Modular clean room and production line for oral solid preparation production

Abstract

The utility model discloses a modularized clean room for oral solid preparation production. The modularized clean room comprises a frame room, a frame reinforcing assembly, a positioning cone plate assembly and a frame bottom face assembly. The frame bottom face assembly is connected with the multiple sets of positioning cone plate assemblies, the frame bottom face assembly is connected with the frame chamber through the multiple sets of positioning cone plate assemblies, and the frame reinforcing assembly is connected into the frame chamber. A production line of a modular clean room based on oral solid preparation production comprises at least six frame chambers, the six frame chambers are sequentially connected in an abutting mode, and the six frame chambers can be arranged to be a weighing and batching module, a wet granulation drying and mixing module, a tabletting module, a coating module, a capsule filling module and a dry granulation module respectively. And a process corridor is arranged on the front sides of the six frame chambers and is communicated with the six frame chambers. The device can be quickly installed on site, and the installation cost is reduced; various requirements are met, and strain is flexible.

Description

Technical Field

[0001] This utility model relates to a modular cleanroom and production line for the production of oral solid dosage forms. Background Technology

[0002] Currently, cleanrooms used in the production of oral solid dosage forms are mostly constructed using the traditional integrated model. During the planning and design phase, the cleanroom layout, area, and purification level are determined based on the drug production process requirements, followed by on-site construction. The construction process involves complex procedures including civil engineering, HVAC system installation, electrical wiring, and purification equipment commissioning. Each stage is closely integrated, requiring collaborative work from different specialized construction teams. The entire construction cycle often lasts several months or even more than a year. If the production process is adjusted during this period, such as adding a new production line or changing material flow paths, it is almost impossible to flexibly modify the existing cleanroom layout. Only large-scale demolition and reconstruction or partial destructive modifications are possible, resulting in high costs and disruption to normal production schedules.

[0003] Moreover, in terms of operation and maintenance, traditional cleanrooms are difficult to troubleshoot due to their high degree of system integration and the intertwining of various subsystems (such as air handling units, supply and return air ducts, lighting and electrical systems). When a fault occurs in one area, it is difficult to troubleshoot, and maintenance requires shutting down a large area, which can easily cause pharmaceutical production to stop and cause huge economic losses to enterprises.

[0004] Traditional cleanrooms are typically constructed all at once after the main building structure is completed, with the interior walls, ceilings, floors, and ventilation and purification systems built according to production needs. Their spatial layout is fixed from the outset, with functional areas such as raw material pretreatment, granulation, tableting and coating, and finished product storage areas divided according to a predetermined plan. Large-scale adjustments later are extremely difficult.

[0005] Traditional fixed-structure cleanrooms lack flexibility. When production lines need to be upgraded, capacity expanded, or process layout adjusted, the internal space is difficult to redistribute because the areas are fixedly connected. For example, if a new high-volume product needs to be added, the granulation area or drying equipment space needs to be expanded. However, due to the fixed walls, the renovation is difficult, requires a long shutdown, and the demolition and reconstruction of some areas consumes a lot of manpower, material resources, and time.

[0006] Patents CN118273563A and CN220036260U disclose a modular pharmaceutical system comprising a production support unit and a production unit, both identical in size and detachable or replaceable. The production unit includes multiple buffer spaces of the same size, which can be flexibly combined to meet different cleanliness requirements. The production support unit includes a finished product transfer room, a solution preparation room, a transport device storage room, and a cleaning and sterilization room. A transport channel connects the production support unit and the production unit, through which transport devices can transport materials. Multiple production units can switch and operate in tandem to produce different finished products, and personnel and material entrances / exits are separated within the production unit. The buffer spaces include personnel buffer spaces, material entry buffer spaces, waste material exit buffer spaces, and product exit buffer spaces, with diverse distribution and connection methods. Furthermore, the arrangement of each functional space within the operating space meets GMP requirements, avoiding cross-contamination of personnel and materials.

[0007] In terms of spatial layout, although the above patents feature modular combinations, they are limited by the initial design. Large-scale process adjustments or the introduction of new processes cannot be achieved through module reorganization, requiring major modifications and replanning, which is time-consuming and labor-intensive. Furthermore, the fixed connections and coordination between different production units make it difficult to quickly respond to temporary and sudden production demands. In terms of functional modules, the independence of production support and production units is limited, making it difficult to meet the needs of special drug processes. The standardized buffer space also lacks versatility due to the varying needs of different pharmaceutical processes. Capacity expansion is limited. Increasing production capacity by adding production units is constrained by site availability, public auxiliary resources, and system coordination. The expansion rate and speed cannot keep up with the company's development, and it will also greatly increase the complexity of management and maintenance, and raise operating costs.

