Breast milk source probiotic and breast milk oligosaccharide co-sealed nozzle

Abstract

The utility model discloses a breast milk source probiotic and breast milk oligosaccharide co-sealed nozzle, and relates to the technical field of packaging. The pipe comprises a core pipe, a middle pipe and an outer pipe which are concentrically arranged from inside to outside, the top end of the middle pipe is provided with an upper flaring section, the middle pipe is connected with the core pipe through the upper flaring section, the top end of the outer pipe is provided with a lower flaring section, the outer pipe is connected with the middle pipe through the lower flaring section, and the outer sides of the upper flaring section and the lower flaring section are integrally provided with obliquely-arranged access ends. And a mixing channel, a gel channel and a coating channel are respectively formed in the core tube, between the core tube and the middle tube and between the middle tube and the outer tube. According to the utility model, the nozzle structure with the three-stage coaxial flow channel design is adopted, the diameter ratio is 1: 2: 4, the laminar flow stability can be ensured, the conical end on the outer tube is matched, the fluid turbulence problem is reduced, the microsphere monodispersity is improved, the nozzle can realize single-step forming of co-sealing of breast milk source probiotics and breast milk oligosaccharide, and high encapsulation efficiency and targeted release are ensured.

Description

Technical Field

[0001] This utility model belongs to the field of packaging technology, and in particular relates to a nozzle for co-sealing breast milk probiotics and breast milk oligosaccharides. Background Technology

[0002] Probiotics derived from breast milk and human milk oligosaccharides (HMOs) S In the field of microsphere encapsulation, traditional preparation methods (such as emulsification and spray drying) have the following drawbacks:

[0003] 1) Uneven particle size: Traditional emulsification methods rely on mechanical shearing force, resulting in a wide distribution of microsphere size (e.g., 50-500um), which affects the accuracy of targeted release into the intestine.

[0004] 2) Insufficient protection against gastric acid: Single-layer coated microspheres (such as sodium alginate) are easily disintegrated in gastric acid (pH 1.5), resulting in a loss of more than 90% of viable bacteria.

[0005] 3) Complex process: Multi-layer coating requires step-by-step operation (such as gelling first and then coating with enteric material), which is time-consuming and results in poor batch consistency. Summary of the Invention

[0006] The purpose of this invention is to provide a nozzle for co-sealing breast milk probiotics and breast milk oligosaccharides. The nozzle structure, with a three-stage coaxial flow channel design and a diameter ratio of 1:2:4, ensures laminar flow stability. Combined with the conical end on the outer tube, it reduces fluid turbulence and improves the monodispersity of microspheres. The nozzle can achieve single-step molding of breast milk probiotics and breast milk oligosaccharides, ensuring high encapsulation rate and targeted release.

[0007] To solve the above-mentioned technical problems, this utility model is achieved through the following technical solution:

[0008] This utility model is a nozzle that co-seals breast milk probiotics and breast milk oligosaccharides, comprising a core tube, a middle tube and an outer tube arranged concentrically from the inside out;

[0009] The top end of the middle tube is provided with an upper flared section, through which the middle tube is connected to the core tube;

[0010] The outer tube has a flared section at its top end, and the outer tube is connected to the middle tube through the flared section;

[0011] Both the upper flared section and the lower flared section have an integrally inclined access end on their outer sides;

[0012] The core tube contains a mixing channel, a gel channel, and a coating channel, which are formed within the core tube, between the core tube and the middle tube, and between the middle tube and the outer tube, respectively.

[0013] A Y-shaped microfluidic chip is connected to the top of the core tube;

[0014] The bottom end of the outer tube is provided with a tapered end, and the cone angle of the tapered end is set in the range of 30-45°.

[0015] Furthermore, the two input terminals of the Y-shaped microfluidic chip are respectively fed with breast milk probiotics and HMOs. S .

[0016] Furthermore, it also includes a first delivery tube, which is connected to the access end of the middle tube, and contains CaCl2 crosslinking liquid.

[0017] Furthermore, it also includes a second delivery tube, which is connected to the inlet end of the outer tube, and the second delivery tube contains enteric material.

[0018] Furthermore, an external connector is provided at the top end and outside the access end of the core tube, and the external connector is a Luer connector.

[0019] Furthermore, the diameter ratio of the core tube, the middle tube, and the outer tube is 1:2:4.

[0020] This utility model has the following beneficial effects:

[0021] This invention features a nozzle structure with a three-stage coaxial flow channel design and a diameter ratio of 1:2:4, which ensures laminar flow stability. Combined with the tapered end on the outer tube, it reduces fluid turbulence and improves the monodispersity of microspheres. The nozzle enables single-step molding of co-encapsulation of breast milk probiotics and breast milk oligosaccharides, ensuring high encapsulation rate and targeted release.

