Anti-coagulation precise drug release pipeline device for upper digestive tract

Abstract

The utility model discloses an anti-condensation precise drug release pipeline device for an upper digestive tract, which comprises a triple-combination drug delivery pipe used for maintaining drug particles atomized by drug atomization equipment in a micron-sized state all the time and delivering the drug particles to a target focus area, the three-layer structure of the triple-combination medicine feeding pipe sequentially comprises a hydrophobic structure layer, a supporting structure layer and a heat insulation structure layer from inside to outside, and the polytetrafluoroethylene layer serves as the hydrophobic structure layer, has extremely high hydrophobicity and prevents medicine particles from being condensed or deposited in the pipe; the glass fiber layer serves as a supporting structure layer and wraps the polytetrafluoroethylene layer, and it is guaranteed that the pipeline is kept stable; the polyurethane foam layer is used as a heat insulation structure layer, wraps the glass fiber layer, has excellent biocompatibility and heat insulation effect, and avoids the influence of temperature fluctuation on the drug stability; according to the triple-combination medicine delivery tube, medicine can be efficiently and accurately delivered to a target focus area, and therefore the treatment effect is improved.

Description

Technical Field

[0001] This utility model relates to the technical field of medical devices and treatment equipment in gastroenterology, specifically an anticoagulant upper gastrointestinal precision drug delivery pipeline device. Background Technology

[0002] Due to the complexity of the digestive system and the physicochemical properties of drugs, traditional oral medications cannot accurately reach the lesion, resulting in low drug efficacy, poor therapeutic effects, and even side effects. Against this backdrop, drug delivery and release technologies have demonstrated significant advantages.

[0003] Current research and development in drug delivery and release technologies aim to improve drug targeting and treatment sustainability. In the treatment of upper gastrointestinal diseases, on the one hand, existing drug delivery systems, such as endoscopes, are expensive and deliver small amounts of medication, failing to meet the treatment needs of chronic gastritis, gastric ulcers, and other diseases. On the other hand, using ordinary drug delivery systems in conjunction with nebulizers can cause drug particles to easily adhere to the inner surface of the tube, agglomerating into larger droplets and leading to drug deposition on the tube wall. Furthermore, some easily degradable drugs are susceptible to thermal decomposition due to changes in body temperature, affecting their activity and stability. Utility Model Content

[0004] The purpose of this invention is to provide an anticoagulation upper gastrointestinal precision drug delivery pipeline device that can ensure drug delivery efficiency and release accuracy while maintaining drug activity and stability.

[0005] The technical solution of this utility model is:

[0006] An anticoagulation upper gastrointestinal precision drug delivery pipeline device includes: a triple-layer composite delivery tube, one end for connecting to the output end of a drug nebulizer, and the other end for insertion into the patient's body. The triple-layer composite delivery tube is used to deliver drug particles atomized by the drug nebulizer to the target lesion area while maintaining them at the micron level. The triple-layer composite delivery tube comprises three layers, from the inside out: a hydrophobic structural layer, made of polytetrafluoroethylene (PTFE), which has extremely high hydrophobicity to prevent drug particles from condensing or depositing inside the tube, ensuring smooth drug passage without blockage or drug waste due to moisture or liquid accumulation, thus maximizing drug delivery efficiency; and a supporting structural layer, made of fiberglass, wrapped around the PTFE layer to ensure the tube withstands pressure or prolonged exposure. The system maintains stability during use, preventing breakage or deformation and ensuring smooth drug delivery. The fiberglass layer also provides some thermal insulation. The insulation layer, a polyurethane foam layer, wraps around the fiberglass layer, offering excellent biocompatibility and insulation to prevent temperature fluctuations from affecting drug stability, especially in environments with significant temperature variations in the digestive tract. This insulation design ensures the drug is not affected by changes in body or external temperature during delivery, reducing the risk of drug degradation due to excessive heat or condensation due to excessive cold. The triple-layered delivery tube prevents atomized drug particles from condensing or degrading, maintaining particle sizes between 1-5 micrometers. This ensures uniform drug distribution within the gastrointestinal tract and maintains drug stability and therapeutic efficacy throughout the process. Simultaneously, the drug flow rate, regulated by valves and flow meters, ensures precise and stable drug release each time, tailored to the properties of different drugs and therapeutic needs. Because the drug particles within the triple-layered delivery tube have a smaller diameter, they can more evenly cover the lesion area, providing precise localized treatment. In this way, the drug's targeting is greatly enhanced, enabling concentrated treatment of the lesion area, reducing the drug's impact on healthy tissues, reducing systemic side effects, and avoiding drug waste.

