A chemical device applied to neural stem cell transplantation extraction

Abstract

The utility model discloses a chemical plant applied to neural stem cell transplantation extraction, including equipment frame and centrifugal extractor, is provided with the water bath heating mechanism that is heated for centrifugal extractor on equipment frame, and equipment frame includes support frame and controller, and water bath heating mechanism includes water bath heating basin, heating wire, heat insulation plugboard, second motor and screw rod, and water bath heating basin is installed on support frame and is slidably connected with it, and heating wire is fixedly installed in water bath heating basin, and heat insulation plugboard is detachably installed in water bath heating basin, and screw rod is fixedly installed on the output shaft of second motor, and the left and right ends of water bath heating basin are provided with the ear plate that cooperates with screw rod. The utility model has the advantages of water bath heating and independent temperature control, and the problems of low heating efficiency, inaccurate temperature control and inconvenient operation of the existing centrifugal extraction equipment are solved.

Description

Technical Field

[0001] This utility model relates to the field of centrifugal extraction technology, specifically a chemical device for the extraction of neural stem cells for transplantation. Background Technology

[0002] Neural stem cell transplantation technology has significant application value in modern regenerative medicine, and the efficient isolation and purification of neural stem cells is one of the key aspects of its clinical application. In the extraction process of neural stem cells, centrifugal extraction is commonly used to separate and purify the cells. This method utilizes the density differences between substances of different phases to achieve effective separation of target components under centrifugal force.

[0003] However, existing centrifugal extraction devices are mostly fixed structures, lacking temperature control functions for the extraction process. In actual operation, extraction efficiency and cell viability are highly dependent on the stability of ambient temperature. Traditional heating methods often use integrated thermostatic chambers or external jacket systems, which suffer from slow heating, low temperature control accuracy, and high energy consumption, making it difficult to meet the differentiated temperature requirements at different stages. Furthermore, when multiple centrifugal extractors share a single heating system, thermal interference can easily occur between them, affecting the independent temperature control capability of each channel. Therefore, a chemical device for neural stem cell transplantation extraction is needed to solve these problems. Utility Model Content

[0004] The purpose of this invention is to provide a chemical device for the extraction of neural stem cells for transplantation, which has the advantages of water bath heating and independent temperature control, and solves the problems of low heating efficiency, inaccurate temperature control and inconvenient operation of existing centrifugal extraction equipment.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a chemical apparatus for extracting neural stem cells for transplantation, comprising an equipment rack and a centrifugal extractor, wherein the equipment rack is provided with a water bath heating mechanism for heating the centrifugal extractor;

[0006] The equipment frame includes a support frame and a controller. The water bath heating mechanism includes a water bath heating basin, an electric heating wire, a heat insulation plate, a second motor, and a lead screw. The water bath heating basin is mounted on the support frame and slidably connected to it. The electric heating wire is fixedly installed inside the water bath heating basin. The heat insulation plate is detachably installed inside the water bath heating basin. The lead screw is fixedly installed on the output shaft of the second motor. The left and right ends of the water bath heating basin are provided with ear plates that cooperate with the lead screw.

[0007] As a preferred embodiment of the chemical apparatus of this invention for the extraction of neural stem cell transplantation, the support frame is provided with guide frames on the left and right sides for sliding engagement with ear plates, the lead screw is mounted on the guide frames and slidably connected thereto, and the ear plates are provided with screw holes that engage with the lead screw.

[0008] As a preferred embodiment of the chemical apparatus for neural stem cell transplantation extraction according to this utility model, the number of centrifugal extractors and heating wires is three, the heating wires are located at the lower end of the centrifugal extractors, the number of heat insulation plates is two, the two sets of heat insulation plates are located between the heating wires, and a temperature sensor is provided in the water bath heating basin.

[0009] As a preferred embodiment of the chemical apparatus for neural stem cell transplantation extraction according to this utility model, the inner end face of the side wall of the water bath heating basin is provided with a damping groove that slides in conjunction with the heat insulation plate, and the heat insulation plate is inserted into the damping groove and slidably connected to the water bath heating basin.

[0010] As a preferred embodiment of the chemical apparatus of this invention for the extraction of neural stem cell transplantation, a handle is provided on the top of the side end face of the heat-insulating plate.

