A pharmaceutical intermediate reaction kettle

Abstract

This utility model relates to the field of reaction vessel technology and discloses a pharmaceutical intermediate reaction vessel, including: a reaction cylinder with a top cover; a support frame fixedly installed at the bottom of the reaction cylinder; and a cleaning assembly inside the reaction cylinder and the top cover. In use, simply start the motor to drive gears one and two to rotate, which in turn drives the stirring frame to rotate inside the reaction cylinder. The rods in the stirring frame stir the reactants, and the bottom of the stirring frame stirs the bottom of the reaction cylinder, reducing material blockage at the bottom outlet. This is convenient and quick. After the reaction is complete and the reactants are removed, simply turn on the water pump to draw cleaning water into the central tube of the stirring frame through a rotary joint. Then, open the solenoid valve inside the nozzle to spray cleaning water from the nozzle, which, in conjunction with the edge of the stirring frame, cleans the inner wall of the reaction cylinder, reducing the burden on operators.

Description

Technical Field

[0001] This utility model relates to the field of reaction vessel technology, specifically a pharmaceutical intermediate reaction vessel. Background Technology

[0002] Pharmaceutical intermediates are actually chemical raw materials or chemical products used in the process of drug synthesis. These chemical products do not require a drug production license and can be produced in ordinary chemical plants. As long as they meet certain standards, they can be used in drug synthesis. However, the production process of pharmaceutical intermediates requires the use of reaction vessels.

[0003] While existing reaction vessels offer convenient internal wall cleaning, improving usability, the materials reacting and mixing inside tend to move downwards due to gravity. The bottom of the reaction vessel's inner wall is the discharge port, and the vessel's stirring structure not only fails to effectively agitate these materials but also easily causes blockages when the user attempts to discharge them. Related technologies, such as the pharmaceutical intermediate reaction vessel disclosed in CN220071612U, incorporate a lifting assembly and a transmission stirring assembly. Adjusting the height of the transmission stirring assembly allows for stirring at the bottom of the reaction vessel, reducing the likelihood of blockages at the discharge port. However, despite this reduction in blockages, drug residues adhere to the inside of the reaction vessel after cooling following stirring. As a closed container, cleaning becomes extremely difficult, presenting certain limitations. Utility Model Content

[0004] (a) Technical problems to be solved

[0005] To address the shortcomings of existing technologies, this invention provides a pharmaceutical intermediate reaction vessel that has the advantages of reducing clogging at the reaction vessel outlet and facilitating cleaning of the interior of the reaction vessel, thus solving the problems of easy clogging at the outlet and difficulty in cleaning the interior of existing reaction vessels.

[0006] (II) Technical Solution

[0007] To achieve the above objectives, this utility model provides the following technical solution: a pharmaceutical intermediate reaction vessel, comprising: a reaction cylinder with a top cover mounted on its top; a support frame fixedly mounted on the bottom of the reaction cylinder; a cleaning assembly disposed inside the reaction cylinder and the top cover; the cleaning assembly comprising: a motor fixedly mounted on the top of the top cover; a first gear fixedly connected to the output end of the motor via a connecting shaft; a second gear meshing with one side of the first gear; the bottom of a rotary joint fixedly connected to the top of the second gear via a pipe; the inlet of the rotary joint fixedly connected to the outlet of a water pump via a pipe; a stirring frame fixedly mounted on the bottom of the second gear; a pipe body disposed at the center of the stirring frame, and a nozzle fixedly mounted inside the pipe body for cleaning the inner wall of the reaction cylinder.

[0008] In some embodiments, the second gear and the stirring frame are connected by a mounting assembly; the mounting assembly includes: a ring body fixedly connected to the bottom of the second gear; a connector fixedly connected to the top of the central tube of the stirring frame; a slider slidably connected radially inside the connector; an insert fixedly connected to one side of the slider; and guide rods slidably connected to both sides of the slider, with springs sleeved on the outside of the guide rods.

[0009] In some embodiments, the second gear, the ring body, and the connector all have through grooves inside for passing cleaning water, and a sealing gasket is provided between the ring body and the connector.

[0010] In some embodiments, one side of the insert is provided with a bevel, and the inside of the ring is provided with a groove that is the same size and shape as the insert.

[0011] In some embodiments, the slider and the plug are a set, and the connector is internally provided with multiple sets.

[0012] In some embodiments, the bottom of the stirring rack is in contact with the bottom of the inner wall of the reaction vessel for cleaning the bottom of the inner wall of the reaction vessel.

