A centrifuge device for the preparation of pharmaceutical intermediates

Abstract

This utility model relates to the field of pharmaceutical equipment technology, and more particularly to a centrifuge device for preparing pharmaceutical intermediates. It includes a support base, an outer barrel mounted on the support base, and a rotating inner barrel rotatably connected inside the outer barrel. Several filter screens are arranged on the wall of the rotating inner barrel, and several guide blocks are connected inside the rotating inner barrel. The filter screens and guide blocks are alternately arranged around the inner barrel, with the guide blocks contacting the edges of the filter screens. Several mounting shells are connected to the outer wall of the rotating inner barrel, and electric slide rails are installed inside each mounting shell. Baffles are slidably connected inside each mounting shell, passing through the rotating inner barrel and located at the connection between the filter screens and guide blocks. The electric slide rails drive the baffles. Driven by the electric slide rails, the baffles extend into the rotating inner barrel during the initial stage of centrifugation, creating a dynamic isolation structure where the baffles and guide blocks alternately surround the filter screens. This achieves physical isolation between the solids and the filter screens, eliminating the need to stop the centrifuge to clean the filter screens and improving separation efficiency.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical equipment technology, and in particular to a centrifuge device for the preparation of pharmaceutical intermediates. Background Technology

[0002] Centrifugation is a physical method that utilizes differences in material density to achieve efficient separation of multiphase components within a centrifugal force field generated by high-speed rotation. In the preparation of pharmaceutical intermediates, centrifuges are widely used in key stages such as reaction solution purification, separation of crystalline products, catalyst recovery, and impurity removal. Their separation efficiency directly affects the purity and yield of intermediates, as well as the stability of subsequent synthetic steps, making them one of the core pieces of equipment for ensuring drug quality and production efficiency.

[0003] A centrifuge device for preparing pharmaceutical intermediates, disclosed in announcement number CN220310715U, employs a double-ring chamber design: the inner ring chamber uses centrifugal force to achieve preliminary separation of the target liquid from impurities, while the outer ring chamber further collects the target liquid; the device is equipped with a removable filter screen to intercept solid particles or high-viscosity impurities. This design simplifies maintenance through a modular filter screen structure, allowing for quick replacement when the filter screen is saturated or damaged.

[0004] Although the aforementioned equipment improves maintenance convenience through replaceable filters, significant drawbacks remain in actual operation: during a single filtration process, high solids content or colloidal substances can easily cause rapid clogging of the filter. Once clogged, separation efficiency drops sharply, leading to retention of the target liquid and extended separation cycles. In such cases, the machine must be stopped to replace or clean the filter, interrupting continuous production and requiring restarting the equipment to reach a stable speed, resulting in additional energy and time costs. This severely restricts the large-scale, efficient preparation of pharmaceutical intermediates. Utility Model Content

[0005] To overcome the drawbacks of low separation efficiency and frequent shutdowns caused by filter clogging, this invention provides a centrifuge device for the preparation of pharmaceutical intermediates, aiming to solve the aforementioned shortcomings.

[0006] A centrifuge device for preparing pharmaceutical intermediates includes a support base, an outer barrel mounted on the support base, a rotating inner barrel rotatably connected inside the outer barrel, a plurality of filter screens disposed on the wall of the rotating inner barrel, and a plurality of guide blocks connected inside the rotating inner barrel. The filter screens and the guide blocks are alternately arranged around each other. The cross-section of the guide block is approximately an isosceles triangle, and the base angles of the isosceles triangle are all in contact with the edge of the filter screen. A guide ring is connected to the top of the rotating inner barrel. The vertical cross-section of the guide ring is a right-angled triangle, and its hypotenuse faces the bottom of the rotating inner barrel. A plurality of mounting shells are connected to the outer wall of the rotating inner barrel. An electric slide rail is installed inside the mounting shell. A baffle is slidably connected inside the mounting shell. The baffle passes through the rotating inner barrel and is located at the connection between the filter screen and the guide block. The electric slide rail is used to drive the baffle.

