A high performance capillary electrophoresis instrument with sample injection detection

Abstract

The utility model relates to the capillary electrophoresis appearance field, concretely relates to a high -efficient capillary electrophoresis appearance with material detection, including material cabinet, the top of material cabinet is hanked with shell, the right side of shell inner chamber bottom is hanked with electrophoresis appearance, the left side of shell inner chamber bottom is hanked with water tank, the lower portion communication of water tank left side has first water supply pipe, the upper portion of shell left side is hanked with transverse board, the top of transverse board is hanked with air cylinder. The utility model discloses through water tank, first water supply pipe, transverse board, air cylinder, water collecting tank, first water pump etc. assembly, adds the cleaning component, is convenient for automatic cleaning to the detection pipe before and after the sample, when washing, only need to draw the liquid through first water supply pipe to the water collecting tank, through the water pressure and clean water flow extrude into the sampling needle, and through the mode of spraying to the detection pipe below flush, sets up first water pump on the sample tube, and the flow size is convenient for setting, and the sample number and total amount are convenient for controlling.

Description

Technical Field

[0001] This utility model relates to the field of capillary electrophoresis apparatus, specifically to a high-efficiency capillary electrophoresis apparatus with feed detection. Background Technology

[0002] Capillary electrophoresis, also known as high-efficiency capillary electrophoresis, is a general term for a class of liquid phase separation and analysis methods and techniques that use capillaries as separation channels and DC high-voltage electric fields as driving forces, based on the characteristics of samples such as charge, size, isoelectric point, polarity, affinity behavior, and phase distribution.

[0003] Capillary electrophoresis is the main equipment for capillary electrophoresis analysis. Its basic principle is to perform electrophoresis on the sample in a quartz capillary filled with electrophoresis solution, thereby achieving biochemical analysis. In the existing technology, the sample introduction of capillary electrophoresis is mainly achieved by negative pressure, but the pressure of negative pressure is usually relatively low, resulting in low sample introduction efficiency.

[0004] Therefore, it is necessary to invent a high-efficiency capillary electrophoresis apparatus with feed detection to solve the above problems. Utility Model Content

[0005] The purpose of this utility model is to provide a high-efficiency capillary electrophoresis apparatus with feed detection, which can effectively solve the above-mentioned technical problems.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a high-efficiency capillary electrophoresis apparatus with feed detection, comprising a material cabinet, a shell attached to the top of the material cabinet, an electrophoresis apparatus attached to the right side of the bottom of the shell, a water tank attached to the left side of the bottom of the shell, a first water supply pipe connected to the lower left side of the water tank, a horizontal plate attached to the upper left side of the shell, a cylinder attached to the top of the horizontal plate, a water collection trough attached to the bottom of the cylinder, and bolts arranged at the bottom of the water collection trough. A first water pump is connected to the bottom of the first water pump, and sampling needles are connected to the bottom of the water collection tank. Second water supply pipes are connected to the bottom of the second water supply pipes, and one-way valves are connected to the bottom of the second water supply pipes. The left side of the one-way valves is connected to the right side of the first water pump. An inlet pipe is connected to the back of the first water pump. A filter is bolted to the middle of the inner cavity of the outer shell, and the other end of the inlet pipe is connected to the top of the filter. A sensing outlet pipe is connected to the lower right side of the filter, and the other end of the sensing outlet pipe is connected to the left side of the electrophoresis apparatus.

[0007] Preferably, the bottom right side of the filter is connected to an induction reflux pipe, and the other end of the induction reflux pipe is connected to a crushing chamber, so that liquids that cannot enter the electrophoresis apparatus can enter the crushing chamber through the induction reflux pipe.

[0008] Preferably, the crushing rollers are rotatably connected to the upper and lower sides of the inner cavity of the crushing box via bearings, and drive motors are bolted to the upper and lower sides of the right side of the crushing box. The output end of the drive motor is bolted to the right side of the crushing rollers. The drive motors serve as the driving source, driving the crushing rollers to rotate rapidly in the crushing box, thereby crushing and mixing the liquid.

[0009] Preferably, the lower left side of the crushing box is connected to a second return pipe, and the other end of the second return pipe is connected to the left side of the filter, so that the crushed liquid can re-enter the filter.

