A reaction vessel for processing epinastine hydrochloride

Abstract

This utility model relates to a reaction vessel for processing epinastine hydrochloride, comprising a vessel body and a temperature control device surrounding its exterior. The vessel body contains a mixing mechanism and a cleaning mechanism. Two injection pipes are connected to the exterior of the vessel body near its top, and two drainage pipes are connected to the exterior of the vessel body near its bottom. This reaction vessel for processing epinastine hydrochloride uses a high-pressure water pump to transmit external cleaning solution or aqueous solution through a connecting pipe to the interior of a connecting cylinder. Multiple nozzles spray the cleaning solution or aqueous solution onto the inner wall of the vessel for cleaning. A scraper removes material adhering to the inner wall of the vessel. Multiple atomizing nozzles at the bottom of an annular hollow pipe rinse the outside of the stirring rod and multiple cleaning pipes. After cleaning, wastewater is discharged from the vessel body through the drainage pipe on the left side.

Description

Technical Field

[0001] This utility model relates to the field of epinastine hydrochloride processing and preparation technology, specifically to a reaction vessel for epinastine hydrochloride processing. Background Technology

[0002] In the 1990s, Boehringer Ingelheim in Germany developed an anti-allergy drug (epistine hydrochloride) that had no sedative effects and weak cardiotoxicity. Compared with the situation in China, the clinical pharmacology research on epinastine hydrochloride is more comprehensive abroad. Preclinical pharmacological studies, including receptor binding characteristics, antihistamine activity, anti-allergic effects, and effects on the central nervous system, were conducted using a multicenter, double-blind, and controlled clinical trial approach. Toxicological studies, including acute, subacute, and long-term toxicity and reproductive toxicity, were also performed. Pharmacokinetic studies, including absorption and metabolism, were also conducted. Clinical studies for the treatment of skin diseases and allergic rhinitis were conducted using the same methods. The results showed that, at the same dosage, epinastine was significantly more effective than other second-generation histamine H1 receptor antagonists such as terfenadine, astemizole, and ketotifen. For the same therapeutic effect, epinastine required a significantly lower dosage. These pharmacological studies demonstrate that epinastine hydrochloride has a significantly better clinical effect in anti-allergy than other second-generation histamine H1 receptor antagonists, while exhibiting significantly fewer toxic side effects. Therefore, the preparation of epinastine hydrochloride is crucial.

[0003] For example, Chinese patent CN216260771U discloses a polypeptide generator, including a reaction vessel, an end cap, a feed inlet, a discharge valve, and a discharge outlet. The top of the reaction vessel is screwed and fixed with an end cap, and feed inlets are symmetrically installed on the end cap. A heating chamber is formed in the inner wall of the reaction vessel. The bottom end of the heating chamber is connected to a liquid inlet pump through a liquid inlet pipe. The liquid inlet pump is installed at the bottom of a liquid storage tank. The top of the heating chamber is connected to the top of the liquid storage tank through a liquid return pipe. An electric heating mechanism is installed on one side of the liquid storage tank. A control board is fixed to one side of the reaction vessel through a connecting frame. The control board is electrically connected to the liquid inlet pump and the electric heating mechanism.

[0004] The aforementioned peptide generator has certain shortcomings. It heats the heat-conducting liquid inside the storage tank through an electric heating mechanism and introduces it into the heating chamber through an inlet pump. After circulating inside the heating chamber, it flows back into the storage tank through a return pipe, stabilizing the heating inside the reactor and making the peptide synthesis reaction more stable. However, the mixed material may adhere to the inner wall of the reactor, which not only increases the cost but also makes subsequent mixing work inconvenient. Therefore, this application proposes a reaction vessel for epinastine hydrochloride processing to solve the above problems. Utility Model Content

[0005] To address the shortcomings of existing technologies, this utility model provides a reaction vessel for processing epinastine hydrochloride, which has advantages such as cleaning the inner wall of the vessel after mixing. This solves the problem that the mixed material may adhere to the inner wall of the reaction vessel, which not only increases costs but also makes subsequent mixing work inconvenient.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a reaction vessel for processing epinastine hydrochloride, comprising a vessel body and a temperature control device covering its outer side, a mixing mechanism inside the vessel body, a cleaning mechanism inside the vessel body, two injection pipes connected to the outer side of the vessel body near its top, and two drainage pipes connected to the outer side of the vessel body near its bottom.