[0013] In some embodiments, the central tube of the stirring rack is provided with a plurality of nozzles, and the nozzles are internally provided with an electrically connected solenoid valve and a battery.

[0014] In some embodiments, both the motor and the rotary joint are mounted on the top of the top cover, and the top cover is fixedly connected to the reaction cylinder by bolts.

[0015] In some embodiments, a one-way valve is provided inside the pipe between the rotary joint and the water pump to reduce the backflow of cleaning water from the water pump toward the rotary joint.

[0016] (III) Beneficial Effects

[0017] Compared with the prior art, the present invention provides a pharmaceutical intermediate reaction vessel, which has the following beneficial effects:

[0018] When using this invention, simply start the motor to drive gears one and two to rotate, which will cause the stirring rack to rotate inside the reaction cylinder. The rods in the stirring rack stir the reactants, and the bottom of the stirring rack stirs the bottom of the reaction cylinder, reducing the possibility of material blockage at the bottom outlet of the reaction cylinder. This is convenient and quick. After the reaction is complete and the reactants are removed, simply turn on the water pump to draw cleaning water into the central pipe of the stirring rack through the rotary joint. Then, open the solenoid valve inside the nozzle to spray the cleaning water out from the nozzle, which, together with the edge of the stirring rack, cleans the inner wall of the reaction cylinder, reducing the burden on the operator. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the structure of this utility model;

[0020] Figure 2 This is a schematic diagram of the cleaning component of this utility model;

[0021] Figure 3 This is a schematic diagram of the internal structure of this utility model;

[0022] Figure 4 This is a schematic diagram of the installation component of this utility model;

[0023] Figure 5 This is a schematic diagram of the internal structure of the connector of this utility model.

[0024] In the picture:

[0025] 11. Reaction cylinder; 12. Top cover; 13. Support frame;

[0026] 2. Cleaning components; 21. Motor; 22. Gear No. 1; 23. Gear No. 2; 24. Rotary joint; 25. Water pump; 26. Mixing frame; 27. Nozzle;

[0027] 3. Mounting components; 31. Ring body; 32. Connector; 33. Slider; 34. Insert block; 35. Guide rod. Detailed Implementation

[0028] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0029] It should be noted that all directional indications in the embodiments of this application are only used to explain the relative positional relationship and movement of each component in a specific posture. If the specific posture changes, the directional indications will also change accordingly.

[0030] In this application, unless otherwise expressly specified and limited, the terms "connection," "fixed," etc., should be interpreted broadly. For example, "fixed" can mean a fixed connection, a detachable connection, or an integral part; it can mean a mechanical connection or an electrical connection; it can mean a direct connection or an indirect connection through an intermediate medium; it can mean the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0031] Furthermore, the use of terms such as "first" and "second" in this application is for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the technical solutions of the various embodiments can be combined with each other, but only on the basis of being achievable by those skilled in the art. If the combination of technical solutions is contradictory or impossible to implement, such a combination of technical solutions should be considered non-existent and not within the scope of protection claimed in this application.

[0032] In use, the reactants are added into the reactor through the feed inlet, and then the motor on the reactor is started to drive the stirring rod to stir the materials inside the reactor, thereby increasing the contact area of ​​the reactants and accelerating the reaction rate.

[0033] In related technologies, such as the pharmaceutical intermediate reaction vessel disclosed in CN220071612U, a lifting assembly and a transmission stirring assembly are provided. This facilitates stirring at the bottom of the reaction vessel by adjusting the height of the transmission stirring assembly, reducing the blockage of the discharge port. However, although it can reduce the blockage of the discharge port, after stirring, drug residues will stick to the inside of the reaction vessel as the drug cools down. As a closed container, the reaction vessel becomes very troublesome to clean, which has certain limitations.

[0034] To address some of the problems in related technologies, this application provides a pharmaceutical intermediate reaction vessel. In use, simply starting the motor 21 drives the first gear 22 and the second gear 23 to rotate, which in turn drives the stirring frame 26 to rotate inside the reaction cylinder 11. The rods in the stirring frame 26 stir the reactants, and the bottom of the stirring frame 26 stirs the bottom of the reaction cylinder 11, reducing the risk of material blockage at the bottom outlet. This is convenient and quick. After the reaction is complete and the reactants are removed, simply turn on the water pump 25 to draw cleaning water through the rotary joint 24 into the central tube of the stirring frame 26. Then, by opening the solenoid valve inside the nozzle 27, cleaning water is sprayed out from the nozzle 27, working in conjunction with the edge of the stirring frame 26 to clean the inner wall of the reaction cylinder 11, reducing the workload of the operator.

