Affinity membrane treatment membrane rack facilitating maintenance

Abstract

The utility model relates to the technical field of affinity membrane, disclose a kind of affinity membrane processing membrane frame convenient to overhaul, including fixed base, the top of the fixed base is provided with base, the four corners of base top are all fixedly connected with support rod, the top of the base is provided with mounting plate, the front side and the back side of mounting plate are all fixedly connected in the surface of support rod, the inside of mounting plate is equipped with multiple fixed slots, the inside of fixed slot is slidably connected with moving plate, the top of moving plate is movably connected with clamping block by shaft rod. In the utility model, through the cooperation of moving plate, clamping block, guide plate and fixed plate and the like structure, press pushing block and drive moving plate to move up, moving plate moves up and drives clamping block to separate from the limiting of guide plate, to cancel the fixing of affinity membrane after shaft rod as center pivot, affinity membrane can be removed, the effect that affinity membrane is quickly disassembled and is convenient to overhaul is realized.

Description

Technical Field

[0001] This utility model relates to the field of affinity membrane technology, and in particular to an affinity membrane treatment frame that is easy to maintain. Background Technology

[0002] Affinity membranes are filter membranes modified with affinity ligands. Affinity membrane separation is a separation method that uses affinity membranes as affinity adsorption media to purify target products. It is a variation of affinity chromatography and is also known as membrane affinity chromatography. Affinity membranes are generally used for protein separation, nucleic acid extraction and purification, and enzyme separation and immobilization.

[0003] Before using affinity membranes to separate proteins, they need to be fixed on a membrane holder, and then the membrane holder is fixed in the protein separation cell with bolts to prevent the affinity membrane from deforming or curling during dynamic adsorption. In the existing technology, the affinity membrane is fixed to the membrane holder by welding or clamping, which makes the subsequent disassembly and assembly of the affinity membrane more complicated and inconvenient for later maintenance or cleaning.

[0004] To address these issues, a membrane frame with an affinity membrane treatment that is easy to maintain is proposed. Utility Model Content

[0005] To overcome the above shortcomings, this utility model provides an affinity membrane treatment frame that is easy to maintain, aiming to improve the problem of complicated disassembly when maintaining affinity membranes in the prior art.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] A membrane holder for easy maintenance of an affinity membrane treatment includes a fixed base, a base on top of the fixed base, support rods fixedly connected to the four corners of the top of the base, an mounting plate on top of the base, the front and rear sides of the mounting plate fixedly connected to the surfaces of the support rods, multiple fixing slots inside the mounting plate, a movable plate slidably connected inside the fixing slots, a clamping block movably connected to the top of the movable plate via a shaft, an affinity membrane disposed on the inner side of the clamping block, guide plates fixedly connected to the front and rear sides of the fixing slots, a fixed plate engaged with the front side of the movable plate, the fixed plate slidably connected inside the mounting plate, a retaining spring fixedly connected to the front side of the fixed plate, the rear side of the retaining spring fixedly connected to the inner wall of the mounting plate, a pushing block at the bottom of the movable plate, the side of the pushing block away from the movable plate extending to the outer side of the mounting plate, a limit groove on the surface of the pushing block, a fixing component on the surface of the fixed base, and a limit component on the surface of the mounting plate.

[0008] As a further description of the above technical solution:

[0009] The fixing component includes a slide groove, which is formed on the front and rear sides of the fixing base. A T-shaped slider is slidably connected inside the slide groove. The top of the T-shaped slider is fixedly connected to the bottom of the base. A fixing block is movably connected inside the fixing base via a shaft. The right side of the fixing block contacts the left side of the T-shaped slider. The rear side of the fixing block is threadedly connected to the inside of the fixing base via a bolt.

[0010] As a further description of the above technical solution:

[0011] The limiting assembly includes a limiting rod, which is movably connected to the surface of the support rod via a shaft. The surface of the limiting rod contacts the inner wall of the limiting groove, and the side of the limiting rod away from the shaft is threadedly connected to the surface of the mounting plate via a bolt.

[0012] As a further description of the above technical solution:

[0013] Both the moving plate and the pushing block are fitted with sealing gaskets, which are fixedly connected to the surface of the mounting plate.

[0014] As a further description of the above technical solution:

[0015] A handle is fixedly connected to the top of the support rod;

[0016] As a further description of the above technical solution:

[0017] A reinforcing plate is fixedly connected to the inner side of the mounting plate, and the outer side of the reinforcing plate is fixedly connected to the surface of the support rod.

[0018] As a further description of the above technical solution:

[0019] A rubber pad is fixedly connected to the surface of the clamping block;

[0020] As a further description of the above technical solution:

[0021] A support block is fixedly connected to the inner wall of the fixing groove.

[0022] This utility model has the following beneficial effects:

[0023] 1. In this utility model, through the cooperation of structures such as the moving plate, clamping block, guide plate and fixing plate, the pressing and pushing block drives the moving plate to move upward. After the moving plate moves upward and drives the clamping block to disengage from the limit of the guide plate, the affinity film can be removed by rotating around the shaft as the center, thus achieving the effect of quick disassembly of the affinity film for easy maintenance.

