A patch with antibacterial and anti-inflammatory effects
By combining nano-silver ion antibacterial fibers and drug sustained-release technology into the dressing, and designing a flexible base layer and porous structure, the problems of poor antibacterial effect, uneven drug release, poor breathability and insufficient adhesion of existing dressings are solved, achieving highly efficient antibacterial, continuous drug release and stable adhesion, and promoting wound healing.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- 翟宇佳
- Filing Date
- 2025-04-11
- Publication Date
- 2026-06-26
Smart Images
Figure CN224404025U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of medical protective patches, specifically a protective patch with antibacterial and anti-inflammatory properties. Background Technology
[0002] With the improvement of modern living standards and the advancement of medical technology, people's demand for wound care products is constantly increasing. Especially in the field of wound care, antibacterial and anti-inflammatory wound dressings have broad application prospects.
[0003] Traditional wound care products, such as bandages and regular dressings, while providing basic protection and bandaging, often lack effective antibacterial and anti-inflammatory properties. They cannot effectively prevent wound infection, prolong healing time, and may even cause secondary infections. Therefore, wound dressings with antibacterial and anti-inflammatory functions have emerged.
[0004] In recent years, advancements in nanotechnology and medical materials have opened up more possibilities for the development of novel wound dressings. Nano-silver ions, due to their excellent antibacterial properties and biocompatibility, have become a hot topic in antibacterial material research. Meanwhile, the development of drug sustained-release technology allows for the slow release of drugs under specific conditions, thus providing a sustained therapeutic effect. Furthermore, humidity sensing technology can reflect the wound condition in real time, helping to adjust care strategies promptly and improve nursing outcomes.
[0005] Against this backdrop, this invention proposes a protective patch with antibacterial and anti-inflammatory functions. This patch combines multiple advanced technologies, including nano-silver ion antibacterial fibers, a drug-releasing layer, and a humidity-sensing layer, aiming to provide a wound care product that can effectively prevent infection and promote wound healing.
[0006] Inadequacy of existing technology
[0007] While there is a wide variety of existing antibacterial and anti-inflammatory patches, they still have some shortcomings in practical use:
[0008] 1. Limited antibacterial effect: Although some skin care patches claim to be antibacterial, their antibacterial effect is limited and they cannot effectively kill a variety of bacteria, especially the stubborn bacteria such as Staphylococcus aureus.
[0009] 2. Uneven drug release: Traditional sustained-release drug technology often cannot precisely control the drug release rate, resulting in unstable drug concentration and affecting the treatment effect.
[0010] 3. Poor breathability: The breathability of the liner directly affects the wound healing speed. Some liners have poor breathability, which can easily cause stuffiness, dampness and other problems, which are not conducive to wound recovery.
[0011] 4. Insufficient Adhesion: The adhesive properties of the dressing are crucial for its stability at the wound site. Some dressings lose adhesion significantly when exposed to wound exudate, causing them to fall off or shift, thus affecting the effectiveness of care. Utility Model Content
[0012] In view of the above-mentioned shortcomings in the existing technology, the purpose of this utility model is to provide a protective patch that is stable in adhesion, breathable, has stable drug release, and has antibacterial and anti-inflammatory properties.
[0013] The technical solution adopted by this utility model to achieve the above-mentioned objectives is: a protective patch with antibacterial and anti-inflammatory properties, comprising, from the outside to the inside, a flexible base layer, a humidity sensing layer, a drug sustained-release layer, an adsorption layer, a skin-friendly adhesive layer, and a release protective layer, stacked sequentially.
[0014] The flexible substrate layer is formed by hot pressing medical-grade non-woven fabric and nano silver ion antibacterial fiber. Its surface has regularly distributed breathable micropores with a pore size of 50-200μm and a pore density of 20-50 pores / cm².
[0015] The humidity sensing layer is composed of a pH-sensitive color-changing material and polyvinyl alcohol in a ratio of 1:3 to 1:5, and is attached to the inner surface of the flexible substrate layer.
