Small molecule chemical medicine impurity purification and separation device

Abstract

The utility model relates to the technical field of chemical medicine impurity purification separation, especially small molecule chemical medicine impurity purification separation device, including support frame, the top of support frame is installed with support plate, and support plate sets up two groups, and the bottom support plate is installed with the purification assembly for small molecule chemical medicine impurity purification, and the purification assembly includes separator, and the separator sets up at the top of support plate, and the separator sets up three groups, and the bottom of separator is connected with the discharge tank, and the bottom of discharge tank is connected with the scraper through flange, the utility model discloses after solution enters the separator, small molecule chemical medicine and impurity are separated because of the difference of physical property, open the discharge tank valve at the bottom of separator, and the impurity falls into the discharge tank, and then is scraped out through the scraper at the bottom, and the impurity is pushed to the pollution storage tank below and is collected, three groups of separators can be used to carry out graded filtration to different nature impurities, reduce target drug loss, and efficiently remove trace impurities, and adapt to the purification demand of different drug varieties simultaneously.

Description

Technical Field

[0001] This utility model relates to the field of purification and separation technology of chemical drug impurities, and in particular to a device for purifying and separating small molecule chemical drug impurities. Background Technology

[0002] Small molecule drugs are organic compounds with well-defined chemical structures and relatively small molecular weights. They exert their pharmacological effects through interactions with biological targets. During the production of small molecule drugs, the presence of impurities may affect the safety, efficacy, and quality stability of the drugs. Therefore, the purification and separation of impurities in small molecule drugs is an important step in drug research and development and production. This requires the use of impurity purification and separation equipment to separate impurities during production. Small molecule drug impurity purification and separation equipment aims to achieve efficient separation and purification of impurities in small molecule drugs, ensuring that the purity of the drugs meets or exceeds industry standards and satisfies the quality requirements of drug production.

[0003] Existing impurity purification and separation devices use a single separation structure, which makes it difficult to achieve precise graded filtration. This results in a significant loss of target components with medicinal value during repeated purification processes. Furthermore, because they cannot adapt to the characteristics of different impurities, the production process is forced to be frequently interrupted to adjust equipment parameters, leading to a substantial decrease in production efficiency.

[0004] Therefore, in view of the problem that the above-mentioned impurity purification and separation devices use a single separation structure to separate impurities, making it difficult to achieve precise graded filtration and resulting in a large loss of target components with medicinal value during repeated purification, a small molecule drug impurity purification and separation device can be designed. Utility Model Content

[0005] To overcome the problem that impurity purification and separation devices rely on a single separation structure, making it difficult to achieve precise graded filtration and resulting in the loss of a large amount of target components with medicinal value during repeated purification, a small molecule drug impurity purification and separation device is proposed.

[0006] The technical solution of this utility model is as follows: a purification and separation device for impurities in small molecule chemical drugs, including a support frame; a support plate is installed at the top of the support frame, and two sets of support plates are provided; a purification component for purifying impurities in small molecule chemical drugs is installed on the lower support plate; the purification component includes a separator; the separator is located at the top of the support plate, and three sets of separators are provided; a discharge tank is connected to the bottom of the separator; and a scraper is connected to the bottom of the discharge tank through a flange.

[0007] Preferably, the top of the separator is connected to an inlet pipe, the inlet end of which is fitted with a movable flange ring, and a snap-fit ​​valve is fitted to the outside of the movable flange ring.

[0008] Preferably, the top of the snap-fit ​​valve is equipped with an adjusting motor, and the output end of the adjusting motor is connected to the adjusting motor.

[0009] Preferably, the liquid outlet end of the separator is connected to a liquid outlet pipe, and a feed tank is provided at the top of the upper support plate, with the liquid inlet end of the liquid inlet pipe connected to the feed tank.

[0010] Preferably, a discharge hopper with a control valve is provided at the middle position of the bottom of the feed tank, and a servo motor is installed at the middle position of the top of the feed tank, with the output end of the servo motor connected to a stirring rod and stirring blades.

[0011] Preferably, a sludge storage tank is provided above the support frame, and a scraper is installed inside the sludge storage tank.

[0012] Preferably, a liquid storage tank is provided below the support frame, and the outlet end of the liquid outlet pipe is located inside the liquid storage tank. An anti-slip plate is provided at the bottom of the support frame.