[0011] As a preferred embodiment of the chemical apparatus of this invention for the extraction of neural stem cell transplantation, the heat-insulating insert is filled with heat-insulating filler, which is made of sand-based foamed resin.

[0012] As a preferred embodiment of the chemical apparatus for extracting neural stem cells for transplantation according to this utility model, the centrifugal extractor includes a mixing tank and a first motor. The side end face of the mixing tank is provided with a light phase inlet, a heavy phase inlet, a light phase outlet and a heavy phase outlet. The bottom upper end face of the water bath heating basin is provided with a preheating pipe that runs through the bottom of the basin.

[0013] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0014] 1. This utility model achieves flexible lifting and lowering of the water bath heating basin through the sliding connection structure between the water bath heating basin and the support frame, combined with the synergistic effect of the second motor drive screw and the guide frame. This design allows the centrifugal extractor to be lowered to the bottom of the support frame when not heated, avoiding spatial interference during pipeline connection and facilitating disassembly and cleaning. In addition, the handle and damping groove structure equipped with the heat insulation plate not only ensures stable positioning and good sealing of the plate, but also simplifies the insertion and removal operation, solving the maintenance difficulties caused by the fixed structure of traditional devices and significantly improving the ease of operation.

[0015] 2. The water bath heating basin of this utility model is divided into three independent areas by two detachable heat-insulating plates. Each area corresponds to a centrifugal extractor and is equipped with an independent heating wire and temperature sensor. Combined with the heat-insulating plates filled with sand-based foamed resin, it can effectively block temperature interference between areas and prevent the plates from floating due to insufficient density. The controller monitors the temperature of each area in real time and dynamically adjusts the power of the heating wire to meet the differentiated temperature requirements of different stages of neural stem cell extraction. At the same time, the preheating pipe at the bottom of the water bath heating basin can preheat the input light and heavy phase materials, shorten the time for the materials to reach the optimal extraction temperature, and further improve the extraction efficiency and consistency. Attached Figure Description

[0016] Figure 1 This is a first-view overall structural diagram of the present invention;

[0017] Figure 2 This is a schematic diagram of the overall structure of the present invention from a second perspective;

[0018] Figure 3 This is a top view of the water bath heating basin of this utility model;

[0019] Figure 4 For the present utility model Figure 3 Sectional view of AA in the middle;

[0020] Figure 5 For the present utility model Figure 2 Enlarged view of section B in the middle.

[0021] In the diagram: 1. Equipment frame; 101. Support frame; 1011. Guide frame; 102. Controller; 2. Centrifugal extractor; 201. Mixing tank; 202. First motor; 203. Light phase inlet; 204. Heavy phase inlet; 205. Light phase outlet; 206. Heavy phase outlet; 3. Water bath heating mechanism; 301. Water bath heating basin; 3011. Damping groove; 3012. Preheating tube; 3013. Ear plate; 3014. Screw hole; 302. Heating wire; 303. Insulation plate; 3031. Insulation filler; 3032. Handle; 304. Second motor; 305. Lead screw; 306. Temperature sensor. Detailed Implementation

[0022] Please see Figures 1-5 A chemical apparatus for extracting neural stem cells for transplantation includes an equipment rack 1 and a centrifugal extractor 2. The equipment rack 1 is equipped with a water bath heating mechanism 3 for heating the centrifugal extractor 2.

[0023] The equipment frame 1 includes a support frame 101 and a controller 102. The water bath heating mechanism 3 includes a water bath heating basin 301, an electric heating wire 302, a heat insulation plate 303, a second motor 304, and a lead screw 305. The water bath heating basin 301 is mounted on the support frame 101 and slidably connected thereto. The electric heating wire 302 is fixedly installed inside the water bath heating basin 301. The heat insulation plate 303 is detachably installed inside the water bath heating basin 301. The lead screw 305 is fixedly installed on the output shaft of the second motor 304. Ear plates 3013 that cooperate with the lead screw 305 are provided at both ends of the water bath heating basin 301.

[0024] Furthermore, the left and right sides of the support frame 101 are provided with guide frames 1011 that are slidably engaged with ear plates 3013, and the lead screw 305 is mounted on the guide frame 1011 and slidably connected thereto. The ear plates 3013 are provided with screw holes 3014 that engage with the lead screw 305.

