A filter device for solid-liquid separation of protein a filler

Abstract

The utility model discloses a kind of filtering devices for protein A filler solid-liquid separation, including fixed column, the upper portion of the outer surface of the front end of fixed column is fixedly installed with flow guide blanking groove, the left and right sides between the upper portion of the outer surface of the one side of flow guide blanking groove and fixed column are fixedly installed with reinforcing plate, the upper end of fixed column is installed with screening assembly, the one side of flow guide blanking groove is installed with feeding and deslagging structure, and the screening assembly includes worm gear reduction motor, rotating shaft, support frame, disc, outer filter screen cylinder and inner filter screen cylinder. The filtering device for protein A filler solid-liquid separation of the utility model, the screening assembly is set, material is filtered easily, the feeding and deslagging structure is set, material is continuously filtered with the cooperation of screening assembly, and impurity is cleaned easily, and the difficulty of cleaning is reduced.

Description

Technical Field

[0001] This utility model relates to the field of protein A packing solid-liquid separation technology, specifically a filtration device for protein A packing solid-liquid separation. Background Technology

[0002] In the solid-liquid separation process of protein A packing material, the traditional method usually uses a vibrating screen for filtration and separation.

[0003] However, existing technologies have the following significant drawbacks:

[0004] 1. Filter screen is prone to clogging: During the filtration process, impurities are easily trapped on the surface of the filter screen. Over time, the filter screen gradually becomes clogged, resulting in a significant decrease in filtration efficiency.

[0005] 2. Need to stop the machine for cleaning: Due to filter clogging, operators need to frequently stop the machine to clean the impurities on the filter, which not only affects production efficiency but also increases maintenance costs;

[0006] 3. Poor continuity: Existing technologies cannot achieve continuous filtration and real-time cleaning, resulting in production interruptions and making it difficult to meet the needs of large-scale or continuous production.

[0007] Therefore, we propose a filtration device for solid-liquid separation using protein A packing material. Utility Model Content

[0008] (a) Technical problems to be solved

[0009] To address the shortcomings of existing technologies, this invention provides a filter device for solid-liquid separation using protein A packing material. This device facilitates continuous filtration and separation of materials, improves processing efficiency, and makes it easy to clean impurities from the filter screen. It effectively solves the problems in the prior art.

[0010] (II) Technical Solution

[0011] To achieve the above objectives, the technical solution adopted by this utility model is as follows: a filter device for solid-liquid separation of protein A packing material, comprising a fixed column, a guide trough fixedly installed on the upper part of the outer surface of the front end of the fixed column, reinforcing plates fixedly installed on the left and right sides of the upper part of the outer surface of one side of the guide trough and the fixed column, a screening assembly installed at the upper end of the fixed column, and a feeding and slag discharge structure installed on one side of the guide trough. The screening assembly includes a worm gear reducer motor and a rotating... The structure includes a shaft, a support frame, a disc, an outer filter cylinder, and an inner filter cylinder. The feeding and slag discharge structure includes a support, a first backwash liquid feeding pipe, a small particle slag discharge trough, a second backwash liquid feeding pipe, a large particle slag discharge trough, a protein A packing feeding pipe, and a flushing head. The outer and inner filter cylinders are located at the top of the guide and discharge trough, and the inner filter cylinder is located in the middle of the outer filter cylinder. Both the outer and inner filter cylinders are fixed to one side of the outer surface of the disc, and the rotating shaft is fixed to the middle of the other side of the outer surface of the disc.

[0012] Preferably, the worm gear reducer motor is fixedly installed in the middle of the outer surface of the upper end of the fixed column, and a coupling is provided between the rotating shaft and the worm gear reducer motor. One end of the outer surface of the rotating shaft is fixedly connected to one end of the outer surface of the output shaft of the worm gear reducer motor through the coupling.

[0013] Preferably, the outer wall of the support frame is mounted on the rotating shaft, and the lower part of the support frame is fixedly connected to the upper part of the outer surface of the front end of the fixed column. A bearing is provided between the rotating shaft and the support frame, and the rotating shaft is rotatably connected to the support frame through the bearing.

