Cell culture plate for liver cancer drug screening
Through the innovative design of connectors, sleeves, clips, and slots, the problem of rapid assembly and disassembly of cell culture plates for liver cancer drug screening has been solved, enabling rapid splicing and disassembly of multiple culture plates, improving experimental efficiency and enhancing sealing and stability.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- WENZHOU MEDICAL UNIV
- Filing Date
- 2025-05-23
- Publication Date
- 2026-05-01
AI Technical Summary
Existing cell culture plates for liver cancer drug screening have a one-piece structure and lack quick assembly and disassembly capabilities, resulting in the waste of the entire plate when only a small number of culture cells are needed.
A cell culture plate for screening liver cancer drugs was designed, which adopts a structure of connector, sleeve, locking block and slot. When the connector is inserted into the sleeve, the locking block is squeezed and pushes the movable plate to compress the spring. After entering the slot, the spring resets and locks in place. Combined with the design of cover, hinge and buckle, multiple culture plates can be quickly assembled and disassembled.
It enables rapid assembly and disassembly of multiple culture plates, reducing waste of culture plates, improving experimental efficiency, enhancing sealing performance and placement stability, and preventing cross-contamination.
Smart Images
Figure CN224186184U_ABST
Abstract
Description
A cell culture plate for screening liver cancer drugs Technical Field
[0001] This utility model relates to the field of cell culture technology, specifically to a cell culture plate for screening liver cancer drugs. Background Technology
[0002] Cell culture plates are a commonly used tool in the development of liver cancer drugs. However, existing cell culture plates have some shortcomings.
[0003] Based on the above, the inventors have discovered the following problem: most current liver cancer drug screening cell culture plates are one-piece structures and do not have a quick disassembly and assembly function, which leads to the waste of the entire culture plate when only a small number of culture cells are needed.
[0004] Therefore, in view of this, we have studied and improved the existing structure and its deficiencies to provide a cell culture plate for screening liver cancer drugs, in order to achieve a more practical value. Summary of the Invention
[0005] The purpose of this invention is to provide a cell culture plate for screening liver cancer drugs, in order to solve the problem mentioned in the background art that most current cell culture plates for screening liver cancer drugs are of a one-piece structure and do not have a quick disassembly and assembly function, which leads to the waste of the entire culture plate when a small number of culture cells are needed.
[0006] In view of the above problems, the technical solution proposed by this utility model is as follows:
[0007] A cell culture plate for screening liver cancer drugs includes a plate body with a cover at the top. A pair of hinges are installed on one side of the cover, with one end of each hinge fixedly connected to one side of the plate body. A groove is formed at the top of the plate body, and a plurality of culture cells are installed at the bottom of the groove. A sleeve is installed at one end of each side of the plate body, and a connection mechanism for connecting the sleeves is installed at the other end of each side of the plate body. The connection mechanism includes a connector, with a locking block installed at both the top and bottom of the connector. A slot is formed at both the top and bottom inner sides of the sleeve, and one end of the locking block engages with the inner side of the slot.
[0008] Furthermore, the connector has an internal cavity, a partition is installed inside the cavity, and springs are installed at the top and bottom of the partition. A movable plate is installed at one end of the spring, and one end of the movable plate is fixedly connected to the other end of the locking block.
[0009] The beneficial effect of adopting the above-mentioned further solution is that, through the cooperation of the connector, cavity, partition, spring, movable plate, and locking block, when the connector is inserted into the sleeve, the locking block is squeezed, which pushes the movable plate to compress the spring. After entering the slot, the spring returns to its original position, so that the locking block is firmly engaged.
[0010] Furthermore, one end of the card block is arc-shaped.
[0011] The beneficial effect of adopting the above-mentioned further solution is that by making one end of the locking block arc-shaped, the arc-shaped structure can reduce the insertion resistance when the connector is inserted into the socket, allowing the connector to enter the socket more smoothly.
[0012] Furthermore, the top and bottom of one end of the connector are provided with a first bevel, and the top and bottom of the inner side of the sleeve are provided with a second bevel.
[0013] The beneficial effect of adopting the above-mentioned further scheme is that, by setting the first and second inclined sides, the connector is further guided to accurately insert into the socket, playing a dual guiding role.
[0014] Furthermore, a sealing ring is installed at the top of the culture cell.
[0015] The beneficial effect of adopting the above-mentioned further solution is that by installing a sealing ring at the top of the culture cell, the sealing performance can be enhanced, preventing culture medium leakage, avoiding cross-contamination between different culture cells, and maintaining the purity of the culture environment.
[0016] Furthermore, a buckle is installed on the other side of the cover, and a fastener is installed on the other side of the plate, with the buckle and fastener engaging and connecting.
[0017] The beneficial effect of adopting the above-mentioned further solution is that, through the snap-fit and fastener engagement, the cover can be firmly fixed to the plate when closed, preventing the cover from being opened accidentally.
[0018] Furthermore, support bases are installed at the four corners of the bottom of the plate, and the bottom of the support bases is provided with anti-slip texture.
