Real-time electrocardiogram monitoring and reverse pressure device for rat in-vitro counterpulsation experiment

Abstract

The utility model relates to medical instrument technical field, concretely relates to a real -time electrocardiogram monitoring and reverse pressurization device for rat extracorporeal counterpulsation experiment. It includes device ontology, is equipped with rat fixed plate outside device ontology, is equipped with electrocardiogram monitoring line between device ontology and rat fixed plate, is equipped with pressurization capsule cover on rat fixed plate, is equipped with pressurization trachea on pressurization capsule cover, and pressurization trachea is connected with the gasbag interface on device ontology, the inside integration of device ontology has electrocardiosignal acquisition module, signal processing module, airflow control module and data storage module. The application can monitor the electrocardiosignal of rat in real time, and exerts reverse pressure on the leg and abdomen of rat in the proper electrocardio interval, to simulate the effect of extracorporeal counterpulsation.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, specifically to a real-time electrocardiogram monitoring and reverse pressure device for rat in vitro counterpulsation experiments. Background Technology

[0002] External counterpulsation (ECP) is a non-invasive treatment method that increases coronary blood flow and improves myocardial blood supply by applying external pressure to the limbs during diastole. Currently, ECP technology is widely used clinically to treat cardiovascular diseases such as angina pectoris and myocardial infarction. However, existing ECP devices are primarily designed for human patients. For example, Chinese Patent CN214858989U discloses an ECP device with a cover, which allows users to actively operate the device for human-computer interaction and entertainment. However, there is a lack of devices specifically designed for animal experiments, especially rat experiments. Rats, as common laboratory animals, play an important role in cardiovascular disease research. Their physiological functions are relatively close to those of humans, and their ease of rearing, rapid reproduction, and clear genetic background make them indispensable research subjects for exploring the pathogenesis of cardiovascular diseases, evaluating the effectiveness of drug treatments, and developing new therapies. Therefore, developing an ECP experimental device suitable for rats has significant scientific and applied value. Utility Model Content

[0003] The technical problem to be solved by this invention is to overcome the shortcomings of the prior art and provide a real-time electrocardiogram monitoring and reverse pressure device for rat external counterpulsation experiments. This device can monitor the electrocardiogram signal of rats in real time and apply reverse pressure to the legs and abdomen of rats in appropriate electrocardiogram zones to simulate the effect of external counterpulsation.

[0004] The technical solution of this utility model is as follows:

[0005] A real-time electrocardiogram monitoring and reverse pressure device for rat external counterpulsation experiments, preferably comprising a device body, a rat fixation plate on the outside of the device body, an electrocardiogram monitoring line between the device body and the rat fixation plate, a pressure bag on the rat fixation plate, a pressure air tube on the pressure bag, and the pressure air tube being connected to the air bag interface on the device body.

[0006] Preferably, the device body integrates an electrocardiogram signal acquisition module, a signal processing module, an airflow control module, and a data storage module.

[0007] Preferably, the front end of the device body is provided with a display screen and an operation panel, and the rear end of the device body is provided with an electrocardiogram interface and an air intake interface.

[0008] Preferably, the ECG monitoring line is connected to the device body via a 3.5mm stereo plug.

[0009] Preferably, both the air intake interface and the airbag interface use quick-connect connectors.

[0010] Preferably, the pressure bag sleeve is provided in several parts, and the pressure bag sleeve is fixed to the bottom and middle of the rat fixation plate.

[0011] Preferably, the device body is also externally connected to an air compressor.

[0012] Compared with the prior art, this utility model has the following advantages:

[0013] This device can monitor the electrocardiogram (ECG) signals of rats in real time, ensuring that reverse pressure is applied within the appropriate ECG region, thus improving the accuracy and effectiveness of the experiment. The device itself has multiple pre-installed pressure ports, allowing users to freely control the number and position of the pressure sleeves according to experimental needs. The device's data storage module records experimental data such as ECG signals, pressure application time, and pressure, and exports the data via a data export interface for subsequent analysis. The design of the pressure sleeves ensures uniform pressure distribution, avoiding unnecessary harm to the rats and ensuring experimental safety. Attached Figure Description

[0014] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, for those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0015] Fig. 1 This is a schematic diagram of the structure of this utility model.

[0016] Fig. 2 This is a front view of the device body of this utility model.

[0017] Fig. 3 This is a schematic diagram of the back of the device body of this utility model.

[0018] In the diagram: 1. Device body; 2. Rat fixation plate; 3. ECG monitoring line; 4. Pressure bag sleeve; 5. Pressure air tube; 6. Air bag interface; 7. Display screen; 8. Operation panel; 9. ECG interface; 10. Air inlet interface; 11. Air compressor. Detailed Implementation

[0019] To enable those skilled in the art to better understand the technical solutions of this utility model, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort should fall within the protection scope of this utility model.

[0020] Example

[0021] like Figs. 1-3 As shown, this embodiment provides a real-time electrocardiogram (ECG) monitoring and reverse compression device for rat external counterpulsation experiments. The device includes a main body 1, which is the core of the entire system, responsible for ECG signal processing, airflow control, and data recording and export. A rat fixation plate 2 is externally mounted on the main body 1 to fix the rat and ensure it remains in a stable position during the experiment for ECG monitoring and reverse compression. An ECG monitoring line 3 is connected between the main body 1 and the rat fixation plate 2 to collect the rat's ECG signal in real time. The ECG signal is processed by the main body 1 to determine... A suitable ECG interval was determined. After preliminary experimental debugging and multiple tests, the ECG signal values ​​R_value, diastolic interval st, and the interval between R_value and diastolic interval dt were observed. These three values ​​were entered into the host computer. After setting, each data point was read in real time. When the data value was greater than the R_value but less than the R_value, the ECG was considered to have reached the R_value. After a delay of dt, diastole began. After another delay of st, diastole ended. The [inflation start time, pressure holding time, and deflation time] were set to (0.12, 0.03-0.05, 0.125) and pressure was applied accurately. The rat fixation plate 2 was equipped with a pressure bag 4, which was equipped with a pressure air tube 5. The pressure air tube 5 was connected to the air bag interface 6 on the device body 1 to transmit compressed air and achieve reverse pressure on the rat's legs and abdomen. The pressure range of the pressure bag was 0.009MPa-0.024MPa.