[0014] Preferably, the pore size of the inner filter cylinder is larger than that of the outer filter cylinder.

[0015] Preferably, the bracket is fixed on the outer surface of the guide trough away from the fixed column. The first backwash liquid feeding pipe, the small particle slag discharge trough, the second backwash liquid feeding pipe, the large particle slag discharge trough, and the protein A packing material feeding pipe are arranged sequentially from the top to the bottom of the bracket. The first backwash liquid feeding pipe, the small particle slag discharge trough, the second backwash liquid feeding pipe, the large particle slag discharge trough, and the protein A packing material feeding pipe are fixedly connected to the bracket. The flushing head is fixed on the lower outer surface of the first backwash liquid feeding pipe and the second backwash liquid feeding pipe away from the bracket. The flushing head is located above the outer filter cylinder and the inner filter cylinder.

[0016] Preferably, one end of the first backwash liquid feed pipe is located at the upper part of the outer filter cylinder, one end of the small particle slag discharge trough extends into the upper part of the inner cavity of the outer filter cylinder, one end of the second backwash liquid feed pipe is located at the upper part of the inner filter cylinder, one end of the large particle slag discharge trough extends into the upper part of the inner filter cylinder, and one end of the protein A filler feed pipe extends into the middle of the inner filter cylinder.

[0017] (III) Beneficial Effects

[0018] Compared with the prior art, the present invention provides a filtration device for solid-liquid separation using protein A packing material, which has the following advantages:

[0019] 1. This protein A packing solid-liquid separation filtration device uses a worm gear reducer motor to drive the outer and inner filter cylinders to rotate, so that the material is filtered under dynamic conditions, avoiding the accumulation of impurities, realizing continuous production, and greatly improving filtration efficiency.

[0020] 2. The protein A packing solid-liquid separation filtration device utilizes a first backwash liquid feeding pipe and a second backwash liquid feeding pipe in conjunction with a flushing head to backwash the outer and inner filter cylinders. At the same time, impurities are automatically discharged through small particle slag discharge troughs and large particle slag discharge troughs, eliminating the need for machine shutdown for cleaning and reducing manual maintenance costs.

[0021] 3. This protein A packing solid-liquid separation filtration device adopts a double-layer structure of an inner filter cylinder (large pore size) and an outer filter cylinder (small pore size), which filters impurities of different particle sizes in stages, improves filtration accuracy, and ensures the purity of the protein A packing. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the overall structure of a protein A packing solid-liquid separation filtration device according to the present invention.

[0023] Figure 2 This is a partial structural schematic diagram of a protein A packing solid-liquid separation filtration device according to the present invention.

[0024] Figure 3 This is a schematic diagram of the screening component in a protein A packing solid-liquid separation filtration device according to the present invention.

[0025] Figure 4 This is a schematic diagram of the feeding and slag discharge structure in a protein A packing solid-liquid separation filtration device according to the present invention.

[0026] In the diagram: 1. Fixed column; 2. Guide chute; 3. Screening assembly; 4. Feeding and slag discharge structure; 5. Reinforcing plate; 6. Worm gear reducer motor; 7. Rotating shaft; 8. Support frame; 9. Disc; 10. Outer filter cylinder; 11. Inner filter cylinder; 12. Bracket; 13. First backwash liquid feed pipe; 14. Small particle slag discharge chute; 15. Second backwash liquid feed pipe; 16. Large particle slag discharge chute; 17. Protein A packing feed pipe; 18. Flushing head. Detailed Implementation

[0027] To make the technical means, creative features, objectives and effects of this utility model easier to understand, the present utility model will be further described below in conjunction with specific embodiments.

[0028] This embodiment is a filtration device for solid-liquid separation using protein A packing material.

