Neutron therapy system for boron neutron capture therapy

Abstract

The present disclosure provides a neutron therapy system for boron neutron capture therapy, comprising: a reflector provided with a containing cavity for containing a neutron target module; a moderator module arranged in the reflector and located on one side of the neutron target module; a filter arranged in the reflector and located on a side of the moderator module away from the neutron target module; and a collimator arranged on a side of the filter away from the moderator module; wherein the reflector comprises a detachably connected reflection seat and a reflection cover, so that the moderator module is detachably connected to the reflector. The neutron therapy system of the present disclosure has the advantages of convenient replacement and low maintenance cost, because the reflection cover is detachably connected to the reflection seat and can be removed to replace the moderator module.

Description

Technical Field

[0001] This disclosure relates to the field of neutron therapy equipment technology, and more particularly to a neutron therapy system for boron neutron capture therapy. Background Technology

[0002] Boron neutron capture therapy (BNCT) is a binary tumor treatment method that combines thermal neutron beams with tumor-friendly boron-doped drugs. It has shown effective treatment results for glioblastoma multiforme, malignant melanoma, and recurrent head and neck tumors. For neutron beams of different energies incident on the body, the distribution of thermal neutrons along the incident direction varies, resulting in three treatment modalities. The first modal uses lower-energy thermal neutrons for treating superficial tumors such as those in the skin. The second modal uses ultrathermal neutrons, with a maximum thermal neutron flux at depths of 2-4 cm and maintaining a high level of thermal neutron distribution up to 10 cm, for treating tumors at depths of 2-10 cm. The third modal uses higher-energy neutrons to maintain a high thermal neutron flux at deeper depths, for treating deeper tumors.

[0003] The initial neutrons produced by proton accelerator target firing are mainly composed of fast neutrons and cannot be directly used for treatment. Therefore, in the boron neutron capture therapy equipment system, the beam shaper is a very important component, which includes a reflector, a moderator, a filter, and a collimator.

[0004] In related technologies, the beam shaper adopts a fixed integrated design. If the modulator's performance is reduced or damaged, it is usually impossible to replace it. The entire beam shaper needs to be replaced, resulting in high maintenance costs. Utility Model Content

[0005] In view of this, embodiments of the present disclosure provide a neutron therapy system for boron neutron capture therapy, which addresses the problems of existing neutron therapy systems, such as the difficulty in replacing the moderator and high maintenance costs.

[0006] Embodiments of this disclosure provide a neutron therapy system for boron neutron capture therapy, comprising:

[0007] The reflector has a receiving cavity for accommodating the neutron target module.

[0008] A moderator module is disposed in the reflector and located on one side of the neutron target module;

[0009] A filter is disposed within the reflector and located on the side of the moderator module opposite to the neutron target module; and

[0010] A collimator is located on the side of the filter opposite to the modulator module;

[0011] The reflector includes a detachably connected reflector base and reflector cover, so that the moderating module can be detachably connected to the reflector.

[0012] According to an embodiment of this disclosure, the reflector base is provided with a first receiving groove and a second receiving groove that are interconnected, and the moderating module is disposed in the first receiving groove.

[0013] The reflective cover includes a connecting portion and a limiting portion disposed on one side of the connecting portion. The limiting portion is located in the second receiving groove, and the connecting portion covers the opening of the first receiving groove. The connecting portion is detachably connected to the reflective base via a connector.

[0014] According to an embodiment of this disclosure, the connecting part is provided with a first connecting hole, the reflector seat is provided with a second connecting hole, the second connecting hole is correspondingly provided with the first connecting hole, and the first connecting hole and the second connecting hole are connected by the connector.

[0015] According to embodiments of this disclosure, the moderating module includes:

[0016] frame;

[0017] A slowing core is disposed within the frame;

[0018] The framework includes:

[0019] The frame body has a receiving cavity, and the moderating core is located in the receiving cavity;

[0020] A first connecting plate is connected to one side of the frame body; and

[0021] The second connecting plate is connected to the other side of the frame body.

[0022] According to an embodiment of this disclosure, a positioning structure is provided between the frame and the reflector base. The positioning structure includes a positioning groove and a positioning element, one of which is located in the frame and the other is located in the reflector base.

[0023] According to embodiments of this disclosure, the reflective cover is provided with a first mounting hole; and / or

[0024] The frame is provided with a second lifting hole.

[0025] According to embodiments of this disclosure, the moderating module includes a first moderating module, a second moderating module, and a third moderating module, any one of which can be detachably connected to the reflector.

[0026] According to an embodiment of this disclosure, the first moderator module includes a heavy water moderator module;

[0027] The thickness of the moderating core of the heavy water moderating module is 180~220 mm.

[0028] According to embodiments of this disclosure, the second moderator module includes a magnesium fluoride moderator module;

[0029] The thickness of the moderating core of the magnesium fluoride moderator module is 200-250 mm.

[0030] According to embodiments of this disclosure, the third moderator module includes an aluminum fluoride moderator module;

[0031] The thickness of the moderating core of the aluminum fluoride moderator module is 120~180 mm.

[0032] The neutron therapy system for boron neutron capture therapy and the neutron beam modulation method provided in the embodiments of this disclosure can achieve at least the following technical effects: the reflector cover and the reflector seat are detachably connected, and the reflector cover can be removed to replace the moderator module, which is beneficial to the convenience of replacement and also helps to reduce maintenance costs. Attached Figure Description

[0033] The above and other objects, features and advantages of this disclosure will become clearer from the following description of embodiments with reference to the accompanying drawings, in which:

[0034] Figure 1 An explosion diagram of a neutron therapy system according to an embodiment of the present disclosure is shown schematically.

[0035] Figure 2 The schematic diagram shows one of the structural schematic diagrams of a neutron therapy system according to an embodiment of the present disclosure (reflector not shown);

[0036] Figure 3 A second schematic diagram of the structure of a neutron therapy system according to an embodiment of the present disclosure is shown.

[0037] Figure 4 The third schematic diagram illustrates the structure of a neutron therapy system according to an embodiment of the present disclosure;

[0038] Figure 5 A schematic diagram of the structure of the reflector according to an embodiment of the present disclosure is shown;

[0039] Figure 6 A schematic diagram of the structure of the reflective cover according to an embodiment of the present disclosure is shown;

[0040] Figure 7A schematic diagram illustrating the structure of a moderating module according to an embodiment of the present disclosure is shown.

[0041] Figure 8 An exploded view of a moderating body module according to an embodiment of the present disclosure is shown schematically.