[0019] The beneficial effect of adopting the above-mentioned further solution is that the stability of the plate is improved by installing support bases at the four corners of the bottom of the plate.
[0020] Compared with existing technologies, the beneficial effects of this utility model are as follows: This liver cancer drug screening cell culture plate, through the cooperation of the cover, hinge, and plate body, facilitates the operation of cell culture cells and reduces external contamination. The culture cells in the groove are used to culture liver cancer cells for drug screening experiments. The sleeves on both sides of the plate body cooperate with the insertion mechanism. Through the locking block on the insertion connector and the locking slot of the sleeve, multiple culture plates can be quickly spliced to meet the needs of high-throughput experiments and improve experimental efficiency. Through the cooperation of the insertion connector, cavity, partition, spring, movable plate, and locking block, when the insertion connector is inserted into the sleeve, the locking block is squeezed, pushing the movable plate to compress the spring. After entering the locking slot, the spring returns to its original position, making the locking block firmly locked. One end of the locking block is arc-shaped. The arc-shaped structure reduces insertion resistance when the connector is inserted into the sleeve, allowing for smoother insertion. The first and second bevels further guide the connector for accurate insertion, providing a dual guiding function. A sealing ring at the top of the culture cell enhances sealing performance, preventing culture medium leakage and cross-contamination between different culture cells, maintaining a pure culture environment. Snap-fit and fastener connections securely fix the cover to the plate when closed, preventing accidental opening. Supports at the four corners of the plate's bottom improve its stability. This invention effectively achieves rapid assembly and disassembly, reducing culture plate waste and possessing high practical value. Attached Figure Description
[0021] Figure 1 is one of the three-dimensional structural schematic diagrams of the embodiments of this utility model;
[0022] Figure 2 is a second three-dimensional structural schematic diagram of an embodiment of this utility model;
[0023] Figure 3 is a three-dimensional structural diagram of the disassembled structure disclosed in the embodiment of this utility model;
[0024] Figure 4 is a cross-sectional view of the connector disclosed in the embodiment of this utility model;
[0025] Figure 5 is an enlarged schematic diagram of structure A in Figure 2, as disclosed in the embodiment of this utility model.
[0026] In the diagram: 100, plate; 10001, groove; 101, cover; 102, support base; 103, hinge; 104, snap fastener; 105, fastener; 106, insertion mechanism; 10601, insertion connector; 10602, locking block; 10603, first bevel; 10604, cavity; 10605, partition; 10606, movable plate; 10607, spring; 107, sleeve; 10701, slot; 10702, second bevel; 108, culture cell; 109, sealing ring. Detailed Implementation
[0027] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0028] Please refer to Figures 1-5. This utility model provides a technical solution: a cell culture plate for screening liver cancer drugs, including a plate body 100. A cover 101 is provided at the top of the plate body 100. A pair of hinges 103 are installed on one side of the cover 101, with one end of each hinge fixedly connected to one side of the plate body 100. A groove 10001 is formed at the top of the plate body 100, and several culture cells 108 are installed at the bottom of the groove 10001. Inserts 107 are installed at one end of each side of the plate body 100, and insertion mechanisms 106 for connecting the inserts 107 are installed at the other ends of each side of the plate body 100. The insertion mechanism 106 includes a connector 10601, with a connector at both the top and bottom. The card block 10602 and the inner top and bottom of the insert 107 are both provided with card slots 10701. One end of the card block 10602 is engaged with the inner side of the card slot 10701. Through the cooperation of the cover 101, hinge 103 and plate 100, it is convenient to operate the cell culture cell 108 and reduce external contamination. The culture cell 108 in the groove 10001 is used to culture liver cancer cells for drug screening experiments. The inserts 107 on both sides of the plate 100 cooperate with the insertion mechanism 106. Through the engagement of the card block 10602 on the insert 10601 and the card slot 10701 of the insert 107, multiple culture plates can be quickly spliced to meet the needs of high-throughput experiments and improve experimental efficiency.
[0029] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0030] Please refer to Figures 1-5. The connector 10601 has an internal cavity 10604. A partition 10605 is installed inside the cavity 10604. Springs 10607 are installed at both the top and bottom of the partition 10605. A movable plate 10606 is installed at one end of the spring 10607. One end of the movable plate 10606 is fixedly connected to the other end of the locking block 10602. One end of the locking block 10602 is arc-shaped. The top and bottom of one end of the connector 10601 are provided with a first bevel 10603. The top and bottom of the inner side of the sleeve 107 are provided with a second bevel 10702. The connector 10601, cavity 10604, partition 10605, and springs 10607... 07. The cooperation of the movable plate 10606 and the locking block 10602 ensures that when the connector 10601 is inserted into the sleeve 107, the locking block 10602 is compressed, pushing the movable plate 10606 to compress the spring 10607. After entering the slot 10701, the spring 10607 returns to its original position, making the locking block 10602 firmly engaged. The arc-shaped design of one end of the locking block 10602 reduces insertion resistance when the connector 10601 is inserted into the sleeve 107, allowing the connector 10601 to enter the sleeve 107 more smoothly. The first inclined side 10603 and the second inclined side 10702 further guide the connector 10601 to accurately insert into the sleeve 107, playing a dual guiding role.
