A sample cup for thrombelastography

Abstract

The utility model provides a kind of sample cup for thrombelastometry, by changing the structure of sample cup, reduce or avoid the possibility of reagent adhering to cup body lateral wall.Sample cup for thrombelastometry includes cup body for accommodating blood sample and reagent, the bottom wall of the cup body has central region and edge region around the central region, the edge region is gradually set to be inclined downward from outside to inside, the central region is axially concave to form reagent pre-embedded groove.The way of setting reagent pre-embedded groove can lock reagent in reagent pre-embedded groove, effectively reduce the probability of reagent adsorption cup lateral wall, reduce the operation error of adding reagent, to improve the accuracy and consistency of test.

Description

Technical Field

[0001] This utility model relates to the field of thromboelastography, specifically to a sample cup for thromboelastography. Background Technology

[0002] In existing thromboelastography (TEG) detection techniques, the inner wall of the blood sample cup (cup body and lid) is often treated with a serrated structure or a frosted surface to enhance the adhesion of the blood sample, reduce stratification or slippage during the detection process, and thus improve measurement accuracy. However, when activators or other reagents are added to the blood sample, the reagents are easily adsorbed onto the side wall of the cup body due to surface tension, resulting in insufficient activation of the coagulation reaction, leading to measurement deviation, and ultimately affecting the reliability of clinical test results. Utility Model Content

[0003] The purpose of this invention is to provide a sample cup for a thromboelastography instrument, which reduces or avoids the possibility of reagents adhering to the side wall of the cup by modifying the structure of the sample cup.

[0004] To achieve the above objectives, this utility model provides a sample cup for a thromboelastography instrument. The sample cup for the thromboelastography instrument includes a cup body for containing blood samples and reagents. The bottom wall of the cup body has a central region and an edge region surrounding the central region. The edge region is gradually inclined downward from the outside to the inside. The central region is axially recessed to form a reagent pre-embedded groove.

[0005] By setting up a reagent pre-embedded slot, the reagent can be locked inside the slot, effectively reducing the probability of reagent adsorption on the side wall of the cup, reducing errors caused by adding reagent, and thus improving the accuracy and consistency of the test.

[0006] Optionally, it also includes a cup lid that can be inserted into the cup body, the cup lid being used to fix the probe, the top of the cup lid being provided with a radially outwardly turned flange; the inner wall of the cup body is radially concave to form a stepped structure, the lower surface of the flange is axially pressed against the platform of the stepped structure; the lower surface of the flange is a straight wall, and the platform of the stepped structure is a straight wall.

[0007] This method ensures that when filling the cup, the two flat surfaces of the flip edge and the work surface make contact first, preventing the cup lid from tilting. It also ensures good coaxiality between the cup lid and the cup body, facilitating loading operations and improving the work efficiency of medical staff.

[0008] Optionally, the top of the cup body forms a socket for inserting the cup lid; the top surface of the cup body extends axially beyond the top surface of the cup lid; and a sealing film is also included, which is fixedly connected to the top surface of the cup body and covers the socket.

[0009] Therefore, since the top of the cup body extends beyond the top of the lid, a sealing film can be installed to seal the inside of the cup body, thus achieving the function of sealing and moisture prevention.

[0010] Optionally, the cup body and the cup lid are coaxially arranged, with the centerline of the cup body passing through the center of the reagent pre-embedded slot. In this way, the reagent pre-embedded slot is also coaxially arranged with the cup body and the cup lid.

[0011] Optionally, the cup lid has a cap head that is axially opposite to the bottom wall of the cup body. The cap head is projected axially to form a first projection, and the reagent pre-embedded slot is projected to form a second projection; the second projection is located within the range of the first projection. This improves the consistency of the test.

[0012] Optionally, the lowest point of the cap is spaced at a predetermined distance from the bottom of the reagent pre-embedded tank. By setting this predetermined distance, it can be ensured that the reagent will not spill outside the reagent pre-embedded tank, making operation convenient and not affecting the test results.

[0013] Optionally, the cap is an arc surface, with its center protruding downwards along the axial direction. Thus, the center of the cap is its lowest point, ensuring that the lowest point of the cap remains coaxial with the reagent pre-embedded tank.

