A soluble microneedle patch preparation device

Abstract

The utility model relates to soluble microneedle patch production technical field, and disclose a kind of soluble microneedle patch preparation device, including base, the base top is provided with preparation mechanism, the preparation mechanism bottom is provided with filling mechanism, the preparation mechanism includes bearing frame, the bearing frame is fixedly connected in base top, the bearing frame inboard is fixedly connected with mixing box, the mixing box front side is fixedly connected with control panel, the mixing box rear side is fixedly connected with fixed frame, the fixed frame top is fixedly connected with first hydraulic cylinder, when using, when needing to prepare work to soluble microneedle patch, first, the raw material required by soluble microneedle patch is put into mixing box, first hydraulic cylinder drives sealing cap to move to the top of mixing box, the top of mixing box can be sealed, and material is fully stirred by servo motor drive rotating shaft and stirring rod, stirring shaft simultaneously.

Description

Technical Field

[0001] This utility model relates to the field of soluble microneedle patch production technology, specifically to a soluble microneedle patch preparation device. Background Technology

[0002] In the production and preparation of soluble microneedle patches, the mixing chamber is a key component that plays an important role in mixing raw materials. However, the existing soluble microneedle patch preparation equipment has structural design defects in the mixing chamber, making it difficult to thoroughly clean its interior. Raw materials and impurities are easily left in its internal corners, stirring paddles, and other parts. These residues can be mixed into new raw materials in subsequent production, which not only affects the purity and quality of the product but may also cause batch contamination problems, increasing production costs and product defect rates.

[0003] Meanwhile, during the preparation of soluble microneedle patches, operations such as raw material mixing inevitably generate air bubbles. Current preparation equipment lacks effective means to eliminate air bubbles. Residual air bubbles can lead to problems such as voids and reduced structural strength in microneedle patches, seriously affecting the performance and effectiveness of microneedle patches, reducing the safety and effectiveness of the products, and making it difficult to meet the high-quality requirements for soluble microneedle patches.

[0004] According to the description in the patent application published on the Internet of Things (authorization announcement number: CN222092321U), the soluble microneedle patch preparation device includes a "tabletop, support plate", etc., to realize the preparation work.

[0005] Regarding the above description, the applicant believes the following issues exist:

[0006] This soluble microneedle patch preparation device utilizes a table, support plate, etc., to carry out the preparation work. During use, the device stores the solution in a solution tank, but it cannot stir the solution, and bubbles are generated during solution storage. If the bubbles cannot be eliminated, the residual bubbles will cause problems such as voids and reduced structural strength in the microneedle patch, which seriously affects the performance and effectiveness of the microneedle patch. Therefore, this device needs to be improved. Utility Model Content

[0007] The purpose of this invention is to provide a soluble microneedle patch preparation device to solve the problems mentioned in the background art.

[0008] To achieve the above objectives, this utility model provides the following technical solution: a soluble microneedle patch preparation device, comprising a base, a preparation mechanism disposed on the top of the base, and a filling mechanism disposed on the bottom of the preparation mechanism;

[0009] The preparation mechanism includes a load-bearing frame, which is fixedly connected to the top of the base. A mixing chamber is fixedly connected to the inner side of the load-bearing frame. A control panel is fixedly connected to the front side of the mixing chamber. A fixing frame is fixedly connected to the rear side of the mixing chamber. A first hydraulic cylinder is fixedly connected to the top of the fixing frame. A sealing cover is fixedly connected to the bottom of the first hydraulic cylinder. The sealing cover is located on the top of the mixing chamber. A servo motor is fixedly connected to the top of the sealing cover. A rotating shaft is fixedly connected to the bottom of the servo motor.

[0010] A stirring rod is fixedly connected to the periphery of the rotating shaft. A support platform is fixedly connected to the left side of the support frame. A vacuum pump is fixedly connected to the top of the support platform. A connecting pipe is fixedly connected to the front side of the vacuum pump. The right end of the connecting pipe is fixedly connected to the inside of the mixing chamber. A conveying pipe is fixedly connected to the bottom of the mixing chamber. A distributor is fixedly connected to the bottom of the conveying pipe. A filling pipe is fixedly connected to the bottom of the distributor. A solenoid valve is fixedly connected to the periphery of the conveying pipe.

[0011] Preferably, the bottom of the sealing cover is in contact with the top of the mixing tank, and two first hydraulic cylinders are provided, which are symmetrically distributed on the left and right sides of the top of the sealing cover, so as to facilitate sealing the top of the mixing tank through the sealing cover, and at the same time facilitate subsequent cleaning of the mixing tank.