[0007] Furthermore, the inner polytetrafluoroethylene layer has an inner diameter of 4mm-6mm and an outer diameter of 4.8mm-6.8mm; the middle glass fiber layer has an inner diameter of 4.8mm-6.8mm and an outer diameter of 5.2mm-7.2mm; and the outer polyurethane foam layer has an inner diameter of 5.2mm-7.2mm and an outer diameter of 6mm-8mm.

[0008] Furthermore, it also includes: a regulating valve, which is installed on the pipeline of the triple-combination drug delivery pipe.

[0009] Furthermore, it also includes a flow meter, which is installed on the pipeline of the triple-combination drug delivery pipeline, located downstream of the regulating valve.

[0010] Furthermore, the flow meter is an 8mm miniature vortex flow meter with a flow rate of 0-50ml / min.

[0011] Furthermore, the regulating valve is an 8mm needle valve.

[0012] Furthermore, the triple-layered drug delivery tube, flow meter, and regulating valve are connected via compression fittings.

[0013] Furthermore, the contact angle of the hydrophobic structural layer is greater than 120°.

[0014] Compared with existing technologies, this invention utilizes the synergistic operation of a triple-layer composite drug delivery tube and external nebulization technology to enable efficient and precise delivery of medication to the target lesion area. The triple-layer composite drug delivery tube maintains drug particles at the micron level, ensuring uniform distribution of the drug within the lesion area, thereby improving treatment efficacy. Specific beneficial effects include:

[0015] This novel composite pipe's hydrophobic and anti-coagulation design effectively prevents drug condensation or deposition within the pipe. The hydrophobicity of the polytetrafluoroethylene layer ensures that the drug will not aggregate, clog, or be wasted throughout the delivery process, maximizing drug delivery efficiency. The polyurethane foam and fiberglass effectively prevent the effects of temperature changes on the drug. This ensures that the drug is not affected by fluctuations in external ambient temperature as it passes through the pipe, guaranteeing the stability and activity of the drug during treatment. The insulation layer design is particularly suitable for long-term use or in complex internal environments, ensuring that the drug retains its effective components.

[0016] This invention utilizes precise atomized drug particles for rapid delivery of medication to the lesion area, acting directly on the local affected site without requiring significant absorption into the bloodstream. This local treatment significantly improves drug bioavailability, maximizing the therapeutic effect in treating gastrointestinal diseases.

[0017] The regulating valve and flow meter in this invention allow for adjustments to the drug release rate, atomized particle size, and release speed according to the patient's specific condition, thereby achieving personalized treatment. It supports continuous drug release and stable treatment, making it suitable for diseases requiring long-term, continuous treatment. Attached Figure Description

[0018] Figure 1 This is a three-dimensional structural diagram of the present invention.

[0019] Figure 2 This is a layer-by-layer exploded view of the triple composite drug delivery tube of this utility model.

[0020] Among them, 1. Triple composite drug delivery tube; 1.1. Polyurethane foam; 1.2. Fiberglass; 1.3. Polytetrafluoroethylene; 2. Control valve; 3. Flow meter. Detailed Implementation

[0021] The following is combined Figures 1 to 2 The specific embodiments of this utility model will be described in detail below. In the description of this utility model, it should be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0022] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature; in the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0023] It should be noted that the external atomizing device involved in this utility model can be purchased from any model on the market according to the needs, and does not involve any innovation.