[0024] 2. In this utility model, the base can be fixed by the cooperation of the sliding groove, T-shaped slider and fixing block structure, which facilitates the disassembly of the base. This solves the problem that when inspecting the affinity membrane, it is necessary to remove the bolts on its surface before it can be taken out of the protein separation pool for inspection, thereby achieving the effect of quick disassembly of the base. Attached Figure Description

[0025] Figure 1 This is a three-dimensional schematic diagram of an affinity membrane treatment frame that is easy to maintain, as proposed in this utility model.

[0026] Figure 2 A three-dimensional structural diagram of a T-shaped slider for an affinity membrane treatment frame that is easy to maintain, as proposed in this utility model.

[0027] Figure 3 A cross-sectional three-dimensional structural diagram of the mounting plate of the affinity membrane treatment membrane frame that is easy to maintain according to this utility model.

[0028] Figure 4 An exploded three-dimensional structural diagram of the fixing plate and the pushing block of the affinity membrane treatment membrane frame that is easy to maintain according to this utility model;

[0029] Figure 5 for Figure 1 Enlarged view of point A in the middle;

[0030] Figure 6 for Figure 1 Enlarged view of point B in the middle;

[0031] Figure 7 for Figure 2 Enlarged view of point C in the middle.

[0032] Legend:

[0033] 1. Fixed base; 2. Base; 3. Support rod; 4. Mounting plate; 5. Fixed groove; 6. Moving plate; 7. Clamping block; 8. Affinity film; 9. Guide plate; 10. Fixed plate; 11. Clamping spring; 12. Pushing block; 13. Limiting groove; 14. Slide groove; 15. T-shaped slider; 16. Fixed block; 17. Limiting rod; 18. Sealing gasket; 19. Handle; 20. Reinforcing plate; 21. Rubber pad; 22. Support block. Detailed Implementation

[0034] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0035] Reference Figure 1-7 This utility model provides an embodiment of an affinity membrane processing frame that is easy to maintain. It includes a fixed base 1, which is bolted to the inside of a protein separation tank. A base 2 is provided on the top of the fixed base 1, and support rods 3 are fixedly connected to the four corners of the top of the base 2. Handles 19 are fixedly connected to the top of the support rods 3, facilitating the movement of the membrane frame by workers. A mounting plate 4 is provided on the top of the base 2, and a reinforcing plate 20 is fixedly connected to the inner side of the mounting plate 4 to prevent breakage at the connection between the mounting plate 4 and the support rods 3. The outer side of the reinforcing plate 20 is fixedly connected to the surface of the support rods 3. The front and rear sides of the mounting plate 4 are fixedly connected to the surface of the support rods 3. Multiple fixing grooves 5 are provided inside the mounting plate 4, and support blocks 22 are fixedly connected to the inner walls of the fixing grooves 5 to limit the clamping blocks 7, preventing excessive rotation of the clamping blocks 7 and ensuring proper closure for fixing the affinity membrane 8. A movable plate 6 is slidably connected inside the fixing grooves 5. A clamping block 7 is movably connected to the top of the 6 via a shaft. A rubber pad 21 is fixedly connected to the surface of the clamping block 7. The rubber pad 21 reduces wear when the clamping block 7 is in long-term contact with the affinity film 8, thus extending the service life of the clamping block 7. An affinity film 8 is provided on the inner side of the clamping block 7. Guide plates 9 are fixedly connected to the front and rear sides of the fixing groove 5. A fixing plate 10 is engaged with the front side of the moving plate 6. The fixing plate 10 is slidably connected inside the mounting plate 4. A retaining spring 11 is fixedly connected to the front side of the fixing plate 10. The rear side is fixedly connected to the inner wall of the mounting plate 4. The bottom of the movable plate 6 is provided with a push block 12. The surfaces of the movable plate 6 and the push block 12 are both covered with sealing gaskets 18. By setting the sealing gaskets 18, the gap between the movable plate 6 and the push plate and the mounting plate 4 is sealed to prevent liquid from entering the interior of the mounting plate 4 and affecting the normal operation of the internal parts. The sealing gaskets 18 are fixedly connected to the surface of the mounting plate 4. The side of the push block 12 away from the movable plate 6 extends to the outside of the mounting plate 4. The surface of the push block 12 is provided with a limiting groove 13.

[0036] Reference Figure 2-6The surface of the fixed base 1 is provided with a fixing component, which includes a slide groove 14. The slide groove 14 is opened on the front and rear sides of the fixed base 1. A T-shaped slider 15 is slidably connected inside the slide groove 14. The top of the T-shaped slider 15 is fixedly connected to the bottom of the base 2. A fixing block 16 is movably connected inside the fixed base 1 through a shaft. The right side of the fixing block 16 contacts the left side of the T-shaped slider 15. The rear side of the fixing block 16 is threadedly connected to the inside of the fixed base 1 by a bolt. First, rotate the bolt to release the limitation on the fixing block 16. Then, rotate the fixing block 16 around the shaft to release the fixation on the T-shaped slider 15 and the base 2. Then, move the base 2 to the left to move the T-shaped slider 15 out of the slide groove 14, and the base 2 can be removed, thereby achieving the effect of quickly removing the base 2 from the protein separation tank.

