A high-pressure homogenizer for preparing a liquid medicine

Abstract

The utility model provides a kind of high-pressure homogenizer for preparation of liquid medicine, it is related to liquid medicine preparation technical field, including base, base upper end is sequentially provided with support frame and material box assembly from left to right, support frame top fixed installation high-pressure cylinder assembly, motor is fixedly installed in material box assembly top, defoaming assembly and homogenization assembly are installed in material box assembly inside, high-pressure pump assembly is installed in the support frame lower portion in base upper end;High-pressure cylinder assembly is driven piston by hydraulic cylinder, the edge of piston is equipped with silica gel elastic scraper, the inside of cavity plate is equipped with conical transition curved surface, cooperate high-pressure pump to realize liquid medicine ultrahigh pressure processing;Defoaming assembly is driven stirring rod by motor, drive horizontal defoaming rod, cross defoaming needle and defoaming net floating with liquid level, realize multistage bubble breaking, realize the efficient homogenization processing of liquid medicine, reduce material waste and pollution risk, improve liquid medicine stability and quality, satisfy aseptic production requirement, applicable to a variety of liquid medicine preparation scene.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical preparation technology, and in particular to a high-pressure homogenizing device for pharmaceutical preparation. Background Technology

[0002] Liquid pharmaceutical preparations are liquid drug formulations prepared through processes such as dissolution and dispersion. They encompass various types, including solutions, suspensions, and emulsions. Their quality depends on uniformity, stability, and safety. High-pressure homogenizers, as core equipment in liquid pharmaceutical preparation, can reduce the particle or droplet size and distribute it uniformly by using shear and impact forces. This improves stability, promotes drug absorption, and meets regulatory standards. At the same time, they can precisely control particle size distribution, ensure batch consistency, adapt to diverse dosage forms such as injections and nano-formulations, improve production efficiency, reduce contamination risks, and provide key support for cutting-edge technologies such as nanomedicine development. They are crucial for ensuring product quality and promoting pharmaceutical innovation.

[0003] However, the existing high-pressure homogenizing device for preparing pharmaceutical solutions still has the following technical problems in practical applications:

[0004] 1) Low defoaming efficiency and easy clogging: There is a high-pressure homogenizing device that eliminates foam by setting a collection hopper and a defoaming net in the material box. However, the defoaming net in the collection hopper is fixed. After long-term use, the mesh is easily blocked by foam residue, resulting in poor material discharge.

[0005] 2) Waste of residual materials: There is a high-pressure homogenizing device that uses a hydraulic cylinder to drive the piston to move left and right to achieve ultra-high pressure treatment of materials. However, there is a dead angle between the piston and the chamber plate, which leads to material waste and may contaminate the next batch of medicine. Utility Model Content

[0006] The purpose of this invention is to provide a high-pressure homogenizing device for preparing pharmaceutical solutions, so as to solve the problems mentioned in the background art.

[0007] To achieve the above objectives, the present invention adopts the following technical solution: a high-pressure homogenizing device for preparing a pharmaceutical solution, comprising a base, wherein a support frame and a material box assembly are arranged sequentially from left to right on the upper end of the base; a high-pressure cylinder assembly is fixedly installed on the top of the support frame, and a motor is fixedly installed on the top of the material box assembly; an antifoaming component and a homogenizing component are installed inside the material box assembly;

[0008] A high-pressure pump assembly located at the lower part of the support frame is installed on the upper end of the base.

[0009] The high-pressure cylinder assembly includes a high-pressure cylinder body. The left end of the high-pressure cylinder body is fixed to the top of the support frame by a first fixing plate. A hydraulic cylinder is installed on the first fixing plate. The output end of the hydraulic cylinder is connected to a piston. A silicone elastic scraper is embedded in the edge of the piston. A cavity plate is provided at the right end of the high-pressure cylinder body. A tapered transition surface is provided on the inner side of the cavity plate. A second discharge pipe is connected to the right end of the cavity plate. A second solenoid valve is installed on the second discharge pipe.

[0010] Preferably, the hopper assembly includes a hopper body, a first discharge pipe is connected to the bottom right side of the hopper body, a first solenoid valve is installed on the first discharge pipe, and a viewing window is provided on the front side of the hopper body.