[0016] The drug sustained-release layer contains a chitosan hydrogel matrix with a drug loading of 5-15 wt%, and embeds several microcapsule structures inside. The microcapsule structures include 0.5-3% berberine extract, 0.1-0.5% borneol nanospheres, and ozone oil microcapsules.
[0017] The adsorption layer is a porous carbon fiber with a through-hole microporous channel on its surface.
[0018] The skin-friendly adhesive layer covers the edge of the adsorption layer and is made of a low-allergenic colloidal material with a breathable groove structure at the edge.
[0019] The release protective layer adopts a double-sided release paper structure, including a central release area and an edge gripping area. The central release area is positioned opposite to the entire flexible substrate layer, and the edge gripping area is located outside the edge of the flexible substrate layer. The central release area is coated with an organosilicon release agent.
[0020] In the above technical solution, the silver content of the nano-silver ion antibacterial fiber is 0.02-0.1wt%, the fiber diameter is 10-50μm, and the surface is formed by plasma etching to form a nano-groove structure with a depth of 50-200nm and a width of 100-500nm.
[0021] In the above technical solution, the berberine extract is microencapsulated and uniformly distributed in a chitosan hydrogel matrix, with the capsule wall material being ethyl cellulose and a wall thickness of 5-15 μm.
[0022] In the above technical solution, the borneol nanospheres are prepared by high-pressure homogenization, with a particle size distribution of 100-500 nm, and are loaded in a mesoporous silica carrier with a carrier pore size of 4-10 nm.
[0023] In the above technical solution, the edge of the flexible substrate extends to form an annular pressure-sensitive adhesive layer, which is composed of acrylic medical adhesive and polyisobutylene in a ratio of 3:1 to 5:1, and the thickness of the annular pressure-sensitive adhesive layer is 50-150μm.
[0024] In the above technical solution, 1-5% of menthol microspheres are added to the annular pressure-sensitive adhesive layer. The wall material of the microspheres is a gelatin-gum arabic composite wall material with a particle size of 10-30μm, and they are uniformly distributed in the pressure-sensitive adhesive layer.
[0025] In the above technical solution, the through-hole micropore channels on the adsorption layer are arranged in a hexagonal honeycomb pattern, the center distance between adjacent micropores is 1.5-2 times the pore diameter, and the pore diameter of the micropore channels is 10-50μm.
[0026] In the above technical solution, the skin-friendly adhesive layer contains gelatin microspheres or aloe vera nanofibers loaded with vitamin E, wherein the gelatin microspheres have a particle size of 10-50 μm and the aloe vera nanofibers have a diameter of 100-500 nm.
[0027] In the above technical solution, the ozone oil microcapsules adopt a double-layer coating structure, with the inner layer being a sodium alginate-chitosan composite membrane and the outer layer being polylactic acid. The total wall thickness is 10-20 μm, and the particle size range is 50-200 μm. The mass ratio of the ozone oil microcapsules to the berberine extract is 1:1-1:3.
[0028] In the above technical solution, the outer surface of the ozone oil microcapsule is loaded with a pH-responsive polymer, which is a dimethylaminoethyl methacrylate-methacrylic acid copolymer, which swells and releases under pH>7.5 conditions.
[0029] The beneficial effects of this utility model are:
[0030] Highly effective antibacterial: It is made of medical-grade non-woven fabric and nano silver ion antibacterial fiber. Nano silver ions can effectively inhibit a variety of common bacteria, with an antibacterial rate of 99.2% against Staphylococcus aureus.
[0031] Continuous drug release: Under the action of the humidity sensing layer, the drug sustained-release layer can continuously release drugs according to changes in wound humidity, prolonging the drug's action time and promoting wound healing.
[0032] Excellent breathability: The flexible base layer has regularly distributed breathable micropores with a pore size of 50-200μm, ensuring that the patch has good breathability and preventing wound infection due to heat and moisture.
[0033] Stable Adhesion Performance: The ring-shaped pressure-sensitive adhesive layer is composed of acrylic medical adhesive and polyisobutylene, with added menthol microspheres, providing not only excellent adhesion but also a cool and comfortable user experience. It maintains stable adhesion even under the influence of wound exudate. Attached Figure Description
[0034] Figure 1 This is a three-dimensional structural diagram of the present invention;
[0035] Figure 2 This is a three-dimensional disassembled structural diagram of the present invention;
[0036] Figure 3 This is a schematic diagram of the cross-sectional connection structure of this utility model.
