within the reaction cup storage space 102 can be vertically moved to a preset position (this preset position is located near the cup outlet 107). During operation, when the reaction... When cup 2 is carried to the preset position by the lifting unit 302, the first lever 406 can be controlled to move to a position close to the cup outlet 107. The swinging of the first lever 406 is then controlled to push the reaction cup 2, located at the preset position, out of the cup outlet 107. The reaction cup 2, sliding out of the cup outlet 107, slides down to the rotary positioning mechanism 6 under the sliding guide of the sliding mechanism 5, and is received by the receiving groove 6021 on the rotating body 602 in the rotary positioning mechanism 6. Then, the rotation of the rotating body 602 is controlled to carry the reaction cup 2 to the extraction station, where workers can directly extract the reaction cup 2 and transfer it to the next process. Throughout this process, the storage, automatic dispensing, and automatic movement to the extraction position of the reaction cup 2 can be controlled, making it easier to retrieve and transfer the reaction cup 2. The degree of automation is greatly improved, making it particularly suitable for scenarios involving large-scale processing of reaction cup 2, effectively reducing workload and improving the efficiency of retrieving and delivering the reaction cup 2.

[0064] In one optional embodiment of this utility model, such as Figure 2 As shown, the lifting mechanism 3 includes a vertically arranged first slide rail 301. The lower part of the first slide rail 301 is disposed in the accommodating cavity 101 and fixed to the bottom inner wall of the accommodating cavity 101. The top of the first slide rail 301 extends upward to the reaction cup storage space 102 and is close to the outlet 107. The lifting part 302 is slidably disposed on the first slide rail 301, and the lifting part 302 can be lifted and moved by means of the first slide rail 301.

[0065] In this embodiment, as Figure 2As shown, the lifting mechanism 3 also includes a first motor 303, a slider 304, and a lead screw 305 located in the accommodating cavity 101. The lead screw 305 is arranged vertically and its bottom is rotatably connected to the bottom inner wall of the outer casing 1. The slider 304 is slidably arranged on the first slide rail 301 and can be connected to the lifting part 302 through a vertically arranged connecting rod or connecting plate. In addition, the slider 304 is also screwed onto the lead screw 305. The first motor 303 is fixed in the accommodating cavity 101 by a bracket, and the output shaft of the first motor 303 is connected to the lead screw 305 through a first transmission belt. During operation, the first motor 303 provides driving force, which drives the lead screw 305 to rotate via the first transmission belt. Since the slider 304 is connected between the lead screw 305 and the first slide rail 301, the rotation of the lead screw 305 will drive the slider 304 to move vertically along the first slide rail 301. Since the lifting part 302 is connected to the slider 304, the lifting part 302 will move synchronously with the slider 304, thereby realizing the automated control of the vertical movement of the lifting part 302, realizing the adjustment of the vertical position of the reaction cup 2, and preparing for cup dispensing.

[0066] Furthermore, such as Figure 2 As shown, a first photoelectric sensor 7 is provided at or near the top of the lead screw 305. When the slider 304 slides to the position of the first photoelectric sensor 7, the lifting part 302 moves to a preset position. Thus, the position signal of the slider 304 can be detected by the first photoelectric sensor 7. When the first photoelectric sensor 7 detects the position signal of the slider 304, it indicates that the lifting part 302 has moved the reaction cup 2 to the preset position, in order to proceed with the next step of pushing the cup out.

[0067] In one optional embodiment of this utility model, such as Figure 2As shown, the bottom surface of the reaction cup storage space 102 is an inverted conical slope that gradually slopes downward from away from the first slide rail 301 to near the first slide rail 301. This inverted conical slope is located in the middle of the outer shell 1. The inverted conical slope divides the interior of the outer shell 1 into the accommodating cavity 101 and the reaction cup storage space 102. A guide cylinder 103 is provided in the reaction cup storage space 102 and around the outer periphery of the first slide rail 301. The lifting part 302 is movably and vertically disposed in the guide cylinder 103. The cylinder wall of the guide cylinder 103 and near the bottom surface of the reaction cup storage space 102 has at least one inlet 1031, so that the reaction cup 2 can slide into the guide cylinder 103 along the bottom surface of the reaction cup storage space 102 and the inlet 1031 and fall to the top of the lifting part 302. Then the lifting part 302 drives the reaction cup 2 to move upward. The preset position can be located at the top opening of the guide cylinder 103. When the lifting part 302 just moves the reaction cup 2 out of the top opening of the guide cylinder 103 to the outside of the guide cylinder 103, the reaction cup 2 is just located near the outlet 107. The pushing mechanism 4 can then push the reaction cup 2 to slide out of the outlet 107.