[0013] The beneficial effects of this invention are as follows: After the solution enters the separator, small molecule drugs and impurities are separated due to differences in physical properties. By opening the discharge tank valve at the bottom of the separator, impurities fall into the discharge tank and are then scraped out by the scraper at the bottom, pushing the impurities to the sludge storage tank below for collection. Through three sets of separators, impurities of different properties can be filtered in stages, reducing the loss of target drugs while efficiently removing trace impurities. At the same time, it can adapt to the purification needs of different drug varieties, reduce equipment modification costs, reduce batch-to-batch differences, improve production efficiency, reduce human intervention errors, and improve process repeatability. Attached Figure Description

[0014] Figure 1 The diagram shown is a first three-dimensional structural schematic of this utility model;

[0015] Figure 2 The diagram shown is a second three-dimensional structural schematic of this utility model;

[0016] Figure 3 The diagram shown is a top-view perspective of the three-dimensional structure of this utility model;

[0017] Figure 4 The diagram shown is a three-dimensional cross-sectional view of the purification component of this utility model.

[0018] Figure 5 The diagram shown is a partial three-dimensional structural schematic of the purification component of this utility model.

[0019] Explanation of reference numerals in the attached drawings: 1. Support frame; 2. Support plate; 3. Anti-slip plate; 401. Separator; 402. Discharge tank; 403. Scraper; 404. Inlet pipe; 405. Movable flange ring; 406. Snap-fit ​​valve; 407. Adjusting motor; 408. Discharge pipe; 409. Feed tank; 410. Discharge hopper; 411. Servo motor; 412. Sludge storage tank; 413. Liquid storage tank. Detailed Implementation

[0020] Please see Figures 1-5 This utility model provides an embodiment of a small molecule drug impurity purification and separation device, including a support frame 1; a support plate 2 is installed at the top of the support frame 1, and the support plate 2 is provided in two sets; a purification component for purifying small molecule drug impurities is installed on the lower support plate 2, the purification component includes a separator 401, the separator 401 is provided at the top of the support plate 2, and the separator 401 is provided in three sets; the bottom end of the separator 401 is connected to a discharge tank 402, and the bottom end of the discharge tank 402 is connected to a scraper 403 through a flange.

[0021] Please see Figures 2-3 In this embodiment, a discharge hopper 410 with a control valve is provided at the middle position of the bottom end of the feed tank 409, a servo motor 411 is installed at the middle position of the top end of the feed tank 409, and the output end of the servo motor 411 is connected to a stirring rod and stirring blades; a sludge storage tank 412 is provided above the support frame 1, and a scraper 403 is provided inside the sludge storage tank 412; a liquid storage tank 413 is provided below the support frame 1, and the liquid outlet end of the liquid outlet pipe 408 is provided inside the liquid storage tank 413; and an anti-slip plate 3 is provided at the bottom end of the support frame 1.

[0022] Material is added from the top of feed tank 409. Servo motor 411 drives stirring rod and blades to rotate, thoroughly stirring the material to ensure uniform mixing and avoid incomplete separation due to uneven local concentration, thereby improving the purity of the target product. It may also help dissolve or disperse impurities, preparing for subsequent separation. The material enters separator 401, where impurities are separated and collected in sludge storage tank 412. Scraper 403 inside the tank can periodically or in real time scrape off impurities adhering to the tank wall to prevent accumulation and ensure efficient collection of impurities. The separated liquid containing the target product flows into storage tank 413 through outlet pipe 408, completing the storage of the purified product. The combination of sludge storage tank 412 and scraper 403 can clean impurities in a timely manner, reducing the contamination of the product by residual impurities, and facilitating subsequent centralized processing, thus improving separation efficiency.

[0023] Please see Figures 4-5In this embodiment, the top end of the separator 401 is connected to an inlet pipe 404, the inlet end of the inlet pipe 404 is equipped with a movable flange ring 405, and the outer side of the movable flange ring 405 is equipped with a snap-fit ​​valve 406; the top end of the snap-fit ​​valve 406 is provided with an adjusting motor 407, and the output end of the adjusting motor 407 is connected to the adjusting motor 407.