[0042] Figure 9 A schematic diagram illustrating the structure of a frame body according to an embodiment of the present disclosure is shown.

[0043] Figure 10 A schematic diagram of the structure of a first connecting plate according to an embodiment of the present disclosure is shown;

[0044] Figure 11 A schematic diagram of the structure of a moderating core according to an embodiment of the present disclosure is shown.

[0045] Figure 12 The diagram illustrates a structural schematic of the positioning structure between the frame and the reflector mount according to an embodiment of the present disclosure.

[0046] Figure label:

[0047] 10: Reflector; 11: Reflector mount; 111: First receiving groove; 112: Second receiving groove; 113: First top surface; 114: Second top surface; 115: Second connecting hole; 116: Positioning groove; 12: Reflector cover; 121: Connecting part; 1211: First connecting hole; 1212: First hoisting hole; 122: Limiting part; 20: Moderator module; 21: Frame; 211: Frame body; 211 1: First through hole; 2112: Third connecting hole; 2113: Second hoisting hole; 212: First connecting plate; 2121: Second through hole; 2122: Limiting groove; 2123: Fourth connecting hole; 213: Second connecting plate; 214: Positioning component; 22: Moderator core; 221: First end face; 222: Second end face; 30: Filter; 40: Collimator; 50: Neutron target module; 60: Filter plate. Detailed Implementation

[0048] To make the objectives, technical solutions, and advantages of this disclosure clearer, the following detailed description is provided in conjunction with specific embodiments and accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this disclosure. All other embodiments obtained by those skilled in the art based on the embodiments of this disclosure without inventive effort are within the scope of protection of this disclosure.

[0049] The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit this disclosure. The terms “comprising,” “including,” etc., as used herein indicate the presence of the stated features, steps, operations, and / or components, but do not exclude the presence or addition of one or more other features, steps, operations, or components.

[0050] In the description of this disclosure, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linkage" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this disclosure based on the specific circumstances.

[0051] Boron neutron capture therapy (BNCT) is a binary tumor treatment method that combines thermal neutron beams with tumor-friendly boron-doped drugs. It has shown effective treatment results for glioblastoma multiforme, malignant melanoma, and recurrent head and neck tumors. For neutron beams of different energies incident on the body, the distribution of thermal neutrons along the incident direction varies, generally falling into three treatment modalities. The first modal uses lower-energy thermal neutrons for treating superficial tumors such as those in the skin. The second modal uses ultrathermal neutrons, with a maximum thermal neutron flux at depths of 2-4 cm and maintaining a high level of thermal neutron distribution up to 10 cm, for treating tumors at depths of 2-10 cm. The third modal uses higher-energy neutrons to maintain a high thermal neutron flux at deeper depths, for treating deeper tumors.

[0052] Boron neutron capture therapy (BNCT) devices based on proton accelerator-driven neutron sources have become the mainstream technology in BNCT device development due to their miniaturization, safety, and ability to be installed in densely populated areas. The initial neutrons produced by proton accelerator targeting are mainly composed of fast neutrons and cannot be directly used for treatment. Therefore, in boron neutron capture therapy systems, beam shaping is a crucial component. The beam shaper is used to shape the initial neutrons produced by the target into a neutron beam suitable for tumor treatment. The beam shaper includes a reflector, a moderator, a filter (or filter bottle, absorber, etc.), and a collimator. Different materials are selected for the beam shaper to meet different treatment beam requirements.

[0053] In related technologies, beam shaping devices employ a fixed, integrated design. If the moderator's performance deteriorates or is damaged, it is usually impossible to replace, requiring the entire beam shaping device to be replaced, resulting in high maintenance costs. Furthermore, the fixed, integrated design of the beam shaping device makes it difficult to flexibly adjust the neutron energy spectrum for tumors at different depths. A single moderator structure can only generate neutron beams in a specific energy range, limiting treatment to tumors at specific depths. For example, a moderator structure suitable for treating mid-to-deep tumors may cause excessive radiation doses to deep normal tissues when treating superficial tumors, damaging normal tissues; conversely, insufficient neutron flux may fail to achieve therapeutic effects when treating deep tumors. To accommodate treatment modes across multiple energy ranges, at least three beam shaping devices are required, further increasing the cost of the treatment system.

[0054] The following is combined with Figures 1 to 12 A neutron therapy system for boron neutron capture therapy is described according to embodiments of the present disclosure.

[0055] In embodiments of this disclosure, such as Figures 1 to 4 As shown, the neutron therapy system includes a reflector 10, a modulator module 20, a filter 30, a collimator 40, and a neutron target module 50. The reflector 10 has a receiving cavity for accommodating the neutron target module 50. The modulator module 20 is disposed within the reflector 10 and located on one side of the neutron target module 50. The filter 30 is disposed within the reflector 10 and located on the side of the modulator module 20 opposite to the neutron target module 50. The collimator 40 is located on the side of the filter 30 opposite to the modulator module 20. The reflector 10 includes a detachably connected reflector base 11 and reflector cover 12, allowing the modulator module 20 to be detachably connected to the reflector 10.

[0056] The reflector 10 has a accommodating space within it, and a portion of the neutron target module 50, the moderator module 20, and the filter 30 are sequentially installed within the reflector 10. A collimator 40 is installed at one end face of the reflector 10. The reflector 10 is made of materials such as graphite and lead. The reflector 10 has a accommodating cavity for accommodating the neutron target module 50.

[0057] The neutron target module 50 includes a target body and a proton beam channel, with one end of the proton beam channel connected to the target body and the other end connected to the proton accelerator. The target body and proton beam channel are located within the housing cavity of the reflector 10. The proton beam generated by the proton accelerator bombards the target body through the proton beam channel, and the proton beam reacts with the target body to produce fast neutrons. Since the fast neutrons have high energy, they need to be slowed down by the moderator module 20 to reduce their energy, ensuring that the neutron energy spectrum meets the therapeutic requirements.

[0058] The filter 30 is made of materials such as bismuth and is used to filter out gamma rays to ensure the purity of neutrons.

[0059] The collimator 40 is made of materials such as bismuth, lead, and polyethylene. The polyethylene can be polyethylene containing lithium 6 and boron. The collimator 40 is used to adjust the diameter of the neutron beam to guide a neutron beam of the target size to the treatment area.

[0060] The neutron target module 50, filter 30, and collimator 40 can be fixedly mounted on the reflector 10. The moderator module 20 is detachably mounted in the reflector 10. It is understood that the target, filter 30, and collimator 40 are coaxially arranged. Different materials and dimensions of the moderator module 20 will result in different neutron energies. Based on the different neutron energies generated, the moderator module 20 is defined as the first moderator module, the second moderator module, and the third moderator module, respectively.