[0068] Furthermore, the bottom surface of the reaction cup storage space 102 has a guide groove (not shown), which extends slopingly downwards along the inclined surface, and the bottom end of the guide groove is connected to the inlet 1031. The reaction cups 2 stored in the reaction cup storage space 102 are arranged sequentially along the guide groove. Because the guide groove is sloping along the bottom surface of the reaction cup storage space 102, the combustible guide grooves of the reaction cups 2 slide sequentially through the inlet 1031 into the guide cylinder 103 and fall onto the lifting unit 302, thus allowing for rapid and orderly processing of multiple reaction cups 2. Alternatively, a conveyor belt can be installed within the guide groove, allowing multiple reaction cups 2 located within the guide groove to be moved towards the inlet 1031 by the conveyor belt, ensuring the stability of the reaction cup movement and preventing cup jamming.

[0069] Furthermore, a valve (not shown) is provided at the inlet 1031, and the opening and closing state of the inlet 1031 is controlled by the valve, thereby controlling the entry of the reaction cup 2 into the guide tube 103.

[0070] In one optional embodiment of this utility model, such as Figure 2 As shown, the lifting part 302 can be a support tray that slides vertically along the first slide rail 301, which can support the reaction cup 2 on the top of the support tray so as to carry the reaction cup 2 vertically. The top of the support tray can be provided with a positioning groove or positioning hole, and the lower part of the reaction cup 2 is embedded in the positioning groove or positioning hole, so as to position the reaction cup 2 on the support tray and ensure the stability of the reaction cup 2.

[0071] In another optional embodiment of this utility model, the lifting part 302 can be a mechanical gripper that slides vertically along the first slide rail 301. The opening and closing and clamping actions of the mechanical gripper can be automatically controlled. The mechanical gripper can hold the reaction cup 2 and move it to a preset position along the first slide rail 301.

[0072] In one optional embodiment of this utility model, such as Figures 1 to 3 As shown, the top of the outer casing 1 has a rearwardly protruding platform 104, and the pushing mechanism 4 is disposed on the protruding platform 104. The pushing mechanism 4 includes a second slide rail 401 arranged horizontally, a slide block 407 that can slide along the second slide rail 401, and a first lever 406 rotatably disposed on the slide block 407. The first lever 406 is connected to the output shaft of a second motor, and the output shaft of the second motor can drive the first lever 406 to swing. During operation, when the lifting unit 302 carries the reaction cup 2 to a preset position, the first lever 406 can move along the second slide rail 401 towards the preset position with the slide block 407. After the first lever 406 moves to a position where it can push the reaction cup 2, it can stop moving. The output shaft of the second motor drives the first lever 406 to swing, thereby pushing the reaction cup 2 located at the preset position to slide out from the outlet 107.

[0073] In this embodiment, as Figure 3 As shown, the pushing mechanism 4 also includes a driving wheel 402, a first driven wheel 403, a second driven wheel 404, and a second transmission belt 405. The first driven wheel 403 is disposed at one end of the second slide rail 401, and the second driven wheel 404 is disposed at the other end of the second slide rail 401. The driving wheel 402 is located on one side of the second slide rail 401. The second transmission belt 405 is arranged around the driving wheel 402, the first driven wheel 403, and the second driven wheel 404. The second transmission belt 405 located between the first driven wheel 403 and the second driven wheel 404 is parallel to the extension direction of the second slide rail 401. The second transmission belt 405 is connected to the slide block 407 so that the slide block 407 can be driven to slide along the second slide rail 401 through the second transmission belt 405, thereby realizing the sliding of the first lever 406 along the second slide rail 401. Of course, in other embodiments, the second slide rail 401 can also be an electric slide rail, which can drive the first lever 406 to slide along the second slide rail 401 without the need for the second transmission belt 405.

[0074] Furthermore, a third motor is provided on the protruding platform 104. The output shaft of the third motor is connected to the drive wheel 402, thereby providing driving force to drive the drive wheel 402 to rotate.

[0075] Furthermore, such as Figure 3As shown, a second photoelectric sensor 8 and / or an infrared detector 9 are provided on the convex platform 104. The second photoelectric sensor 8 and / or infrared detector 9 are used to collect the position signal of the first lever 406. When the first lever 406 moves into position, the first lever 406 is controlled to swing.