[0012] Preferably, the rotating shaft is rotatably connected inside the sealing cover, and a stirring shaft is fixedly connected to the periphery of the rotating shaft, so as to facilitate the stirring of the raw materials required for the soluble microneedle patch by the stirring shaft.

[0013] Preferably, a pressure gauge is fixedly connected to the periphery of the connecting pipe, and a connecting frame is fixedly connected to the periphery of the connecting pipe. The connecting frame is fixedly connected to the left side of the mixing tank to facilitate ensuring the stability of the connecting pipe through the connecting frame.

[0014] Preferably, the first hydraulic cylinder, servo motor, vacuum pump, and solenoid valve are electrically connected to the control panel, facilitating centralized control of the equipment via the control panel.

[0015] Preferably, the filling mechanism includes a mounting frame, which is fixedly connected to the rear side of the base. A second hydraulic cylinder is fixedly connected to the rear side of the mounting frame. A movable stage is fixedly connected to the front side of the second hydraulic cylinder. The movable stage is slidably connected to the inside of the base. A forming mold is inserted into the top of the movable stage. The forming mold is located at the bottom of the filling tube.

[0016] Preferably, the molding die has a molding hole inside, and the molding hole is circular. The top of the molding die is in contact with the bottom of the filling tube, which facilitates the molding of the mixed solution through the molding die.

[0017] Compared with the prior art, this utility model provides a soluble microneedle patch preparation device, which has the following beneficial effects:

[0018] 1. This soluble microneedle patch preparation device, through its prepared mechanism, allows for the preparation of soluble microneedle patches. First, the raw materials required for the soluble microneedle patches are placed into a mixing chamber. A first hydraulic cylinder moves the sealing cover to the top of the mixing chamber, sealing the top. Simultaneously, a servo motor drives a rotating shaft and stirring rod / shaft to thoroughly stir the materials, ensuring uniform mixing and consistency of the soluble microneedle patch composition. A vacuum pump connected to the mixing chamber via a connecting pipe creates a negative pressure environment by extracting air from the mixing chamber, reducing the pressure inside air bubbles, causing them to expand, burst, and escape from the material. This prevents residual air bubbles from affecting the molding quality and performance of the microneedle patches, improving product yield. After mixing, a solenoid valve on the conveying pipe precisely controls the material's delivery and shut-off. Combined with a distributor and filling tube, the mixed material is accurately distributed to each forming hole of the molding die, ensuring quantitative filling of the microneedle patches and improving production accuracy.

[0019] 2. This soluble microneedle patch preparation device, through the set filling mechanism, uses a second hydraulic cylinder to drive a moving stage to slide inside the base, which can flexibly adjust the position of the molding die. When the moving stage moves backward inside the base until it can no longer move, the molding die can be easily and accurately placed under the filling tube for material filling. After filling, the molding die can be easily removed, which is convenient for subsequent processing and improves the practicality of the device and the continuity of production. Attached Figure Description

[0020] To more clearly illustrate the technical solutions in the embodiments of this utility model, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0021] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0022] Figure 2 This is a schematic diagram of the left-side structure of this utility model;

[0023] Figure 3 This is a schematic diagram of the fabrication mechanism;

[0024] Figure 4 This is a schematic diagram of the cross-sectional structure of the mixing box;

[0025] Figure 5 This is a schematic diagram of the top structure of the load-bearing platform;

[0026] Figure 6 This is a schematic diagram of the bottom structure of the mixing tank;

[0027] Figure 7 This is a schematic diagram of the filling mechanism.

[0028] In the diagram: 1. Base; 2. Preparation mechanism; 3. Filling mechanism; 21. Support frame; 22. Mixing tank; 23. Control panel; 24. Support platform; 25. Fixing frame; 26. First hydraulic cylinder; 27. Servo motor; 28. Sealing cover; 29. ​​Stirring rod; 291. Rotating shaft; 292. Stirring shaft; 293. Vacuum pump; 294. Pressure gauge; 295. Connecting pipe; 296. Connecting frame; 297. Delivery pipe; 298. Diverter; 299. Filling pipe; 2991. Solenoid valve; 31. Mounting frame; 32. Second hydraulic cylinder; 33. Moving platform; 34. Molding mold. Detailed Implementation

[0029] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0030] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0031] This utility model provides the following technical solution:

[0032] Example 1

[0033] Please see Figure 1-7 This utility model provides a technical solution: a soluble microneedle patch preparation device, including a base 1, a preparation mechanism 2 is provided on the top of the base 1, and a filling mechanism 3 is provided at the bottom of the preparation mechanism 2;