[0061] For example, after the neutron beam is slowed down by the first moderator module, a first neutron beam is obtained, with an energy less than or equal to 0.5 eV. The first neutron beam mainly consists of thermal neutrons, and its half-value depth is less than or equal to 2 cm, making it suitable for treating superficial tumors of the skin, oral mucosa, or within 2 cm of depth. In other words, the first neutron beam is suitable for superficial treatment.

[0062] After being slowed down by the second moderator module, the neutron beam becomes a second neutron beam with an energy range of 0.5 eV to 10 kilovolts. This second neutron beam primarily consists of hyperthermal neutrons, also with an energy range of 0.5 eV to 10 kilovolts. After being slowed down by human tissue, these hyperthermal neutrons create a thermal neutron flux peak at a depth of 2–7 cm, maintaining a therapeutic dose within 10 cm. This method is suitable for treating gliomas, head and neck tumors, and tumors at depths of 2–10 cm. In other words, the second neutron beam is suitable for mid-to-deep treatment modalities.

[0063] After being slowed down by the third moderator module, the neutron beam becomes the third neutron beam, with an energy range of 1 eV to 40 kilovolts. The third neutron beam mainly consists of hyperthermal neutrons, which also have an energy range of 1 eV to 40 kilovolts. Through deep moderation, the thermal neutron flux remains above 1*10^6 volts at depths of 2–12 cm. 9 With a beam density of n / cm² / s, this method is suitable for treating deep-seated tumors, particularly those deeper than 10 cm, or for conditions requiring high beam intensity. In other words, the third neutron beam is suitable for deep-treatment modes.

[0064] This allows for the extraction of three neutron beams within a single neutron therapy system, corresponding to three energy bands: thermal neutron, ultrathermal neutron, and higher energy. The structure of the moderator module 20 and the reflector 10 enables the neutron therapy system to combine the characteristics of outputting multiple energy spectra with low cost, allowing for three treatment modes: shallow, intermediate-deep, and deep treatment.

[0065] The superficial treatment mode extracts thermal neutrons with energies less than or equal to 0.5 eV, used to treat superficial tumors in the skin or less than 2 cm deep. The intermediate-deep treatment mode extracts hyperthermal neutrons with energies ranging from 0.5 eV to 10 keV, used to treat tumors 2–10 cm deep. The deep treatment mode extracts hyperthermal neutrons with energies ranging from 1 eV to 40 k eV, used to treat tumors deeper than 10 cm or conditions requiring high beam intensity. Switching between the three treatment modes is simple, requiring only the replacement of the moderator module 20 at a specific location.

[0066] In some embodiments, the reflector 10 includes a detachably connected reflector base 11 and reflector cover 12. The reflector base 11 has a receiving groove adapted to the demodulating module 20. For example, the demodulating module 20 can be a square body, and the receiving groove is a square receiving groove. The reflector base 11 and reflector cover 12 can be connected by screws, snap-fits, or other means. A first demodulating module, a second demodulating module, or a third demodulating module can be placed in the receiving groove according to treatment needs.

[0067] In some embodiments, a receiving groove is formed by the top surface of the reflector 11 recessed towards the bottom surface of the reflector 11, so that the modulator module 20 can be placed into the receiving groove or removed from the receiving groove in a vertical direction.

[0068] In some embodiments, a receiving groove is formed by recessing one side of the reflector seat 11 toward the opposite side of the reflector seat 11, so that the modulator module 20 can be placed into the receiving groove or removed from the receiving groove in a horizontal direction.

[0069] The reflector cover 12 is detachably connected to the reflector base 11. If the performance of the moderator module 20 deteriorates or it becomes damaged, the reflector cover 12 can be removed and the moderator module 20 replaced. This facilitates replacement and reduces maintenance costs. Furthermore, by replacing different types of moderator modules 20, the neutron therapy system can offer multiple treatment modes.

[0070] In the embodiments of this disclosure, the reflector cover 12 and the reflector base 11 are detachably connected, and the reflector cover 12 can be removed to replace the moderator module 20, which not only facilitates replacement but also helps to reduce maintenance costs.

[0071] like Figure 1 , Figure 2 , Figure 5 and Figure 6 As shown, in an optional embodiment, the reflector base 11 is provided with a first receiving groove 111 and a second receiving groove 112 that are interconnected, and the modulator module 20 is disposed in the first receiving groove 111. The reflector cover 12 includes a connecting part 121 and a limiting part 122 disposed on one side of the connecting part 121. The limiting part 122 is located in the second receiving groove 112, and the connecting part 121 covers the opening of the first receiving groove 111. The connecting part 121 is detachably connected to the reflector base 11 through a connector.

[0072] The reflector 10 can be a square, and it consists of two separable reflective parts, defined as a reflector base 11 and a reflector cover 12. The moderating module 20 can be square, and the reflector base 11 is provided with a first receiving groove 111 adapted to the moderating module 20.

[0073] In some embodiments, such as Figure 5 and Figure 6 As shown, the reflector base 11 is stepped, the length of the reflector cover 12 is the same as the length of the reflector base 11, the width of the reflector cover 12 is smaller than the width of the reflector base 11, and the height of the reflector cover 12 is smaller than the height of the reflector base 11. The reflector base 11 has a first top surface 113 and a second top surface 114 arranged parallel to each other in the vertical direction. The first top surface 113 is lower than the second top surface 114, and the first receiving groove 111 is located in the area between the first top surface 113 and the second top surface 114. The length and width of the first receiving groove 111 are adapted to the length and width of the modulating module 20. The modulating module 20 has multiple thickness specifications, and the depth of the first receiving groove 111 is set according to actual needs, so that the first receiving groove 111 can accommodate modulating modules 20 of various thicknesses.

[0074] The reflector base 11 is also provided with a second receiving groove 112. The bottom surface of the second receiving groove 112 is higher than the bottom surface of the first receiving groove 111. One wall surface of the second receiving groove 112 is on the same plane as one wall surface of the first receiving groove 111. The depth of the second receiving groove 112 is less than the depth of the first receiving groove 111.

[0075] like Figure 6As shown, the reflector cover 12 consists of two parts: a connecting portion 121 and a limiting portion 122. The connecting portion 121 is cuboid in shape, and a limiting portion 122 is formed on the side of the connecting portion 121 facing the reflector base 11. The two limiting portions 122 are spaced apart. The distance between the two limiting portions 122 is adapted to the length dimension of the modulating module 20. The length, width, and thickness dimensions of the limiting portion 122 are adapted to the length, width, and depth dimensions of the second receiving groove 112.