[0007] As an improvement to the above solution, the top of the outer barrel is provided with a detachable barrel lid, and a fixing frame is connected to the top. The fixing frame divides the barrel lid into two parts, and a connecting rod extending into the rotating inner barrel is fixedly connected to the middle of the fixing frame. Several levers are connected to the connecting rod.

[0008] As an improvement to the above solution, scrapers are connected to both the left and right sides of the end of the mounting shell near the outer barrel, and the scrapers are slidably connected to the inner wall of the outer barrel.

[0009] As an improvement to the above solution, the mounting housing is connected to sliding plates on both the left and right sides, and the sliding plates are provided with longitudinal stripes.

[0010] As an improvement to the above solution, the guide block has several transverse grooves.

[0011] As an improvement to the above solution, the lid of the outer barrel is provided with a transparent observation window.

[0012] Compared with the prior art, the present invention has the following advantages:

[0013] 1. The baffle, driven by an electric slide rail, extends into the inner rotating drum during the initial stage of centrifugation. This creates a dynamic isolation structure where the baffle and guide block alternately surround the filter screen. During high-speed rotation, large solid particles are guided to move along the inclined surface of the guide block to both sides and are blocked by the baffle. This achieves physical isolation between the solids and the filter screen, preventing filter screen blockage and ensuring that the liquid continuously passes through the filter screen into the outer drum. This eliminates the need to stop the machine to clean the filter screen during a single centrifugation cycle, thereby improving separation efficiency.

[0014] 2. After the main liquid is separated, the electric slide rail pulls the baffle back into the housing, allowing the accumulated solid-liquid mixture to directly contact the filter screen for secondary filtration. At the same time, the scraper rotates and scrapes off the residual liquid from the inner wall of the outer tank. The liquid flows in a directional direction along the slide plate with longitudinal stripes to the collection port, realizing the automatic cleaning and secondary recycling of residues, reducing product yield loss, and solving the problem of production interruption and restart energy consumption caused by cleaning the filter screen. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0016] Figure 2 This is a schematic diagram showing the connection relationship between the guide block and the guide ring of this utility model.

[0017] Figure 3 This is a cross-sectional view showing the connection relationship between the outer casing and the rotating inner tub of this utility model.

[0018] Figure 4 This is a cross-sectional view showing the connection relationship between the electric slide rail and the baffle of this utility model.

[0019] Figure 5 This is a schematic diagram showing the connection relationship between the scraper and the sliding plate of this utility model.

[0020] The meanings of the labels in the attached diagram are as follows: 1: support base, 2: outer barrel, 3: rotating inner barrel, 4: filter screen, 5: guide block, 6: guide ring, 7: mounting shell, 8: electric slide rail, 9: baffle, 10: fixing frame, 11: connecting rod, 12: lever, 13: scraper, 14: sliding plate, 15: groove, 16: observation window. Detailed Implementation

[0021] To make the objectives, technical solutions, and advantages of this utility model clearer, the following will describe this utility model in further detail with reference to the accompanying drawings. It is hereby declared that the terms "up," "down," "left," "right," "front," "back," "inner," and "outer," etc., appearing or about to appear in this document, are based solely on the accompanying drawings and are not intended to specifically limit this utility model.