[0025] The second motor 304 drives the lead screw 305 to rotate, thereby causing the ear plate 3013 to slide up and down along the lead screw 305, which facilitates the raising and lowering of the water bath heating basin 301. When heating is required for the centrifugal extractor 2, the water bath heating basin 301 is raised so that the lower end of the centrifugal extractor 2 is immersed in the water bath heating basin 301. When not in use, it is lowered to the bottom of the support frame 101, which facilitates the connection of the pipeline of the centrifugal extractor 2 and disassembly and cleaning.

[0026] Furthermore, there are three centrifugal extractors 2 and three heating wires 302. The heating wires 302 are located at the lower end of the centrifugal extractor 2. There are two heat insulation plates 303. The two sets of heat insulation plates 303 are located between the heating wires 302. A temperature sensor 306 is installed in the water bath heating basin 301.

[0027] The water bath heating basin 301 is divided into three areas by the heat insulation plate 303, and each area corresponds to a centrifugal extractor 2. The water bath temperature of each centrifugal extractor 2 can be adjusted individually. The temperature is detected by the temperature sensor 306 and adjusted by the controller 102 to meet the temperature requirements of different extraction stages.

[0028] Furthermore, the inner end face of the side wall of the water bath heating basin 301 is provided with a damping groove 3011 that slides with the heat insulation plate 303. The heat insulation plate 303 is inserted into the damping groove 3011 and slidably connected to the water bath heating basin 301.

[0029] The damping groove 3011 positions the heat insulation plate 303 to prevent it from shifting, and at the same time avoids gaps between the heat insulation plate 303 and the water bath heating basin 301, which would cause hot water exchange between different chambers and affect temperature control.

[0030] Furthermore, a handle 3032 is provided on the top of the side end face of the heat insulation plate 303.

[0031] The handle 3032 makes it easy to lift the heat insulation plate 303, preventing the heat insulation plate 303 from getting stuck in the damping groove 3011 and making it difficult to pull out, thus improving the ease of operation of the equipment.

[0032] Furthermore, the heat insulation insert 303 is filled with heat insulation filler 3031, which is made of sand-based foamed resin.

[0033] The thermal insulation filler 3031, made of sand-based foamed resin, can effectively insulate the temperature difference between the two cavities. Moreover, the density of sand-based foamed resin is greater than that of water, which prevents the thermal insulation insert 303 from floating.

[0034] Furthermore, the centrifugal extractor 2 includes a mixing tank 201 and a first motor 202. The side end face of the mixing tank 201 is provided with a light phase inlet 203, a heavy phase inlet 204, a light phase outlet 205 and a heavy phase outlet 206. The bottom upper end face of the water bath heating basin 301 is provided with a preheating pipe 3012 that is connected to the bottom therethrough.

[0035] A preheating pipe 3012 is installed near the light phase inlet 203 and the heavy phase inlet 204 of the water bath heating basin 301. A rubber tube passes through the preheating pipe 3012 and is connected to the light phase inlet 203 and the heavy phase inlet 204. By preheating the added light phase material and heavy phase material, the optimal extraction temperature is quickly reached.

