A sampling device for detecting a chemical liquid

Abstract

This utility model discloses a sampling device for liquid drug testing, including a sampling base with a sampling seat at its bottom. The sampling seat has a sampling pipe communicating with a liquid flow channel inside. A first pipe for vacuuming and a second pipe for injecting high-pressure gas are connected to the sampling base. This utility model relates to the field of liquid drug testing technology. By setting up a first pipe for vacuuming and a second pipe for injecting high-pressure gas, after a single sampling is completed, high-pressure gas is injected through the second pipe. The powerful impact of the high-pressure gas flow thoroughly flushes the sampling pipe, effectively removing residual liquid drug adhering to the inner wall of the sampling pipe. After sealing the cover, gas is extracted from the sampling pipe through the first pipe, creating a vacuum inside the sampling pipe. This ensures the cleanliness of the sampling pipe, prevents external impurities from entering the pipe, and avoids the impact of oxidizing the liquid drug on subsequent sampling.

Description

Technical Field

[0001] This utility model relates to the field of liquid drug detection technology, specifically a sampling device for drug liquid detection. Background Technology

[0002] Drug sampling is a crucial step in the pharmaceutical production process, directly impacting drug quality monitoring and the safety and efficacy of the final product. Currently, existing drug sampling methods are mainly divided into two categories: suction sampling and direct sampling. Suction sampling typically utilizes negative pressure to extract the drug solution from the container using a sampler (such as a syringe or pipette). Direct sampling, on the other hand, directly extracts the drug sample from the container and is more widely used. In direct sampling, the sampling port usually needs to be flushed before sampling to remove any residual or potentially oxidized drug solution from the previous sampling. This process typically lasts about 20 seconds to ensure the sampling port is clean. The sampling port is usually cleaned by spraying alcohol and wiping. However, this traditional cleaning method has several drawbacks, making it difficult to guarantee the complete removal of residual drug solution from the sampling port and the sampling tubing connecting to it. For example, alcohol spraying and wiping can only clean the outer surface of the sampling port; its cleaning effect on residual medication inside the sampling tube is very limited. Even small amounts of medication remaining in the sampling tube after the previous sampling may react with oxygen in the air, causing oxidation and deterioration. This oxidized medication will remain in the sampling tube, forming contaminants that are difficult to remove. The oxidized medication remaining in the sampling tube will mix into the new sample during the next sampling, leading to inaccurate sampling results that fail to accurately reflect the actual condition of the medication. Utility Model Content

[0003] In view of the shortcomings of the existing technology, this utility model provides a sampling device for drug liquid detection, which solves the problem that the existing direct sampling has shortcomings in terms of the cleanliness of the sampling port and sampling pipe, which makes it difficult to ensure the accuracy and reliability of the sampling.

[0004] To achieve the above objectives, this utility model provides the following technical solution: a sampling device for detecting liquid medicine, comprising a sampling seat, a shaft disposed within the sampling seat, a sealing head disposed at the bottom end of the shaft and inserted into the liquid flow channel of the sampling seat, a sampling seat disposed at the bottom of the sampling seat, and a sampling pipe disposed inside the sampling seat and communicating with the liquid flow channel, wherein the sealing head, when at its lowest point, is pressed against the inlet of the sampling pipe; a first pipe for vacuuming and a second pipe for filling with high-pressure gas are connected to the sampling seat, the first pipe and the second pipe being disposed close to the inlet of the sampling pipe.

[0005] Preferably, the sampling seat includes an extension seat integrally formed with the sampling seat and a base detachably connected to the lower part of the extension seat.

[0006] Preferably, the sampling conduit includes an upper liquid chamber disposed within an extension seat and a lower liquid chamber disposed within a base, the upper liquid chamber and the lower liquid chamber being disposed opposite to each other.

[0007] Preferably, a sampling port is provided at the bottom of the downstream liquid chamber.

[0008] Preferably, a cover plate connected to the base is provided below the sampling port.

[0009] The beneficial effects of this utility model are as follows: By using the sampling device for drug liquid detection provided by this utility model, and by setting up a first pipe for vacuuming and a second pipe for filling with high-pressure gas, after a single sampling is completed, high-pressure gas is filled through the second pipe. The powerful impact of the high-pressure gas flow thoroughly flushes the sampling pipe, effectively removing residual drug liquid adhering to the inner wall of the sampling pipe, including hard-to-reach bends and dead corners. The high-pressure gas flow can completely blow the residual drug liquid out of the pipe, ensuring that there is no drug liquid residue in the sampling pipe. This fundamentally solves the problem of difficulty in removing residual drug liquid from the pipe in the prior art, preventing the drug liquid from stagnating and oxidizing in the sampling pipe. After the cover is closed, the gas in the sampling pipe is extracted through the first pipe, creating a vacuum inside the sampling pipe. The vacuum environment not only ensures the cleanliness of the sampling pipe and prevents external impurities from entering the pipe, but also further removes water vapor and residual trace oxygen from the sampling pipe. In this way, the influence of oxidized drug liquid on the next sampling can be avoided.