[0008] Therefore, a modular cleanroom and production line for oral solid dosage form production is proposed to address the above issues. Utility Model Content

[0009] The purpose of this invention is to overcome the shortcomings of existing solutions by providing a modular cleanroom and production line for the production of oral solid dosage forms, which can be quickly installed on-site, reducing installation costs; and can meet diverse needs and adapt flexibly.

[0010] To achieve the above objectives, this utility model provides the following technical solution: a modular cleanroom for the production of oral solid dosage forms, comprising a frame chamber, a frame reinforcement assembly, a positioning cone plate assembly, and a frame bottom surface assembly;

[0011] Multiple sets of positioning cone plate assemblies are connected to the bottom surface assembly of the frame, and the frame chamber is connected through the multiple sets of positioning cone plate assemblies. The frame reinforcement assembly is connected to the interior of the frame chamber.

[0012] Preferably, the frame room includes a top frame beam, vertical secondary beams, vertical main beams, a bottom frame beam, a top frame connecting beam, and a bottom frame connecting beam; the top frame beam, the vertical secondary beams, the vertical main beams, the bottom frame beam, the top frame connecting beam, and the bottom frame connecting beam are interconnected to form the main frame.

[0013] Preferably, the frame reinforcement component includes multiple reinforcing ribs, which are respectively connected between the two top beams of the frame at the upper end and between the two bottom beams of the frame at the lower end.

[0014] Preferably, multiple concrete column bases of equal height are poured on the ground, and a set of positioning cone plate assemblies are connected to each concrete column base, the positioning cone plate assemblies being connected to the frame chamber.

[0015] Preferably, the positioning cone plate assembly includes a base plate and a positioning cone; the positioning cone is connected to the base plate, the lower end face of the base plate is connected to the concrete column pier, a positioning hole is opened on the lower end face of the frame chamber, and the positioning cone is inserted into the positioning hole.

[0016] Preferably, the frame bottom component includes a steel plate, a self-leveling floor, and a PVC floor. The steel plate is laid on multiple reinforcing ribs, the self-leveling floor is laid on the steel plate, and the PVC floor is laid on the self-leveling floor.

[0017] Preferably, the frame interior is provided with an airlock room, a process equipment room, an auxiliary equipment room, and a suspended ceiling mezzanine; the airlock room is further divided into a personnel airlock room and a material airlock room.

[0018] Preferably, it also includes a cleanroom air supply duct and a cleanroom return air duct; the airlock room and the process equipment room are respectively provided with a process equipment room air supply outlet and an airlock room air supply outlet, and the cleanroom air supply duct is respectively connected to the process equipment room air supply outlet and the airlock room air supply outlet; the airlock room and the process equipment room are also provided with an airlock room return air outlet and a process equipment room return air outlet, and the airlock room return air outlet and the process equipment room return air outlet are connected to the cleanroom return air duct.

[0019] Preferably, the reinforcing rib is an I-beam.

[0020] The production line for modular cleanrooms based on oral solid dosage form production includes at least six frame chambers connected sequentially. The six frame chambers can be respectively configured as a weighing and dispensing module, a wet granulation, drying and mixing module, a tableting module, a coating module, a capsule filling module and a dry granulation module; a process corridor is provided in front of the six frame chambers, connecting the six frame chambers.

[0021] Compared with existing technologies, the beneficial effects of this utility model are as follows: The modular cleanroom and production line for oral solid dosage form production can significantly reduce construction time. Utilizing modular and prefabricated assembly construction, modules are prefabricated in the factory and quickly assembled on-site. Compared to the months-long construction period of traditional cleanrooms, this utility model can be completed in just a few weeks, allowing pharmaceutical companies to start production earlier and respond quickly to the market. It ensures stable timeliness: Factory prefabrication is unaffected by inclement weather or coordination issues, avoiding delays. Pharmaceutical companies can precisely arrange supporting work, reducing additional costs. It offers flexibility and adaptability: Oral solid dosage form processes are highly variable; the modular cleanroom can be rearranged, disassembled, or have modules added as needed to adapt to process changes without major reconstruction, protecting initial investment. It can precisely adapt to the different cleanroom requirements of different pharmaceutical companies and products, allowing for customized combinations to meet diverse needs and suitability for pilot production and large-scale mass production.