[0035] This application is described below with reference to the accompanying drawings and specific embodiments:

[0036] Combination Figures 1-5 This application provides a pharmaceutical intermediate reaction vessel, including: a reaction cylinder 11 with a top cover 12 mounted on its top; a support frame 13 fixedly mounted on the bottom of the reaction cylinder 11; a cleaning assembly 2 disposed inside the reaction cylinder 11 and the top cover 12; the cleaning assembly 2 includes: a motor 21 fixedly mounted on the top of the top cover 12; a first gear 22 fixedly connected to the output end of the motor 21 via a connecting shaft; a second gear 23 meshing with one side of the first gear 22; the bottom of a rotary joint 24 fixedly connected to the top of the second gear 23 via a pipe; the inlet of the rotary joint 24 fixedly connected to the outlet of a water pump 25 via a pipe; a stirring frame 26 fixedly mounted on the bottom of the second gear 23; a tube body disposed at the center of the stirring frame 26, and a nozzle 27 fixedly mounted inside the tube body for cleaning the inner wall of the reaction cylinder 11.

[0037] In use, the reactants are added into the reactor 11 through the feed inlet at the top of the reactor 11. Then, the motor 21 is started via the control panel, driving the first gear 22 to rotate. Through the meshing connection between the first gear 22 and the second gear 23, the second gear 23 is driven to rotate. The second gear 23 drives the stirring frame 26 to rotate inside the reactor 11. The rods in the stirring frame 26 stir the reactants, and the bottom of the stirring frame 26 stirs the bottom of the reactor 11, thereby reducing the possibility of material blockage at the bottom outlet of the reactor 11. The process is quick and convenient. After the reaction is complete and the reactants are removed, the water pump 25 is turned on, and the water pump pipe of the water pump 25 is inserted into the water tank containing cleaning water. The water pump 25 is turned on, and the cleaning water is introduced into the rotary joint 24. Then, the cleaning water flows along the rotary joint 24 into the tube in the center of the stirring frame 26. Then, the solenoid valve inside the nozzle 27 is turned on, so that the cleaning water is sprayed out from the nozzle 27 as the stirring frame 26 rotates. The edge of the stirring frame 26 scrapes off the reactants adhering to the inner wall of the reaction cylinder 11, thereby cleaning the inner wall of the reaction cylinder 11 and reducing the burden on the operator.

[0038] In some embodiments, the second gear 23 and the stirring rack 26 are connected by a mounting assembly 3; the mounting assembly 3 includes: a ring 31, which is fixedly connected to the bottom of the second gear 23; a connector 32 is fixedly connected to the top of the central tube of the stirring rack 26; a slider 33 is slidably connected radially inside the connector 32; an insert block 34 is fixedly connected to one side of the slider 33; guide rods 35 are slidably connected to both sides of the slider 33, and springs are sleeved on the outside of the guide rods 35.

[0039] When using the mixer 26, to install it, align the slider 33 and insert 34 on the top of the connector 32 with the inner groove of the ring 31 and insert them upwards. As the slider 33 moves upwards, the bottom edge of the connector 32 will press against the inclined surface of the insert 34, thereby pushing the slider 33 and insert 34 and compressing the spring outside the guide rod 35. When the insert 34 reaches the inner groove of the ring 31, the spring will push the slider 33, causing the insert 34 to be inserted into the inner groove of the ring 31, thus achieving the installation of the connector 32. This is convenient and quick. When the mixer 26 needs to be disassembled, the operator only needs to press the sliders 33 on both sides to slide the insert 34 out of the inner groove of the ring 31, thereby releasing the connection between the ring 31 and the connector 32 and removing the mixer 26 for easy cleaning or replacement.

[0040] In some embodiments, the second gear 23, the ring body 31, and the connector 32 are all provided with through grooves for the passage of cleaning water, and a sealing gasket is provided between the ring body 31 and the connector 32 to enhance the sealing at the connection between the ring body 31 and the connector 32 and to minimize the possibility of water leakage affecting the proportion of reactants.

[0041] In some embodiments, a bevel is provided on one side of the insert 34, and a groove with the same size and shape as the insert 34 is provided inside the ring 31. This allows the edge of the ring 31 to push the slider 33 and the insert 34 by pressing the bevel of the insert 34 when the connector 32 is moved upward, thereby preventing the insert 34 from obstructing the connector 32 from continuing to slide upward and facilitating the installation of the connector 32.

[0042] In some embodiments, the slider 33 and the insert 34 are a set, and the connector 32 is provided with multiple sets inside to enhance the stability of the installation.