[0029] like Figure 1-4 As shown, the system includes a fixed column 1, a guide chute 2 fixedly installed on the upper part of the outer surface of the front end of the fixed column 1, reinforcing plates 5 fixedly installed on the left and right sides of the upper part of the outer surface of one side of the guide chute 2 between the guide chute 2 and the fixed column 1, a screening assembly 3 installed at the upper end of the fixed column 1, and a feeding and slag discharge structure 4 installed on one side of the guide chute 2. The screening assembly 3 includes a worm gear reducer motor 6, a rotating shaft 7, a support frame 8, a disc 9, an outer filter cylinder 10, and an inner filter cylinder 11. The structure 4 includes a support 12, a first backwash liquid feed pipe 13, a small particle slag discharge trough 14, a second backwash liquid feed pipe 15, a large particle slag discharge trough 16, a protein A packing feed pipe 17, and a flushing head 18. The outer filter cylinder 10 and the inner filter cylinder 11 are located at the upper part of the guide discharge trough 2, and the inner filter cylinder 11 is located in the middle of the outer filter cylinder 10. Both the outer filter cylinder 10 and the inner filter cylinder 11 are fixed on one side of the outer surface of the disc 9, and the rotating shaft 7 is fixed in the middle of the other side of the outer surface of the disc 9.

[0030] The worm gear reducer motor 6 is fixedly installed in the middle of the upper outer surface of the fixed column 1. A coupling is provided between the rotating shaft 7 and the worm gear reducer motor 6. One end of the outer surface of the rotating shaft 7 is fixedly connected to one end of the outer surface of the output shaft of the worm gear reducer motor 6 through the coupling. The support frame 8 is installed on the outer wall of the rotating shaft 7, and the lower part of the support frame 8 is fixedly connected to the upper part of the front outer surface of the fixed column 1. A bearing is provided between the rotating shaft 7 and the support frame 8, and the rotating shaft 7 is rotatably connected to the support frame 8 through the bearing. The aperture of the inner filter screen cylinder 11 is larger than the aperture of the outer filter screen cylinder 10. The bracket 12 is fixed on the outer surface of the guide trough 2 away from the fixed column 1. The first backwash liquid feed pipe 13, the small particle slag discharge trough 14, the second backwash liquid feed pipe 15, the large particle slag discharge trough 16, and the protein A filler feed pipe 17 are sequentially fed from the bracket. The support 12 is arranged from top to bottom, and the first backwash liquid feed pipe 13, the small particle slag discharge trough 14, the second backwash liquid feed pipe 15, the large particle slag discharge trough 16 and the protein A filler feed pipe 17 are fixedly connected to the support 12. The flushing head 18 is fixed to the lower outer surface of the first backwash liquid feed pipe 13 and the second backwash liquid feed pipe 15 away from the support 12, and the flushing head 18 is located at the upper part of the outer filter cylinder 10 and the inner filter cylinder 11. One end of the first backwash liquid feed pipe 13 is located at the upper part of the outer filter cylinder 10, one end of the small particle slag discharge trough 14 extends into the upper part of the inner cavity of the outer filter cylinder 10, one end of the second backwash liquid feed pipe 15 is located at the upper part of the inner filter cylinder 11, one end of the large particle slag discharge trough 16 extends into the upper part of the inner filter cylinder 11, and one end of the protein A filler feed pipe 17 extends into the middle part of the inner filter cylinder 11.

[0031] It should be noted that this utility model is a filter device for solid-liquid separation using protein A packing. The material is fed into the inner filter cylinder 11 through the protein A packing feeding pipe 17, where it undergoes preliminary filtration. Then, it is filtered again through the outer filter cylinder 10. The inner filter cylinder 11 removes large particles of impurities, while the outer filter cylinder 10 removes small particles. The filtered material is then guided and discharged through the guide feed trough 2. The rotation of the worm gear reducer motor 6 drives the rotating shaft 7 to rotate. The disc 9 rotates, causing the outer filter cylinder 10 and the inner filter cylinder 11 to rotate. This rotates the impurities trapped at the bottom to the top, where water is supplied through the first backwash liquid feed pipe 13 and the second backwash liquid feed pipe 15. Water is discharged through the flushing head 18, backwashing the outer filter cylinder 10 and the inner filter cylinder 11. Small particles of impurities are discharged through the small particle discharge trough 14, while large particles of impurities are discharged through the inner filter cylinder 11. This allows for continuous filtration of materials and continuous cleaning of impurities without the need to stop the machine for cleaning.