[0010] Furthermore, a detachable base is provided beneath the sampling holder, making maintenance and cleaning of the sampling holder much more convenient. When the base is damaged or heavily contaminated, it can be disassembled separately for repair or replacement without replacing the entire sampling holder. This significantly reduces equipment maintenance costs and extends the equipment's lifespan. Attached Figure Description

[0011] Figure 1 This is the front view of the present utility model;

[0012] Figure 2 This is the left view of the present invention.

[0013] Explanation of the reference numerals in the figure:

[0014] 1. Sampling seat, 2. Shaft, 3. Sealing head, 4. Extension seat, 5. Base, 6. First pipe, 7. Second pipe, 8. Upper liquid chamber, 9. Cover plate, 10. Lower liquid chamber, 11. Sampling port. Detailed Implementation

[0015] To better explain and facilitate understanding of the present invention, a detailed description of the invention is provided below with reference to the accompanying drawings and specific embodiments. This utility model discloses a sampling device for detecting pharmaceutical solutions, including a sampling base. A first pipe for vacuuming and a second pipe for filling with high-pressure gas are connected to the sampling base. A sampling port is located at the bottom of the downstream liquid chamber, and a cover plate connected to the base is located below the sampling port. High-pressure gas is injected into the sampling pipe, and the high-pressure gas flow flushes the sampling pipe, removing residual pharmaceutical solution and ensuring that no pharmaceutical solution remains in the sampling pipe, preventing any residual solution from oxidizing and remaining in the sampling pipe before the next sampling. After sealing the cover plate, gas is drawn from the sampling pipe through the first pipe, creating a vacuum inside to ensure the cleanliness of the sampling pipe. This also further removes moisture from the sampling pipe, reducing contact between the pharmaceutical solution and oxygen, thereby reducing the risk of oxidation and degradation.

[0016] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Various changes can be made to the implementation scheme as long as the effects of the present invention can be achieved.

[0017] Those skilled in the art can connect the components in this case sequentially. The specific connection and operation sequence should refer to the working principle described below. The detailed connection methods are well-known technologies in the field. The working principle and process are mainly described below.

[0018] like Figures 1 to 2 As shown in the embodiment of this application, a sampling device is proposed, including a sampling seat 1, a shaft 2 is provided inside the sampling seat 1, a handle is provided on the top of the shaft 2, and the shaft 2 is threadedly connected to the sampling seat 1.

[0019] In this embodiment, a sampling seat is provided at the bottom of the sampling seat 1, and the sampling bottle is connected to the sampling seat during the sampling process. The sampling seat has a sampling pipe that communicates with the liquid flow channel. Furthermore, a sealing head 3 is provided at the bottom end of the shaft 2, which is inserted into the liquid flow channel of the sampling seat 1. When the sealing head 3 is at its lowest point, it is pressed against the inlet of the sampling pipe. After the shaft 2 is screwed on, the sealing head 3 is disengaged from the inlet of the sampling pipe, and the liquid flowing in the liquid flow channel enters the sampling bottle through the sampling pipe.

[0020] Furthermore, in this embodiment, the sampling seat is connected to a first pipe 6 for vacuuming and a second pipe 7 for introducing high-pressure gas. The first pipe 6 and the second pipe 7 are positioned close to the inlet of the sampling pipe. The first pipe 6 is connected to a vacuum pump and has a valve. The second pipe 7 is connected to a gas supply pipe, which is equipped with a booster pump and also has a valve. Both valves can be manual valves (e.g., ball valves) or solenoid valves. The purpose is that after sampling, when the sealing head 3 is resealed at the inlet of the sampling pipe, high-pressure gas is introduced into the sampling pipe. The high-pressure gas flow flushes the sampling pipe, removing any residual medication and preventing any residual medication from oxidizing and remaining in the sampling pipe before the next sampling, thus avoiding affecting the sampling results. After the cover plate 9 is closed, the gas in the sampling pipe is drawn out through the first pipe 6 to make the inside a vacuum state, ensuring the cleanliness of the sampling pipe. At the same time, the water vapor in the sampling pipe is further removed, reducing the contact between the drug solution and oxygen, thereby reducing the risk of oxidation and degradation, and ensuring the accuracy and reliability of each sampling.