[0011] Preferably, the defoaming component includes a connecting bearing, which is fixedly installed at the top center inside the material box body. A stirring rod is detachably installed at the lower end of the connecting bearing. A wedge-shaped groove is provided on the outer side of the stirring rod. A floating collar is slidably sleeved in the wedge-shaped groove. A connecting collar is fixedly sleeved on the outer side of the floating collar. A transverse defoaming rod is fixedly connected to both sides of the connecting collar. Multiple cross defoaming needles are evenly arranged at the bottom of the transverse defoaming rod. A defoaming net is installed at the end of the transverse defoaming rod away from the connecting collar. A limiting block is provided at the bottom of the stirring rod. The output shaft of the motor passes through the top of the material box body and is fixedly connected to the connecting bearing.

[0012] Preferably, the high-pressure pump assembly includes a high-pressure pump body, with a feed pipe connected to the left side of the high-pressure pump body. The feed pipe passes through the side plate of the support frame and is connected to an external liquid supply source. A third discharge pipe is connected to the upper end of the high-pressure pump body. The other end of the third discharge pipe passes through the bottom right side of the high-pressure cylinder and is connected to the internal cavity of the high-pressure cylinder. A one-way valve is installed on the third discharge pipe.

[0013] Preferably, the homogenizing component includes a homogenizer, which is fixedly installed on the top left side of the material box body. Multiple homogenizing heads are fixedly installed on the right side inside the homogenizer via a second fixing plate. The feed ends of the multiple homogenizing heads are all connected to a diversion pipe. The silicone elastic scraper is made of food-grade silicone rubber, and its cross-section is trapezoidal. The gap between the scraper and the inner wall of the high-pressure cylinder is ≤0.1mm. The right end of the second discharge pipe penetrates the material box body and is connected to the diversion pipe.

[0014] Compared with the prior art, the advantages and positive effects of this utility model are as follows:

[0015] 1. By setting up a defoaming component that can adaptively float with the liquid level, the high-speed cutting action of the cross defoaming needles and the interception friction of the defoaming net are used to achieve multi-stage foam breaking. This avoids the defect of traditional fixed defoaming nets being easily clogged by residue, improves defoaming efficiency, extends the mesh clogging cycle, ensures smooth liquid discharge and reduces foam residue rate, and significantly improves the quality of the liquid.

[0016] 2. An innovative design combines a conical transition surface with a silicone elastic scraper in the high-pressure cylinder assembly. As the piston moves, the scraper adheres closely to the cylinder wall to remove residues from dead corners. Combined with the conical flow channel, it guides the accumulation of the liquid medicine, reducing the material residue rate between the piston and the chamber plate. This not only reduces raw material waste but also avoids the risk of residual liquid medicine contaminating the next batch, meeting GMP aseptic production requirements and ensuring the safety and batch consistency of the prepared liquid medicine. Attached Figure Description

[0017] Figure 1 This utility model provides a perspective view of the main structure of a high-pressure homogenizing device for preparing pharmaceutical solutions.

[0018] Figure 2 This utility model provides a three-dimensional view of the internal structure of a high-pressure homogenizing device for preparing pharmaceutical solutions.

[0019] Figure 3 This utility model provides a three-dimensional structural view of an antifoaming component in a high-pressure homogenizing device for preparing pharmaceutical solutions.

[0020] Figure 4 This utility model provides a three-dimensional structural view of a high-pressure cylinder assembly in a high-pressure homogenizing device for preparing pharmaceutical solutions.

[0021] Figure 5 This invention proposes a high-pressure homogenizing device for preparing pharmaceutical solutions. Figure 2 Structural plan at point A.

[0022] Legend: 1. Base; 2. Support frame; 3. Material bin assembly; 31. Material bin body; 32. Viewing window; 33. First discharge pipe; 34. First solenoid valve; 4. Motor; 5. Defoaming assembly; 51. Connecting bearing; 52. Stirring rod; 53. Wedge-shaped groove; 54. Floating collar; 55. Connecting collar; 56. Horizontal defoaming rod; 57. Cross defoaming needle; 58. Defoaming net; 59. Limiting block; 6. High-pressure cylinder assembly; 61. 61. High-pressure cylinder; 62. First fixed plate; 63. Hydraulic cylinder; 64. Piston; 65. Silicone elastic scraper; 66. Cavity plate; 67. Conical transition surface; 68. Second discharge pipe; 69. Second solenoid valve; 70. High-pressure pump assembly; 71. High-pressure pump body; 72. Feed pipe; 73. Third discharge pipe; 74. Check valve; 81. Homogenizer; 82. Second fixed plate; 83. Homogenizer head; 84. Diverter pipe. Detailed Implementation

[0023] To better understand the above-mentioned objectives, features, and advantages of this utility model, the present utility model will be further described below with reference to the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments can be combined with each other.