[0076] In one optional embodiment of this utility model, such as Figure 1 , Figure 4 As shown, the sliding mechanism 5 includes a long strip-shaped connecting block that is inclined downward from the cup outlet 107 to the rotary positioning mechanism 6. The connecting block has a groove 501 extending from the cup outlet 107 to the rotary positioning mechanism 6. The reaction cup 2 that slides out from the cup outlet 107 enters the groove 501. The groove 501 serves as a sliding guide so that the reaction cup 2 can slide from the cup outlet 107 to the rotary positioning mechanism 6.

[0077] In one optional embodiment of this utility model, such as Figure 1 , Figure 4 As shown, the rotary positioning mechanism 6 includes a base 601 and a fourth motor 603. The base 601 is a polygonal block structure with a cylindrical mounting recess at its top. The rotating body 602 is a cylindrical structure adapted to the mounting recess and is rotatably disposed within it. The fourth motor 603 is located below and connected to the base 601, and its output shaft is connected to the rotating body 602. The output shaft of the fourth motor 603 can drive the rotating body 602 to rotate within the mounting recess. The base 601 has a notch communicating with a sliding groove 501. A plurality of receiving grooves 6021 are evenly and spaced along the circumference of the base 601 near its edge. The sidewalls of the multiple receiving grooves 6021 are open so that the receiving grooves 6021 that rotate with the rotating body 602 to a position opposite to the sliding mechanism 5 can communicate with the slide groove 501 through the notch on the base 601 through the opening on the sidewall. This allows the reaction cup 2 that slides down the slide groove 501 to fall into the receiving groove 6021 after passing through the notch, thereby positioning the reaction cup 2 on the rotating body 602 so that the reaction cup 2 can rotate with the rotating body 602 to the removal position.

[0078] Furthermore, such as Figure 4As shown, the base 601 has a take-out groove that communicates with the mounting recess. The location of the take-out groove is the take-out station. A rotatable second lever 604 is provided on the base 601 near the take-out groove. The second lever 604 is connected to the output shaft of the fifth motor. When the receiving groove 6021 containing the reaction cup 2 rotates to the position communicating with the take-out groove, the output shaft of the fifth motor drives the second lever 604 to swing, so as to push the reaction cup 2 located in the receiving groove 6021 into the take-out groove, thereby realizing the transfer of the reaction cup 2 to the take-out station. After that, the operator can take out the reaction cup 2 from the take-out station and proceed to the next process.

[0079] Furthermore, such as Figure 4 As shown, an optical fiber sensor 606 is installed on the base 601 near the extraction slot. The optical fiber sensor 606 is used to detect the position signal of the reaction cup 2 in the extraction slot. When the reaction cup 2 is present at the extraction station, the signal can be collected and transmitted through the optical fiber sensor 606 so that the staff can know the position information of the reaction cup 2 in a timely manner. In addition, the setting of the optical fiber sensor 606 can also ensure the accuracy of the rotation angle of the rotating body 602 each time, so that the rotating body 602 stops in time after rotating into position, so that the second lever 604 can smoothly push the reaction cup 2 located in the receiving slot 6021 into the extraction slot.

[0080] Furthermore, such as Figure 4 As shown, a circular positioning disk 605 is horizontally positioned below the fourth motor 603. The center of the positioning disk 605 is connected to the output shaft of the fourth motor 603. The fourth motor 603 drives the positioning disk 605 to rotate synchronously with the rotating body 602. Multiple positioning notches 6051 are located on the edge of the positioning disk 605, and these notches correspond vertically to multiple receiving slots 6021. A third photoelectric sensor 607 is located on one side of the positioning disk 605. The third photoelectric sensor 607 detects the position signal of the positioning notch 6051. Based on the position of the positioning notch 6051, the position of the receiving slot 6021 as it rotates with the rotating body 602 can be determined. By transmitting this position signal to the host or display, the operator can know the position of the reaction cup 2 as it rotates with the rotating body 602, facilitating the removal of the reaction cup 2.

[0081] Furthermore, such as Figure 1 As shown, a connecting rod 105 is fixedly installed on the outer wall of the outer casing 1. The connecting rod 105 extends to the position of the rotary positioning mechanism 6 and is connected to the base 601 and / or the fourth motor 603 through the connecting rod 105, thereby fixing the position of the rotary positioning mechanism 6 and ensuring that the position of the rotary positioning mechanism 6 relative to the outer casing 1 is stable.

[0082] In one optional embodiment of this utility model, such as Figure 1 , Figure 2 As shown, a top cover 106 that can be flipped open or closed is provided on the top of the outer shell 1. The reaction cup 2 to be processed can be placed into the reaction cup storage space 102 by opening the top cover 106.