[0014] Optionally, the inner wall of the cup body is provided with a plurality of vertically extending cup body grooves, which are evenly distributed around the circumference of the cup body. The presence of vertically extending and circumferentially distributed grooves on the inner wall of the cup body increases the contact surface area between the blood sample and the inner wall of the cup body, thereby improving binding stability.

[0015] Optionally, a vertically extending groove is also provided on a portion of the cup lid located inside the cup body, and the groove is evenly distributed around the circumference of the cup lid. This increases the contact surface area between the blood sample and the outer wall of the cup lid to improve binding stability.

[0016] Optionally, at least one of the outer wall of the cup lid and the inner wall of the cup body has a frosted surface. This can further improve the adhesion between the blood sample and the inner wall of the cup and the outer wall of the cup lid.

[0017] Other features and advantages of this specification will become clear from the following detailed description of exemplary embodiments with reference to the accompanying drawings. Attached Figure Description

[0018] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments of this specification and, together with their description, serve to explain the principles of this specification.

[0019] Figure 1 This is a schematic diagram of the sample cup structure in an embodiment of this utility model;

[0020] Figure 2 yes Figure 1 Axial projection view of the middle section of the structure;

[0021] Figure 3 yes Figure 1 Schematic diagram of the middle cup body;

[0022] Figure 4 yes Figure 1 A schematic diagram of the structure of the cup lid.

[0023] Figure label:

[0024] 100-Cup body; 101-Cup body groove; 102-Bottom wall; 102-1-Central area; 102-2-Edge area; 103-Reagent pre-embedded groove; 103-1-Second projection; 200-Cup lid; 201-Flanged edge; 104-Tabletop; 105-Insert; 300-Sealing film; 202-Cap; 202-1-First projection. Detailed Implementation

[0025] This invention provides a sample cup for a thromboelastography instrument, which reduces or avoids the possibility of reagents adhering to the side wall of the cup by modifying the structure of the sample cup.

[0026] To enable those skilled in the art to better understand the present invention, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0027] Relational terms such as “first” and “second” are used merely to distinguish one component from another that has the same name, without necessarily requiring or implying any such actual relationship or order between the components.

[0028] Please refer to Figures 1 to 4 , Figure 1 This is a schematic diagram of the sample cup structure in an embodiment of this utility model; Figure 2 yes Figure 1 Axial projection view of the middle section of the structure; Figure 3 yes Figure 1 Schematic diagram of the middle cup body; Figure 4 yes Figure 1 A schematic diagram of the structure of the cup lid.

[0029] As a core device for clinical assessment of blood coagulation function, the accuracy and reliability of thromboelastography results depend to some extent on the rationality of the sample cup's structural design. Existing sample cups typically consist of a cup body and a cup lid. The cup body holds the blood sample, and during testing, the cup lid is immersed in the blood and works in conjunction with the probe to detect viscosity changes during the coagulation process.

[0030] like Figure 1 , Figure 3 and Figure 4 As shown, the sample cup includes a cup body 100 for containing blood samples and reagents, and a cup lid 200 that can be inserted into the cup body 100 to fix the probe. The space defined between the cup lid 200 and the cup body 100 is used to contain the blood sample. The bottom wall 102 of the cup body 100 has a central region 102-1 and an edge region 102-2 surrounding the central region 102-1. The edge region 102-2 is gradually inclined downward from the outside to the inside, and the central region 102-1 is axially recessed to form a reagent pre-embedded groove 103. "Outer" and "inner" are used with reference to the radial surface of the cup body 100; the direction pointing radially towards the central axis of the cup body 100 is "inner," and vice versa. "Upper" and "lower" refer to the normal use state of the sample cup (e.g., ...). Figure 1 (As shown in the diagram), the side pointing towards the ground is down, and the opposite side is up.

[0031] like Figure 2 As shown, the edge region 102-2 is arranged circumferentially around the central region 102-1. The edge region 102-2 has a bucket-shaped structure, with a large-diameter end and a small-diameter end. The large-diameter end is connected to the bottom of the cup body 100, and the small-diameter end is connected to the reagent pre-embedded groove 103, which is located in the central region 102-1. The radial dimension of the reagent pre-embedded groove 103 is smaller than the radial dimension of the bottom wall 102 of the cup body 100.

[0032] In specific operations, for example, when adding reagents during testing, 20 μL of reagent is added to the recessed reagent pre-embedded groove 103. Under the action of liquid tension, the reagent will be locked in the recessed reagent pre-embedded groove 103 and will not be adsorbed on the edge area 102-2.