[0037] In the diagram: 1 Flexible base layer, 2 Humidity sensing layer, 3 Drug sustained-release layer, 4 Adsorption layer, 5 Skin-friendly adhesive layer, 6 Release protective layer, 7 Circular pressure-sensitive adhesive layer, 8 Berberine extract, 9 Borneol nanospheres, 10 Menthol microspheres, 11 Ozone oil microcapsules. Detailed Implementation
[0038] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0039] Example 1: Overall Structure and Material Analysis of the Patches
[0040] Please see Figure 1-3 A protective patch with antibacterial and anti-inflammatory properties includes a flexible base layer 1, a humidity sensing layer 2, a drug sustained-release layer 3, an adsorption layer 4, a skin-friendly adhesive layer 5, and a release protective layer 6, which are stacked sequentially from the outside to the inside.
[0041] The flexible substrate 1 is formed by hot pressing medical-grade non-woven fabric and nano silver ion antibacterial fiber. Its surface has regularly distributed breathable micropores with a pore size of 50-200μm and a pore density of 20-50 pores / cm2. The nano silver ion antibacterial fiber has a silver content of 0.02-0.1wt% and a fiber diameter of 10-50μm. Its surface is formed by plasma etching to form a nanogroove structure with a depth of 50-200nm and a width of 100-500nm.
[0042] The humidity sensing layer 2 is composed of a pH-sensitive color-changing material and polyvinyl alcohol in a ratio of 1:3 to 1:5, and is attached to the inner surface of the flexible substrate layer 1. The pH-sensitive color-changing material is bromocresol purple.
[0043] The drug-release layer 3 comprises a chitosan hydrogel matrix with a drug loading of 5-15 wt%, and internally encapsulates 0.5-3% berberine extract 8, 0.1-0.5% borneol nanospheres 9, and ozone oil microcapsules 11. The berberine extract 8 is microencapsulated and uniformly distributed within the chitosan hydrogel matrix, with ethyl cellulose as the capsule wall material and a wall thickness of 5-15 μm. The borneol nanospheres 9 are prepared using a high-pressure homogenization method, with a particle size distribution of 100-500 nm, and are loaded onto a mesoporous silica carrier. The carrier has a pore size of 4-10 nm; the ozone oil microcapsules 11 adopt a double-layer coating structure, with an inner layer of sodium alginate-chitosan composite membrane and an outer layer of polylactic acid, with a total wall thickness of 10-20 μm and a particle size range of 50-200 μm. The mass ratio of ozone oil microcapsules 11 to berberine extract 8 is 1:1-1:3; the outer surface of the ozone oil microcapsules 11 is loaded with a pH-responsive polymer, which is a dimethylaminoethyl methacrylate-methacrylic acid copolymer, which swells and releases under pH>7.5 conditions.
[0044] In this invention, ozone reacts with glycerol to form an ozone complex. Ozone, with its strong oxidizing properties, oxidizes the unsaturated fatty acids in glycerol, generating a new, unstable glycerol trimolecular ozone complex. Specifically, ozone reacts with the unsaturated fatty acids in glycerol to form highly pure ozone oil, which is then microencapsulated to form ozone oil microcapsules 11.
[0045] The adsorption layer 4 is a porous carbon fiber with a through-hole micropore channel on its surface. The through-hole micropore channel on the adsorption layer 4 is arranged in a hexagonal honeycomb pattern, with the center distance between adjacent micropores being 1.5-2 times the pore diameter, and the pore diameter of the micropore channel being 10-50 μm.
[0046] The skin-friendly adhesive layer 5 covers the edge of the adsorption layer 4. It is made of a low-allergenic colloidal material and has a breathable groove structure on the edge. The skin-friendly adhesive layer 5 contains gelatin microspheres or aloe vera nanofibers loaded with vitamin E. The gelatin microspheres have a particle size of 10-50 μm and the aloe vera nanofibers have a diameter of 100-500 nm.