[0034] The preparation mechanism 2 includes a load-bearing frame 21, which is fixedly connected to the top of the base 1. A mixing box 22 is fixedly connected to the inner side of the load-bearing frame 21. A control panel 23 is fixedly connected to the front side of the mixing box 22. A fixing frame 25 is fixedly connected to the rear side of the mixing box 22. A first hydraulic cylinder 26 is fixedly connected to the top of the fixing frame 25. A sealing cover 28 is fixedly connected to the bottom of the first hydraulic cylinder 26. The sealing cover 28 is located on the top of the mixing box 22. A servo motor 27 is fixedly connected to the top of the sealing cover 28. A rotating shaft 291 is fixedly connected to the bottom of the servo motor 27.

[0035] A stirring rod 29 is fixedly connected to the outer periphery of the rotating shaft 291. A support platform 24 is fixedly connected to the left side of the support frame 21. A vacuum pump 293 is fixedly connected to the top of the support platform 24. A connecting pipe 295 is fixedly connected to the front side of the vacuum pump 293. The right end of the connecting pipe 295 is fixedly connected to the inside of the mixing box 22. A conveying pipe 297 is fixedly connected to the bottom of the mixing box 22. A distributor 298 is fixedly connected to the bottom of the conveying pipe 297. A filling pipe 299 is fixedly connected to the bottom of the distributor 298. A solenoid valve 2991 is fixedly connected to the outer periphery of the conveying pipe 297.

[0036] The bottom of the sealing cover 28 is in contact with the top of the mixing tank 22. There are two first hydraulic cylinders 26, which are symmetrically distributed on the left and right sides of the top of the sealing cover 28. This facilitates sealing the top of the mixing tank 22 through the sealing cover 28 and also facilitates subsequent cleaning of the inside of the mixing tank 22.

[0037] The rotating shaft 291 is rotatably connected to the inside of the sealing cover 28, and the stirring shaft 292 is fixedly connected to the outside of the rotating shaft 291, so as to facilitate the stirring of the raw materials required for the soluble microneedle patch through the stirring shaft 292.

[0038] A pressure gauge 294 is fixedly connected to the outside of the connecting pipe 295, and a connecting frame 296 is fixedly connected to the outside of the connecting pipe 295. The connecting frame 296 is fixedly connected to the left side of the mixing box 22, so as to ensure the stability of the connecting pipe 295 through the connecting frame 296. The first hydraulic cylinder 26, servo motor 27, vacuum pump 293 and solenoid valve 2991 are electrically connected to the control panel 23, so as to facilitate centralized control of the equipment through the control panel 23.

[0039] Example 2

[0040] Please see Figure 1-7Furthermore, based on Embodiment 1, the filling mechanism 3 further includes a mounting frame 31, which is fixedly connected to the rear side of the base 1. A second hydraulic cylinder 32 is fixedly connected to the rear side of the mounting frame 31. A movable platform 33 is fixedly connected to the front side of the second hydraulic cylinder 32. The movable platform 33 is slidably connected to the inside of the base 1. A molding mold 34 is inserted into the top of the movable platform 33. The molding mold 34 is located at the bottom of the filling tube 299. A molding hole is opened inside the molding mold 34, and the molding hole is circular. The top of the molding mold 34 is in contact with the bottom of the filling tube 299, which facilitates the molding of the mixed solution through the molding mold 34.

[0041] In actual operation, when this device is used to prepare soluble microneedle patches, the raw materials required for the soluble microneedle patches are first put into the mixing box 22. The first hydraulic cylinder 26 drives the sealing cover 28 to move to the top of the mixing box 22 to seal the top of the mixing box 22. The molding mold 34 is then inserted into the top of the moving platform 33. The second hydraulic cylinder 32 drives the moving platform 33 to slide inside the base 1, which can flexibly adjust the position of the molding mold 34. When the moving platform 33 moves backward inside the base 1 until it can no longer move, the molding mold 34 can be accurately placed under the filling tube 299 for material filling.

[0042] At this time, the servo motor 27 drives the rotating shaft 291, stirring rod 29, and stirring shaft 292 to fully stir the material, which can achieve uniform mixing of raw materials and ensure the consistency of soluble microneedle patch components. During the stirring process, the vacuum pump 293 draws air out of the mixing box 22 to form a negative pressure environment, reduce the pressure inside the bubbles, and cause the bubbles to expand, burst, and escape from the material, avoiding bubble residue from affecting the molding quality and performance of the microneedle patch and improving the product qualification rate.