[0033] In another, more specific example, the cup lid 200 has a cap 202 axially opposite to the bottom wall 102 of the cup body 100. The cap 202 is projected axially to form a first projection 202-1, and the reagent pre-embedded slot 103 is projected to form a second projection 103-1; the second projection 103-1 is located within the range of the first projection 202-1. This improves the consistency of the test.

[0034] By setting up a reagent pre-embedded groove 103, the reagent can be locked inside the reagent pre-embedded groove 103, which effectively reduces the probability of the reagent adsorbing onto the side wall of the cup body 100, reduces the error caused by adding reagent, and thus improves the accuracy and consistency of the test.

[0035] like Figure 1 and Figure 4As shown, in another aspect, the current design of some sample cups adopts a structure where both the top of the lid 200 and the bottom of the cup body 100 have rounded surfaces. However, during the actual cupping operation, since the rounded surface of the top of the lid 200 contacts the rounded surface of the bottom of the cup body 100 first, the contact point between the two is not fixed but changes continuously as the cupping action proceeds. This causes the lid 200 to easily tilt at the moment of contact. This tilting phenomenon not only disrupts the coaxiality between the lid 200 and the cup body 100, making it difficult to align them precisely and increasing the difficulty of loading, but may also cause sample spillage or contamination due to excessive tilt angle, adversely affecting the experimental results.

[0036] Furthermore, the inconvenience caused by the tilted lid 200 forces medical staff to spend more time and effort adjusting the position of the lid 200 to restore its coaxiality with the cup body 100. This process undoubtedly reduces work efficiency and increases workload. To solve the above problems, the top of the lid 200 of the sample cup of this application is provided with a radially outward-curving flange 201; the inner wall of the cup body 100 is radially concave to form a stepped structure, and the lower surface of the flange 201 is axially pressed against the platform 104 of the stepped structure; the lower surface of the flange 201 is a straight wall, and the platform 104 of the stepped structure is a straight wall.

[0037] This method ensures that when filling the cup, the two planes of the flange 201 and the table surface 104 make contact first, and the cup lid 200 will not tilt. This ensures that the cup lid 200 and the cup body 100 have good coaxiality, which facilitates loading operations and improves the work efficiency of medical staff.

[0038] In other embodiments, the top of the cup body 100 forms an insertion port 105 for the cup lid 200 to be inserted; the top surface of the cup body 100 extends axially beyond the top surface of the cup lid 200; a sealing film 300 is also included, which is fixedly connected to the top surface of the cup body 100 and covers the insertion port 105. The sealing film 300 may be an easy-tear film for convenient operation.

[0039] Therefore, the top of the cup body 100 extends beyond the top of the cup lid 200, allowing the sealing film 300 to form a seal inside the cup body 100, thereby achieving the function of sealing and moisture isolation.

[0040] In the aforementioned embodiments, the cup body 100 and the cup lid 200 are coaxially arranged, and the center line of the cup body 100 passes through the center of the reagent pre-embedded groove 103. In this way, the reagent pre-embedded groove 103 is also coaxially arranged with the cup body 100 and the cup lid 200.

[0041] The lowest point of the cap 202 is at a predetermined distance from the bottom of the reagent pre-embedded tank 103. For example, this predetermined distance is 0.4 mm. By setting this predetermined distance, it is ensured that the reagent will not spill outside the reagent pre-embedded tank 103, facilitating operation and not affecting the test results. Specifically, the cap 202 has an arc-shaped surface, and the center of the cap 202 protrudes downwards along the axial direction. Therefore, the center of the cap 202 is the lowest point of the cap 202.

[0042] In the aforementioned embodiments, the inner wall of the cup body 100 is provided with a plurality of vertically extending cup body grooves 101, which are evenly distributed around the circumference of the cup body 100. The lid 200, located partially inside the cup body 100, is also provided with vertically extending lid grooves, which are evenly distributed around the circumference of the lid 200. This increases the contact surface area between the blood sample and the inner wall of the cup body 100 and the outer wall of the lid 200, thereby improving adhesion stability. Furthermore, at least one of the outer wall of the lid 200 and the inner wall of the cup body 100 is a frosted surface. This further enhances the adhesion between the blood sample and the inner wall of the cup body 100 and the outer wall of the lid 200.