[0076] During assembly, the modulator module 20 is first placed in the first receiving groove 111, and then the reflector cover 12 is placed on top of the first receiving groove 111 and the second receiving groove 112. The limiting part 122 of the reflector cover 12 is located at the second receiving groove 112, and the limiting part 122 is in close contact with the groove wall of the second receiving groove 112. The bottom surface of the connecting part 121 is in close contact with the first top surface 113, and the top surface of the connecting part 121 can be flush with the second top surface 114. The width of the reflector cover 12 is smaller than the width of the reflector base 11, which is beneficial to the weight reduction of the reflector cover 12, and thus facilitates the installation and disassembly.

[0077] In some embodiments, such as Figure 5 and Figure 6 As shown, the connecting part 121 is provided with a first connecting hole 1211, the axis of which is horizontal. The first connecting hole 1211 passes through two opposite sides of the connecting part 121 and is a through hole. The reflector base 11 is provided with a second connecting hole 115, which is coaxially arranged with the first connecting hole 1211. The second connecting hole 115 can be a blind hole. The connector includes a connecting rod, which is a columnar body. The connecting rod passes through the first connecting hole 1211 and the second connecting hole 115 to connect the reflector base 11 and the reflector cover 12. Connecting the reflector cover 12 and the reflector base 11 through the connecting rod facilitates assembly and disassembly. The second connecting hole 115 can also be a threaded hole. The connector includes a screw, which passes through the first connecting hole 1211 and is screwed into the second connecting hole 115 to connect the reflector base 11 and the reflector cover 12. Connecting the reflector cover 12 and the reflector base 11 using a screw improves the reliability of the connection and facilitates assembly and disassembly.

[0078] The top surface of the first receiving groove 111 is flush with the first top surface 113 of the reflector seat 11, and the bottom surface of the second receiving groove 112 is lower than the first top surface 113. When the modulating module 20 is placed, the second receiving groove 112 exposes part of the modulating module 20, which is conducive to the convenience of placement; when the modulating module 20 is removed, the second receiving groove 112 exposes part of the modulating module 20, which is conducive to the convenience of removal.

[0079] In some embodiments, the reflector cover 12 and the reflector base 11 can both be regular square bodies. The length dimension of the reflector cover 12 is the same as the length dimension of the reflector base 11, the width dimension of the reflector cover 12 is the same as the width dimension of the reflector base 11, and the height dimension of the reflector cover 12 is smaller than the height dimension of the reflector base 11.

[0080] A first receiving groove 111 is formed by a recess from the top surface of the reflector base 11 towards its bottom surface. The length and width of the first receiving groove 111 are adapted to the length and width of the modulating module 20. A second receiving groove 112 is formed by a recess from one side of the reflector base 11 towards its opposite side, and the second receiving groove 112 communicates with the first receiving groove 111. The bottom surface of the second receiving groove 112 is higher than the bottom surface of the first receiving groove 111, and one wall surface of the second receiving groove 112 is on the same plane as one wall surface of the first receiving groove 111. The depth of the second receiving groove 112 is less than the depth of the first receiving groove 111. A first connecting hole 1211 is provided on the reflector cover 12, with the axis of the first connecting hole 1211 being vertical. A second connecting hole 115 is provided on the reflector base 11, and the second connecting hole 115 is coaxially arranged with the first connecting hole 1211.

[0081] During the assembly process, the modulator module 20 is first placed in the first receiving groove 111, and then the reflector cover 12 is placed on top of the first receiving groove 111 and the second receiving groove 112. After that, the connector is inserted into the first connecting hole 1211 and the second connecting hole 115 to realize the connection between the reflector cover 12 and the reflector base 11.

[0082] In the embodiments of this disclosure, the reflector base 11 is provided with a first receiving groove 111 and a second receiving groove 112 that are interconnected. The first receiving groove 111 is used to place the modulating module 20. During the process of placing or removing the modulating module 20, the second receiving groove 112 allows a part of the modulating module 20 to be exposed. The second receiving groove 112 facilitates the operation when placing or removing the modulating module 20. The width of the reflector cover 12 is smaller than the width of the reflector base 11, which is conducive to the miniaturization and weight reduction of the reflector cover 12, and thus facilitates the assembly and disassembly.

[0083] like Figures 7 to 11 As shown, in an optional embodiment, the moderating module 20 includes a frame 21 and a moderating core 22, with the moderating core 22 disposed within the frame 21. The frame 21 includes a frame body 211, a first connecting plate 212, and a second connecting plate 213. The frame body 211 has a receiving cavity, in which the moderating core 22 is located. The first connecting plate 212 is connected to one side of the frame body 211, and the second connecting plate 213 is connected to the other side of the frame body 211.

[0084] The moderating core 22 can be either solid or liquid. Materials for the moderating core 22 include magnesium fluoride, aluminum fluoride, heavy water, calcium fluoride, and magnesium oxide. The moderating module 20 can be square, the frame 21 can be square, and the moderating core 22 can be cylindrical.

[0085] The frame 21 can be an aluminum alloy frame 21, including 6061 aluminum alloy. The length and width of the frame 21 can be fixed values, and the thickness of the frame 21 is adapted to the thickness of the moderating core 22. For example, the length of the frame 21 can be 400 mm, and the width of the frame 21 can be 400 mm.

[0086] The frame body 211, the first connecting plate 212, and the second connecting plate 213 are provided with through holes adapted to the moderating core 22. After the moderating core 22 passes through the through holes on the frame body 211, the first connecting plate 212 is installed at one end of the frame body 211, and the second connecting plate 213 is installed at the other end of the frame body 211, thereby realizing the assembly of the moderating core 22 and the frame 21.

[0087] In some embodiments, such as Figure 11 As shown, the moderating core 22 is solid, and steps are formed at its opposite ends, resulting in a first end face 221 and a second end face 222 spaced apart at the ends of the moderating core 22. A first through hole 2111 is provided on the frame body 211, forming a receiving cavity for the frame body 211. The diameter of the first through hole 2111 is adapted to the diameter of the main body of the moderating core 22. The first connecting plate 212 is provided with a second through hole 2121 and a limiting groove 2122 communicating with the second through hole 2121. The diameter of the second through hole 2121 is adapted to the diameter at the step, and the diameter of the limiting groove 2122 is adapted to the diameter of the main body of the moderating core 22. The structure of the second connecting plate 213 is the same as that of the first connecting plate 212, and the second connecting plate 213 is provided with a second through hole and a limiting groove communicating with the second through hole.