[0047] The release protective layer 6 adopts a double-sided release paper structure, including a central release area and an edge gripping area. The central release area is set opposite to the entire flexible substrate layer 1, and the edge gripping area is located outside the edge of the flexible substrate layer 1. The central release area is coated with an organosilicon release agent.
[0048] In one embodiment of this utility model, the edge of the flexible substrate layer 1 extends to form an annular pressure-sensitive adhesive layer 7. The annular pressure-sensitive adhesive layer 7 is composed of acrylic medical adhesive and polyisobutylene in a ratio of 3:1 to 5:1, and the thickness of the annular pressure-sensitive adhesive layer 7 is 50-150μm. 1-5% of menthol microspheres 10 are added to the annular pressure-sensitive adhesive layer 7. The wall material of the microspheres is a gelatin-gum arabic composite wall material with a particle size of 10-30μm, and they are uniformly distributed in the pressure-sensitive adhesive layer.
[0049] Example 2: Preparation of Basic Type of Patches
[0050] Step 1: Preparation of flexible substrate 1
[0051] 1. Raw material processing:
[0052] Medical-grade nonwoven fabric (20 g / m2) and nano silver ion antibacterial fiber (0.05 wt% silver content, 30 μm fiber diameter) were mixed at a mass ratio of 7:3.
[0053] The silver nanofibers were pretreated with plasma (200W power, 5min) to form a groove structure with a depth of about 100nm and a width of 300nm on the surface.
[0054] 2. Hot-pressing composite:
[0055] The mixed materials were pressed into a composite layer with a thickness of 0.2 mm using a two-roll hot press (temperature 150℃, pressure 5MPa).
[0056] A permeable micropore with a diameter of 100μm and a pore density of 30 pores / cm2 is formed on the surface by laser drilling.
[0057] Step 2: Composite of humidity sensing layer 2
[0058] 1. Material preparation:
[0059] Bromocresol purple (pH-sensitive color-changing material) and polyvinyl alcohol (PVA-1788) were dissolved in deionized water at a ratio of 1:4 and stirred to form a homogeneous solution.
[0060] 2. Film forming process:
[0061] The solution was coated on the inner surface of the flexible substrate 1 (wet film thickness 50 μm) and dried at 60 °C to form a composite film with a thickness of 10 μm.
[0062] Step 3: Preparation of drug sustained-release layer 3
[0063] 1. Berberine microencapsulation:
[0064] Berberine extract 8 (berberine content ≥90%) was mixed with ethyl cellulose (wall material) at a mass ratio of 1:3, and microcapsules with a wall thickness of 10 μm were prepared by spray drying (inlet temperature 180℃).
[0065] 2. Loading of Borneol Nanospheres 9:
[0066] Borneol was dissolved in ethanol and mixed with a mesoporous silica carrier with a pore size of 6 nm. After high-pressure homogenization (100 MPa) and drying, borneol nanospheres with a particle size of 200-400 nm were obtained.
[0067] 3. Ozone oil microencapsulation:
[0068] ①Core material emulsification:
[0069] Ozone oil was added to 5 wt% Tween 80 emulsifier and emulsified at high speed in a 40°C water bath (12,000 rpm for 15 min) to form stable droplets with a particle size ≤10 μm.
[0070] ② Double-layer coating preparation:
[0071] Inner layer coagulation: The core material emulsion and 1.5% sodium alginate solution (pH=5.0) are mixed at a volume ratio of 1:3 and stirred for 30 min. Then, 0.8% chitosan acetate solution (deacetylation degree 90%, pH=4.5) is added dropwise to form a sodium alginate-chitosan composite film (thickness 8-12μm) through electrostatic adsorption.
[0072] Outer layer spraying and curing: The above microcapsules are suspended in a 3% polylactic acid (PLA, Mw=50kDa) dichloromethane solution and coated by fluidized bed spraying (inlet temperature 45℃, atomization pressure 0.2MPa) to form an outer polylactic acid film (thickness 5-8μm), and finally a double-layer microcapsule (total wall thickness 13-20μm) is obtained.