[0024] Example

[0025] like Figure 1 As shown, an anticoagulation upper gastrointestinal precision drug delivery pipeline device includes: a triple-compound drug delivery tube 1, one end of which is connected to the output end of a drug nebulizer, and the other end is inserted into the patient's body. The triple-compound drug delivery tube 1 is used to deliver drug particles atomized by the drug nebulizer to the target lesion area while maintaining them at the micron level. Figure 2As shown, the triple-layer composite drug delivery tube 1 comprises three layers, from the inside out: a hydrophobic structural layer, a supporting structural layer, and a thermal insulation structural layer. The polytetrafluoroethylene (PTFE) layer 1.3 serves as the hydrophobic structural layer, with a contact angle greater than 120°, exhibiting extremely high hydrophobicity. This prevents drug particles from condensing or depositing inside the tube, ensuring smooth drug passage without blockage or waste due to moisture or liquid accumulation, thus maximizing drug delivery efficiency. The fiberglass layer 1.2 serves as the supporting structural layer, wrapping around the PTFE layer 1.3 to ensure the tube withstands pressure... The glass fiber layer is designed to remain stable even under prolonged use, preventing cracking or deformation and ensuring smooth drug delivery. It also provides some thermal insulation. The polyurethane foam layer 1.1, serving as a thermal insulation structure layer, is wrapped around the glass fiber layer 1.2. It offers excellent biocompatibility and thermal insulation, preventing temperature fluctuations from affecting drug stability. Especially in cases of significant temperature variations within the digestive tract, the thermal insulation design ensures that the drug is not affected by changes in body or external temperature during delivery, thereby reducing the risk of drug degradation due to excessively high temperatures or drug coagulation due to excessively low temperatures.

[0026] The triple-layered drug delivery tube 1 prevents the atomized drug particles from condensing or degrading, maintaining their size between 1-5 micrometers. This ensures uniform drug distribution throughout the gastrointestinal tract and maintains drug stability and therapeutic efficacy throughout the process. Because the drug particles within the triple-layered drug delivery tube 1 have a smaller diameter, they can more evenly cover the lesion area, providing precise local treatment. This significantly enhances drug targeting, enabling concentrated treatment of the lesion area, reducing the impact of the drug on healthy tissue, minimizing systemic side effects, and avoiding drug waste.

[0027] The triple-layer composite drug delivery tube 1 is made of polytetrafluoroethylene, fiberglass, and polyurethane foam, which have high biocompatibility and can come into contact with human tissues and fluids without causing rejection or discomfort. This combination of materials ensures the safety of the device and is suitable for patients undergoing long-term treatment or with chronic diseases.

[0028] Specifically, the inner polytetrafluoroethylene layer 1.3 has an inner diameter of 4mm-6mm and an outer diameter of 4.8mm-6.8mm; the middle fiberglass layer 1.2 has an inner diameter of 4.8mm-6.8mm and an outer diameter of 5.2mm-7.2mm; and the outer polyurethane foam layer 1.1 has an inner diameter of 5.2mm-7.2mm and an outer diameter of 6mm-8mm. This triple-layered drug delivery tube 1 is easier to insert into the patient's body. At the same time, this diameter also facilitates the large-volume delivery of the drug mist, shortens the delivery time, and avoids patient discomfort.

[0029] like Figure 1As shown, it also includes: a regulating valve 2 and a flow meter. The regulating valve 2 is installed on the triple-combination drug delivery pipe 1. The flow meter 3 is installed on the triple-combination drug delivery pipe 1, located downstream of the regulating valve 2. The drug flow rate regulated by the regulating valve 2 and the flow meter 3 ensures the accuracy and stability of each drug release according to the properties of different drugs and treatment needs.

