Deep hole plate with adjusting function

Abstract

This utility model discloses a deep-hole plate with an adjustable function, comprising: an inner shell, characterized in that a fixing plate is fixedly connected to the upper surface of the inner shell, the fixing plate has a circular inner hole, the fixing plate has a sliding groove, and a slider is slidably connected inside the sliding groove; an outer shell is provided below the inner shell, and a slot is provided on the upper surface of the outer shell. By setting the outer shell and the inner shell on the deep-hole plate, the two shells have square inner holes and circular inner holes respectively, and the inner shell can be inserted into the inner shell for fixation. Even if it is temporarily needed to use the circular inner hole for liquid storage, it can be used immediately. Moreover, this device is more convenient to carry, eliminating the need to carry two deep-hole plates at the same time.

Description

Technical Field

[0001] This utility model relates to the field of deep hole plate technology, and in particular to a deep hole plate with adjustment function. Background Technology

[0002] Deep well plates are an indispensable multi-functional tool for a variety of laboratory applications, including sample storage, liquid handling, and high-throughput screening. Made of durable polypropylene, deep well plates offer excellent chemical resistance, making them suitable for storing a wide range of samples under extreme conditions. The V-shaped bottom design of the wells minimizes dead volume, ensuring maximum sample recovery and precise liquid transfer, which is crucial for accurate experimental results. Researchers can choose from a variety of surface treatments, including untreated and special coatings, to meet specific experimental needs, such as cell culture or immunological assays. The availability of sterile and non-sterile options provides flexibility for applications, ensuring that researchers can select the appropriate plate according to their specific requirements. Incorporating deep well plates into laboratory practice optimizes efficiency, improves accuracy, and supports high-throughput research, making them an indispensable tool for scientific advancement.

[0003] However, most existing deep-hole plates can only use one type of inner hole shape to store liquids. When it is necessary to store or process liquids with different properties, deep-hole plates with different inner hole shapes are required. In this case, it is inconvenient to prepare multiple deep-hole plates. After searching, it was found that the technical solution provided by the utility model with application number "201210421568.1" also has the above problems. Utility Model Content

[0004] The purpose of this invention is to provide a deep-hole plate with an adjustable function, which solves the problem that most existing deep-hole plates can only use one type of inner hole shape to store liquids. When it is necessary to store or process liquids with different properties, deep-hole plates with different inner hole shapes are required. In this case, multiple deep-hole plates need to be prepared, which is inconvenient to carry.

[0005] To achieve the above objectives, a deep hole plate with an adjustable function is provided, comprising: an inner shell, a fixing plate fixedly connected to the upper surface of the inner shell, a circular inner hole formed on the fixing plate, a sliding groove formed on the fixing plate, a slider slidably connected inside the sliding groove, an outer shell disposed below the inner shell, and a slot formed on the upper surface of the outer shell.

[0006] According to the aforementioned deep hole plate with adjustment function, the upper surface of the fixing plate is provided with a circular inner hole.

[0007] According to the aforementioned deep-hole plate with adjustment function, a square inner hole is formed on the upper surface of the outer shell.

[0008] According to the aforementioned deep-hole plate with adjustable function, a base is fixedly connected to the bottom of the outer casing.

[0009] The above solution has the following advantages: This patent sets an outer shell and an inner shell on a deep hole plate. The two shells have square inner holes and circular inner holes respectively. With the help of the limiting structure, the inner shell can be inserted into the outer shell for fixation. Even if the circular inner hole is temporarily needed to store liquid, it can be used immediately. Moreover, the device is more convenient to carry, and there is no need to carry two deep hole plates at the same time.

[0010] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0011] The present invention will be further described below with reference to the accompanying drawings and embodiments;

[0012] Figure 1 This is a schematic diagram of the overall structure of a deep hole plate with adjustment function according to the present invention;

[0013] Figure 2 This is a schematic diagram of the limiting structure of a deep hole plate with adjustment function according to the present invention;

[0014] Figure 3 This is a front view of a deep-hole plate with an adjustable function according to this utility model;

[0015] Figure 4 This is a schematic diagram of the upper angle structure of a deep hole plate with adjustable function according to this utility model.

[0016] Legend:

[0017] 1. Outer shell; 2. Square inner hole; 3. Slot; 4. Inner shell; 5. Fixing plate; 6. Circular inner hole; 7. Slide groove; 8. Slider; 9. Base. Detailed Implementation

[0018] This section will describe in detail the specific embodiments of the present utility model. The preferred embodiments of the present utility model are shown in the accompanying drawings. The purpose of the drawings is to supplement the textual description with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the present utility model, but they should not be construed as limiting the scope of protection of the present utility model.

[0019] Reference Figure 1-4This utility model provides a deep hole plate with an adjustable function, comprising: an inner shell 4, a fixing plate 5 fixedly connected to the upper surface of the inner shell 4, a circular inner hole 6 formed on the fixing plate 5, a sliding groove 7 formed on the fixing plate 5, a slider 8 slidably connected inside the sliding groove 7, an outer shell 1 provided below the inner shell 4, and a slot 3 formed on the upper surface of the outer shell 1. By setting a sliding limiting structure on the device, the inner shell 4 and the outer shell 1 can be easily fixed, preventing the inner shell 4 from falling out when the machine is used to process the liquid in the hole.

