A pharmaceutical intermediate storage device

Abstract

This utility model belongs to the field of storage equipment technology, specifically disclosing a pharmaceutical intermediate storage device, including a tank body, a tank bottom, and a drying box. The tank body and the tank bottom are fixedly connected by a valve. The side wall of the tank body has a first vent hole and a second vent hole. An outer tank is fitted outside the tank body. The side wall of the tank bottom is configured as a vent plate, and an outer bottom tank is fitted outside the bottom. The drying box is fixedly connected to the circular hole. A sealing plug is detachably connected to the top of the drying box, and a third vent hole is opened on its side wall. This utility model increases the dehumidification area by setting the tank body and tank bottom for layered storage and dehumidification. By setting the sealing plug, the silica gel particles can be replaced individually, reducing the entry of external moisture. By setting the vent holes, the dehumidification area can be increased, improving storage efficiency.

Description

Technical Field

[0001] This utility model belongs to the field of storage device technology, specifically a pharmaceutical intermediate storage device. Background Technology

[0002] In the pharmaceutical intermediate production field, the storage stability of raw materials and intermediate products directly affects the quality of the final drug. This is especially true for moisture-sensitive intermediates (such as acyl chlorides, active esters, and organometallic compounds), where moisture absorption, clumping, degradation, and deterioration during storage are particularly prominent issues. Currently, the industry commonly uses sealed storage containers combined with desiccants, but the following technical bottlenecks remain: a gradient distribution of moisture density within the container (higher moisture at the bottom, dry at the top). Traditional containers only place desiccant bags at the top, which has limited effectiveness, and replacing the desiccant requires opening the lid, allowing moisture to re-enter. This fails to address the moisture absorption problem of the bottom material. Therefore, a device is needed that can perform layered storage and three-dimensional dehumidification, increasing the dehumidification area. Utility Model Content

[0003] To address the above technical problems, this utility model provides a device capable of layered storage and three-dimensional dehumidification, thereby solving the problem of poor dehumidification effect due to the single dehumidification area in traditional storage.

[0004] To solve the above technical problems, the technical solution of this utility model is as follows: a pharmaceutical intermediate storage device, including a tank body, a tank bottom, and a drying box. The tank body and the tank bottom are fixedly connected by a valve. A circular hole is opened in the middle of the top of the tank body, and a discharge port is opened at the bottom of the tank bottom. A first vent hole is opened in the lower part of the side wall of the tank body, and a second vent hole is opened in the upper part of the opposite side wall. An outer tank is fitted on the outside of the tank body. The side wall of the tank bottom is configured as a vent plate, and an outer bottom tank is fitted on the outside. A vent membrane is fixedly connected to the inner wall of the tank body and the tank bottom. The drying box is fixedly connected to the circular hole. A sealing plug is detachably connected to the top of the drying box, and a third vent hole is opened on the side wall. The bottom of the drying box is conical and the lower end extends into the tank body. Highly hygroscopic silica gel particles are arranged between the outer bottom tank and the side wall of the tank bottom. Color-changing silica gel particles are arranged inside the drying box.

[0005] Furthermore, the breathable membrane material is PTFE with a pore size of 0.45 μm.

[0006] Furthermore, the bottom of the tank is conical, and a sealing opening is provided at the bottom of the outer bottom tank.

[0007] Furthermore, a slide gate valve is installed on the discharge port, and a support leg is fixedly connected to the bottom of the outer tank.

[0008] Furthermore, the bottom of the tank body and the top of the tank bottom are both fixedly connected to sealing flanges, and bolt holes are evenly opened on the sealing flanges. The tank body and the tank bottom are fixedly connected to the valve through the sealing flanges.

[0009] Furthermore, the upper part of the side wall of the drying box is provided with an external thread, and the inner wall of the circular hole is provided with an internal thread that mates with the external thread. The drying box and the circular hole are connected by threads.

[0010] This utility model has the following advantages compared with the prior art:

[0011] 1. This utility model, by setting up a tank body and a tank bottom and connecting them with a valve, can achieve layered management and increase the dehumidification area. By setting the side wall of the tank bottom as a venting plate, the material at the bottom of the tank can communicate with the highly hygroscopic silica gel particles to absorb moisture. By opening a first vent at the bottom of the tank body and a second vent at the top, the moisture of the material at the bottom of the tank body can enter the drying box above, increasing the dehumidification area and improving the storage effect.