[0010] Preferably, the upper right side of the water tank is connected to a third water supply pipe, and the other end of the third water supply pipe is connected to the top of the filter, so that the cleaning liquid can enter the filter through the third water supply pipe and clean the inside of the filter.

[0011] Preferably, a placement rack is bolted to the middle of the left side of the water tank, and detection tubes are inserted into the inner side of the placement rack so that the detection tubes can be temporarily stored on the placement rack in an orderly and quick manner.

[0012] Preferably, the lower left side of the electrophoresis apparatus is connected to a drain pipe, so that the liquid after electrophoresis detection can be discharged from the outer shell through the drain pipe.

[0013] Preferably, a sewage tank is bolted to the lower left side of the water tank, and the back of the sewage tank is connected to the other end of the drain pipe, so that the wastewater is temporarily stored in the sewage tank.

[0014] The technical effects and advantages provided by this utility model in the above technical solution are as follows:

[0015] 1. By adding cleaning components, including a water tank, a first water supply pipe, a horizontal plate, a cylinder, a water collection tank, and a first water pump, the function of automatic cleaning of the detection tube before and after sample loading is realized.

[0016] The advantages and positive effects of this utility model compared to the prior art are described in detail below;

[0017] Firstly, regarding cleaning efficiency, this invention uses a first water supply pipe to draw liquid into a collection tank, and then uses water pressure to force clean water into the sampling needle, achieving a highly efficient and rapid cleaning process. Compared with traditional manual cleaning methods, cleaning efficiency is greatly improved, saving labor and time costs.

[0018] Secondly, in terms of cleaning effect, this utility model uses a spray-type rinsing method to clean the detection tube, so that the cleaning water can fully contact the inner wall of the detection tube and effectively remove residual samples and impurities. Compared with the traditional cleaning method, the cleaning effect of this utility model is more thorough, ensuring the cleanliness of the detection tube, thereby improving the accuracy and reliability of the detection.

[0019] In addition, this utility model is equipped with a first water pump on the sample inlet tube, which makes it easy to set the flow rate and thus control the number and total amount of samples loaded. This design makes the operation more flexible, and users can adjust the sample loading amount according to actual needs, avoiding sample waste and experimental errors.

[0020] 2. This utility model, through the ingenious design and combination of components such as a filter, induction outlet pipe, induction reflux pipe, crushing box, and crushing roller, achieves automated and intelligent operation in the liquid sample detection process. Compared with the prior art, it has the following significant advantages:

[0021] First, this invention incorporates multiple sensing systems that automatically identify liquids that cannot enter the electrophoresis apparatus and re-bleed them until they meet the apparatus's requirements. This technical feature directly overcomes the problems of low liquid sample processing efficiency and high operator skill requirements in existing technologies, significantly improving detection efficiency and reducing operational difficulty.

[0022] Secondly, this invention allows for the extraction of multiple samples for testing during operation, significantly improving the accuracy and reliability of the tests. This feature enables the invention to meet the needs of large-scale, batch testing while ensuring testing quality. Furthermore, the invention includes a water tank and multiple water supply pipes, which automatically clean the internal components after liquid testing. This design not only ensures the hygiene of the device and avoids cross-contamination but also prevents the waste of chemical reagents during cleaning, reducing operating costs.

[0023] Meanwhile, the automatic cleaning function avoids errors in the next test, ensuring the accuracy of the test results; furthermore, the structure of this utility model is compact, occupies a small area, is easy to install and transport, and meets the space constraints of the laboratory.

[0024] Finally, this invention improves detection efficiency and reduces operating costs while also embodying environmental protection principles. By reducing wastewater discharge, it lowers the environmental impact, aligning with my country's sustainable development strategy. Attached Figure Description

[0025] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this invention. For those skilled in the art, other drawings can be obtained based on these drawings.

[0026] Figure 1 This is a front view of the overall structure of this utility model;

[0027] Figure 2This is a front sectional view of the overall structure of this utility model;

[0028] Figure 3 For the present utility model Figure 2 Enlarged view of the structure at point A in the middle;

[0029] Figure 4 For the present utility model Figure 2 Enlarged view of the structure at point B in the middle;

[0030] Figure 5 For the present utility model Figure 2 Enlarged view of the structure at point C.

