Reciprocating type driving rod with electromagnet

Abstract

The utility model provides a reciprocating type driving rod with an electromagnet, which belongs to the technical field of medical detection and comprises a shaft rod and an electromagnet module, the electromagnet module is fixedly connected with the shaft rod and comprises an iron core, a coil and a protective cover, the protective cover is connected with the iron core, and an annular sealing cavity is formed between the protective cover and the iron core. The coil is located in the annular sealing cavity and wound around the iron core with the shaft rod as the center. The device has the beneficial effects that a magnetic field can be generated or disconnected by controlling the on-off of the current of the coil in the enrichment process, and the coil is wound on the iron core by taking the shaft rod as the center, so that when the shaft rod is positioned in the center of the reaction chamber, the magnetic field can be generated or disconnected on the premise of ensuring that the shaft rod and the electromagnet module do not generate position interference; and the magnetic field generated by the electromagnet module is also located at the central position of the reaction chamber, so that the magnetic fields at all positions in the reaction chamber are uniformly distributed, and the magnetic enrichment effect of the CTCs-magnetic bead compound is ensured.

Description

Technical Field

[0001] This utility model belongs to the field of medical testing technology and relates to a reciprocating drive rod with an electromagnet. Background Technology

[0002] The detection of circulating tumor cells (CTCs) is of great significance for early cancer diagnosis, disease monitoring, treatment evaluation, and prognosis. CTCs are extremely rare in blood (only 0-100 CTCs per mL), making the enrichment and detection of CTCs from blood a crucial issue. Among various enrichment methods, immunomagnetic bead assays are widely used due to their rapid and non-destructive separation. This method is based on the binding of CTC surface-specific antigens to antibodies on magnetic beads, achieving enrichment through an external magnetic field, followed by detection using surface-enhanced Raman scattering (SERS) technology.

[0003] Currently, there are very few devices based on SERS technology for screening and separating circulating tumor cells. For example, there is an invention patent with application number CN202010514536.0 entitled "A Screening and Separating Device, Method and Application for Circulating Tumor Cells". This device has a piston and a glass tube equipped with a magnetic component. It transfers liquid through the reciprocating motion of the piston and enriches CTCs-magnetic bead complexes through the magnetic component and the glass tube.

[0004] Because the piston and the glass tube (magnetic component) exist independently in the above device, the following problems exist:

[0005] 1. The glass tube contains a permanent magnet. Although the CTCs-magnetic bead composite can be adsorbed onto the surface of the glass tube during the magnetic enrichment process, the permanent magnet needs to be removed first during the cleaning process to remove the magnetic field from the glass tube before the CTCs-magnetic bead composite can be cleaned off. The process is quite troublesome.

[0006] 2. Because the piston rod is located in the center of the reaction chamber, the glass tube cannot make the center of the magnetic field in the center of the reaction chamber due to positional interference, which leads to uneven magnetic field distribution. The CTCs-magnetic bead complex far from the center of the magnetic field cannot be effectively enriched because the magnetic field strength is too weak.

[0007] Based on the above problems, there is still much room for improvement and optimization in key aspects such as the synergy of mechanical structure and the optimization of magnetic field spatial distribution in existing circulating tumor cell screening and separation devices. Utility Model Content

[0008] The purpose of this invention is to address the aforementioned problems in the existing technology by proposing a reciprocating drive rod with an electromagnet.

[0009] The objective of this utility model can be achieved through the following technical solution: A reciprocating drive rod with an electromagnet, comprising: a shaft and an electromagnet module, wherein the electromagnet module is fixedly connected to the shaft, the electromagnet module includes an iron core, a coil and a protective cover, the protective cover is connected to the iron core and an annular sealed cavity is formed between the two, the coil is located in the annular sealed cavity, and the coil is wound around the iron core with the shaft as the center.

[0010] Preferably, the iron core includes a base portion and a circular boss portion protruding from a surface of the base portion, and the coil is wound around the outer peripheral surface of the circular boss portion.

[0011] Preferably, the protective cover includes a top cover and a peripheral wall portion that protrudes axially from the edge of the top cover, the top cover and the peripheral wall portion forming an opening, the chassis portion sealing the opening, the edge of one surface of the chassis portion being sealed to the end face of the peripheral wall portion, the circular boss portion being located inside the opening, and the annular sealing cavity being formed between the outer peripheral surface of the circular boss portion and the inner peripheral surface of the peripheral wall portion.