[0088] During assembly, the moderating core 22 is first passed through the first through hole 2111 on the frame body 211. Then, a first connecting plate 212 and a second connecting plate 213 are respectively installed at both ends of the frame body 211. The outer surface of the first connecting plate 212 can be flush with the first end face 221 of the moderating core 22. The bottom surface of the limiting groove 2122 of the first connecting plate 212 is in contact with the second end face 222 of the moderating core 22. The inner surface of the first connecting plate 212 is in contact with the frame body 211. Then, the first connecting plate 212 and the frame body 211 are connected. The connection method between the second connecting plate 213 and the frame body 211 is the same as that of the first connecting plate 212, thereby realizing the assembly of the moderating core 22 and the frame 21.

[0089] In some embodiments, the first connecting plate 212 and the second connecting plate 213 are connected to the frame body 211 by fasteners. For example, as Figure 9 and Figure 10 As shown, the frame body 211 has a third connecting hole 2112 on two opposite surfaces, and the first connecting plate 212 and the second connecting plate 213 both have a fourth connecting hole 2123. The fourth connecting hole 2123 is adapted to the third connecting hole 2112, and the number of the fourth connecting hole 2123 and the third connecting hole 2112 are the same. For example, there are four third connecting holes 2112 and four fourth connecting holes 2123. The fourth connecting hole 2123 can be a through hole, and the third connecting hole 2112 can be a threaded hole. Fasteners include screws, which are screwed into the fourth connecting holes 2123 and the third connecting holes 2112 to achieve screw connection between the first connecting plate 212 and the second connecting plate 213 and the frame body 211.

[0090] In some embodiments, the moderating core 22 is a liquid. The first connecting plate 212 and the second connecting plate 213 do not require through holes for the moderating core 22 to pass through. The first connecting plate 212 and the second connecting plate 213 can be connected to the frame body 211 via fasteners. The frame body 211 has three third connecting holes 2112 on two opposing surfaces, and both the first connecting plate 212 and the second connecting plate 213 have fourth connecting holes 2123. The first connecting plate 212 can be assembled with the frame body 211 first, forming a receiving cavity. The cavity is filled with the liquid moderating core 22. After filling, the second connecting plate 213 is connected to the frame body 211, thereby assembling the moderating core 22 and the frame 21.

[0091] In the embodiments of this disclosure, the frame 21 includes a frame body 211, a first connecting plate 212, and a second connecting plate 213. Regardless of whether the moderating core 22 is solid or liquid, the combination of the three can facilitate the assembly of the moderating core 22 and the frame 21, which is beneficial to the ease of preparation of the moderating module 20.

[0092] In an optional embodiment, a positioning structure is provided between the frame 21 and the reflector seat 11. The positioning structure includes a positioning groove 116 and a positioning element 214. One of the positioning groove 116 and the positioning element 214 is provided in the frame 21, and the other is provided in the reflector seat 11.

[0093] In some embodiments, such as Figure 12As shown, the bottom surface of the first receiving groove 111 of the reflector base 11 is provided with a positioning groove 116. A positioning element 214 is provided on the bottom surface of the frame body 211. The positioning element 214 includes a positioning rod and a positioning post, and the positioning element 214 is adapted to the positioning groove 116. During the vertical hoisting of the modulating module 20, the positioning element 214 is inserted into the positioning groove 116 to position the modulating module 20, preventing the modulating module 20 from shaking or moving within the first receiving groove 111.

[0094] In some embodiments, a positioning element 214 is provided on the bottom surface of the first receiving groove 111 of the reflector seat 11. The positioning element 214 includes a positioning rod and a positioning post. A positioning groove 116 is provided on the bottom surface of the frame body 211, and the positioning element 214 is adapted to the positioning groove 116. During the vertical hoisting of the moderation module 20, the positioning element 214 is inserted into the positioning groove 116 to achieve positioning of the moderation module 20 and prevent the moderation module 20 from shaking or moving in the first receiving groove 111.

[0095] In the embodiments of this disclosure, the first receiving groove 111 needs to be able to install modulating modules 20 of various thicknesses. The groove depth of the first receiving groove 111 is usually greater than the thickness of the modulating module 20. The modulating module 20 and the reflector seat 11 are positioned by a positioning structure, which can ensure the accuracy of the position of the modulating module 20 in the reflector 10.

[0096] like Figure 6 , Figure 8 and Figure 9 As shown, in an optional embodiment, the reflective cover 12 is provided with a first lifting hole 1212 and / or the frame 21 is provided with a second lifting hole 2113.

[0097] The number of first lifting holes 1212 is not specifically limited. For example, there may be four first lifting holes 1212, spaced apart on the top surface of the reflector cover 12. The first lifting holes 1212 may be threaded holes. The reflector cover 12 can be lifted using a lifting tool, which includes eye bolts. The four eye bolts are screwed into the four first lifting holes 1212 one by one. The reflector cover 12 can then be lifted or placed in the first receiving groove 111 and the second receiving groove 112 of the reflector base 11, which facilitates the installation and removal of the reflector cover 12.

[0098] The number of second lifting holes 2113 is not specifically limited. For example, there may be four second lifting holes 2113, spaced apart on the top surface of the frame body 211. These second lifting holes 2113 can be threaded holes. The modulating module 20 can be lifted using a lifting device. The lifting device includes eye bolts; four eye bolts are screwed into each of the four second lifting holes 2113, and the modulating module 20 is then placed into or removed from the reflector base 11 using the lifting device. This facilitates the installation and removal of the modulating module 20.

[0099] The following is a detailed description of the installation and disassembly process of the moderating module 20.

[0100] The installation process is as follows: First, screw the lifting ring to the first lifting hole 1212 on the frame 21 of the modulator module 20. Then, use a lifting tool to lift the modulator module 20 into the first receiving groove 111 of the reflector base 11. Next, remove the lifting ring from the frame 21. Then, screw the lifting ring to the second lifting hole 2113 on the reflector cover 12. Use a lifting tool to lift the reflector cover 12 to the reflector base 11, so that the limiting part 122 is located in the second receiving groove 112. Then, remove the lifting ring from the connecting part 121. Finally, insert the connector into the first connecting hole 1211 of the reflector cover 12 and the second connecting hole 115 of the reflector base 11, thereby assembling the reflector base 11, the modulator module 20, and the reflector cover 12.