[0043] After mixing, the solenoid valve 2991 installed on the conveying pipe 297 can precisely control the conveying and shut-off of the material. Together with the distributor 298 and the filling pipe 299, the mixed material can be accurately distributed to each forming hole of the forming mold 34 to ensure the quantitative filling of the microneedle patch and improve production accuracy.

[0044] After the material in the molding die 34 is filled, the solenoid valve 2991 is closed, and the moving table 33 is driven forward again under the action of the second hydraulic cylinder 32. The molding die 34 after filling can be removed, which facilitates subsequent processing and improves the practicality of the device and the continuity of production.

[0045] The two first hydraulic cylinders 26, servo motor 27, vacuum pump 293 and solenoid valve 2991 are all electrically connected to the control panel 23, realizing the automated control of the preparation process. Operators only need to set parameters through the control panel 23 to complete a series of operations such as material mixing, degassing and filling, which reduces the intensity of manual operation, improves production efficiency, and reduces errors caused by human factors.

[0046] The control panel model 23 used in this case is a Siemens S7-1200 series.

[0047] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

Claims

1. A device for preparing soluble microneedle patches, comprising a base (1), characterized in that: The base (1) is provided with a preparation mechanism (2) at the top and a filling mechanism (3) at the bottom. The preparation mechanism (2) includes a load-bearing frame (21), which is fixedly connected to the top of the base (1). A mixing box (22) is fixedly connected to the inner side of the load-bearing frame (21). A control panel (23) is fixedly connected to the front side of the mixing box (22). A fixing frame (25) is fixedly connected to the rear side of the mixing box (22). A first hydraulic cylinder (26) is fixedly connected to the top of the fixing frame (25). A sealing cover (28) is fixedly connected to the bottom of the first hydraulic cylinder (26). The sealing cover (28) is located on the top of the mixing box (22). A servo motor (27) is fixedly connected to the top of the sealing cover (28). A rotating shaft (291) is fixedly connected to the bottom of the servo motor (27). A stirring rod (29) is fixedly connected to the periphery of the rotating shaft (291). A support platform (24) is fixedly connected to the left side of the support frame (21). A vacuum pump (293) is fixedly connected to the top of the support platform (24). A connecting pipe (295) is fixedly connected to the front side of the vacuum pump (293). The right end of the connecting pipe (295) is fixedly connected to the inside of the mixing box (22). A conveying pipe (297) is fixedly connected to the bottom of the mixing box (22). A distributor (298) is fixedly connected to the bottom of the conveying pipe (297). A filling pipe (299) is fixedly connected to the bottom of the distributor (298). A solenoid valve (2991) is fixedly connected to the periphery of the conveying pipe (297).

2. The apparatus for preparing soluble microneedle patches according to claim 1, characterized in that: The bottom of the sealing cover (28) is in contact with the top of the mixing box (22). There are two first hydraulic cylinders (26), which are symmetrically distributed on the left and right sides of the top of the sealing cover (28).

3. The apparatus for preparing soluble microneedle patches according to claim 1, characterized in that: The rotating shaft (291) is rotatably connected to the inside of the sealing cover (28), and a stirring shaft (292) is fixedly connected to the periphery of the rotating shaft (291).

4. The apparatus for preparing soluble microneedle patches according to claim 1, characterized in that: A pressure gauge (294) is fixedly connected to the periphery of the connecting pipe (295), and a connecting frame (296) is fixedly connected to the periphery of the connecting pipe (295). The connecting frame (296) is fixedly connected to the left side of the mixing box (22).

5. The apparatus for preparing soluble microneedle patches according to claim 1, characterized in that: The first hydraulic cylinder (26), servo motor (27), vacuum pump (293) and solenoid valve (2991) are electrically connected to the control panel (23).

6. The apparatus for preparing soluble microneedle patches according to claim 1, characterized in that: The filling mechanism (3) includes a mounting frame (31), which is fixedly connected to the rear side of the base (1). A second hydraulic cylinder (32) is fixedly connected to the rear side of the mounting frame (31). A moving platform (33) is fixedly connected to the front side of the second hydraulic cylinder (32). The moving platform (33) is slidably connected to the inside of the base (1). A forming mold (34) is inserted into the top of the moving platform (33). The forming mold (34) is located at the bottom of the filling tube (299).

7. The apparatus for preparing a soluble microneedle patch according to claim 6, characterized in that: The molding die (34) has a molding hole inside, and the molding hole is circular. The top of the molding die (34) is in contact with the bottom of the filling tube (299).

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