[0012] Preferably, the top cover, the chassis, and the circular boss are concentrically arranged, and the shaft passes through the center of the top cover, the chassis, and the circular boss.

[0013] Preferably, the surface of the circular boss portion is sealed to the inner wall surface of the top cover portion.

[0014] Preferably, the shaft is a hollow structure and is provided with a wiring hole extending along its axial direction. The portion of the shaft located in the contact area between the top cover and the circular boss is provided with a wiring opening. The wiring opening passes through the wall of the shaft and communicates with the wiring hole. Both ends of the coil are inserted into the wiring hole through the wiring opening.

[0015] Preferably, the surface of the circular boss is provided with a groove, and the two ends of the coil pass through the groove through the area sealed between the circular boss and the top cover.

[0016] Preferably, a sealing ring is provided on the outer peripheral surface of the electromagnet module, and the electromagnet module forms a piston structure through the sealing ring.

[0017] Preferably, a piston block is provided on the shaft, and the piston block and the electromagnet module are arranged sequentially in the direction toward the top of the shaft.

[0018] Preferably, the top of the shaft is provided with a connecting part.

[0019] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0020] 1. During the enrichment process, the magnetic field can be generated or disconnected by controlling the on and off of the coil current. The coil is wound around the iron core with the shaft as the center. When the shaft is located in the center of the reaction chamber, the magnetic field generated by the electromagnet module is also located in the center of the reaction chamber, ensuring that the shaft and the electromagnet module do not interfere with each other. This makes the magnetic field distribution in the reaction chamber uniform and ensures the magnetic enrichment effect of the CTCs-magnetic bead composite.

[0021] 2. Designing wiring holes inside the shaft can meet the wiring requirements of the coil, which not only enables concealed wiring but also eliminates the possibility of the coil ends being exposed to the liquid environment due to wiring.

[0022] 3. The main function of the shaft is to drive the piston structure (Example 1) or piston block (Example 2) to reciprocate, thereby achieving automatic liquid transfer within the reaction chamber. During liquid transfer, the piston structure or piston block divides the reaction chamber into an upper chamber and a lower chamber, with the liquid located in the upper chamber. When it is necessary to drain the liquid from the upper chamber, the shaft moves upward, causing the liquid in the upper chamber to transfer to the lower chamber; when the shaft moves downward, the liquid in the lower chamber is drained from the reaction chamber. Liquid transfer is achieved through the reciprocating motion of the shaft in conjunction with the piston structure or piston block. Attached Figure Description

[0023] Figure 1 This is an exploded view of the reciprocating drive rod of this utility model.

[0024] Figure 2 This is a schematic diagram of the reciprocating drive rod of this utility model.

[0025] Figure 3 This is a schematic diagram of the iron core structure of this utility model.

[0026] Figure 4 This is a schematic diagram of the assembled iron core and protective cover of this utility model.

[0027] Figure 5 This is a structural schematic diagram of Embodiment 1 of the present invention.

[0028] Figure 6 This is a schematic diagram of the structure of Embodiment 2 of this utility model.

[0029] In the diagram, 100 is the shaft; 110 is the wiring hole; 120 is the wiring opening; 130 is the connecting part; 200 is the electromagnet module; 210 is the iron core; 211 is the chassis; 212 is the circular boss; 213 is the groove; 220 is the coil; 230 is the protective cover; 231 is the top cover; 232 is the peripheral wall; 240 is the annular sealing cavity; and 300 is the piston block. Detailed Implementation

[0030] The following are specific embodiments of the present invention, which are described in conjunction with the accompanying drawings. However, the present invention is not limited to these embodiments.

[0031] like Figures 1 to 6 As shown, a reciprocating drive rod with an electromagnet includes: a shaft 100 and an electromagnet module 200. The electromagnet module 200 is fixedly connected to the shaft 100. The electromagnet module 200 includes an iron core 210, a coil 220 and a protective cover 230. The protective cover 230 is connected to the iron core 210 and forms an annular sealed cavity 240 between the two. The coil 220 is located in the annular sealed cavity 240 and is wound around the iron core 210 with the shaft 100 as the center.