[0043] In some embodiments, the bottom of the stirring rack 26 is in contact with the bottom of the inner wall of the reaction cylinder 11 for cleaning the bottom of the inner wall of the reaction cylinder 11.

[0044] In some embodiments, a plurality of nozzles 27 are provided on the central tube of the stirring rack 26, and an electrically connected solenoid valve and a battery are provided inside the nozzle 27. The plurality of nozzles 27 can enhance the cleaning effect on the inner wall of the reaction cylinder 11.

[0045] In some embodiments, the motor 21 and the rotary joint 24 are both mounted on the top of the top cover 12, and the top cover 12 is fixedly connected to the reaction cylinder 11 by bolts. By unscrewing the bolts, the top cover 12 can be removed from the top of the reaction cylinder 11. Then, by moving the top cover upward, the stirring rack 26 can be removed from the inside of the reaction cylinder 11, which facilitates cleaning or replacement.

[0046] In some embodiments, a one-way valve is provided inside the pipe between the rotary joint 24 and the water pump 25 to allow water to flow from the water pump 25 toward the rotary joint 24, thereby reducing the backflow of cleaning water and increasing the service life of the water pump 25.

[0047] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. In addition, those skilled in the art can combine and integrate the different embodiments or examples described in this specification.

[0048] Furthermore, the technical solutions of the various embodiments can be combined with each other, but only if they are based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection claimed in this application.

[0049] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A pharmaceutical intermediate reaction vessel, characterized in that, include: A reaction cylinder (11) is provided with a top cover (12) installed on its top; a support frame (13) is fixedly installed on the bottom of the reaction cylinder (11); a cleaning assembly (2) is provided inside the reaction cylinder (11) and the top cover (12); the cleaning assembly (2) includes: A motor (21) is fixedly installed on the top of the top cover (12); the output end of the motor (21) is fixedly connected to a first gear (22) via a connecting shaft; a second gear (23) is meshed on one side of the first gear (22); the top of the second gear (23) is fixedly connected to the bottom of a rotary joint (24) via a pipe; the inlet of the rotary joint (24) is fixedly connected to the outlet of a water pump (25) via a pipe; a stirring rack (26) is fixedly installed at the bottom of the second gear (23); a pipe is provided in the center of the stirring rack (26), and a nozzle (27) is fixedly installed inside the pipe for cleaning the inner wall of the reaction cylinder (11).

2. The pharmaceutical intermediate reaction vessel according to claim 1, characterized in that, The second gear (23) is connected to the stirring rack (26) via a mounting assembly (3); the mounting assembly (3) includes: The ring (31) is fixedly connected to the bottom of the second gear (23); the top of the central tube of the stirring rack (26) is fixedly connected to the connector (32); the inside of the connector (32) is slidably connected to the slider (33) in the radial direction; the side of the slider (33) is fixedly connected to the insert (34); the two sides of the slider (33) are slidably connected to the guide rod (35), and the outside of the guide rod (35) is sleeved with a spring.

3. The pharmaceutical intermediate reaction vessel according to claim 2, characterized in that, The second gear (23), the ring body (31) and the connector (32) all have through grooves inside for passing cleaning water, and a sealing gasket is provided between the ring body (31) and the connector (32).

4. The pharmaceutical intermediate reaction vessel according to claim 2, characterized in that, The insert (34) has a bevel on one side, and the ring (31) has a groove inside that is the same size and shape as the insert (34).

5. A pharmaceutical intermediate reaction vessel according to claim 2, characterized in that, The slider (33) and the insert (34) are a set, and the connector (32) has multiple sets inside.

6. The pharmaceutical intermediate reaction vessel according to claim 1, characterized in that: The bottom of the stirring rack (26) is in contact with the bottom of the inner wall of the reaction cylinder (11) for cleaning the bottom of the inner wall of the reaction cylinder (11).

7. The pharmaceutical intermediate reaction vessel according to claim 1, characterized in that: The stirring rack (26) has a plurality of nozzles (27) on its central tube, and each nozzle (27) has an electrically connected solenoid valve and a battery inside.

8. The pharmaceutical intermediate reaction vessel according to claim 1, characterized in that: The motor (21) and the rotary joint (24) are both installed on the top of the top cover (12), and the top cover (12) is fixedly connected to the reaction cylinder (11) by bolts.

9. A pharmaceutical intermediate reaction vessel according to claim 1, characterized in that: A one-way valve is provided inside the pipe between the rotary joint (24) and the water pump (25) to allow water to flow from the water pump (25) toward the rotary joint (24) in order to reduce the backflow of cleaning water.

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