[0031] Explanation of reference numerals in the attached figures:

[0032] 1. Material cabinet; 2. Outer shell; 3. Electrophoresis apparatus; 4. Water tank; 5. First water supply pipe; 6. Horizontal plate; 7. Cylinder; 8. Water collection tank; 9. First water pump; 10. Sampling needle; 11. Second water supply pipe; 12. One-way valve; 13. Liquid inlet pipe; 14. Filter screen; 15. Induction liquid outlet pipe; 16. Induction return pipe; 17. Crushing box; 18. Crushing roller; 19. Drive motor; 20. Second return pipe; 21. Third water supply pipe; 22. Placement rack; 23. Detection tube; 24. Drain pipe; 25. Wastewater tank. Detailed Implementation

[0033] To enable those skilled in the art to better understand the technical solution of this utility model, the present utility model will be further described in detail below with reference to the accompanying drawings.

[0034] This utility model provides, for example Figure 1-5 The high-efficiency capillary electrophoresis apparatus shown includes a material cabinet 1, a housing 2 bolted to the top of the material cabinet 1, an electrophoresis apparatus 3 bolted to the right side of the bottom of the housing 2, a water tank 4 bolted to the left side of the bottom of the housing 2, a first water supply pipe 5 connected to the lower left side of the water tank 4, a horizontal plate 6 bolted to the upper left side of the housing 2, a cylinder 7 bolted to the top of the horizontal plate 6, a water collection tank 8 bolted to the bottom of the cylinder 7, and first water pumps 9 arranged and bolted to the bottom of the water collection tank 8. The bottoms of the first water pumps 9 are all connected to... The sampling needle 10 and the bottom of the water collection tank 8 are connected to the second water supply pipe 11. The bottom of the second water supply pipe 11 is connected to the one-way valve 12. The left side of the one-way valve 12 is connected to the right side of the first water pump 9. The back of the first water pump 9 is connected to the liquid inlet pipe 13. The middle of the inner cavity of the outer shell 2 is connected to the filter 14. The other end of the liquid inlet pipe 13 is connected to the top of the filter 14. The lower right side of the filter 14 is connected to the sensing liquid outlet pipe 15. The other end of the sensing liquid outlet pipe 15 is connected to the left side of the electrophoresis apparatus 3.

[0035] The bottom right side of the filter 14 is connected to the induction return pipe 16, and the other end of the induction return pipe 16 is connected to the crushing box 17, so that liquids that cannot enter the electrophoresis apparatus 3 can enter the crushing box 17 through the induction return pipe 16.

[0036] The crushing rollers 18 are rotatably connected to the upper and lower sides of the inner cavity of the crushing box 17 via bearings. The upper and lower sides of the right side of the crushing box 17 are bolted with drive motors 19, and the output end of the drive motors 19 is bolted to the right side of the crushing rollers 18. The drive motors 19 serve as the driving source, driving the crushing rollers 18 to rotate rapidly in the crushing box 17, thereby crushing and mixing the liquid.

[0037] The lower left side of the crushing chamber 17 is connected to a second return pipe 20, and the other end of the second return pipe 20 is connected to the left side of the filter 14, so that the crushed liquid can re-enter the filter 14.

[0038] The upper right side of the water tank 4 is connected to a third water supply pipe 21, and the other end of the third water supply pipe 21 is connected to the top of the filter 14, so that the cleaning liquid can enter the filter 14 through the third water supply pipe 21 and clean the inside of the filter 14.

[0039] A placement rack 22 is bolted to the middle of the left side of the water tank 4. Detection tubes 23 are inserted into the inner side of the placement rack 22, so that the detection tubes 23 can be temporarily stored on the placement rack 22 in an orderly and quick manner.

[0040] The lower left side of the electrophoresis apparatus 3 is connected to a drain pipe 24, which allows the liquid after electrophoresis detection to be discharged from the outer casing 2 through the drain pipe 24.

[0041] A sewage tank 25 is bolted to the lower left side of the water tank 4, and the back of the sewage tank 25 is connected to the other end of the drain pipe 24, so that the wastewater is temporarily stored in the sewage tank 25.