[0022] Of course, any product implementing this utility model does not necessarily need to achieve all of the advantages described above at the same time. Attached Figure Description

[0023] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 This is a schematic diagram of the structure of a nozzle for co-sealing human milk probiotics and human milk oligosaccharides according to the present invention;

[0025] Figure 2 This is a cross-sectional view of the structure of this utility model;

[0026] The attached diagram lists the components represented by each number as follows:

[0027] 1-Core tube, 2-Middle tube, 3-Outer tube, 4-Mixing channel, 5-Gel channel, 6-Coating channel, 201-Upper flared section, 202-Inlet end, 301-Lower flared section, 302-Conical end. Detailed Implementation

[0028] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0029] Please see Figure 1-2 As shown, this utility model is a nozzle for co-sealing breast milk probiotics and breast milk oligosaccharides, comprising a core tube 1, a middle tube 2 and an outer tube 3 arranged concentrically from the inside out;

[0030] The top end of the middle tube 2 is provided with an upper flared section 201, and the middle tube 2 is connected to the core tube 1 through the upper flared section 201;

[0031] The outer tube 3 has a lower flared section 301 at its top end, and the outer tube 3 is connected to the middle tube 2 through the lower flared section 301;

[0032] Both the upper flared section 201 and the lower flared section 301 have an integrally provided inclined access end 202 on their outer sides;

[0033] Mixing channel 4, gel channel 5, and coating channel 6 are formed inside core tube 1, between core tube 1 and middle tube 2, and between middle tube 2 and outer tube 3, respectively.

[0034] A Y-shaped microfluidic chip is connected to the top of the core tube 1;

[0035] The bottom end of the outer tube 3 is provided with a tapered end 302, and the cone angle of the tapered end 302 is set in the range of 30-45°.

[0036] The Y-shaped microfluidic chip has two input terminals for breast milk probiotics and HMOs, respectively. S .

[0037] It also includes a first delivery pipe, which is connected to the access end 202 of the middle pipe 2, and contains CaCl2 crosslinking liquid.

[0038] It also includes a second delivery tube, which is connected to the access end 202 of the outer tube 3, and contains enteric material.

[0039] Among them, the top end of the core tube 1 and the outside of the access end 202 are provided with external connectors, which are Luer connectors.

[0040] The diameter ratio of the core tube 1, the middle tube 2, and the outer tube 3 is 1:2:4.

[0041] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0042] The preferred embodiments of this utility model disclosed above are merely illustrative of the present utility model. These preferred embodiments do not exhaustively describe all details, nor do they limit the utility model to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of this utility model, thereby enabling those skilled in the art to better understand and utilize it. This utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A nozzle for co-sealing breast milk-derived probiotics and breast milk oligosaccharides, characterized in that: It includes a core tube (1), a middle tube (2) and an outer tube (3) arranged concentrically from the inside out; The top end of the middle tube (2) is provided with an upper flared section (201), and the middle tube (2) is connected to the core tube (1) through the upper flared section (201); The outer tube (3) has a lower flared section (301) at its top end, and the outer tube (3) is connected to the middle tube (2) through the lower flared section (301); Both the upper flared section (201) and the lower flared section (301) are integrally provided with inclined access ends (202) on their outer sides. A mixing channel (4), a gel channel (5), and a coating channel (6) are formed inside the core tube (1), between the core tube (1) and the middle tube (2), and between the middle tube (2) and the outer tube (3), respectively. A Y-shaped microfluidic chip is connected to the top of the core tube (1); The bottom end of the outer tube (3) is provided with a tapered end (302), and the cone angle of the tapered end (302) is set in the range of 30-45°.

2. The nozzle for co-sealing breast milk probiotics and breast milk oligosaccharides according to claim 1, characterized in that, The two input terminals of the Y-shaped microfluidic chip are respectively fed with breast milk probiotics and HMO. S .

3. The nozzle for co-sealing breast milk probiotics and breast milk oligosaccharides according to claim 1, characterized in that, It also includes a first delivery tube, which is connected to the access end (202) of the middle tube (2), and contains CaCl2 crosslinking liquid.

4. The nozzle for co-sealing breast milk probiotics and breast milk oligosaccharides according to claim 1, characterized in that, It also includes a second delivery tube, which is connected to the access end (202) of the outer tube (3), and the second delivery tube contains enteric material.

5. The nozzle for co-sealing breast milk probiotics and breast milk oligosaccharides according to claim 1, characterized in that, The core tube (1) has an external connector at its top end and the access end (202), and the external connector is a Luer connector.

6. The nozzle for co-sealing breast milk probiotics and breast milk oligosaccharides according to claim 1, characterized in that, The diameter ratio of the core tube (1), the middle tube (2) and the outer tube (3) is 1:2:4.

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