[0022] In traditional cleanrooms, a single malfunction can easily affect the entire area. This new module, however, operates relatively independently; a malfunction in one module only requires shutting down that module for repair, without interfering with other modules and ensuring continuous production. The module's compact internal structure facilitates convenient and efficient daily maintenance, reducing operational difficulty and workload, shortening maintenance time, and improving operational efficiency. Attached Figure Description

[0023] The accompanying drawings are provided to further illustrate the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention, but do not constitute a limitation thereof. In the drawings:

[0024] Figure 1 This is a front view of the frame chamber of this utility model;

[0025] Figure 2 This is a side view of the frame chamber of this utility model;

[0026] Figure 3 This is a top view of the frame chamber of this utility model;

[0027] Figure 4 This is a bottom view of the frame chamber of this utility model;

[0028] Figure 5 This is a front view of the positioning cone plate assembly of this utility model;

[0029] Figure 6 This is a top view of the positioning cone plate assembly of this utility model;

[0030] Figure 7 This is a detailed view showing the location of the positioning hole in this utility model;

[0031] Figure 8 This is a front view of the connection of the frame chamber of this utility model;

[0032] Figure 9This is a side view of the connection of the frame chamber of this utility model;

[0033] Figure 10 for Figure 9 Enlarged view of point A in the middle;

[0034] Figure 11 This is a schematic diagram showing the connection between the two frame chambers of this utility model;

[0035] Figure 12 This is a schematic diagram of the bottom frame component of this utility model;

[0036] Figure 13 This is a schematic diagram of the internal room layout of the frame chamber of this utility model;

[0037] Figure 14 This is a top view of the internal room layout of the frame chamber of this utility model;

[0038] Figure 15 This is a schematic diagram of the ventilation system layout inside the frame of this utility model;

[0039] Figure 16 This is a schematic diagram of the production line for the modular cleanroom of this utility model.

[0040] In the diagram: 1. Top beam of the frame; 2. Vertical secondary beam of the frame; 3. Vertical main beam of the frame; 4. Bottom beam of the frame; 5. Top connecting beam of the frame; 6. Bottom connecting beam of the frame; 7. Reinforcing rib; 8. Positioning cone; 9. Base plate; 10. Positioning hole; 11. Ground; 12. Concrete column pier; 13. Positioning cone plate assembly; 14. Frame chamber; 15. Steel plate; 16. Self-leveling floor; 17. PVC floor; 18. Airlock chamber; 18-1. Personnel airlock chamber; 18-2. Logistics 19. Airlock Room; 20. Process Equipment Room; 21. Auxiliary Equipment Room; 22. Ceiling Mezzanine; 23. Cleanroom Air Supply Duct; 24. Process Equipment Room Air Supply Outlet; 25. Airlock Room Air Supply Outlet; 26. Process Equipment Room Air Return Outlet; 27. Cleanroom Air Return Duct; 28. Weighing and Batching Module; 29. ​​Wet Granulation, Drying and Mixing Module; 30. Tableting Module; 31. Coating Module; 32. Capsule Filling Module; 33. Dry Granulation Module; 34. Process Corridor. Detailed Implementation

[0041] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0042] Please see Figure 1-15 The modular cleanroom for oral solid dosage form production includes a frame chamber 14, a frame reinforcement assembly, a positioning cone plate assembly 13, and a frame bottom assembly; multiple sets of positioning cone plate assemblies 13 are connected to the frame bottom assembly, and the frame chamber 14 is connected through the multiple sets of positioning cone plate assemblies 13; the frame reinforcement assembly is connected inside the frame chamber 14.

[0043] Please see Figure 1 , 2 1, 2, 3, 4, The frame room 14 includes a top frame beam 1, a vertical secondary frame beam 2, a vertical main frame beam 3, a bottom frame beam 4, a top frame connecting beam 5, and a bottom frame connecting beam 6; the top frame beam 1, the vertical secondary frame beam 2, the vertical main frame beam 3, the bottom frame beam 4, the top frame connecting beam 5, and the bottom frame connecting beam 6 are interconnected to form the main frame.