[0083] The working process of the reaction cup handling device for mass spectrometry magnetic bead method of this utility model is as follows:

[0084] First, open the top cover 106 and place the reaction cup 2 to be processed into the reaction cup storage space 102. When it is necessary to remove the reaction cup 2, the first motor 303 drives the lifting part 302 to move down along the first slide rail 301 to below the inlet 1031. Then, the valve at the inlet 1031 can be opened, and the reaction cup 2 in the reaction cup storage space 102 can slide down to the inlet 1031 and slide into the guide cylinder 103, falling onto the lifting part 302 (when the reaction cup 2 is on the lifting part 302, the valve is closed to prevent the reaction cup 2 from causing blockage in the inlet 1031 or the guide cylinder 103). Then, the first motor 303 is started again to drive the lifting part 302 to move up along the first slide rail 301 to the preset position. When the reaction cup 2 reaches the preset position, the drive wheel 402 drives the second transmission belt 405 to move, thereby driving the slide block 407 and the first lever 406 to move along the second slide rail 401 towards the preset position. After the reaction cup 2 is moved to a certain position, it can stop moving. Then, the output shaft of the second motor drives the first lever 406 to swing. The first lever 406 pushes the reaction cup 2, which is located at a preset position, to slide out of the outlet 107 into the slide groove 501. The reaction cup 2 slides down the slide groove 501 and falls into the receiving groove 6021 on the rotating body 602 after passing through the notch on the base 601. The receiving groove 6021 positions the reaction cup 2, and the reaction cup 2 can rotate synchronously with the rotating body 602. When the reaction cup 2 rotates with the rotating body 602 to a preset angle, the receiving groove 6021 containing the reaction cup 2 is connected to the take-out groove. At this time, the output shaft of the fifth motor drives the second lever 604 to swing. The second lever 604 pushes the reaction cup 2 located in the receiving groove 6021 into the take-out groove. The operator can take out the reaction cup 2 located at this position and transfer it to the next process.

[0085] The features and advantages of the reaction cup handling device for mass spectrometry magnetic bead method of this utility model are as follows:

[0086] This reaction vessel handling device for mass spectrometry magnetic bead method can realize the storage, automatic dispensing, and automatic movement of reaction vessel 2 to the dispensing position, making it easier to pick up and transfer reaction vessel 2, greatly improving the degree of automation. It is especially suitable for scenarios with large-scale processing of reaction vessel 2, effectively reducing workload and improving the handling efficiency of reaction vessel 2.

[0087] It should be noted that in the description of this application, the terms "first," "second," etc., are used only for descriptive purposes and to distinguish similar objects; there is no order between them, nor should they be construed as indicating or implying relative importance. Furthermore, in the description of this application, unless otherwise stated, "a plurality of" means two or more.

[0088] The various embodiments described in this specification are presented in a progressive manner. The same or similar parts between the embodiments can be referred to each other. Each embodiment focuses on the differences from other embodiments.

[0089] The above are merely a few embodiments of this utility model. Although the embodiments disclosed in this utility model are as described above, the content is only for the purpose of facilitating understanding of this utility model and is not intended to limit this utility model. Any person skilled in the art to which this utility model pertains may make any modifications and changes in the form and details of the embodiments without departing from the spirit and scope disclosed in this utility model. However, the patent protection scope of this utility model shall still be determined by the scope defined in the appended claims.

Claims

1. A reaction cup pick-and-place device for magnetic bead mass spectrometry, characterized by, include: The outer casing has a accommodating cavity and a reaction vessel storage space for storing reaction vessels, the reaction vessel storage space being located above the accommodating cavity; A lifting mechanism is disposed within the accommodating cavity, and at least a portion of the lifting mechanism extends into the reaction cup storage space. The lifting mechanism has a lifting part that can be lifted and moved vertically, and the lifting part is used to carry the reaction cup in the reaction cup storage space to a preset position in the vertical direction. A pushing mechanism is disposed on the top of the housing. The pushing mechanism has a movable and swingable first lever. The top or near the top of the housing has a cup outlet communicating with the reaction cup storage space. The cup outlet is close to the preset position. When the reaction cup is carried to the preset position by the lifting part, the first lever is moved to a position close to the cup outlet and the reaction cup is pushed out of the cup outlet by the swing of the first lever. A sliding mechanism and a rotating positioning mechanism are provided. The sliding mechanism is connected between the cup outlet and the rotating positioning mechanism. The sliding mechanism is used to allow the reaction cup to slide from the cup outlet to the rotating positioning mechanism. The rotary positioning mechanism has a rotating body with a receiving groove, and the rotating body is used to carry the reaction cup that has slid into the receiving groove to the removal station.