[0022] Example: A centrifuge device for the preparation of pharmaceutical intermediates, such as Figures 1-5As shown, the device includes a support base 1, an outer tub 2, a rotating inner tub 3, filter screens 4, guide blocks 5, guide rings 6, a mounting shell 7, an electric slide rail 8, and a baffle 9. The outer tub 2 is mounted on the support base 1, and the rotating inner tub 3 is rotatably connected inside the outer tub 2. Four filter screens 4 are installed on the wall of the rotating inner tub 3, and four guide blocks 5 are connected inside the rotating inner tub 3. The filter screens 4 and guide blocks 5 are arranged alternately around each other. The horizontal cross-section of the guide block 5 is approximately an isosceles triangle, and the base angles of the isosceles triangle are all in contact with the edge of the filter screen 4. The top of the rotating inner tub 3 is connected to the guide ring 6, and the vertical cross-section of the guide ring 6 is a right triangle. The inner drum 3 is angular, with its cross-section hypotenuse facing the bottom of the inner drum 3. The inclined surface of the guide ring 6 forces the upward liquid to fold back downward to prevent overflow. The outer wall of the inner drum 3 is connected to eight mounting shells 7. An electric slide rail 8 is installed inside the mounting shell 7. A baffle 9 is slidably connected inside the mounting shell 7. The front end of the baffle 9 passes through the wall of the inner drum 3 and is located at the connection between the filter screen 4 and the guide block 5. The electric slide rail 8 is used to drive the baffle 9. During centrifugation, the inner drum 3 rotates at high speed. The guide block 5 diverts large solid particles to both sides. The baffle 9 extends to prevent solids from contacting the filter screen 4. The liquid passes through the filter screen 4 and enters the outer drum 2 for collection.

[0023] like Figure 2 As shown, it also includes a fixing frame 10, a connecting rod 11, and a lever 12. The top of the outer barrel 2 is provided with a detachable barrel cover, and the fixing frame 10 is connected to the top. The fixing frame 10 divides the barrel cover into two parts. The connecting rod 11, which extends into the rotating inner barrel 3, is fixedly connected to the middle of the fixing frame 10. Twelve levers 12 are connected to the connecting rod 11. The connecting rod 11, which is fixed to the barrel cover, extends into the rotating inner barrel 3. The levers 12 break up the solid clumps that swing with the liquid flow. No additional power is required. Automatic operation is achieved by using the flow energy of centrifugal liquid.

[0024] like Figure 3 and Figure 5 As shown, it also includes a scraper 13. The scraper 13 is connected to both the left and right sides of the end of the mounting shell 7 near the outer barrel 2. The scraper 13 is slidably connected to the inner wall of the outer barrel 2. The scraper 13 rotates synchronously with the mounting shell 7 and closely adheres to the inner wall of the outer barrel 2 to scrape the liquid attached to the inner wall of the outer barrel 2, thereby improving the product yield.

[0025] like Figure 3 and Figure 5 As shown, it also includes a slide plate 14. The slide plate 14 is connected to both the left and right sides of the mounting housing 7. The slide plate 14 is provided with longitudinal stripes. The longitudinal stripes of the slide plate 14 disrupt the surface tension of the liquid and accelerate the drainage.

[0026] like Figure 3 As shown, the guide block 5 has several transverse grooves 15, which temporarily retain some solid particles.

[0027] like Figure 1As shown, it also includes an observation window 16. The lid of the outer tank 2 is equipped with a transparent observation window 16, through which the liquid level of the rotating inner tank 3 can be observed in real time, and the staff can precisely control the rotation speed according to the liquid level.

[0028] The operator opens the lid of the outer barrel 2, pours the liquid to be centrifuged into the rotating inner barrel 3, then closes the lid, places the collection container in front of the support base 1, and starts the electric slide rail 8 to push all the baffles 9 through the rotating inner barrel 3. Each filter screen 4 has a baffle 9 protruding from both sides, separating the filter screen 4 from the guide block 5. Then the centrifuge device is started, and the rotating inner barrel 3 rotates inside the outer barrel 2. The mounting shell 7 and the baffles 9 also rotate with the rotating inner barrel 3. Under the action of centrifugation, solid-liquid separation is achieved. A small portion of the solids are blocked by the filter screen 4, and most of the solids are separated by the groove 15 of the guide block 5. Upon contact, solid particles are temporarily embedded in the transverse groove 15 of the guide block 5 to reduce their moving speed. They then move to the left and right sides along the inner side of the guide block 5 and are eventually blocked by the baffle 9, thus limiting the contact between the solid and the filter screen 4 and ensuring the passing efficiency of the filter screen 4. After passing through the filter screen 4, the liquid enters the outer barrel 2 and flows out from the bottom of the outer barrel 2 and is collected by the collection container. At the same time, the liquid in the inner barrel 3 rotates. The lever 12 fixed to the connecting rod 11 remains stationary during centrifugation. The moving solid is broken and dispersed after hitting the lever 12, thus ensuring that the liquid can be completely separated.