[0043] Compared with existing technologies, the advantages of this application are:

[0044] First, improve reagent utilization efficiency: By designing a recessed reagent pre-embedded groove 103-shaped reagent groove, the reagent is ensured to be concentrated in the groove, reducing the possibility of reagent adsorption to the side wall, improving reagent utilization efficiency and reducing measurement error.

[0045] Second, improve the cup-filling operation: ensure that the cup lid 200 is in contact with the cup body 100 plane when filling the cup, prevent the cup lid 200 from tilting, improve the coaxiality of the cup filling, simplify the operation steps, and improve the work efficiency of medical staff.

[0046] Third, protecting the lyophilized reagent: The lid 200 and the bottom of the cup body 100 are kept at a distance of 0.4mm, which effectively prevents the lyophilized reagent from spilling out of the cup, ensuring the integrity of the reagent and improving the accuracy of the test results.

[0047] Fourth, the simple and easy-to-use moisture-proof design: the moisture-proof design is achieved by adding an easy-tear film, which is simple to operate, low in cost, and ensures the stability of the sample cup during transportation and storage.

[0048] This article uses specific examples to illustrate the principles and implementation methods of this utility model. The descriptions of the above embodiments are only for the purpose of helping to understand the core ideas of this utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made to this utility model without departing from the principles of this utility model, and these improvements and modifications also fall within the protection scope of the claims of this utility model.

Claims

1. A sample cup for a thromboelastography instrument, characterized in that, The device includes a cup (100) for holding blood samples and reagents. The bottom wall (102) of the cup (100) has a central region (102-1) and an edge region (102-2) surrounding the central region (102-1). The edge region (102-2) is axially inclined downward from the outside to the inside. The central region (102-1) is axially recessed to form a reagent pre-embedded groove (103).

2. The sample cup for a thromboelastography instrument according to claim 1, characterized in that, It also includes a cup lid (200) that can be inserted into the cup body (100), the cup lid (200) being used to fix the probe, and the top of the cup lid (200) being provided with a radially outwardly extending flange (201); The inner wall of the cup body (100) is radially concave to form a stepped structure, and the lower surface of the flange (201) is axially pressed against the platform (104) of the stepped structure. The lower surface of the flange (201) is a straight wall, and the platform (104) of the stepped structure is a straight wall.

3. The sample cup for a thromboelastography instrument according to claim 2, characterized in that, The top of the cup body (100) forms a socket (105) for inserting the cup lid (200); The top surface of the cup body (100) extends axially beyond the top surface of the cup lid (200); The sample cup for the thromboelastography instrument also includes a sealing membrane (300), which is fixedly connected to the top surface of the cup body (100) and covers the inlet (105).

4. The sample cup for a thromboelastography instrument according to claim 2 or 3, characterized in that, The cup body (100) and the cup lid (200) are coaxially arranged, and the center line of the cup body (100) passes through the center of the reagent pre-embedded groove (103).

5. The sample cup for a thromboelastography instrument according to claim 2 or 3, characterized in that, The cup lid (200) has a cap (202) that is axially opposite to the bottom wall (102) of the cup body (100). The cap (202) is projected axially to form a first projection (202-1), and the reagent pre-embedded groove (103) is projected to form a second projection (103-1). The second projection (103-1) is located within the range of the first projection (202-1).

6. The sample cup for a thromboelastography instrument according to claim 5, characterized in that, The lowest position of the cap (202) is at a set distance from the bottom of the reagent pre-embedded tank (103).

7. The sample cup for a thromboelastography instrument according to claim 5, characterized in that, The cover (202) is an arc surface, and the middle part of the cover (202) protrudes downward along the axial direction.

8. The sample cup for a thromboelastography instrument according to claim 2 or 3, characterized in that, The inner wall of the cup body (100) is provided with a plurality of vertically extending cup body grooves (101), which are evenly distributed around the circumference of the cup body (100).

9. The sample cup for a thromboelastography instrument according to claim 8, characterized in that, The cup lid (200) is also provided with a vertically extending lid groove on a part located inside the cup body (100), and the lid groove is evenly distributed around the circumference of the cup lid (200).

10. The sample cup for a thromboelastography instrument according to claim 9, characterized in that, At least one of the outer wall of the cup lid (200) and the inner wall of the cup body (100) is frosted.

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