[0032] The entire electromagnet module 200 is fixedly connected to the shaft 100 by welding, threading, or pins. The shaft 100 can be connected to an electric actuator to perform reciprocating motion. When the shaft 100 moves, the electromagnet module 200 also moves accordingly, and there is no motion interference between the two. The iron core 210 is made of a high-permeability material. When current passes through the coil 220, the iron core 210 generates a magnetic field.

[0033] It should be noted that, since this drive rod needs to operate in the liquid environment of the reaction chamber, the coil 220 needs to be located in a sealed environment to prevent electromagnet leakage or short circuits. Therefore, a protective cover 230 is specifically designed. The protective cover 230 can be sealed to the iron core 210 to form a partially hollow (i.e., annular sealed cavity 240) sealed disc structure. When the electromagnet module 200 is in the liquid environment of the reaction chamber, the coil 220 is located within the annular sealed cavity 240 and will not come into contact with the liquid, thus preventing leakage or short circuits.

[0034] The coil 220 is wound around the iron core 210 with the shaft 100 as the center. This means that the center of the coil 220 is concentric with the shaft 100, thus forming a magnetic field centered on the shaft 100. When the shaft 100 is located at the center of the reaction chamber, the center of the magnetic field generated by the electromagnet module 200 is naturally located at the center of the reaction chamber, ensuring a uniform magnetic field distribution within the reaction chamber.

[0035] It should be further noted that in the field of liquid biopsy, circulating tumor cells (CTCs) are cancer cells that detach from primary or metastatic tumors and enter the bloodstream, possessing significant clinical diagnostic and therapeutic value. To isolate a small number of CTCs from a large number of normal blood cells, immunomagnetic beads are typically used for enrichment. The magnetic beads are modified with specific antibodies that recognize and bind to specific antigens on the surface of CTCs. The resulting CTCs-magnetic bead complex is magnetic and is attracted to the electromagnet module 200 under the influence of a magnetic field (energized coil 220), thus achieving separation and enrichment. For subsequent collection of the CTCs-magnetic bead complex, simply removing the magnetic field (de-energizing coil 220) allows the CTCs-magnetic bead complex to separate from the electromagnet module 200 under the washing solution.

[0036] Therefore, in this design, the magnetic field can be generated or disconnected by controlling the current in coil 220. Furthermore, coil 220 is wound around shaft 100 on iron core 210. When shaft 100 is located at the center of the reaction chamber, ensuring that shaft 100 and electromagnet module 200 do not interfere with each other, the magnetic field generated by electromagnet module 200 is also located at the center of the reaction chamber. This results in a uniform magnetic field distribution throughout the reaction chamber, ensuring the magnetic enrichment effect of the CTCs-magnetic bead composite.

[0037] like Figures 1 to 6 As shown, based on the above embodiment, the iron core 210 includes a base portion 211 and a circular boss portion 212 protruding from a surface of the base portion 211, and the coil 220 is wound around the outer peripheral surface of the circular boss portion 212.

[0038] Based on the above embodiments, the protective cover 230 includes a top cover portion 231 and a peripheral wall portion 232 that protrudes axially from the edge of the top cover portion 231. The top cover portion 231 and the peripheral wall portion 232 enclose to form an open mouth. The base portion 211 seals the open mouth. The edge of one surface of the base portion 211 is sealed to the end face of the peripheral wall portion 232. The circular boss portion 212 is located inside the open mouth. An annular sealing cavity 240 is formed between the outer peripheral surface of the circular boss portion 212 and the inner peripheral surface of the peripheral wall portion 232.

[0039] Specifically, the iron core 210 is preferably a plug structure or a stepped shaft structure. The outer circumferential surface of the circular boss provides an ideal winding surface for the coil 220, and the magnetic field is concentrated on the surface of the circular boss. The top cover 231 and the peripheral wall 232 of the protective cover 230 form an open cavity, which is sealed by the chassis 211, forming an annular sealed cavity 240, completely isolating the coil 220 from the external environment. This is especially important for operation in liquid environments, effectively preventing leakage or short circuits.