[0012] 2. This utility model facilitates the replacement of color-changing silica gel particles inside the drying box by setting a sealing plug, and prevents external moisture from entering when the drying box is directly disassembled during replacement. By fixing a breathable membrane to the inner wall of the tank body and bottom, it can ensure the passage of moisture while preventing the lower particulate material from flowing away.

[0013] 3. This utility model utilizes the upper space inside the container to absorb moisture by setting a suspended desiccant box, which is more effective than placing it at the bottom. The independent replacement port design greatly reduces moisture intrusion when changing the desiccant, effectively reducing the risk of material absorbing moisture and clumping, and ensuring material flowability. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model.

[0015] Figure 2 This is a schematic diagram of the structure of the drying box of this utility model.

[0016] Figure 3 This is a schematic diagram of the tank body of this utility model.

[0017] Figure 4 This is a schematic diagram of the bottom part of the can of this utility model.

[0018] In the diagram: 1. Tank body, 2. Outer tank, 3. Tank bottom, 4. Outer bottom tank, 5. Highly hygroscopic silica gel granules, 6. Discharge port, 7. Slide valve, 8. Valve, 9. Drying box, 10. Third vent, 11. Sealing plug, 12. Second vent, 13. First vent, 14. Sealing flange, 15. External thread, 16. Round hole, 17. Bolt hole, 18. Support leg. Detailed Implementation

[0019] The present invention will be further described below with reference to the accompanying drawings.

[0020] like Figures 1 to 4 The pharmaceutical intermediate storage device shown includes a tank body 1, a tank bottom 3, and a drying box 9. The tank body 1 is cylindrical, and the tank bottom 3 is conical for easy material handling. To increase storage space, the drying box 9 is also conical with a rounded bottom. To increase the moisture flow area and dehumidification area, the tank body 1 and tank bottom 3 are fixedly connected by a valve 8, which divides the pharmaceutical intermediate into upper and lower layers for separate dehumidification, thus increasing the dehumidification area. To accommodate the material, a circular hole 16 is provided in the center of the top of the tank body 1, through which the drying box 9 can pass and be fixedly connected. To ensure better sealing, a sealing ring is fixedly connected to the upper side wall of the drying box 9 on the round hole 16. After the drying box 9 is fixedly connected to the round hole 16, the sealing ring can play a good sealing role, preventing moisture in the air from entering. For easy material removal, a discharge port 6 is opened at the bottom of the tank bottom 3. To increase the dehumidification area and allow more material to come into contact with the air, a first vent hole 13 is opened at the lower part of the side wall of the tank body 1, and a second vent hole 12 is opened at the upper part of the opposite side wall. Moisture in the material at the bottom of the tank body 1 flows out through the first vent hole 13 and rises through the gap between the outer tank 2 and the side wall of the tank body 1. After entering the third vent through the second vent 12, the material is absorbed by the color-changing silica gel particles. To ensure the airtightness of the device, an outer tank 2 is fitted over the outer side of the tank body 1. To enable layered dehumidification and increase the dehumidification area, the side wall of the tank bottom 3 is configured as a vent plate, and an outer bottom tank 4 is fitted over the outer side. Ventilation membranes are fixedly connected to the inner walls of both the tank body 1 and the tank bottom 3. The vent membranes prevent small particles from passing through the perforated side walls, thus avoiding waste, while also not hindering the flow of moisture and air. The drying box 9 is fixedly connected to the round hole 16, and a sealing plug 11 is detachably connected to the top of the drying box 9. The side wall of the sealing plug 11 is provided with a sealing seal. A sealing ring is installed, and the sealing plug 11 is inserted into the top wall of the drying box 9. In order to absorb the moisture inside the device, a third vent hole 10 is provided on the side wall. In order to increase the storage space inside the can body 1, the bottom of the drying box 9 is set into a conical shape and the lower end extends into the can body 1. In order to absorb the moisture of the raw materials in the bottom 3 of the can, highly hygroscopic silica gel particles 5 are provided between the outer bottom can 4 and the side wall of the bottom 3 of the can. Color-changing silica gel particles are provided inside the drying box 9. In order to facilitate the observation of the internal conditions and the condition of the desiccant, an observation window is provided on the upper part of the side wall of the can body 1 and the opposite position of the outer can 2, so as to facilitate timely replacement of the desiccant.

[0021] It should be noted that in this embodiment, all perforated plates and vent holes have the same diameter and must be less than 1 mm.

[0022] In order to ensure air circulation without allowing small particles to escape, the breathable membrane material is set to PTFE with a pore size of 0.45μm.