[0024] Many specific details are set forth in the following description in order to provide a full understanding of the present invention. However, the present invention can also be implemented in other ways than those described herein, and therefore the present invention is not limited to the specific embodiments disclosed in the following specification.

[0025] Please see Figure 1 , Figure 2 and Figure 4 A high-pressure homogenizing device for preparing a pharmaceutical solution includes a base 1. A support frame 2 and a material box assembly 3 are sequentially arranged from left to right on the upper end of the base 1. A high-pressure cylinder assembly 6 is fixedly installed on the top of the support frame 2, and a motor 4 is fixedly installed on the top of the material box assembly 3. An defoaming component 5 and a homogenizing component 8 are installed inside the material box assembly 3. A high-pressure pump assembly 7 located below the support frame 2 is installed on the upper end of the base 1. The high-pressure cylinder assembly 6 includes a high-pressure cylinder body 61. The left end of the high-pressure cylinder body 61 is fixed to the top of the support frame 2 via a first fixing plate 62. A hydraulic cylinder 63 is installed on the first fixing plate 62. A piston 64 is connected to the output end of the hydraulic cylinder 63. A silicone elastic scraper 65 is embedded in the edge of the piston 64. A cavity plate 66 is provided on the right end of the high-pressure cylinder body 61. A conical transition surface 67 is provided on the inner side of the cavity plate 66. A second discharge pipe 68 is connected to the right end of the cavity plate 66, and a second solenoid valve 69 is installed on the second discharge pipe 68.

[0026] It should be specifically noted that the silicone elastic scraper 65 is made of food-grade silicone rubber, and its cross-section is trapezoidal. The gap between it and the inner wall of the high-pressure cylinder 61 is ≤0.1mm, ensuring that no liquid remains when the piston moves. The conical transition surface 67 on the inner side of the cavity plate 66 guides the liquid to gather at the discharge port, and works with the elastic scraper to remove dead corner residue between the piston and the cavity plate.

[0027] Please see Figure 1 , Figure 2 and Figure 3 The material bin assembly 3 includes a material bin body 31, a first discharge pipe 33 connected to the bottom right side of the material bin body 31, a first solenoid valve 34 installed on the first discharge pipe 33, and a viewing window 32 provided on the front side of the material bin body 31.

[0028] It should be noted that the viewing window 32 is made of double-layered tempered glass. After observing the status through the viewing window 32 and confirming that there is no foam, the first solenoid valve 34 is opened, and the liquid medicine is transported to the subsequent process through the first discharge pipe 33.

[0029] Please see Figure 4 The defoaming component 5 includes a connecting bearing 51, which is fixedly installed at the top center inside the material box body 31. A stirring rod 52 is detachably installed at the lower end of the connecting bearing 51. A wedge-shaped groove 53 is provided on the outer side of the stirring rod 52. A floating collar 54 is slidably sleeved in the wedge-shaped groove 53. A connecting collar 55 is fixedly sleeved on the outer side of the floating collar 54. A transverse defoaming rod 56 is fixedly connected to both sides of the connecting collar 55. A plurality of cross defoaming needles 57 are evenly arranged at the bottom of the transverse defoaming rod 56. A defoaming net 58 is installed at the end of the transverse defoaming rod 56 away from the connecting collar 55. A limiting block 59 is provided at the bottom of the stirring rod 52.

[0030] It should be specifically noted that the output shaft of the motor 4 passes through the top of the material box body 31 and is fixedly connected to the connecting bearing 51, driving the stirring rod 52 to rotate.

[0031] Furthermore, the limiting block 59 prevents the floating collar from moving excessively downward, ensuring that the defoaming component works within its effective range. The floating structure avoids the problem of the defoaming net being fixed and blocked. Combined with the dual function of the cross needles and the mesh, it improves the defoaming efficiency and extends the mesh blocking cycle.