[0021] Furthermore, it should be noted in detail that the flow channel of sampling seat 1 has flanges at both ends, with bolt holes circumferentially opened. Both the first pipe 6 and the second pipe 7 include openings on both sides of the extension seat 4 and pipes connected to these openings, which communicate with the sampling pipes. The openings are coaxial with the lowest bolt holes on the flanges at both ends of the flow channel. During machining, the drill bit passes through the bolt holes and drills holes in the sampling seat 1 to form the openings. This method minimizes the overall height while maintaining the main structure of the sampling seat 1, making it suitable for use in space-constrained scenarios. Generally, for ease of machining, the horizontal line of the opening is lower than the bottom of the flange.

[0022] The sampling holder in this embodiment includes an extension seat 4 integrally formed with the sampling holder 1 and a base 5 detachably connected to the lower part of the extension seat 4. Exemplarily, the extension seat 4 and the base 5 are connected by a threaded connection or a flange connection, preferably a threaded connection. The detachable connection allows the base 5 to be replaced according to the model of the sampling bottle, thus adapting to sampling bottles with different interface sizes without replacing the entire sampling holder. At the same time, the detachable base 5 makes the maintenance and cleaning of the sampling holder more convenient; when the base 5 is damaged or heavily contaminated, it can be disassembled separately for repair or replacement.

[0023] The sampling conduit in this embodiment includes an upper flow chamber 8 disposed within the extension seat 4 and a lower flow chamber 10 disposed within the base 5, with the upper flow chamber 8 and the lower flow chamber 10 positioned opposite each other. The diameter of the lower flow chamber 10 must be equal to or greater than the diameter of the upper flow chamber 8 to ensure the normal outflow of the liquid medicine.

[0024] Additionally, a sampling port 11 is provided at the bottom of the downstream liquid chamber 10, and a sampling bottle is connected to the sampling port 11. Generally, the sampling port 11 is a threaded port.

[0025] Preferably, a cover plate 9 connected to the base 5 is provided below the sampling port 11. The connection between the cover plate 9 and the base 5 can be a rotary connection, a sliding connection, or a bolted assembly connection. In this embodiment, a rotary connection is preferred, that is, the edge of the cover plate 9 is rotatably connected to the base 5 via a rotating shaft, and the sampling port 11 can be closed or opened by moving the cover plate 9. In addition, a sealing ring is provided between the cover plate 9 and the base 5.

[0026] Furthermore, this embodiment also discloses the sampling process of the sampling device, as follows:

[0027] S1. Open the cover plate 9, and turn the shaft 2 to disengage the plug head 3 from the inlet of the sampling pipe, so that the inlet is opened and the liquid flowing in the liquid channel flows out through the sampling pipe to flush the sampling pipe.

[0028] S2. Twist shaft 2 in the opposite direction to seal the inlet of the sampling pipe with the plug head 3, and thread the sampling bottle to the sampling port 11; repeat opening and closing the inlet of the sampling pipe to complete one sampling operation, and then remove the sampling bottle;

[0029] S3. Open the second pipe 7, and high-pressure air is injected into the sampling pipe. The sampling pipe is flushed by the high-pressure airflow to remove the residual drug solution in the sampling pipe. After 1 minute, close the second pipe 7.

[0030] S4. Close the cover plate 9, open the first pipe 6, extract the gas in the sampling pipe to make the inside a vacuum, and then close the first pipe 6.

[0031] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A sampling device for detecting a pharmaceutical solution, comprising a sampling seat, wherein a shaft is disposed within the sampling seat, and a sealing head is disposed at the bottom end of the shaft and inserted into the liquid flow channel of the sampling seat, characterized in that: The bottom of the sampling seat is provided with a sampling base, and the sampling base has a sampling pipe that communicates with the liquid flow channel. When the sealing head is at the lowest end, it is pressed against the inlet of the sampling pipe. The sampling seat is connected to a first pipe for vacuuming and a second pipe for filling with high-pressure gas. The first pipe and the second pipe are set close to the inlet of the sampling pipe.

2. The sampling device for detecting pharmaceutical solutions according to claim 1, characterized in that: The sampling seat includes an extension seat integrally formed with the sampling seat and a base detachably connected to the underside of the extension seat.

3. The sampling device for detecting pharmaceutical solutions according to claim 1, characterized in that: The sampling conduit includes an upper liquid chamber disposed within an extension seat and a lower liquid chamber disposed within a base, the upper liquid chamber and the lower liquid chamber being disposed opposite to each other.

4. The sampling device for detecting pharmaceutical solutions according to claim 3, characterized in that: A sampling port is provided at the bottom of the downstream liquid chamber.

5. A sampling device for detecting pharmaceutical solutions according to claim 4, characterized in that: A cover plate connected to the base is provided below the sampling port.

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