[0101] The disassembly process is as follows: First, disassemble the connector between the reflector cover 12 and the reflector base 11. Then, screw the lifting ring into the second lifting hole 2113 on the reflector cover 12, and use a lifting tool to remove the reflector cover 12 from above the reflector base 11, removing the lifting ring from the reflector cover 12. Next, screw the lifting ring into the first lifting hole 1212 on the frame 21 of the modulator module 20, and use a lifting tool to remove the modulator module 20 from the first receiving groove 111 of the reflector base 11, removing the lifting ring from the frame 21, thereby removing the modulator module 20.

[0102] In an optional embodiment, the modulator module 20 includes a first modulator module, a second modulator module, and a third modulator module, any one of which can be detachably connected to the reflector 10.

[0103] The first, second, and third moderator modules differ in materials and dimensions. The neutron beam generated by the target, after being moderated by the three moderator modules, produces neutrons with different energies.

[0104] For example, after the neutron beam is slowed down by the first moderator module, a first neutron beam is obtained, with an energy less than or equal to 0.5 eV. The first neutron beam mainly consists of thermal neutrons, and its half-value depth is less than or equal to 2 cm, making it suitable for treating superficial tumors of the skin, oral mucosa, or within 2 cm of depth. In other words, the first neutron beam is suitable for superficial treatment.

[0105] After being slowed down by the second moderator module, the neutron beam becomes a second neutron beam with an energy range of 0.5 eV to 10 kilovolts. This second neutron beam primarily consists of hyperthermal neutrons, also with an energy range of 0.5 eV to 10 kilovolts. After being slowed down by human tissue, these hyperthermal neutrons create a thermal neutron flux peak at a depth of 2–7 cm, maintaining a therapeutic dose within 10 cm. This method is suitable for treating gliomas, head and neck tumors, and tumors at depths of 2–10 cm. In other words, the second neutron beam is suitable for mid-to-deep treatment modalities.

[0106] After being slowed down by the third moderator module, the neutron beam becomes the third neutron beam, with an energy range of 1 eV to 40 kilovolts. The third neutron beam mainly consists of hyperthermal neutrons, which also have an energy range of 1 eV to 40 kilovolts. Through deep moderation, the thermal neutron flux remains above 1*10^6 volts at depths of 2–12 cm. 9 With a beam density of n / cm² / s, this method is suitable for treating deep-seated tumors, particularly those deeper than 10 cm, or for conditions requiring high beam intensity. In other words, the third neutron beam is suitable for deep-treatment modes.

[0107] This allows for the extraction of three neutron beams within a single neutron therapy system, corresponding to three energy bands: thermal neutron, ultrathermal neutron, and higher energy. The structure of the moderator module 20 and the reflector 10 enables the neutron therapy system to combine the characteristics of outputting multiple energy spectra with low cost, allowing for three treatment modes: shallow, intermediate-deep, and deep treatment.

[0108] The moderating module 20 is detachably connected to the reflector 10. Depending on the treatment area and requirements, the appropriate moderating module 20 is installed in the reflector 10. By replacing the moderating module 20, multiple treatment modes can be implemented on a single neutron therapy system, providing a wide treatment depth coverage, achieving dose distribution from the epidermis to a depth of 12 cm.

[0109] In the embodiments of this disclosure, the neutron therapy system includes multiple moderator modules 20. By replacing the moderator modules 20, neutron beams with multiple energy spectra can be generated. The multiple neutron beams enable the neutron therapy system to have multiple treatment modes, thereby enabling the neutron therapy system to have both multiple treatment modes and low cost.

[0110] In an optional embodiment, the first moderator module includes a heavy water moderator module 20, wherein the thickness of the moderator core 22 of the heavy water moderator module 20 is 180-220 mm.

[0111] Monte Carlo simulations determined the thickness of the heavy water moderator module 20 to be 180–220 mm. Using the heavy water moderator module 20, its low atomic number characteristics reduce neutron energy to below 0.025 eV, generating a first neutron beam with a beam half-value depth of less than or equal to 2 cm, making it suitable for treating superficial tumors of the skin, oral mucosa, or within 2 cm in depth.

[0112] In some embodiments, the thickness of the heavy water moderating core 22 is 200 mm. The fabrication process of the heavy water moderating module 20 is described below.

[0113] The frame body 211, the first connecting plate 212, and the second connecting plate 213 can be made of aluminum alloy. The frame body 211 has a first through hole 2111 for containing heavy water, while the first connecting plate 212 and the second connecting plate 213 do not have through holes. The frame body 211 has a length of 400 mm, a width of 400 mm, and a thickness slightly greater than 200 mm. The thickness of the first connecting plate 212 and the second connecting plate 213 can be 5 mm. The first connecting plate 212 and the frame body 211 are connected by fasteners, forming a cavity for containing heavy water. The cavity is filled with heavy water to a depth of 200 mm. Then, the second connecting plate 213 is connected to the frame body 211 by fasteners. This completes the fabrication of the heavy water moderating module 20.

[0114] In some embodiments, the heavy water moderating module 20 employs a double-layer sealing structure. Polytetrafluoroethylene (PTFE) is coated on the wall surface of the first through-hole 2111 of the frame body 211, the inner surface of the first connecting plate 212, and the inner surface of the second connecting plate 213, forming a 1 mm thick PTFE layer on the inner wall surface of the frame 21. This improves the sealing performance of the frame 21, preventing heavy water leakage and contamination. The thickness of the PTFE layer is not specifically limited.

[0115] The thickness of the heavy water moderating core 22 can be 180 mm or 220 mm. Based on the simulated thickness of the heavy water moderating core 22, a frame body 211 of the corresponding thickness is prepared, and the heavy water moderating core 22 is filled in the frame 21 to prepare the heavy water moderating module 20 of the required thickness.

[0116] The heavy water moderator module 20 enables the neutron therapy system to have a superficial treatment mode, suitable for treating superficial tumors of the skin, oral mucosa, or up to 2 cm in depth.

[0117] In an optional embodiment, the second moderator module includes a magnesium fluoride moderator module 20, wherein the thickness of the moderator core 22 of the magnesium fluoride moderator module 20 is 200-250 mm.

[0118] Monte Carlo simulations determined the thickness of the magnesium fluoride moderator module 20 to be 200–250 mm. Using the magnesium fluoride moderator module 20, a second neutron beam is generated. This second neutron beam primarily consists of hyperthermal neutrons with an energy range of 0.5 eV to 10 kilovolts. After being moderated by human tissue, the beam forms a thermal neutron flux peak at a depth of 2–7 cm, maintaining a therapeutic dose within 10 cm. This method is suitable for treating gliomas, head and neck tumors, and tumors at depths of 2–10 cm.