[0042] Refer to the instruction manual appendix Figure 1-5 Working principle: A cleaning component is added to facilitate automatic cleaning of the detection tube 23 before and after sample loading. During cleaning, the liquid is simply drawn into the collection tank 8 through the first water supply pipe 5, and the cleaning water is forced into the sampling needle 10 by water pressure. The detection tube 23 below is then rinsed by spraying. A first water pump 9 is installed on the sample inlet tube to facilitate setting the flow rate and control the number and total amount of samples loaded. During the use of the device, multiple samples are extracted for testing. Multiple sensing systems are set up to automatically identify liquids that cannot enter the electrophoresis apparatus 3, causing the liquid to be re-flowed and broken up until it enters the electrophoresis apparatus 3. A water tank 4 and multiple water supply pipes are set up to automatically clean the internal components after the liquid testing is completed, avoiding errors in the next test.

[0043] The foregoing description only illustrates certain exemplary embodiments of the present invention. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the above drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A high-efficiency capillary electrophoresis apparatus with feed detection, comprising a material cabinet (1), characterized in that: The top of the material cabinet (1) is bolted with a shell (2). An electrophoresis apparatus (3) is bolted to the right side of the bottom of the inner cavity of the shell (2). A water tank (4) is bolted to the left side of the bottom of the inner cavity of the shell (2). A first water supply pipe (5) is connected to the lower left side of the water tank (4). A horizontal plate (6) is bolted to the upper left side of the shell (2). A cylinder (7) is bolted to the top of the horizontal plate (6). A water collection tank (8) is bolted to the bottom of the cylinder (7). A first water pump (9) is bolted to the bottom of the water collection tank (8). A sampling needle (10) is connected to the bottom of each of the first water pumps (9). The bottom of the water collection tank (8) is connected to a second water supply pipe (11), and the bottom of the second water supply pipe (11) is connected to a one-way valve (12). The left side of the one-way valve (12) is connected to the right side of the first water pump (9). The back of the first water pump (9) is connected to an inlet pipe (13). A filter (14) is bolted to the middle of the inner cavity of the outer shell (2), and the other end of the inlet pipe (13) is connected to the top of the filter (14). The lower right side of the filter (14) is connected to a sensing outlet pipe (15), and the other end of the sensing outlet pipe (15) is connected to the left side of the electrophoresis apparatus (3).

2. The high-efficiency capillary electrophoresis apparatus with feed detection according to claim 1, characterized in that: The bottom right side of the filter (14) is connected to an induction return pipe (16), and the other end of the induction return pipe (16) is connected to a crushing box (17).

3. The high-efficiency capillary electrophoresis apparatus with feed detection according to claim 2, characterized in that: The crushing box (17) has crushing rollers (18) rotatably connected to the upper and lower sides of the inner cavity via bearings. The right side of the crushing box (17) is bolted with drive motors (19) at both the upper and lower sides, and the output end of the drive motors (19) is bolted to the right side of the crushing rollers (18).

4. A high-efficiency capillary electrophoresis apparatus with feed detection according to claim 2, characterized in that: The lower left side of the crushing box (17) is connected to a second return pipe (20), and the other end of the second return pipe (20) is connected to the left side of the filter (14).

5. A high-efficiency capillary electrophoresis apparatus with feed detection according to claim 1, characterized in that: The upper right side of the water tank (4) is connected to a third water supply pipe (21), and the other end of the third water supply pipe (21) is connected to the top of the filter (14).

6. The high-efficiency capillary electrophoresis apparatus with feed detection according to claim 1, characterized in that: A placement rack (22) is bolted to the middle of the left side of the water tank (4), and detection tubes (23) are inserted into the inner side of the placement rack (22).

7. A high-efficiency capillary electrophoresis apparatus with feed detection according to claim 1, characterized in that: The lower left side of the electrophoresis apparatus (3) is connected to a drain pipe (24).

8. A high-efficiency capillary electrophoresis apparatus with feed detection according to claim 1, characterized in that: A sewage tank (25) is bolted to the lower left side of the water tank (4), and the back of the sewage tank (25) is connected to the other end of the drain pipe (24).

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