[0040] Based on the above embodiment, the top cover 231, the chassis 211, and the circular boss 212 are concentrically arranged, and the shaft 100 passes through the center of the top cover 231, the chassis 211, and the circular boss 212. This design ensures that the center of the magnetic field generated by the coil 220 and the iron core 210 coincides with the shaft 100.

[0041] Based on the above embodiment, the surface of the circular boss portion 212 is sealed to the inner wall surface of the top cover portion 231.

[0042] like Figures 1 to 6 As shown, based on the above embodiment, the shaft 100 has a hollow structure and is provided with a wiring hole 110 extending along its axial direction. The portion of the shaft 100 located in the contact area between the top cover portion 231 and the circular boss portion 212 is provided with a wiring opening 120. The wiring opening 120 passes through the wall portion of the shaft 100 and communicates with the wiring hole 110. Both ends of the coil 220 pass through the wiring opening 120 and are inserted into the wiring hole 110.

[0043] Based on the above embodiment, a groove 213 is provided on the surface of the circular boss portion 212, and the two ends of the coil 220 pass through the groove 213 through the area sealed between the circular boss portion 212 and the top cover portion 231.

[0044] The wiring hole 110 designed inside the shaft 100 can meet the wiring requirements of the coil 220, which not only enables concealed wiring but also eliminates the possibility of the two ends of the coil 220 being exposed to the liquid environment due to wiring. In addition, since the coil 220 on the outer circumference of the circular boss 212 cannot directly pass through the sealing surface between the circular boss 212 and the top cover 231, a groove 213 is specially provided on the surface of the circular boss 212. The two ends of the coil 220 pass through the groove 213, pass through the sealing surface between the circular boss 212 and the top cover 231, and then pass through the wiring opening 120 into the wiring hole 110, and finally extend out of the shaft 100 and connect to the power supply.

[0045] Example 1:

[0046] like Figure 1 , Figure 5 As shown, a sealing ring is provided on the outer peripheral surface of the electromagnet module 200, and the electromagnet module 200 forms a piston structure through the sealing ring.

[0047] In Example 1, the outer peripheral surface of the electromagnet module 200 is fitted with a sealing ring and can be used as a piston. That is, the piston and the electromagnet are integrated together. It can both drive the liquid transfer in the reaction chamber as a piston and generate a magnetic field as an electromagnet. During the enrichment stage, the CTCs-magnetic bead composite is adsorbed on the surface of the electromagnet module 200.

[0048] Example 2:

[0049] like Figure 1 , Figure 6 As shown, a piston block 300 is provided on the shaft 100, and the piston block 300 and the electromagnet module 200 are arranged sequentially in the direction toward the top of the shaft 100.

[0050] It should be noted that Embodiment 1 and Embodiment 2 represent two different ways of forming the piston structure. In this design, the main function of the shaft 100 is to drive the piston structure (Embodiment 1) or the piston block 300 (Embodiment 2) to reciprocate, thereby achieving automatic liquid transfer within the reaction chamber.

[0051] During pipetting, the piston structure or piston block 300 divides the reaction chamber into an upper chamber and a lower chamber, with the liquid located in the upper chamber. When it is necessary to drain the liquid from the upper chamber, the shaft 100 moves upward, causing the liquid in the upper chamber to transfer to the lower chamber; when the shaft 100 moves downward, the liquid in the lower chamber is drained from the reaction chamber. Pipetting is performed through the reciprocating motion of the shaft 100 in conjunction with the piston structure or piston block 300.

[0052] like Figure 5 , Figure 6 As shown, a connecting part 130 is provided at the top of the shaft 100. The electric push rod is connected to the connecting part 130 at the top of the shaft 100, so the electric push rod can drive the shaft 100 to perform reciprocating motion.

[0053] like Figures 1 to 6 As shown, when this drive rod is used in a circulating tumor cell screening and separation device, its working principle is as follows:

[0054] During the enrichment operation, coil 220 can be energized to generate a magnetic field that can attract and fix the CTCs-magnetic bead composite.

[0055] During the cleaning operation, the coil 220 can be de-energized to remove the magnetic field, and the cleaning fluid can flush the CTCs-magnetic bead complex into the solution in the reaction chamber. Then, the electric push rod drives the shaft 100 to reciprocate, and the piston structure or piston block 300 on the shaft 100 reciprocates in the reaction chamber, thereby discharging the liquid in the reaction chamber.