[0032] Please see Figure 1 and Figure 2The high-pressure pump assembly 7 includes a high-pressure pump body 71. A feed pipe 72 is connected to the left side of the high-pressure pump body 71. The feed pipe 72 passes through the side plate of the support frame 2 and is connected to an external liquid supply source. A third discharge pipe 73 is connected to the upper end of the high-pressure pump body 71. The other end of the third discharge pipe 73 passes through the bottom rightmost part of the high-pressure cylinder 61 and is connected to the internal cavity of the high-pressure cylinder 61. A one-way valve 74 is installed on the third discharge pipe 73 to prevent the high-pressure liquid from flowing back and to ensure that the flow direction is unique.

[0033] Please see Figure 2 and Figure 5 The homogenizing component 8 includes a homogenizer 81, which is fixedly installed on the top left side of the material box body 31. Multiple homogenizing heads 83 are fixedly installed on the right side inside the homogenizer 81 through a second fixing plate 82. The feed ends of the multiple homogenizing heads 83 are all connected to a diversion pipe 84.

[0034] Furthermore, the right end of the second discharge pipe 68 penetrates the main body 31 of the material box and is connected to the diversion pipe 84.

[0035] Please see Figures 1-5 The working principle of the entire equipment in specific use is as follows: Step 1, Pretreatment of medicine and feeding stage of high pressure pump: The medicine to be homogenized is transported from the external supply source to the high pressure pump body 71 of the high pressure pump assembly 7 through the feed pipe 72. After the high pressure pump body 71 is started, the low pressure medicine is pressurized by the movement of impeller or plunger and transported to the high pressure cylinder assembly 6 through the third discharge pipe 73. The one-way valve 74 on the third discharge pipe prevents the high pressure medicine from flowing back and ensures that the flow direction is unique. The high pressure medicine enters from the third discharge pipe interface on the bottom right side of the high pressure cylinder 61, pushing the piston 64 to move to the left and gradually filling the cavity between the piston and the cavity plate 66. At this time, the second solenoid valve 69 is in the closed state to prevent the medicine from flowing out in advance.

[0036] Step 2, High-Pressure Pressurization and Homogenization Stage: After the liquid medicine in the high-pressure cylinder is filled to the set volume, the high-pressure pump continues to run. At the same time, the hydraulic cylinder 63 drives the piston 64 to move to the right. The hydraulic cylinder is fixed by the first fixing plate 62. The silicone elastic scraper 65 on the edge of the piston is in close contact with the inner wall of the high-pressure cylinder to ensure that no liquid medicine is retained when the piston moves. The conical transition surface 67 on the inner side of the cavity plate 66 guides the liquid medicine to gather towards the discharge port. The elastic scraper removes the dead corner residue between the piston and the cavity plate. When the pressure in the high-pressure cylinder reaches the set value, the second solenoid valve 69 opens. The high-pressure liquid medicine flows into the diversion pipe 84 through the second discharge pipe 68 and is evenly distributed to the multiple homogenizing heads 83 of the homogenizing component 8. The liquid medicine passes through the narrow gap of the homogenizing head at high speed. Using shear force, impact force and cavitation effect, the particle or droplet size is refined to the submicron level to achieve uniform dispersion.

[0037] Step 3, Defoaming and Liquid Collection Stage: The homogenized liquid is sprayed from the homogenizing head and falls into the main body 31 of the material box assembly 3. The liquid generates foam due to high-speed spraying. At this time, the motor 4 is started, and the output shaft drives the stirring rod 52 to rotate through the connecting bearing 51. At the same time, the floating collar 54 floats up and down along the wedge-shaped groove 53 of the stirring rod with the liquid level, ensuring that the horizontal defoaming rod 56 always acts on the foam layer. The cross defoaming needle 57 rotates at high speed to cut the foam and destroy the bubble film. The defoaming net 58 intercepts the residual foam and further breaks the bubbles through mechanical impact and friction. The defoamed liquid is briefly placed in the main body of the material box and its status is observed through the viewing window 32. After confirming that there is no foam, the first solenoid valve 34 is opened, and the liquid is transported to the subsequent process through the first discharge pipe 33.

[0038] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments for application in other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present utility model without departing from the technical solution of the present utility model shall still fall within the protection scope of the present utility model.