[0029] After most of the liquid has been separated, the electric slide rail 8 is activated, pulling the baffle 9 back into the mounting housing 7. This allows both the solids and liquids blocked by the baffle 9 to come into contact with the filter screen 4. The liquid passes through the filter screen 4 into the outer tank 2, and the mounting housing 7 rotates with the rotating inner tank 3. The scraper 13 at the end of the mounting housing 7 can scrape off the residual liquid on the inner wall of the outer tank 2. The liquid flows down along the slide plate 14, thereby reducing the residual liquid in the future. After centrifugation, the rotating inner tank 3 is idled for a period of time to completely collect the internal liquid. Then, the centrifuge device is turned off, the tank lid is opened, and the filter screen 4 is replaced and cleaned, or the solids on the filter screen 4 and inside the rotating inner tank 3 are directly scraped off.

[0030] During centrifugation, the liquid moves upward along the inner wall of the rotating inner barrel 3. The inclined surface of the guide ring 6 can restrict the liquid from entering the outer barrel 2 from the top of the rotating inner barrel 3. During centrifugation, the operator can directly observe the remaining liquid volume and the liquid height during centrifugation through the observation window 16 to control the rotation speed of the rotating inner barrel 3.

[0031] The above embodiments are merely preferred embodiments of the present utility model and are not intended to limit the scope of the present utility model. Therefore, all equivalent changes made based on the content described in the claims of the present utility model should be included within the scope of the claims of the present utility model.

Claims

1. A centrifugal device for the preparation of pharmaceutical intermediates, characterized in that, Includes a support base (1), on which an outer barrel (2) is mounted. A rotating inner barrel (3) is rotatably connected inside the outer barrel (2). Several filter screens (4) are arranged on the wall of the rotating inner barrel (3). Several guide blocks (5) are connected inside the rotating inner barrel (3). The filter screens (4) and the guide blocks (5) are arranged alternately around each other. The cross-section of the guide block (5) is approximately an isosceles triangle, and the base angles of the isosceles triangle are all in contact with the edge of the filter screen (4). The top of the rotating inner barrel (3) is connected to... There is a guide ring (6), the vertical cross-section of which is a right triangle, with the hypotenuse of the cross-section facing the bottom of the rotating inner barrel (3). The outer wall of the rotating inner barrel (3) is connected to several mounting shells (7). An electric slide rail (8) is installed inside the mounting shell (7). A baffle (9) is slidably connected inside the mounting shell (7). The baffle (9) passes through the rotating inner barrel (3) and is located at the connection between the filter screen (4) and the guide block (5). The electric slide rail (8) is used to drive the baffle (9).

2. The centrifuge apparatus for preparing pharmaceutical intermediates as described in claim 1, characterized in that, The outer barrel (2) is provided with a detachable barrel lid at the top, and a fixing frame (10) is connected to the top. The fixing frame (10) divides the barrel lid into two parts. A connecting rod (11) extending into the rotating inner barrel (3) is fixedly connected to the middle of the fixing frame (10). Several levers (12) are connected to the connecting rod (11).

3. The centrifuge apparatus for preparing pharmaceutical intermediates as described in claim 2, characterized in that, The mounting housing (7) is connected to scrapers (13) on both the left and right sides of the end near the outer barrel (2), and the scrapers (13) are slidably connected to the inner wall of the outer barrel (2).

4. The centrifuge apparatus for preparing pharmaceutical intermediates as described in claim 3, characterized in that, The mounting housing (7) is connected to a sliding plate (14) on both the left and right sides, and the sliding plate (14) is provided with longitudinal stripes.

5. A centrifuge apparatus for preparing pharmaceutical intermediates as described in claim 4, characterized in that, The guide block (5) has several transverse grooves (15).

6. A centrifuge apparatus for preparing pharmaceutical intermediates as described in claim 5, characterized in that, The lid of the outer barrel (2) is provided with a transparent observation window (16).

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