[0056] This design makes the drive rod more flexible and convenient to use, and greatly improves the level of automation. Furthermore, the magnetic field strength of the electromagnet can be controlled by adjusting the current, thereby optimizing the enrichment effect. Therefore, in actual operation, this device can select the appropriate magnetic field strength according to the detection requirements and conditions to ensure the best enrichment effect.

[0057] It should be noted that all directional indicators (such as up, down, left, right, front, back, etc.) in this utility model embodiment are only used to explain the relative positional relationship and movement of each component in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indicator will also change accordingly.

[0058] Furthermore, in this utility model, the use of terms such as "first," "second," and "a" is for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this utility model, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0059] In this utility model, unless otherwise explicitly specified and limited, the terms "connection," "fixing," etc., should be interpreted broadly. For example, "fixing" can mean a fixed connection, a detachable connection, or an integral part; it can mean a mechanical connection or an electrical connection; it can mean a direct connection or an indirect connection through an intermediate medium; it can mean the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0060] Furthermore, the technical solutions of the various embodiments of this utility model can be combined with each other, but only if they are based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection claimed by this utility model.

Claims

1. A reciprocating drive rod with an electromagnet, characterized in that, include: The shaft (100) and electromagnet module (200) are fixedly connected to the shaft (100). The electromagnet module (200) includes an iron core (210), a coil (220) and a protective cover (230). The protective cover (230) is connected to the iron core (210) and forms an annular sealed cavity (240) between them. The coil (220) is located in the annular sealed cavity (240) and is wound around the iron core (210) with the shaft (100) as the center.

2. The reciprocating drive rod with an electromagnet as described in claim 1, characterized in that: The iron core (210) includes a base portion (211) and a circular boss portion (212) protruding from a surface of the base portion (211), and the coil (220) is wound around the outer peripheral surface of the circular boss portion (212).

3. A reciprocating drive rod with an electromagnet as described in claim 2, characterized in that: The protective cover (230) includes a top cover (231) and a peripheral wall (232) that protrudes axially from the edge of the top cover (231). The top cover (231) and the peripheral wall (232) enclose an opening. The base (211) seals the opening. The edge of one surface of the base (211) is sealed to the end face of the peripheral wall (232). The circular boss (212) is located inside the opening. The annular sealing cavity (240) is formed between the outer peripheral surface of the circular boss (212) and the inner peripheral surface of the peripheral wall (232).

4. A reciprocating drive rod with an electromagnet as described in claim 3, characterized in that: The top cover (231), the chassis (211), and the circular boss (212) are arranged concentrically, and the shaft (100) passes through the center of the top cover (231), the chassis (211), and the circular boss (212).

5. A reciprocating drive rod with an electromagnet as described in claim 3, characterized in that: The surface of the circular boss (212) is sealed to the inner wall of the top cover (231).

6. A reciprocating drive rod with an electromagnet as described in claim 3, characterized in that: The shaft (100) is a hollow structure and is provided with a wiring hole (110) extending along its axial direction. The portion of the shaft (100) located in the contact area between the top cover (231) and the circular boss (212) is provided with a wiring opening (120). The wiring opening (120) passes through the wall of the shaft (100) and communicates with the wiring hole (110). Both ends of the coil (220) are inserted into the wiring hole (110) through the wiring opening (120).

7. A reciprocating drive rod with an electromagnet as described in claim 6, characterized in that: The surface of the circular boss (212) is provided with a groove (213), and the two ends of the coil (220) pass through the groove (213) through the area sealed between the circular boss (212) and the top cover (231).

8. A reciprocating drive rod with an electromagnet as described in claim 1, characterized in that: The outer peripheral surface of the electromagnet module (200) is provided with a sealing ring, and the electromagnet module (200) forms a piston structure through the sealing ring.

9. A reciprocating drive rod with an electromagnet as described in claim 1, characterized in that: A piston block (300) is provided on the shaft (100), and the piston block (300) and the electromagnet module (200) are arranged sequentially in the direction toward the top of the shaft (100).

10. A reciprocating drive rod with an electromagnet as described in claim 1, characterized in that: The top of the shaft (100) is provided with a connecting part (130).

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