[0044] Specifically, the top crossbeam 1, the vertical main beam 3, and the top connecting beam 5 of the frame are made of 150*150 square tubular profiles; the vertical secondary beam 2 is made of 100*100 square tubular profiles; and the bottom crossbeam 4 and the bottom connecting beam 6 are made of 150*100 rectangular tubular profiles. These profiles are welded together to form the basic frame of the modular structure. The dimensions of this frame, while meeting the requirements for road transportation, can be customized according to the size or capacity of the process equipment, with several standard specifications, such as 10.5m×4m×4.2m (length, width, and height). This not only meets the layout requirements of oral solid dosage form process equipment but also facilitates road transportation.

[0045] Please see Figure 3 , 4 12. The frame reinforcement component includes multiple reinforcing ribs 7, which are connected between the two top beams 1 at the upper end of the frame and between the two bottom beams 4 at the lower end of the frame. The reinforcing ribs 7 are I-beams. These I-beam profiles are evenly distributed at the bottom and top of the modular frame structure to strengthen the module and also to secure the floor and ceiling materials.

[0046] Please see Figure 8 Multiple concrete column bases 12 of equal height are poured on the ground 11. A set of positioning cone plate assemblies 13 are connected to each concrete column base 12, and the positioning cone plate assemblies 13 are connected to the frame chamber 14.

[0047] Specifically, concrete column piers 12 are poured on the ground 11, and the upper surfaces of all concrete column piers 12 are on the same horizontal plane. Positioning cone plate assemblies 13 are installed on the upper surfaces of the concrete column piers 12. There are multiple positioning holes 10 at the bottom and top edges of the frame chamber 14. When the frame chamber 14 is lifted and lowered, the positioning cones 8 on the positioning cone plate assemblies 13 are inserted into the positioning holes 10 at the bottom of the frame chamber 14. When multiple sets of frame chambers 14 are installed side by side, they can be fixed by inserting the positioning cone plate assemblies 13 into the multiple positioning holes 10 at the bottom and top edges of the frame chamber 14. The arrangement and number of frame chambers 14 can be designed according to the process requirements. All frame chambers 14 can be connected by the positioning cone plate assemblies 13.

[0048] Please see Figure 5 , 6 7. The positioning cone plate assembly 13 includes a base plate 9 and a positioning cone 8; the positioning cone 8 is connected to the base plate 9, the lower end face of the base plate 9 is connected to the concrete column pier 12, and a positioning hole 10 is opened on the lower end face of the frame chamber 14, and the positioning cone 8 is inserted into the positioning hole 10.

[0049] Specifically, the positioning holes 10 are located at the bottom and top of the frame chamber 14, and each frame chamber 14 has multiple positioning holes 10 at its bottom and top. Depending on functional requirements, one, two, or more positioning cones 8 can be welded onto a base plate 9. The welding spacing of the positioning cones 8 is designed according to the spacing of the positioning holes 10 after the modules are installed. When two connected modules are installed, the positioning cones 8 are inserted into the positioning holes 10 through the positioning cone plate assembly 13, which can fix the two connected modules.

[0050] Please see Figure 12 The frame bottom components include a steel plate 15, a self-leveling floor 16, and a PVC floor 17. The steel plate 15 is laid on multiple reinforcing ribs 7, the self-leveling floor 16 is laid on the steel plate 15, and the PVC floor 17 is laid on the self-leveling floor 16.

[0051] Specifically, a 6mm steel plate 15 is laid on top of the H-beam reinforcing ribs 7, followed by a self-leveling floor 16, and finally a PVC floor 17, completing the floor of the frame chamber 14. The equipment is installed on the ground, which is strong enough to support its weight. When the equipment needs to be fixed, holes can be drilled in the ground to pierce the 6mm steel plate 15, and bolts can be used to connect the equipment feet to the 6mm steel plate 15. When the frame chamber 14 is shipped, the internal equipment does not need to be disassembled and can be shipped together with the frame chamber 14. In this way, after installation, commissioning, and verification are completed in the factory, the entire complete module can be shipped to the user's site. On-site, only the utilities need to be connected for use, saving time on on-site installation, commissioning, and verification.