[0024] The small molecule drug mixture to be purified is transported to the separator 401 through the inlet pipe 404. The movable flange ring 405 allows for flexible connection and disassembly of the inlet pipe 404 to external pipelines, facilitating equipment installation, maintenance, and pipeline replacement. The snap-fit ​​valve 406 is installed on the outside of the movable flange ring 405 and is driven by the regulating motor 407. The output end of the regulating motor 407 is connected to the snap-fit ​​valve 406. When the motor is running, it can drive the valve core of the snap-fit ​​valve 406 to move, thereby precisely controlling the liquid flow rate entering the separator 401. By controlling the snap-fit ​​valve 406 through the regulating motor 407, the inlet flow rate can be flexibly adjusted according to the characteristics of different small molecule drug mixtures and purification process requirements, making the equipment highly adaptable and capable of handling purification tasks for various types of small molecule drug impurities. The precise coordination between the regulating motor 407 and the snap-fit ​​valve 406, as well as the reasonable design of the separator 401, ensures the stability of the equipment during operation, reduces the impact of flow fluctuations and other factors on the separation effect, and improves the reliability and service life of the equipment.

[0025] The solution of the small molecule drug to be purified is poured into the feed tank 409 on the upper support plate 2. The servo motor 411 is started, and its output stirring rod and blades stir the solution to ensure uniform mixing of the materials, preparing for subsequent separation. The solution flows into the inlet pipe 404 through the discharge hopper 410. The operation of the motor 407 is adjusted to control the opening and closing of the snap valve 406, thereby regulating the solution flow rate. The solution is then distributed to the three sets of separators 401 through the inlet pipe 404. After entering the separator 401, the small molecule drug and impurities are separated due to differences in physical properties. Small molecule drugs enter the outlet pipe 408 through the outlet end of separator 401 and flow to the storage tank 413 below for storage. Impurities precipitate or remain at the bottom of separator 401. After separation, the valve of the discharge tank 402 at the bottom of separator 401 is opened, and impurities fall into the discharge tank 402 and are scraped out by the scraper 403 at the bottom, pushing the impurities to the sludge storage tank 412 below for collection. The separated small molecule drugs flow into the storage tank 413 through the outlet pipe 408 and can be exported through an external pipeline for subsequent concentration, crystallization and other treatments.

Claims

1. A device for purifying and separating impurities in small molecule chemical drugs, comprising a support frame (1); characterized in that: The support frame (1) is equipped with a support plate (2) at the top, and the support plate (2) is provided in two sets. The lower support plate (2) is equipped with a purification component for purifying impurities of small molecule drugs. The purification component includes a separator (401). The separator (401) is located at the top of the support plate (2), and the separator (401) is provided in three sets. The bottom end of the separator (401) is connected to a discharge tank (402), and the bottom end of the discharge tank (402) is connected to a scraper (403) through a flange.

2. The small molecule drug impurity purification and separation device according to claim 1, characterized in that: The separator (401) is connected to the top of the liquid inlet pipe (404), and a movable flange ring (405) is installed at the liquid inlet end of the liquid inlet pipe (404). A snap-fit ​​valve (406) is installed on the outside of the movable flange ring (405).

3. The small molecule drug impurity purification and separation device according to claim 1, characterized in that: The top of the snap-fit ​​valve (406) is equipped with an adjusting motor (407), and the output end of the adjusting motor (407) is connected to the adjusting motor (407).

4. The small molecule drug impurity purification and separation device according to claim 2, characterized in that: The separator (401) has an outlet pipe (408) connected to its outlet end, and a feed tank (409) is provided at the top of the upper support plate (2), with the inlet end of the inlet pipe (404) connected to the feed tank (409).

5. The small molecule drug impurity purification and separation device according to claim 4, characterized in that: A discharge hopper (410) with a control valve is provided at the middle position of the bottom of the feed tank (409), and a servo motor (411) is installed at the middle position of the top of the feed tank (409), and the output end of the servo motor (411) is connected to a stirring rod and stirring blades.

6. The small molecule drug impurity purification and separation device according to claim 1, characterized in that: A sludge storage tank (412) is provided above the support frame (1), and a scraper (403) is provided inside the sludge storage tank (412).

7. The small molecule drug impurity purification and separation device according to claim 4, characterized in that: A liquid storage tank (413) is provided below the support frame (1), and the liquid outlet end of the liquid outlet pipe (408) is located inside the liquid storage tank (413). An anti-slip plate (3) is provided at the bottom of the support frame (1).

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