[0037] Reference Figure 1-5 The surface of the mounting plate 4 is provided with a limiting component, which includes a limiting rod 17. The limiting rod 17 is movably connected to the surface of the support rod 3 via a shaft. The surface of the limiting rod 17 contacts the inner wall of the limiting groove 13. The side of the limiting rod 17 away from the shaft is connected to the surface of the mounting plate 4 by a bolt thread. After rotating the bolt to release the fixing of the limiting rod 17, the limiting rod 17 is rotated around the shaft to move it out of the limiting groove 13, thereby pushing the block 12 to its limit.

[0038] Working principle: When the affinity membrane 8 needs to be inspected, first use a tool to remove the bolts on the surface of the fixing block 16. Then, rotate the fixing block 16 around the shaft to remove the limit on the T-shaped slider 15. Move the base plate to the left to remove the T-shaped slider 15 from the slide groove 14, and the base 2 can be removed from the fixing seat 1, thus achieving the effect of quickly removing the base 2 from the protein separation cell. When removing the affinity membrane 8, first use a tool to remove the bolts on the surface of the limiting rod 17. Rotate the limiting rod 17 around the shaft to move it out of the limiting groove 13. The pusher block 12 is released, and then the pusher block 12 is pressed to move the moving plate 6 upward. The moving plate 6 moves upward and causes the clamping block 7 to disengage from the guide plate 9, so that the clamping block 7 opens outward around the shaft to release the fixation of the affinity membrane 8. At the same time, the moving plate 6 moves upward and pushes the fixing plate 10 to squeeze and press the spring sheet 11 to make it elastically compressed, so that the affinity membrane 8 can be removed. The above operation can be reversed to reinstall the affinity membrane 8 inside the protein separation cell, thereby achieving the effect of quickly disassembling the affinity membrane 8 and facilitating its maintenance.

[0039] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A membrane frame for easy maintenance of affinity membrane treatment, comprising a fixing base (1), characterized in that: The top of the fixed base (1) is provided with a base (2), and support rods (3) are fixedly connected to the four corners of the top of the base (2). The top of the base (2) is provided with a mounting plate (4), and the front and rear sides of the mounting plate (4) are fixedly connected to the surface of the support rods (3). Multiple fixing grooves (5) are opened inside the mounting plate (4). A movable plate (6) is slidably connected inside the fixing groove (5). A clamping block (7) is movably connected to the top of the movable plate (6) through a shaft. An affinity membrane (8) is provided on the inner side of the clamping block (7). A guide plate (9) is fixedly connected to the front and rear sides of the fixing groove (5). The front side of the movable plate (6) is engaged with a fixed plate (10), the fixed plate (10) is slidably connected to the inside of the mounting plate (4), the front side of the fixed plate (10) is fixedly connected with a clamping spring (11), the rear side of the clamping spring (11) is fixedly connected to the inner wall of the mounting plate (4), the bottom of the movable plate (6) is provided with a pushing block (12), the side of the pushing block (12) away from the movable plate (6) extends to the outside of the mounting plate (4), the surface of the pushing block (12) is provided with a limiting groove (13), the surface of the fixed seat (1) is provided with a fixing component, and the surface of the mounting plate (4) is provided with a limiting component.

2. The affinity membrane treatment frame for easy maintenance according to claim 1, characterized in that: The fixing assembly includes a slide groove (14) which is formed on the front and rear sides of the fixing base (1). A T-shaped slider (15) is slidably connected inside the slide groove (14). The top of the T-shaped slider (15) is fixedly connected to the bottom of the base (2). A fixing block (16) is movably connected inside the fixing base (1) via a shaft. The right side of the fixing block (16) contacts the left side of the T-shaped slider (15). The rear side of the fixing block (16) is threadedly connected to the inside of the fixing base (1) via a bolt.

3. The affinity membrane treatment frame for easy maintenance according to claim 1, characterized in that: The limiting assembly includes a limiting rod (17), which is movably connected to the surface of the support rod (3) via a shaft. The surface of the limiting rod (17) contacts the inner wall of the limiting groove (13), and the side of the limiting rod (17) away from the shaft is connected to the surface of the mounting plate (4) by a bolt thread.

4. The affinity membrane treatment frame for easy maintenance according to claim 1, characterized in that: The surfaces of the movable plate (6) and the push block (12) are both fitted with sealing gaskets (18), which are fixedly connected to the surface of the mounting plate (4).

5. The affinity membrane treatment frame for easy maintenance according to claim 1, characterized in that: A handle (19) is fixedly connected to the top of the support rod (3).

6. The affinity membrane treatment frame for easy maintenance according to claim 1, characterized in that: A reinforcing plate (20) is fixedly connected to the inner side of the mounting plate (4).

7. The affinity membrane treatment frame for easy maintenance according to claim 1, characterized in that: A rubber pad (21) is fixedly connected to the surface of the clamping block (7).

8. The affinity membrane treatment frame for easy maintenance according to claim 1, characterized in that: A support block (22) is fixedly connected to the inner wall of the fixing groove (5).

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