[0052] Please see Figure 13 , 14The frame room 14 is equipped with an airlock room 18, a process equipment room 19, an auxiliary equipment room 20, and a suspended ceiling mezzanine 21; the airlock room 18 is equipped with a personnel airlock room 18-1 and a material airlock room 18-2.

[0053] Specifically, the frame room 14 is divided into different areas. Based on the process requirements of oral solid dosage forms, it can be divided into an airlock room 18, a process equipment room 19, an auxiliary equipment room 20, and a suspended ceiling mezzanine 21. The airlock room 18 is further divided into a personnel airlock room 18-1 and a material airlock room 18-2. The airlock room 18 and the process equipment room 19 are clean areas, while the auxiliary equipment room 20 and the suspended ceiling mezzanine 21 are non-clean areas. Personnel can enter the process equipment room 19 after passing through the personnel airlock room 18-1 air shower, and materials can enter the process equipment room 19 after passing through the material airlock room 18-2 air shower, thus separating personnel and material flows and avoiding cross-contamination. The auxiliary equipment and HVAC systems can be installed in the auxiliary equipment room 20, eliminating the need to enter the clean area during maintenance. The suspended ceiling mezzanine 21 is mainly used for arranging air ducts, water pipes, cable trays, and other facilities.

[0054] Please see Figure 15 It also includes a cleanroom air supply duct 22 and a cleanroom return air duct 27; an air supply outlet 23 for the process equipment room and an air supply outlet 24 for the airlock room are respectively provided in the airlock room 18 and the process equipment room 19, and the cleanroom air supply duct 22 is connected to the air supply outlet 23 for the process equipment room and the air supply outlet 24 for the airlock room; an air supply outlet 25 for the airlock room and a return air outlet 26 for the process equipment room are also provided in the airlock room 18 and the process equipment room 19, and the air supply outlet 25 for the airlock room and the return air outlet 26 for the process equipment room are connected to the cleanroom return air duct 27.

[0055] Specifically, the cleanroom supply air duct 22 delivers clean air to the process equipment room supply air outlet 23 and the airlock room supply air outlet 24, supplying air to the clean area and controlling the temperature and humidity of the clean area. The airlock room return air outlet 25 and the process equipment room return air outlet 26 are connected to the cleanroom return air duct 27, and the pressure difference in the clean area is controlled by the flow rate of the supply and return air.

[0056] Please see Figure 16 The production line based on a modular cleanroom for oral solid dosage form production includes at least six frame chambers 14, which are connected sequentially. The six frame chambers 14 can be respectively configured as a weighing and dispensing module 28, a wet granulation, drying and mixing module 29, a tableting module 30, a coating module 31, a capsule filling module 32 and a dry granulation module 33; a process corridor 34 is provided in front of the six frame chambers 14, connecting the six frame chambers 14.

[0057] Specifically, there are six standard frame rooms 14. Based on the oral solid dosage form process, the six modules are: weighing and dispensing module 28, wet granulation, drying and mixing module 29, tableting module 30, coating module 31, capsule filling module 32, and dry granulation module 33, connected in series via a process corridor 34. Each module's clean area is independent, yet the process corridor 34 allows for the flow of personnel and materials, enabling normal production processes. These six modules can essentially cover most processes in oral solid dosage form production. If process adjustments are needed, modules can be added or removed, allowing for different module combinations as required. For large-scale production, where the equipment is relatively large, two connected modules can be combined into one large module, effectively doubling the area of ​​the process equipment room 19, sufficient to accommodate the equipment needed for large-scale production.

[0058] This modular cleanroom and production line for oral solid dosage forms significantly reduces construction time. Utilizing modular and prefabricated assembly construction, modules are prefabricated in the factory and quickly assembled on-site. Compared to the months-long construction period of traditional cleanrooms, this new design can be completed in weeks, allowing pharmaceutical companies to start production earlier and respond quickly to the market. It ensures stable timeliness: factory prefabrication is unaffected by inclement weather or coordination issues, avoiding delays. Pharmaceutical companies can precisely schedule supporting work, reducing additional costs. It offers flexibility: oral solid dosage form processes are highly variable, and the modular cleanroom can be rearranged, disassembled, or have modules added as needed to adapt to process changes without major reconstruction, protecting initial investment. It can precisely adapt to the different cleanroom requirements of different pharmaceutical companies and products, allowing for customized combinations to meet diverse needs and suitability for pilot production and large-scale mass production.