[0030] In some embodiments, flow meter 3 is an 8mm 0-50ml / min miniature vortex flow meter, and regulating valve 2 is an 8mm needle-type shut-off valve. This is to allow for direct observation of the amount of medication delivered to the patient, in order to control the dosage and achieve optimal therapeutic effect while avoiding waste. The selected miniature vortex flow meter has a suitable range, is compatible with the dosage, and is small in size, with the same diameter as the composite drug delivery tube, allowing for a more suitable connection with the pipeline. If the flow meter detects that the dosage is sufficient or even excessive, it can directly close the regulating valve to stop the delivery. The 8mm needle-type shut-off valve provides excellent sealing, ensuring complete interruption of drug delivery.

[0031] like Figure 1 As shown, the triple-combined drug delivery tube 1, flow meter 3, and regulating valve 2 are connected by a compression fitting.

[0032] The above-disclosed embodiments are merely preferred embodiments of the present invention. However, the embodiments of the present invention are not limited thereto, and any variations that can be conceived by those skilled in the art should fall within the protection scope of the present invention.

Claims

1. A precise drug delivery conduit device for the upper gastrointestinal tract with anticoagulation properties, characterized in that, include: The triple-layered drug delivery tube (1) has one end for connecting to the output end of an external drug nebulizer and the other end for insertion into the patient's body. The triple-layered drug delivery tube (1) is used to deliver the drug particles atomized by the drug nebulizer to the target lesion area while maintaining them at the micron level. The triple-layered drug delivery tube (1) comprises three layers, from the inside out: The hydrophobic structural layer, which is a polytetrafluoroethylene layer (1.3), is used to prevent drug particles from condensing and depositing in the triple-layer drug delivery tube (1) and to ensure that the drug can pass through smoothly. The supporting structural layer, which is a glass fiber layer (1.2), is wrapped around the hydrophobic structural layer to ensure that the pipe maintains structural stability under compression or long-term use; The thermal insulation layer is a polyurethane foam layer (1.1) wrapped around the glass fiber layer (1.2) to prevent the temperature fluctuations of the drug during delivery from affecting the drug's stability.

2. The anticoagulation upper gastrointestinal precise drug delivery pipeline device according to claim 1, characterized in that, The inner polytetrafluoroethylene layer (1.3) has an inner diameter of 4mm-6mm and an outer diameter of 4.8mm-6.8mm; the middle glass fiber layer (1.2) has an inner diameter of 4.8mm-6.8mm and an outer diameter of 5.2mm-7.2mm; and the outer polyurethane foam layer (1.1) has an inner diameter of 5.2mm-7.2mm and an outer diameter of 6mm-8mm.

3. The anticoagulation upper gastrointestinal precise drug delivery pipeline device according to claim 1, characterized in that, Also includes: A regulating valve (2) is installed on the pipeline of the triple-combination drug delivery pipe (1).

4. The anticoagulation upper gastrointestinal precise drug delivery pipeline device according to claim 3, characterized in that, It also includes a flow meter (3), which is installed on the pipeline of the triple-combination drug delivery pipe (1) and located behind the regulating valve (2).

5. The anticoagulation upper gastrointestinal precise drug delivery pipeline device according to claim 4, characterized in that, The flow meter (3) is an 8mm 0-50ml / min miniature vortex flow meter.

6. The anticoagulation upper gastrointestinal precise drug delivery pipeline device according to claim 3, characterized in that, The regulating valve (2) is an 8mm needle valve.

7. The anticoagulation upper gastrointestinal precise drug delivery pipeline device according to claim 4, characterized in that, The triple-combined drug delivery tube (1), flow meter (3), and regulating valve (2) are connected by a compression fitting.

8. The anticoagulation upper gastrointestinal precise drug delivery pipeline device according to claim 1, characterized in that, The contact angle of the hydrophobic structural layer is greater than 120°.

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