[0032] It should be noted that, in this document, relational terms such as first and second (number one, number two), etc., are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0033] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model.

Claims

1. A filter device for solid-liquid separation using protein A packing material, comprising a fixed column (1), characterized in that: A guide chute (2) is fixedly installed on the upper part of the outer surface of the front end of the fixed column (1). Reinforcing plates (5) are fixedly installed on the left and right sides of the upper part of the outer surface of one side of the guide chute (2) between it and the fixed column (1). A screening assembly (3) is installed at the upper end of the fixed column (1). A feeding and slag discharge structure (4) is installed on one side of the guide chute (2). The screening assembly (3) includes a worm gear reducer motor (6), a rotating shaft (7), a support frame (8), a disc (9), an outer filter cylinder (10), and an inner filter cylinder (11). The feeding and slag discharge structure (4) includes... The bracket (12), the first backwash liquid feed pipe (13), the small particle slag discharge trough (14), the second backwash liquid feed pipe (15), the large particle slag discharge trough (16), the protein A packing feed pipe (17), and the flushing head (18) are located at the upper part of the guide feed trough (2), the inner filter cylinder (11) is located at the middle part of the outer filter cylinder (10), and the outer filter cylinder (10) and the inner filter cylinder (11) are both fixed on one side of the outer surface of the disc (9), and the rotating shaft (7) is fixed at the middle part of the other side of the outer surface of the disc (9).

2. The filtration device for solid-liquid separation using protein A packing material according to claim 1, characterized in that: The worm gear reducer motor (6) is fixedly installed on the middle part of the upper outer surface of the fixed column (1). A coupling is provided between the rotating shaft (7) and the worm gear reducer motor (6). The outer surface of one end of the rotating shaft (7) is fixedly connected to the outer surface of one end of the output shaft of the worm gear reducer motor (6) through the coupling.

3. The filtration device for solid-liquid separation using protein A packing material according to claim 2, characterized in that: The support frame (8) is mounted on the outer wall of the rotating shaft (7), and the lower part of the support frame (8) is fixedly connected to the upper part of the front end outer surface of the fixed column (1). A bearing is provided between the rotating shaft (7) and the support frame (8), and the rotating shaft (7) is rotatably connected to the support frame (8) through the bearing.

4. The filtration device for solid-liquid separation using protein A packing material according to claim 3, characterized in that: The pore size of the inner filter cylinder (11) is larger than that of the outer filter cylinder (10).

5. A filtration device for solid-liquid separation using protein A packing material according to claim 4, characterized in that: The bracket (12) is fixed on the outer surface of the guide trough (2) away from the fixed column (1). The first backwash liquid feeding pipe (13), the small particle slag discharge trough (14), the second backwash liquid feeding pipe (15), the large particle slag discharge trough (16) and the protein A filler feeding pipe (17) are arranged sequentially from the top to the bottom of the bracket (12). The first backwash liquid feeding pipe (13), the small particle slag discharge trough (14), the second backwash liquid feeding pipe (15), the large particle slag discharge trough (16) and the protein A filler feeding pipe (17) are fixedly connected to the bracket (12). The flushing head (18) is fixed on the lower outer surface of the first backwash liquid feeding pipe (13) and the second backwash liquid feeding pipe (15) away from the bracket (12). The flushing head (18) is located on the upper part of the outer filter cylinder (10) and the inner filter cylinder (11).

6. A filtration device for solid-liquid separation using protein A packing material according to claim 5, characterized in that: One end of the first backwash liquid feed pipe (13) is located at the upper part of the outer filter cylinder (10), one end of the small particle slag discharge trough (14) extends into the upper part of the inner cavity of the outer filter cylinder (10), one end of the second backwash liquid feed pipe (15) is located at the upper part of the inner filter cylinder (11), one end of the large particle slag discharge trough (16) extends into the upper part of the inner filter cylinder (11), and one end of the protein A filler feed pipe (17) extends into the middle part of the inner filter cylinder (11).

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