[0007] Furthermore, both the injection pipe and the drainage pipe are equipped with solenoid valves, and the temperature control device is an electric heating device.

[0008] Furthermore, the mixing mechanism includes a bent plate fixed to the top of the tank, a motor fixed to the upper surface of the bent plate, a first gear fixed to the outer side of the motor output shaft, a second gear meshing with the outer side of the first gear, a cylinder welded inside the second gear, the bottom end of the cylinder penetrating the upper surface of the tank and extending into the tank, and multiple cleaning pipes connected to its left and right sides, stirring rods fixed to both the front and rear sides of the cylinder, and two scrapers fixed to the opposite ends of the stirring rods on the front and rear sides.

[0009] Furthermore, both scraper rods are in movable contact with the inner wall of the tank cavity, the cylinder and the tank are rotatably connected by bearings, and the opposite ends of the cleaning pipes on the left and right sides are connected to a nozzle device.

[0010] Furthermore, the cleaning mechanism includes a connecting cylinder vertically fixed inside the bending plate, two supports fixed to the inner wall of the tank cavity near its top, the ends of the two supports away from the inner wall of the tank being fixed to the same annular hollow pipe, the bottom end of the annular hollow pipe being connected to multiple atomizing nozzles, the annular hollow pipe and the outer side of the connecting cylinder being connected to a connecting pipe, and two valve bodies being provided on the outer side of the connecting pipe.

[0011] Furthermore, the annular hollow tube is circular in shape and the cylinder is located inside the annular hollow tube, and the connecting cylinder is rotatably connected to the top of the cylinder through a sealed bearing.

[0012] Compared with the prior art, the technical solution of this application has the following beneficial effects:

[0013] This epinastine hydrochloride processing reactor connects to an external high-pressure water pump via a connecting pipe. The pump then delivers external cleaning solution or aqueous solution through the connecting pipe to the interior of the reactor. Multiple nozzles spray the cleaning solution or aqueous solution onto the inner wall of the reactor for cleaning. A scraper removes material adhering to the inner wall of the reactor. Multiple atomizing nozzles at the bottom of the annular tube rinse the outside of the stirring rod and multiple cleaning pipes. After cleaning, wastewater is discharged from the reactor through the drain pipe on the left side. This design solves the problem of mixed material adhering to the inner wall of the reactor, which not only increases costs but also hinders subsequent mixing operations. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model;

[0015] Figure 2 This is a schematic diagram of the hybrid mechanism of this utility model;

[0016] Figure 3 This is a schematic diagram of the cleaning mechanism of this utility model.

[0017] In the diagram: 1. Tank body, 2. Mixing mechanism, 201. Bending plate, 202. Motor, 203. First gear, 204. Second gear, 205. Cylinder, 206. Cleaning pipe, 207. Stirring rod, 208. Scraper, 3. Temperature control device, 4. Cleaning mechanism, 401. Support, 402. Annular empty pipe, 403. Atomizing nozzle, 404. Connecting pipe, 405. Valve body, 406. Connecting cylinder, 5. Injection pipe, 6. Drainage pipe. Detailed Implementation

[0018] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0019] Please see Figure 1 The reaction vessel for processing epinastine hydrochloride in this embodiment includes a tank body 1 and a temperature control device 3 covering its outer side. A mixing mechanism 2 is provided inside the tank body 1, and a cleaning mechanism 4 is provided inside the tank body 1. Two injection pipes 5 are connected to the outer side of the tank body 1 near its top, and two drainage pipes 6 are connected to the outer side of the tank body 1 near its bottom.

[0020] Both injection pipes 5 and drainage pipe 6 are equipped with solenoid valves, and the temperature control device 3 is an electric heating device.

[0021] Understandably, purified water is transferred to the inside of tank 1 through the right injection pipe 5, epinastine is added through the left injection pipe 5, and then the temperature inside tank 1 is raised by the temperature control device 3. Concentrated hydrochloric acid is added dropwise and mixing begins. The mixed material is discharged through the right drain pipe 6 for the next processing step.