2. The reaction cup handling device for mass spectrometry magnetic bead method as described in claim 1, characterized in that, The lifting mechanism includes a vertically arranged first slide rail, the lower part of which is disposed in the accommodating cavity, and the top of which extends upward to the reaction cup storage space and is close to the outlet of the cup. The lifting part is slidably disposed on the first slide rail.

3. A reaction cup pick-and-place device for magnetic bead mass spectrometry as defined in claim 2, wherein, The lifting mechanism further includes a first motor, a slider, and a lead screw located within the accommodating cavity. The lead screw is arranged vertically and its bottom is rotatably connected to the bottom inner wall of the housing. The slider is slidably disposed on the first slide rail and connected to the lifting part. The slider is also screwed onto the lead screw. The first motor is fixed to the accommodating cavity by a bracket, and the output shaft of the first motor is connected to the lead screw by a first transmission belt.

4. A reaction cup pick-and-place device for magnetic bead mass spectrometry as defined in claim 2, wherein, The bottom surface of the reaction cup storage space is an inclined surface that gradually slopes downward from away from the first slide rail to closer to the first slide rail. A guide cylinder is provided in the reaction cup storage space and around the outer perimeter of the first slide rail. The lifting part is movably and vertically disposed in the guide cylinder. The guide cylinder has at least one inlet near the bottom surface of the reaction cup storage space, so that the reaction cup can slide sequentially along the bottom surface of the reaction cup storage space and the inlet into the guide cylinder and fall to the top of the lifting part.

5. The reaction cup pick-and-place device for magnetic bead mass spectrometry of claim 1, wherein, The top of the outer casing has a protruding platform, and the pushing mechanism is disposed on the protruding platform; The pushing mechanism includes a second slide rail arranged in a horizontal direction, a slide block that can slide along the second slide rail, a first lever that is rotatably mounted on the slide block, and the first lever is connected to the output shaft of a second motor to drive the first lever to swing.

6. A reaction cup pick-and-place device for magnetic bead mass spectrometry as defined in claim 5, wherein, The pushing mechanism further includes a driving wheel, a first driven wheel, a second driven wheel, and a second transmission belt. The first driven wheel and the second driven wheel are respectively disposed at both ends of the second slide rail. The driving wheel is located on one side of the second slide rail. The second transmission belt is arranged around the driving wheel, the first driven wheel, and the second driven wheel. The second transmission belt located between the first driven wheel and the second driven wheel is parallel to the extension direction of the second slide rail. The second transmission belt is connected to the slide block to drive the slide block to slide along the second slide rail. A third motor is provided on the protruding platform, and the output shaft of the third motor is connected to the drive wheel.

7. A reaction cup pick-and-place device for magnetic bead mass spectrometry as defined in claim 6, wherein, A second photoelectric sensor and / or an infrared detector are provided on the protruding platform. The second photoelectric sensor and / or the infrared detector are used to collect the position signal of the first lever.

8. The reaction cup pick-and-place device for magnetic bead mass spectrometry of claim 1, wherein, The sliding mechanism includes a connecting block that is inclined downward from the cup outlet to the rotary positioning mechanism. The connecting block has a groove extending from the cup outlet to the rotary positioning mechanism. The groove is used for the reaction cup to slide from the cup outlet to the rotary positioning mechanism.

9. A reaction cup pick-and-place device for magnetic bead mass spectrometry as defined in claim 8, wherein, The rotary positioning mechanism includes a base and a fourth motor. The base has a mounting recess, and the rotating body is rotatably disposed in the mounting recess. The fourth motor is disposed below the base and its output shaft is connected to the rotating body. The fourth motor is used to drive the rotating body to rotate within the mounting recess. The base has a notch communicating with the slide groove, and a plurality of receiving grooves are provided on the base at intervals along the circumference of the base near its edge. The sidewalls of the plurality of receiving grooves are open so that the receiving grooves that rotate with the rotating body to a position relative to the sliding mechanism communicate with the slide groove through the openings.

10. The reaction cup handling device for mass spectrometry magnetic bead method as described in claim 9, characterized in that, The base has a take-out groove that communicates with the mounting recess. The location of the take-out groove is the take-out station. A rotatable second lever is provided on the base near the take-out groove. The second lever is connected to the output shaft of the fifth motor. When the receiving groove containing the reaction cup rotates to the position communicating with the take-out groove, the fifth motor drives the second lever to swing, so as to push the reaction cup located in the receiving groove into the take-out groove through the second lever.

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