[0119] In some embodiments, the thickness of the magnesium fluoride moderator core 22 is 220 mm. The preparation process of the magnesium fluoride moderator module 20 is described below.

[0120] The frame body 211, the first connecting plate 212, and the second connecting plate 213 can be made of aluminum alloy. The frame body 211 has a first through hole 2111 for accommodating the magnesium fluoride moderator core 22, and the first connecting plate 212 and the second connecting plate 213 have second through holes 2121 for accommodating the magnesium fluoride moderator core 22. The length and width of the frame body 211, the first connecting plate 212, and the second connecting plate 213 can all be 400 mm. The thickness of the frame body 211 can be 210 mm, and the thickness of the first connecting plate 212 and the second connecting plate 213 can be 5 mm. The magnesium fluoride moderator core 22 is passed through the first through hole 2111 of the frame body 211. Then, the first connecting plate 212 is installed on one side of the frame body 211 using fasteners, and the second connecting plate 213 is installed on the other side of the frame body 211 using fasteners, thus completing the fabrication of the magnesium fluoride moderator module 20.

[0121] The thickness of the magnesium fluoride moderator core 22 can be 200 mm or 250 mm. Based on the simulated thickness of the magnesium fluoride moderator core 22, a frame 21 of the corresponding thickness is prepared, and the magnesium fluoride moderator core 22 is installed on the frame 21, thereby preparing the magnesium fluoride moderator module 20 of the required thickness.

[0122] The magnesium fluoride moderator module 20 enables the neutron therapy system to have a mid-to-deep treatment mode, suitable for treating tumors at a depth of 2 to 10 cm.

[0123] In an optional embodiment, the third moderator module includes an aluminum fluoride moderator module 20, wherein the thickness of the moderator core 22 of the aluminum fluoride moderator module 20 is 120-180 mm.

[0124] Monte Carlo simulations determined the thickness of the aluminum fluoride moderator module 20 to be 120–180 mm. The aluminum fluoride moderator module 20 was selected to utilize its moderation cross-section characteristics to retain a portion of the fast neutron component, generating 1 eV–40 kHz hyperthermal neutrons and producing a third neutron beam. Through the deep moderation effect, the thermal neutron flux remained above 1 × 10⁻⁶ at depths of 2–12 cm. 9 n / cm² / s, suitable for treating deep tumors, tumors deeper than 10 cm or conditions requiring high treatment beam intensity.

[0125] In some embodiments, the thickness of the aluminum fluoride moderator core 22 is 160 mm. The preparation process of the aluminum fluoride moderator module 20 is described below.

[0126] The frame body 211, the first connecting plate 212, and the second connecting plate 213 can be made of aluminum alloy. The frame body 211 has a first through hole 2111 for accommodating the aluminum fluoride moderating core 22, and the first connecting plate 212 and the second connecting plate 213 have second through holes 2121 for accommodating the aluminum fluoride moderating core 22. The length and width of the frame body 211, the first connecting plate 212, and the second connecting plate 213 can all be 400 mm. The thickness of the frame body 211 can be 150 mm, and the thickness of the first connecting plate 212 and the second connecting plate 213 can be 5 mm. The aluminum fluoride moderating core 22 is passed through the first through hole 2111 of the frame body 211. Then, the first connecting plate 212 is installed on one side of the frame body 211 using fasteners, and the second connecting plate 213 is installed on the other side of the frame body 211 using fasteners, thereby completing the fabrication of the aluminum fluoride moderating module 20.

[0127] The thickness of the aluminum fluoride moderating core 22 can be 120 mm or 180 mm. Based on the simulated thickness of the aluminum fluoride moderating core 22, a frame 21 of the corresponding thickness is prepared, and the aluminum fluoride moderating core 22 is installed on the frame 21, thereby preparing the aluminum fluoride moderating module 20 of the required thickness.

[0128] The aluminum fluoride moderator module 20 enables the neutron therapy system to have a deep treatment mode, suitable for treating tumors deeper than 10 cm.

[0129] The thickness of the heavy water modulator module 20 is 180-220 mm, the thickness of the magnesium fluoride modulator module 20 is 200-250 mm, and the thickness of the aluminum fluoride modulator module 20 is 120-180 mm. It is understood that the depth of the first receiving groove 111 on the reflector mount 11 is greater than 250 mm, thus allowing the heavy water modulator module 20, magnesium fluoride modulator module 20, and aluminum fluoride modulator module 20 to all be installed in the first receiving groove 111.

[0130] like Figure 4 As shown, in an optional embodiment, the neutron therapy system further includes a filter 60, which is detachably disposed between the filter 30 and the collimator 40.

[0131] The filter 60 is made of a thermal neutron absorbing material, for example, lithium 6. The thickness of the filter 60 is set according to actual needs; for example, the thickness of the filter 60 can be 100 micrometers. The filter 60 can selectively filter the low-energy components in the ultrathermal neutron beam, ensuring that the ratio of ultrathermal neutrons to thermal neutrons is greater than or equal to 20. A gap exists between the filter 30 and the collimator 40, the gap being adapted to the thickness of the filter 60.

[0132] When performing superficial treatment, filter 60 is removed. When performing intermediate and deep treatment, filter 60 is placed between filter 30 and collimator 40, which helps to improve the treatment effect of intermediate and deep treatment.

[0133] In an optional embodiment, the neutron therapy system further includes a pressure sensing module capable of identifying the type of the current moderator module 20. For example, the pressure sensing module can identify the type of the moderator module 20 by weight, ensuring safe use.

[0134] The material of the moderator core 22 of the moderator module 20 may also include calcium fluoride, magnesium oxide, etc. By replacing the moderator module 20, neutron beams with different energy spectra can be extracted.

[0135] The neutron beam modulation method for a neutron therapy system for boron neutron capture therapy disclosed herein includes:

[0136] Based on the treatment parameters, select the first, second, or third modulatory module that is compatible with the treatment parameters;

[0137] The first, second, or third moderator module, which is adapted to the treatment parameters, is installed in the reflector 10 of the neutron therapy system.

[0138] Align the collimator 40 of the neutron therapy system with the treatment area and start the neutron therapy system;

[0139] The first moderator module is used to moderate the neutron beam generated by the neutron target module 50 to generate a first neutron beam, the energy of which is less than 0.5 eV.