[0022] Please see Figure 2 In this embodiment, the mixing mechanism 2 includes a bent plate 201 fixed to the top of the tank 1. A motor 202 is fixed to the upper surface of the bent plate 201. A first gear 203 is fixed to the outside of the output shaft of the motor 202. A second gear 204 meshes with the outside of the first gear 203. A cylinder 205 is welded inside the second gear 204. The bottom end of the cylinder 205 penetrates the upper surface of the tank 1 and extends into the tank 1. Multiple cleaning pipes 206 are connected to its left and right sides. Stirring rods 207 are fixed to both the front and rear sides of the cylinder 205. Two scraper rods 208 are fixed to the opposite ends of the stirring rods 207 on the front and rear sides.

[0023] Both scraper rods 208 are in contact with the inner wall of the inner cavity of the tank 1. The cylinder 205 is rotatably connected to the tank 1 through a bearing. The opposite ends of the cleaning pipes 206 on the left and right sides are connected to a nozzle device.

[0024] Understandably, starting the motor 202 will cause the cylinder 205 to rotate, improving cleaning efficiency, and the scraper 208 will scrape off the material adhering to the inner wall of the tank 1.

[0025] Please see Figure 3 In this embodiment, the cleaning mechanism 4 includes a connecting cylinder 406 vertically fixed inside the bending plate 201. Two supports 401 are fixed to the inner wall of the inner cavity of the tank 1 near its top. The ends of the two supports 401 away from the inner wall of the tank 1 are fixed with the same annular hollow pipe 402. The bottom end of the annular hollow pipe 402 is connected to multiple atomizing nozzles 403. The annular hollow pipe 402 and the outer side of the connecting cylinder 406 are both connected to connecting pipes 404. Two valve bodies 405 are provided on the outer side of the connecting pipe 404. The connecting pipe 404 is connected to an external high-pressure water pump. The high-pressure water pump transmits external cleaning liquid or aqueous solution to the inside of the connecting cylinder 406 through the connecting pipe 404. The cleaning liquid or aqueous solution is then sprayed onto the inner wall of the tank 1 for cleaning through multiple nozzle devices.

[0026] The annular tube 402 is circular in shape, and the cylinder 205 is located inside the annular tube 402. Multiple atomizing nozzles 403 at the bottom of the annular tube 402 can rinse the outside of the stirring rod 207 and multiple cleaning tubes 206. After cleaning, the wastewater can be discharged from the tank 1 through the left drain pipe 6. The connecting cylinder 406 is rotatably connected to the top of the cylinder 205 through a sealed bearing. Purified water is transferred to the inside of the tank 1 through the right injection pipe 5. The motor 202 is started to rotate the second gear 204, thereby driving the cylinder 205 and multiple stirring rods 207 to slowly stir the purified water in the tank 1. Epistylsalicylate is added through the left injection pipe 5. Then, the temperature inside the tank 1 is raised by the temperature control device 3. Concentrated hydrochloric acid is added dropwise and mixing begins. The mixed material is discharged through the right drain pipe 6 for the next processing step.

[0027] Understandably, connecting pipe 404 to an external high-pressure water pump allows external cleaning liquid or aqueous solution to be transferred through pipe 404 to the inside of connecting cylinder 406. Multiple nozzles then spray the cleaning liquid or aqueous solution onto the inner wall of tank 1 for cleaning. Scraper 208 scrapes off material adhering to the inner wall of tank 1. Multiple atomizing nozzles 403 at the bottom of annular pipe 402 rinse the outside of stirring rod 207 and multiple cleaning pipes 206. After cleaning, wastewater is discharged from tank 1 through left-side drain pipe 6. This solves the problem that mixed materials might adhere to the inner wall of the reactor, increasing costs and hindering subsequent mixing.

[0028] All electrical components mentioned in this article are electrically connected to the main controller and power supply, and all electrical components mentioned are conventional and known devices. This application will not elaborate further. The main controller can be a conventional and known device such as a computer that performs control. The control circuit of the main controller can be implemented by a person skilled in the art through simple programming. The power supply is also common knowledge in the art. Furthermore, this utility model is mainly used to protect mechanical devices, so this utility model will not explain the control method and circuit connection in detail. At the same time, any parts of this utility model that are not described in detail are all common technologies known to those skilled in the art.