[0022] Preferably, the device body 1 integrates an electrocardiogram (ECG) signal acquisition module, a signal processing module, an airflow control module, and a data storage module. The ECG signal acquisition module is used to acquire ECG data with high fidelity; the signal processing module is responsible for signal filtering, amplification, and feature extraction; the airflow control module precisely regulates the airflow to achieve a preset pressurization cycle; and the data storage module is used to securely store all experimental data for subsequent analysis.

[0023] Preferably, the front end of the device body 1 is provided with a display screen 7 and an operation panel 8, and the rear end of the device body 1 is provided with an electrocardiogram interface 9 and an air inlet interface 10.

[0024] Preferably, the ECG monitoring line 3 is connected to the device body 1 via a 3.5mm stereo plug. This ensures a secure and convenient connection to the ECG interface 9 of the device body 1, improving the overall reliability and ease of use of the system.

[0025] Preferably, both the air intake interface 10 and the airbag interface 6 use quick-connect connectors. This design not only simplifies the connection process but also effectively prevents air leakage or operational errors caused by unstable connections.

[0026] Preferably, several pressure sleeves 4 are provided, and the pressure sleeves 4 are fixed to the bottom and middle of the rat fixation plate 2. This arrangement can distribute pressure more evenly, ensuring that the reverse pressure applied to the rat is both effective and comfortable.

[0027] Preferably, the device body 1 is also externally connected to an air compressor 11. The air compressor 11 serves as a stable air source supply, providing a continuous and controllable airflow to the pressurized bladder 4, further enhancing the overall performance of the system and the reliability of the experiment.

[0028] Working principle:

[0029] First, ECG signal acquisition and processing: The ECG monitoring line 3 connects the rat to the device body 1, acquiring the rat's ECG signal in real time. The signal processing module inside the device body 1 filters, amplifies, and analyzes the ECG signal to determine the appropriate ECG interval. Second, airflow control and reverse pressurization: Within the determined ECG interval, the airflow control module of the device body 1 delivers compressed air to the pressurization sleeve 4 through the pressurization tube 5, applying reverse pressure to the rat's legs and abdomen. The design of the pressurization sleeve 4 ensures uniform pressure distribution, avoiding unnecessary harm to the rat. Third, data recording and export: The data storage module of the device body 1 records experimental data such as ECG signals, pressurization time, and pressurization pressure, and exports the data through the data export interface for subsequent analysis. Finally, flexible application of multiple pressurization interfaces: The device body 1 has multiple pressurization interfaces, allowing users to freely control the number and position of the pressurization sleeves 4 according to experimental needs, adapting to different experimental requirements.

[0030] Although the present invention has been described in detail with reference to the accompanying drawings and preferred embodiments, it is not limited thereto. Various equivalent modifications or substitutions can be made to the embodiments of the present invention by those skilled in the art without departing from the spirit and essence of the present invention, and such modifications or substitutions should all be within the scope of the present invention. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should also be included within the protection scope of the present invention. Therefore, the protection scope of the present invention should be determined by the scope of the claims.

Claims

1. A real-time electrocardiogram monitoring and reverse pressure device for rat in vitro counterpulsation experiments, characterized in that, The device includes a main body (1), a rat fixation plate (2) is provided on the outside of the main body (1), an electrocardiogram monitoring line (3) is provided between the main body (1) and the rat fixation plate (2), a pressure bag (4) is provided on the rat fixation plate (2), a pressure tube (5) is provided on the pressure bag (4), and the pressure tube (5) is connected to the air bag interface (6) on the main body (1).

2. The real-time electrocardiogram monitoring and reverse pressure device for rat in vitro counterpulsation experiments as described in claim 1, characterized in that, The device body (1) integrates an electrocardiogram signal acquisition module, a signal processing module, an airflow control module, and a data storage module.

3. The real-time electrocardiogram monitoring and reverse pressure device for rat in vitro counterpulsation experiments as described in claim 1, characterized in that, The device body (1) has a display screen (7) and an operation panel (8) at the front end, and an electrocardiogram interface (9) and an air inlet interface (10) at the rear end.

4. The real-time electrocardiogram monitoring and reverse pressure device for rat in vitro counterpulsation experiments as described in claim 1, characterized in that, The electrocardiogram monitoring line (3) is connected to the device body (1) via a 3.5mm stereo plug.

5. The real-time electrocardiogram monitoring and reverse pressure device for rat in vitro counterpulsation experiments as described in claim 3, characterized in that, Both the air intake interface (10) and the airbag interface (6) use quick-connect connectors.

6. The real-time electrocardiogram monitoring and reverse pressure device for rat in vitro counterpulsation experiments as described in claim 1, characterized in that, The pressure bladder (4) is provided in several parts and is fixed to the bottom and middle of the rat fixation plate (2).

7. The real-time electrocardiogram monitoring and reverse pressure device for rat in vitro counterpulsation experiments as described in claim 1, characterized in that, The device body (1) is also externally connected to an air compressor (11).

Images