[0059] In traditional cleanrooms, a single malfunction can easily affect the entire area. This new module, however, operates relatively independently; a malfunction in one module only requires shutting down that module for repair, without interfering with other modules and ensuring continuous production. The module's compact internal structure facilitates convenient and efficient daily maintenance, reducing operational difficulty and workload, shortening maintenance time, and improving operational efficiency.

[0060] Finally, it should be noted that the above are merely preferred embodiments of this utility model and are not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A modular cleanroom for the production of oral solid dosage forms, characterized in that, Includes frame chamber (14), frame reinforcement assembly, positioning cone plate assembly (13) and frame bottom surface assembly; Multiple sets of positioning cone plate assemblies (13) are connected to the bottom surface assembly of the frame, and the frame chamber (14) is connected through the multiple sets of positioning cone plate assemblies (13). The frame reinforcing assembly is connected inside the frame chamber (14).

2. The modular cleanroom for the production of oral solid dosage forms according to claim 1, characterized in that, The frame chamber (14) includes a top crossbeam (1), a vertical secondary beam (2), a vertical main beam (3), a bottom crossbeam (4), a top connecting beam (5), and a bottom connecting beam (6); the top crossbeam (1), the vertical secondary beam (2), the vertical main beam (3), the bottom crossbeam (4), the top connecting beam (5), and the bottom connecting beam (6) are interconnected to form the main frame.

3. The modular cleanroom for the production of oral solid dosage forms according to claim 2, characterized in that, The frame reinforcement assembly includes multiple reinforcing ribs (7), which are respectively connected between the two top beams (1) at the upper end of the frame and between the two bottom beams (4) at the lower end of the frame.

4. The modular cleanroom for the production of oral solid dosage forms according to claim 2, characterized in that, Multiple concrete column bases (12) of equal height are poured on the ground (11), and a set of positioning cone plate assemblies (13) are connected to each concrete column base (12), and the positioning cone plate assemblies (13) are connected to the frame chamber (14).

5. The modular cleanroom for the production of oral solid dosage forms according to claim 4, characterized in that, The positioning cone plate assembly (13) includes a base plate (9) and a positioning cone (8); the positioning cone (8) is connected to the base plate (9), the lower end face of the base plate (9) is connected to the concrete column pier (12), the lower end face of the frame chamber (14) is provided with a positioning hole (10), and the positioning cone (8) is inserted into the positioning hole (10).

6. The modular cleanroom for the production of oral solid dosage forms according to claim 3, characterized in that, The frame bottom assembly includes a steel plate (15), a self-leveling floor (16), and a PVC floor (17). The steel plate (15) is laid on a plurality of reinforcing ribs (7), the self-leveling floor (16) is laid on the steel plate (15), and the PVC floor (17) is laid on the self-leveling floor (16).

7. The modular cleanroom for the production of oral solid dosage forms according to claim 1, characterized in that, The frame room (14) is equipped with an airlock room (18), a process equipment room (19), an auxiliary equipment room (20), and a suspended ceiling mezzanine (21); the airlock room (18) is equipped with a personnel airlock room (18-1) and a material airlock room (18-2).

8. The modular cleanroom for the production of oral solid dosage forms according to claim 7, characterized in that, It also includes a cleanroom air supply duct (22) and a cleanroom return air duct (27); the airlock room (18) and the process equipment room (19) are respectively provided with a process equipment room air supply outlet (23) and an airlock room air supply outlet (24), and the cleanroom air supply duct (22) is connected to the process equipment room air supply outlet (23) and the airlock room air supply outlet (24); the airlock room (18) and the process equipment room (19) are also provided with an airlock room return air outlet (25) and a process equipment room return air outlet (26), and the airlock room return air outlet (25) and the process equipment room return air outlet (26) are connected to the cleanroom return air duct (27).

9. The modular cleanroom for the production of oral solid dosage forms according to claim 3, characterized in that, The reinforcing rib (7) is an I-beam.

10. A modular cleanroom production line for the production of oral solid dosage forms, characterized in that, It includes at least six frame chambers (14), which are connected in sequence. The six frame chambers (14) can be respectively configured as a weighing and dispensing module (28), a wet granulation, drying and mixing module (29), a tableting module (30), a coating module (31), a capsule filling module (32) and a dry granulation module (33); a process corridor (34) is provided in front of the six frame chambers (14) to connect the six frame chambers (14).

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