[0029] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0030] The working principle of the above embodiments is as follows:

[0031] First, the inner wall of tank 1 and the outer side of stirring rod 207 need to be thoroughly cleaned. Connect pipe 404 to an external high-pressure water pump, and use the high-pressure water pump to transfer external cleaning solution or aqueous solution to the inside of connecting cylinder 406 through pipe 404. The cleaning solution or aqueous solution is then sprayed onto the inner wall of tank 1 through multiple nozzles. Starting motor 202 will rotate cylinder 205 to improve cleaning efficiency. Scraper 208 can scrape off the material adhering to the inner wall of tank 1. Multiple atomizing nozzles 403 at the bottom of annular tube 402 can clean the outer side of stirring rod 207 and multiple cleaning tubes 206. After rinsing, the wastewater can be discharged from tank 1 through the left drain pipe 6. When it is necessary to process epinastine hydrochloride, purified water is transferred to the inside of tank 1 through the right injection pipe 5, and the motor 202 is started to rotate the second gear 204, thereby driving the cylinder 205 and multiple stirring rods 207 to slowly stir the purified water in tank 1. Epinastine is added through the left injection pipe 5, and then the temperature inside tank 1 is raised by the temperature control device 3. Concentrated hydrochloric acid is added dropwise and mixing begins. The mixed material is discharged through the right drain pipe 6 for the next processing step.

[0032] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0033] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A reaction tank for processing of epinastine hydrochloride, comprising a tank body (1) and a temperature control device (3) arranged on the outer side of the tank body (1), characterized in that: The tank (1) is equipped with a mixing mechanism (2) inside, a cleaning mechanism (4) inside, two injection pipes (5) are connected to the outside of the tank (1) near its top, and two drainage pipes (6) are connected to the outside of the tank (1) near its bottom.

2. The reaction kettle for processing of epinastine hydrochloride according to claim 1, wherein: Both of the injection pipes (5) and the drain pipe (6) are equipped with solenoid valves, and the temperature control device (3) is an electric heating device.

3. The reaction vessel for processing epinastine hydrochloride according to claim 1, characterized in that: The mixing mechanism (2) includes a bent plate (201) fixed to the top of the tank (1). A motor (202) is fixed on the upper surface of the bent plate (201). A first gear (203) is fixed on the outer side of the output shaft of the motor (202). A second gear (204) meshes with the outer side of the first gear (203). A cylinder (205) is welded inside the second gear (204). The bottom end of the cylinder (205) penetrates the upper surface of the tank (1) and extends into the tank (1). Multiple cleaning pipes (206) are connected to its left and right sides. Stirring rods (207) are fixed on both the front and rear sides of the cylinder (205). Two scrapers (208) are fixed at the opposite ends of the stirring rods (207) on the front and rear sides.

4. The reaction vessel for processing epinastine hydrochloride according to claim 3, characterized in that: Both scraper rods (208) are in contact with the inner wall of the inner cavity of the tank (1). The cylinder (205) is rotatably connected to the tank (1) through a bearing. The opposite ends of the cleaning pipes (206) on the left and right sides are connected to a nozzle device.

5. A reaction vessel for processing epinastine hydrochloride according to claim 3, characterized in that: The cleaning mechanism (4) includes a connecting cylinder (406) vertically fixed inside the bending plate (201). Two supports (401) are fixed on the inner wall of the inner cavity of the tank (1) near its top. The two supports (401) are fixed with the same annular hollow tube (402) at the end away from the inner wall of the tank (1). The bottom end of the annular hollow tube (402) is connected to multiple atomizing nozzles (403). The annular hollow tube (402) and the outer side of the connecting cylinder (406) are both connected to a connecting pipe (404). Two valve bodies (405) are provided on the outer side of the connecting pipe (404).

6. A reaction vessel for processing epinastine hydrochloride according to claim 5, characterized in that: The annular hollow tube (402) is circular in shape and the cylinder (205) is located inside the annular hollow tube (402). The connecting cylinder (406) is rotatably connected to the top of the cylinder (205) through a sealed bearing.

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