[0031] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0032] Please refer to Figures 1-5. A sealing ring 109 is installed at the top of the culture cell 108, a buckle 104 is installed on the other side of the cover 101, and a fastener 105 is installed on the other side of the plate 100. The buckle 104 and the fastener 105 are engaged and connected. Support seats 102 are installed at the four corners of the bottom of the plate 100. The bottom of the support seats 102 is provided with anti-slip texture. The sealing ring 109 installed at the top of the culture cell 108 can enhance the sealing performance, prevent culture medium leakage, avoid cross-contamination between different culture cells 108, and maintain the purity of the culture environment. The buckle 104 and the fastener 105 are engaged and connected, so that when the cover 101 is closed, it can be firmly fixed to the plate 100 to prevent the cover 101 from being opened accidentally. The support seats 102 installed at the four corners of the bottom of the plate 100 can improve the placement stability of the plate 100.
[0033] Specifically, the working principle of this liver cancer drug screening cell culture plate is as follows: During use, the cooperation of the cover 101, hinge 103, and plate 100 facilitates the operation of the cell culture cells 108 while reducing external contamination. The culture cells 108 within the groove 10001 are used to culture liver cancer cells for drug screening experiments. The inserts 107 on both sides of the plate 100 cooperate with the insertion mechanism 106, and the insertion is achieved through the locking block 10602 on the connector 10601 and the locking groove 10701 of the insert 107. The snap-fit mechanism enables rapid assembly of multiple culture plates, meeting the demands of high-throughput experiments and improving experimental efficiency. Through the cooperation of connector 10601, cavity 10604, partition 10605, spring 10607, movable plate 10606, and locking block 10602, when connector 10601 is inserted into sleeve 107, locking block 10602 is compressed, pushing movable plate 10606 to compress spring 10607. After entering slot 10701, spring 10607 returns to its original position, securing locking block 10602 firmly. The locking mechanism, with one end of the locking block 10602 being arc-shaped, reduces insertion resistance when the connector 10601 is inserted into the sleeve 107, allowing for smoother entry. The first inclined side 10603 and the second inclined side 10702 further guide the connector 10601 into the sleeve 107 accurately, providing a dual guiding function. A sealing ring 109 installed at the top of the culture cell 108 enhances the sealing performance and prevents leakage. To prevent culture medium leakage and avoid cross-contamination between different culture cells 108, thus maintaining a pure culture environment, the cover 101 is securely fixed to the plate 100 when closed by snap-fit 104 and fastener 105, preventing accidental opening. Support bases 102 are installed at the four corners of the bottom of the plate 100 to improve its stability. This invention effectively achieves quick assembly and disassembly, reduces waste of culture plates, and has high practical value.
Claims
1. A hepatocarcinoma drug screening cell culture plate, characterized in that, The plate includes a plate body (100), with a cover (101) at the top. A pair of hinges (103) are installed on one side of the cover (101), with one end of the hinges (103) fixedly connected to one side of the plate body (100). A groove (10001) is formed at the top of the plate body (100), and several culture cells (108) are installed at the bottom of the groove (10001). Inserts (107) are installed at one end of each side of the plate body (100). The other end of both sides of the plate (100) is equipped with a plug-in mechanism (106) for connecting the sleeve (107). The plug-in mechanism (106) includes a plug connector (10601). The top and bottom ends of the plug connector (10601) are equipped with a locking block (10602). The top and bottom inner sides of the sleeve (107) are provided with a locking groove (10701). One end of the locking block (10602) is engaged with the inner side of the locking groove (10701).
2. The hepatocarcinoma drug screening cell culture plate according to claim 1, wherein, The connector (10601) has a cavity (10604) inside. A partition (10605) is installed inside the cavity (10604). A spring (10607) is installed at the top and bottom of the partition (10605). A movable plate (10606) is installed at one end of the spring (10607). One end of the movable plate (10606) is fixedly connected to the other end of the locking block (10602).
3. The cell culture plate for screening liver cancer drugs according to claim 1, characterized in that, One end of the card block (10602) is arc-shaped.
4. The hepatocarcinoma drug screening cell culture plate according to claim 1, wherein, The connector (10601) has a first inclined edge (10603) at one top and one bottom, and the sleeve (107) has a second inclined edge (10702) at both the inner top and inner bottom.
5. The cell culture plate for screening liver cancer drugs according to claim 1, characterized in that, A sealing ring (109) is installed at the top of the culture cell (108).
6. The hepatocarcinoma drug screening cell culture plate according to claim 1, wherein, A buckle (104) is installed on the other side of the cover (101), and a fastener (105) is installed on the other side of the plate (100). The buckle (104) and the fastener (105) are engaged and connected.
7. The hepatocarcinoma drug screening cell culture plate according to claim 1, wherein the hepatocarcinoma drug screening cell culture plate is a 96-well plate. The bottom of the plate (100) is equipped with a support base (102) at each of the four corners, and the bottom of the support base (102) is provided with anti-slip texture.