[0140] The second moderator module is used to moderate the neutron beam generated by the neutron target module 50 to generate a second neutron beam with an energy range of 0.5 eV to 10 k eV.

[0141] The third moderator module is used to moderate the neutron beam generated by the neutron target module 50 to generate a third neutron beam with an energy range of 1 eV to 40 k eV.

[0142] As shown above, the neutron therapy system includes a reflector 10, a neutron target module 50 mounted on the reflector 10, a moderator module 20, a filter 30, and a collimator 40. The moderator module 20 is detachably mounted in the reflector 10. The neutron therapy system can be equipped with multiple moderator modules 20, and the moderator cores 22 of the multiple moderator modules 20 have different materials and thicknesses. For example, there may be three moderator modules 20, namely a heavy water moderator module 20, a magnesium fluoride moderator module 20, and an aluminum fluoride moderator module 20.

[0143] Based on parameters such as the location and depth of the patient's tumor, a superficial treatment mode is selected. The heavy water moderator module 20 is placed in the first receiving slot 111 of the reflector base 11, and the reflector cover 12 is placed on top. The reflector cover 12 and the reflector base 11 are connected via connectors. The neutron therapy system is activated. The neutron beam generated by the neutron target module 50 is moderated by the heavy water moderator module 20, producing a first neutron beam with an energy less than or equal to 0.5 eV. After being filtered by the filter 30 and collimated by the collimator 40, the first neutron beam is directed to the patient's tumor area. This method is suitable for treating superficial tumors of the skin, oral mucosa, or within 2 cm in depth.

[0144] Based on parameters such as the location and depth of the patient's tumor, a mid-to-deep treatment mode is selected for treatment. First, the reflector cover 12 is lifted and removed using a hoist. Then, the heavy water moderator module 20 is lifted out of the first receiving tank 111 using the same hoist. Next, the magnesium fluoride moderator module 20 is lifted into the first receiving tank 111 using the same hoist. Finally, the reflector cover 12 is lifted to the reflector base 11 using the same hoist, and the reflector cover 12 and reflector base 11 are connected using a connector. The neutron therapy system is then activated. The neutron beam generated by the neutron target module 50 is moderated by the magnesium fluoride moderator module 20, generating a second neutron beam with an energy range of 0.5 eV to 10 k eV. After being filtered by the filter 30 and collimated by the collimator 40, the second neutron beam is directed to the patient's tumor area, suitable for treating tumors at depths of 2 to 10 cm.

[0145] Based on parameters such as the location and depth of the patient's tumor, a deep treatment mode is selected for treatment. First, the reflector cover 12 is lifted and removed using a lifting device. Then, the magnesium fluoride moderator module 20 is lifted out of the first receiving slot 111 using the same device. Next, the aluminum fluoride moderator module 20 is lifted into the first receiving slot 111 using the same device. Finally, the reflector cover 12 is lifted to the reflector base 11 using the same device, and the reflector cover 12 and reflector base 11 are connected using a connector. The neutron therapy system is then activated. The neutron beam generated by the neutron target module 50 is moderated by the aluminum fluoride moderator module 20, producing a third neutron beam. The energy range of the third neutron beam is 1 eV to 40 k eV. After being filtered by the filter 30 and collimated by the collimator 40, the third neutron beam is directed to the patient's tumor area, suitable for treating tumors deeper than 10 cm.

[0146] When using different treatment modes, only the slowing body module 20 needs to be replaced. Each replacement of the slowing body module 20 takes less than 15 minutes, making the replacement convenient.

[0147] By replacing the moderator module 20, the neutron beam can be controlled, and multiple moderation requirements can be met in a single neutron therapy system, enabling the extraction of multiple energy spectra. At the same time, it is low-cost and easy to replace.

[0148] The above description is merely a specific embodiment of this disclosure, but the scope of protection of this application is not limited thereto. Any changes or substitutions made within the spirit and principles of this disclosure should be covered within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.

Claims

1. A neutron therapy system for boron neutron capture therapy, characterized in that, include: The reflector has a receiving cavity for accommodating the neutron target module. A moderator module is disposed in the reflector and located on one side of the neutron target module; A filter is disposed within the reflector and located on the side of the moderator module opposite to the neutron target module; and A collimator is located on the side of the filter opposite to the modulator module; The reflector includes a detachably connected reflector base and reflector cover, so that the moderating module can be detachably connected to the reflector.

2. The neutron therapy system according to claim 1, characterized in that, The reflector base is provided with a first receiving slot and a second receiving slot that are interconnected, and the moderating module is disposed in the first receiving slot. The reflective cover includes a connecting portion and a limiting portion disposed on one side of the connecting portion. The limiting portion is located in the second receiving groove, and the connecting portion covers the opening of the first receiving groove. The connecting portion is detachably connected to the reflective base via a connector.

3. The neutron therapy system according to claim 2, characterized in that, The connecting part is provided with a first connecting hole, and the reflector base is provided with a second connecting hole. The second connecting hole is provided in correspondence with the first connecting hole, and the first connecting hole and the second connecting hole are connected by the connector.

4. The neutron therapy system according to claim 1, characterized in that, The moderating module includes: frame; A slowing core is disposed within the frame; The framework includes: The frame body has a receiving cavity, and the moderating core is located in the receiving cavity; A first connecting plate is connected to one side of the frame body; and The second connecting plate is connected to the other side of the frame body.

5. The neutron therapy system according to claim 4, characterized in that, A positioning structure is provided between the frame and the reflector base. The positioning structure includes a positioning groove and a positioning element. One of the positioning groove and the positioning element is located in the frame, and the other is located in the reflector base.

6. The neutron therapy system according to claim 4, characterized in that, The reflective cover is provided with a first lifting hole; and / or The frame is provided with a second lifting hole.

7. The neutron therapy system according to any one of claims 1-6, characterized in that, The moderating module includes a first moderating module, a second moderating module, and a third moderating module, any one of which can be detachably connected to the reflector.

8. The neutron therapy system according to claim 7, characterized in that, The first moderator module includes a heavy water moderator module; The thickness of the moderating core of the heavy water moderating module is 180~220 mm.

9. The neutron therapy system according to claim 7, characterized in that, The second moderator module includes a magnesium fluoride moderator module; The thickness of the moderating core of the magnesium fluoride moderator module is 200-250 mm.

10. The neutron therapy system according to claim 7, characterized in that, The third moderator module includes an aluminum fluoride moderator module; The thickness of the moderating core of the aluminum fluoride moderator module is 120~180 mm.

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