Claims

1. A high-pressure homogenizing device for preparing pharmaceutical solutions, comprising a base (1), characterized in that: The base (1) is provided with a support frame (2) and a material box assembly (3) from left to right on the upper end; a high pressure cylinder assembly (6) is fixedly installed on the top of the support frame (2), and a motor (4) is fixedly installed on the top of the material box assembly (3); a defoaming assembly (5) and a homogenizing assembly (8) are installed inside the material box assembly (3). A high-pressure pump assembly (7) located at the lower part of the support frame (2) is installed on the upper end of the base (1). The high-pressure cylinder assembly (6) includes a high-pressure cylinder body (61). The left end of the high-pressure cylinder body (61) is fixed to the top of the support frame (2) by a first fixing plate (62). A hydraulic cylinder (63) is installed on the first fixing plate (62). A piston (64) is connected to the output end of the hydraulic cylinder (63). A silicone elastic scraper (65) is embedded in the edge of the piston (64). A cavity plate (66) is provided at the right end of the high-pressure cylinder body (61). A conical transition surface (67) is provided on the inner side of the cavity plate (66). A second discharge pipe (68) is connected to the right end of the cavity plate (66). A second solenoid valve (69) is installed on the second discharge pipe (68).

2. The high-pressure homogenizing device for preparing a pharmaceutical solution according to claim 1, characterized in that: The material box assembly (3) includes a material box body (31), a first discharge pipe (33) is connected to the bottom right side of the material box body (31), a first solenoid valve (34) is installed on the first discharge pipe (33), and a viewing window (32) is provided on the front side of the material box body (31).

3. The high-pressure homogenizing device for preparing pharmaceutical solutions according to claim 1, characterized in that: The defoaming component (5) includes a connecting bearing (51), which is fixedly installed at the top center inside the material box body (31). A stirring rod (52) is detachably installed at the lower end of the connecting bearing (51). A wedge-shaped groove (53) is provided on the outer side of the stirring rod (52). A floating collar (54) is slidably sleeved in the wedge-shaped groove (53). A connecting collar (55) is fixedly sleeved on the outer side of the floating collar (54). A transverse defoaming rod (56) is fixedly connected on both sides of the connecting collar (55). A plurality of cross defoaming needles (57) are evenly arranged at the bottom of the transverse defoaming rod (56). A defoaming net (58) is installed at the end of the transverse defoaming rod (56) away from the connecting collar (55). A limiting block (59) is provided at the bottom of the stirring rod (52).

4. The high-pressure homogenizing device for preparing a pharmaceutical solution according to claim 3, characterized in that: The output shaft of the motor (4) passes through the top of the main body (31) of the hopper and is fixedly connected to the connecting bearing (51).

5. The high-pressure homogenizing device for preparing a pharmaceutical solution according to claim 1, characterized in that: The high-pressure pump assembly (7) includes a high-pressure pump body (71), with a feed pipe (72) connected to the left side of the high-pressure pump body (71). The feed pipe (72) passes through the side plate of the support frame (2) and is connected to an external liquid supply source. A third discharge pipe (73) is connected to the upper end of the high-pressure pump body (71). The other end of the third discharge pipe (73) passes through the bottom right side of the high-pressure cylinder (61) and is connected to the internal cavity of the high-pressure cylinder (61). A one-way valve (74) is installed on the third discharge pipe (73).

6. The high-pressure homogenizing device for preparing a pharmaceutical solution according to claim 1, characterized in that: The homogenizing component (8) includes a homogenizer (81), which is fixedly installed on the top left side of the material box body (31). Multiple homogenizing heads (83) are fixedly installed on the right side inside the homogenizer (81) through a second fixing plate (82). The feed ends of the multiple homogenizing heads (83) are all connected to a diversion pipe (84).

7. The high-pressure homogenizing device for preparing a pharmaceutical solution according to claim 1, characterized in that: The silicone elastic scraper (65) is made of food-grade silicone rubber, and its cross-section is trapezoidal. The gap between it and the inner wall of the high-pressure cylinder (61) is ≤0.1mm.

8. The high-pressure homogenizing device for preparing a pharmaceutical solution according to claim 2, characterized in that: The right end of the second discharge pipe (68) passes through the main body of the material box (31) and is connected to the diversion pipe (84).

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