[0023] To facilitate material handling, the bottom of the tank 3 is designed to be conical. To facilitate the replacement of the highly hygroscopic silica gel particles 5 inside the outer bottom tank 4, a sealing opening is provided at the bottom of the outer bottom tank 4.

[0024] In order to separate the raw materials into layers and facilitate discharge, a gate valve 7 is installed on the discharge port 6, and a support leg 18 is fixedly connected to the bottom of the outer tank 2.

[0025] In order to tightly seal the tank body 1 and the tank bottom 3, sealing flanges 14 are fixedly connected to the bottom of the tank body 1 and the top of the tank bottom 3. Bolt holes 17 are evenly opened on the sealing flanges 14, and bolts are passed through the bolt holes 17 for fixed connection. The tank body 1 and the tank bottom 3 are fixedly connected to the valve 8 through the sealing flanges 14.

[0026] In order to enable the detachable connection of the drying box 9 and ensure a seal after installation, an external thread 15 is provided on the upper part of the side wall of the drying box 9, and an internal thread that mates with the external thread 15 is provided on the inner wall of the round hole 16. The drying box 9 and the round hole 16 are connected by threads.

[0027] The specific working process of this utility model is as follows:

[0028] When storing pharmaceutical intermediates, first fill the drying box 9 with color-changing silica gel granules, and fill the outer bottom tank 4 with highly hygroscopic silica gel granules. Secure the tank body 1 and tank bottom 3 to both sides of the valve 8 with bolts, ensuring the discharge port 6 on the tank bottom 3 faces downwards. Then close the valve 8 and place the pharmaceutical intermediates into the tank body 1 through the round hole 16 at the top. When the tank body is two-thirds full, screw the drying box 9 into the round hole 16 to ensure a tight seal. Then open the valve 8, allowing the pharmaceutical intermediates in the tank body 1 to fall into the lower tank bottom 3. The tank bottom 3 will then be full of pharmaceutical intermediates. During the descent, airflow carries moisture into the silica gel granules, accelerating moisture absorption. When needed, remove the material from the lower discharge port 6. Observe the silica gel granules constantly; replace them promptly if discoloration is observed to improve dehumidification efficiency. Following these steps for storing pharmaceutical intermediates can prevent clumping, increase the dehumidification area, and improve storage efficiency.

Claims

1. A pharmaceutical intermediate storage device, comprising a tank body (1), a tank bottom (3), and a drying box (9), wherein the tank body (1) and the tank bottom (3) are fixedly connected by a valve (8), a circular hole (16) is provided in the middle of the top of the tank body (1), and a discharge port (6) is provided at the bottom of the tank bottom (3), characterized in that: The lower part of the side wall of the can body (1) is provided with a first vent hole (13) and the upper part of the opposite side is provided with a second vent hole (12). The outer can (2) is sleeved on the outside of the can body (1). The side wall of the bottom of the can (3) is provided with a vent plate and the outer bottom can (4) is sleeved on the outside. The inner walls of the can body (1) and the bottom of the can (3) are fixedly connected with vent membranes. The drying box (9) is fixedly connected to the round hole (16). The top of the drying box (9) is detachably connected with a sealing plug (11) and the side wall is provided with a third vent hole (10). The bottom of the drying box (9) is set in a conical shape and the lower end extends into the can body (1). Highly hygroscopic silica particles (5) are provided between the outer bottom can (4) and the side wall of the bottom of the can (3). Color-changing silica particles are provided inside the drying box (9).

2. The pharmaceutical intermediate storage device according to claim 1, characterized in that: The breathable membrane material is PTFE with a pore size of 0.45 μm.

3. The pharmaceutical intermediate storage device according to claim 1, characterized in that: The bottom of the tank (3) is conical, and the bottom of the outer bottom tank (4) has a sealing opening.

4. The pharmaceutical intermediate storage device according to claim 1, characterized in that: A slide valve (7) is installed on the discharge port (6), and a support leg (18) is fixedly connected to the bottom of the outer tank (2).

5. The pharmaceutical intermediate storage device according to claim 1, characterized in that: The bottom of the tank body (1) and the top of the tank bottom (3) are both fixedly connected to sealing flanges (14). Bolt holes (17) are evenly opened on the sealing flanges (14). The tank body (1) and the tank bottom (3) are fixedly connected to the valve (8) through the sealing flanges (14).

6. The pharmaceutical intermediate storage device according to claim 1, characterized in that: The upper side wall of the drying box (9) is provided with an external thread (15), and the inner wall of the round hole (16) is provided with an internal thread that matches the external thread (15). The drying box (9) and the round hole (16) are connected by threads.

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