[0020] The upper surface of the fixing plate 5 has a circular inner hole 6. In deep-well plates (such as 96-well plates, 384-well plates, etc.), the circular inner hole 6 is mainly used to optimize the accuracy, stability, and compatibility of experimental operations. Its specific functions are as follows: The circular hole wall has no sharp edges, allowing for smoother liquid flow, preventing reagent residue in corners, and improving pipetting and mixing efficiency. A uniform meniscus is formed on the liquid surface inside the circular hole, facilitating accurate measurements (such as spectrophotometry and fluorescence detection). Square holes may cause liquid surface deformation due to uneven surface tension, while circular holes reduce such errors. During absorbance, fluorescence, or luminescence detection, the light passes through the liquid along a consistent path, reducing scattering or refraction interference. This is consistent with the optical systems of most microplate readers. Optimized for circular orifices to ensure data reliability, automated pipette tips are typically circular, allowing for more precise alignment with the orifice and reducing the risk of collisions or misalignment. The circular orifice structure facilitates smooth liquid injection, reducing the probability of air bubble formation (air bubbles can affect test results). Circular orifices adhere more tightly to pads and membrane seals (such as PCR plate sealing films), preventing evaporation or cross-contamination. During shaking or centrifugation, circular orifices effectively suppress liquid splashing, reducing the risk of inter-orifice contamination. Circular orifice molds are simple to manufacture, and the consistency between orifices is high during injection molding, making them suitable for large-scale production. This design is the result of a comprehensive trade-off between engineering, biology, and materials science, and is suitable for high-throughput experimental scenarios such as molecular biology, drug screening, and clinical testing.

[0021] A square inner hole 2 is formed on the upper surface of the outer shell 1, and a base 9 is fixedly connected to the bottom of the outer shell 1. The square inner hole 2 in the deep-well plate (such as some cell culture plates or special experimental plates) is mainly optimized for specific experimental needs, and its function complements that of the circular hole. The core advantages and application scenarios of the square inner hole 2 are as follows: The right-angled structure of the square hole provides a larger effective growth area than the circular hole (the square area is 27% larger than the circular area at the same hole diameter), which is especially suitable for the culture and expansion of adherent cells. The right-angled edges can reduce cell accumulation at the edge of the hole (circular holes are prone to edge effects), making the cell distribution more uniform and facilitating microscopic observation or imaging analysis. The square hole has a higher matching degree with the square field of view (FOV) of most microscopes, avoiding edge image cropping caused by circular holes (such as confocal microscopy, high content screening). During automated imaging, the square hole is easier to stitch together multi-well images and perform data analysis (such as cell counting, morphological analysis). The square hole can be separated into different regions by physical or chemical methods (such as scratch assays, chemotaxis). (Experiments) Right-angled boundaries are easier to manipulate. Some microfluidic chips or 3D culture scaffolds are designed in a square shape to facilitate docking with square wells (such as organ-on-a-chip models). Square wells have a larger liquid surface area, providing a more stable gas exchange environment in open cultures (such as CO2 incubators). The different tension distribution at the liquid surface edges of square wells may reduce edge concentration during liquid evaporation (requires surface treatment technology). Square well structures are easier to implement complex designs through 3D printing technology (such as gradient wells, multi-chamber wells). Some optical-grade plastics (such as COP) can reduce stress refraction and improve imaging clarity in square injection molding. Square wells require surface hydrophilic / hydrophobic treatment to reduce abnormal aggregation of cells or reagents at the corners. Edge refraction may affect fluorescence quantification, requiring software correction or the use of black well plates to reduce interference. In summary, the core value of square wells lies in providing space and compatibility optimization for cell culture and imaging analysis. Although some liquid handling uniformity is sacrificed, it is irreplaceable in specific fields (such as cell experiments and high-content screening). When making a selection, it is necessary to consider the experimental type (liquid reaction vs. cell manipulation), detection method (absorbance vs. imaging), and equipment compatibility.

[0022] Working principle: When a square deep-hole plate is needed for liquid storage, the liquid can be directly dripped into the square inner hole 2 for storage. If a circular hole is needed for liquid storage, the inner shell 4 is inserted into the outer shell 1, and the slider 8 is slid to the left to fix the outer shell 1 and the inner shell 4. Then the liquid can be dripped into the circular inner hole 6 for storage.

[0023] The embodiments of the present utility model have been described in detail above with reference to the accompanying drawings. However, the present utility model is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present utility model.

Claims

1. A deep-hole plate with adjustment function, comprising: The inner shell (4) is characterized in that a fixing plate (5) is fixedly connected to the upper surface of the inner shell (4), a circular inner hole (6) is opened on the fixing plate (5), a sliding groove (7) is opened on the fixing plate (5), a slider (8) is slidably connected inside the sliding groove (7), an outer shell (1) is provided below the inner shell (4), and a slot (3) is opened on the upper surface of the outer shell (1).

2. A deep-hole plate with adjustment function according to claim 1, characterized in that, The upper surface of the fixing plate (5) is provided with a circular inner hole (6).

3. A deep-hole plate with adjustment function according to claim 1, characterized in that, The upper surface of the outer shell (1) is provided with a square inner hole (2).

4. A deep-hole plate with adjustment function according to claim 1, characterized in that, The bottom of the outer shell (1) is fixedly connected to a base (9).

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