[0036] When using this device, first place the equipment frame 1 in a suitable working position, connect the power supply, and set the required temperature parameters through the controller 102. Then start the second motor 304, which drives the lead screw 305 to rotate, causing the water bath heating basin 301 to descend along the lead screw 305 via the ear plate 3013 to the bottom of the support frame 101, facilitating the pipeline connection to the centrifugal extractor 2. Pass the light phase material and heavy phase material conveying rubber tubes through the preheating pipe 3012 and connect them to the light phase inlet 203 and heavy phase inlet 204 of the mixing tank 201 of the centrifugal extractor 2, respectively. Connect the pipelines of the light phase outlet 205 and the heavy phase outlet 206. After the pipeline connection is completed, start the second motor 304 again to raise the water bath heating basin 301, so that the lower end of the centrifugal extractor 2 is immersed in the water bath heating basin 301. Since there are three centrifugal extractors 2 and three heating wires 302, and they are divided into three independent areas by two heat insulation plates 303, the heating power of the heating wires 302 in each area can be adjusted by the controller 102 according to the temperature requirements of different extraction stages. The temperature sensor 306 detects the temperature of each area in the water bath heating basin 301 in real time and feeds it back to the controller. Controller 102 enables precise temperature control. When temperature zones need adjustment, the insulation plate 303 can be pulled out of the damping groove 3011 and reinserted for adjustment via the handle 3032 on the top of the side end face of the insulation plate 303. The damping groove 3011 not only positions the insulation plate 303 to prevent displacement but also avoids the exchange of hot water between different chambers affecting temperature control. Furthermore, the sand-based foamed resin insulation filler 3031 inside the insulation plate 303 effectively blocks temperature conduction and prevents it from floating. After connecting the material pipeline and adjusting the temperature of the water bath heating basin 301, the machine is started. The first motor 202 of the centrifugal extractor 2 drives the mixing tank 201 to rotate. The light phase material and the heavy phase material enter the mixing tank 201 from the inlet respectively. Under the preheating effect of the preheating pipe 3012 and the continuous heating effect of the water bath heating basin 301, the optimal extraction temperature is quickly reached, and the mixture is fully mixed and extracted. The extracted light phase and heavy phase flow out from the corresponding outlets respectively. After the extraction is completed, the second motor 304 is started to lower the water bath heating basin 301, the first motor 202 and the heating wire 302 are turned off, and the pipelines are disassembled to clean the centrifugal extractor 2 and the water bath heating basin 301 for the next use.

[0037] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A chemical apparatus for extracting neural stem cells for transplantation, comprising an apparatus rack (1) and a centrifugal extractor (2), characterized in that: The equipment rack (1) is equipped with a water bath heating mechanism (3) for heating the centrifugal extractor (2); The equipment frame (1) includes a support frame (101) and a controller (102). The water bath heating mechanism (3) includes a water bath heating basin (301), an electric heating wire (302), a heat insulation plate (303), a second motor (304), and a lead screw (305). The water bath heating basin (301) is mounted on the support frame (101) and slidably connected thereto. The electric heating wire (302) is fixedly installed inside the water bath heating basin (301). The heat insulation plate (303) is detachably installed inside the water bath heating basin (301). The lead screw (305) is fixedly installed on the output shaft of the second motor (304). The left and right ends of the water bath heating basin (301) are provided with ear plates (3013) that cooperate with the lead screw (305).

2. The chemical apparatus for neural stem cell transplantation extraction as described in claim 1, characterized in that: The support frame (101) is provided with guide frames (1011) that are slidably engaged with ear plates (3013) on the left and right sides. The lead screw (305) is mounted on the guide frame (1011) and slidably connected to it. The ear plate (3013) is provided with screw holes (3014) that are engaged with the lead screw (305).

3. The chemical apparatus for neural stem cell transplantation extraction as described in claim 1, characterized in that: The centrifugal extractor (2) and the heating wire (302) are three in number. The heating wire (302) is located at the lower end of the centrifugal extractor (2). The heat insulation plate (303) is two in number. The two sets of heat insulation plates (303) are located between the heating wire (302). A temperature sensor (306) is installed in the water bath heating basin (301).

4. The chemical apparatus for neural stem cell transplantation extraction as described in claim 1, characterized in that: The inner end face of the side wall of the water bath heating basin (301) is provided with a damping groove (3011) that slides with the heat insulation plate (303). The heat insulation plate (303) is inserted into the damping groove (3011) and slidably connected to the water bath heating basin (301).

5. The chemical apparatus for neural stem cell transplantation extraction as described in claim 1, characterized in that: A handle (3032) is provided on the top of the side end face of the heat insulation plate (303).

6. The chemical apparatus for neural stem cell transplantation extraction as described in claim 1, characterized in that: The heat insulation insert (303) is filled with heat insulation filler (3031), which is made of sand-based foamed resin.

7. The chemical apparatus for neural stem cell transplantation extraction as described in claim 1, characterized in that: The centrifugal extractor (2) includes a mixing tank (201) and a first motor (202). The side end face of the mixing tank (201) is provided with a light phase inlet (203), a heavy phase inlet (204), a light phase outlet (205), and a heavy phase outlet (206). The bottom upper end face of the water bath heating basin (301) is provided with a preheating pipe (3012) that is connected to the bottom therethrough.

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