[0073] ③ Post-processing:
[0074] After vacuum freeze-drying (pre-freezing at -40℃, sublimation drying at 20Pa for 12h), microcapsules with a particle size of 50-200μm were screened, and the ozone oil encapsulation rate was ≥85%.
[0075] 4. Hydrogel matrix composite:
[0076] Chitosan (90% degree of deacetylation) was dissolved in 2% acetic acid solution, and berberine microcapsules (10wt% drug loading), borneol microspheres (0.3wt% drug loading), and ozone oil microcapsules (8wt% drug loading) were added. After cross-linking, a hydrogel layer with a thickness of 0.5 mm was formed.
[0077] Step 4: Processing of Adsorption Layer 4
[0078] 1. Porous carbon fiber treatment:
[0079] use Laser processing was used to fabricate hexagonal honeycomb micropore channels on the surface of a 0.3 mm thick porous carbon fiber layer (70% porosity). The pore diameter was 30 μm, the center distance was 45 μm, and the channel cross-section was conical (inlet pore diameter 35 μm, outlet pore diameter 25 μm).
[0080] Step 5: Apply the skin-friendly adhesive layer 5
[0081] 1. Colloid preparation:
[0082] The hypoallergenic acrylate adhesive (medical grade) and vitamin E-loaded gelatin microspheres (particle size 20 μm) were mixed at a mass ratio of 95:5 and stirred until evenly dispersed.
[0083] 2. Edge coating:
[0084] A slit coater was used to coat the edge of the adsorption layer 4 with an adhesive layer (80 μm thick), and a 2 mm wide breathable mesh structure was reserved in the edge area.
[0085] Step 6: Assembly of release protective layer 6
[0086] 1. Release paper processing:
[0087] Double-sided release paper (80g / m2) is used, with silicone release agent coated in the center area (release force 0.5N / 25mm), and uncoated areas are left in the edge gripping area.
[0088] 2. Lamination and bonding:
[0089] The layers are stacked in the following order: "flexible base layer 1 - humidity sensing layer 2 - drug sustained release layer 3 - adsorption layer 4 - skin-friendly adhesive layer 5". Finally, a release protective layer 6 is covered and the layers are rolled (pressure 0.1MPa) to complete the encapsulation.
[0090] Example 3: Protective film with annular pressure-sensitive adhesive layer 7
[0091] Additional step: Preparation of the annular pressure-sensitive adhesive layer 7
[0092] 1. Colloidal compounding:
[0093] Acrylic medical adhesive and polyisobutylene were mixed at a mass ratio of 4:1, and 3wt% menthol microspheres 10 (the wall material is gelatin-gum arabic, with a particle size of 20μm) were added and stirred evenly.
[0094] 2. Edge shaping:
[0095] An adhesive layer (100 μm thick) is applied to the edge extension area of the flexible base layer 1 to form a 5 mm wide annular pressure-sensitive adhesive tape. After curing at 80 °C, a basic type of protective film is prepared. During the preparation process, the annular pressure-sensitive adhesive tape is aligned and bonded to the edge of the skin-friendly adhesive layer 5.
[0096] Example 4: Technical Effects of the Implementation Method
[0097] In use, first remove the release protective layer 6, i.e., the double-sided release paper, and then cover the wound with the dressing. At this time, the dressing adheres to the skin outside the wound through the ring-shaped pressure-sensitive adhesive tape and the skin-friendly adhesive layer 5. The skin-friendly adhesive layer 5 can prevent wound exudate from seeping outwards to the ring-shaped pressure-sensitive adhesive tape, thus avoiding the dressing failing to adhere effectively due to exudate at the edges. Then, the wound exudate generates capillary gradient force through the conical microporous channel (the measured adsorption rate is 40% higher than that of the cylindrical channel), accelerating its directional flow towards the adsorption layer 4. After absorbing the exudate, the adsorption layer 4 returns the liquid through the microporous channel. The moisture-sensing layer 2 is transferred to the drug layer, triggering a humidity response to release the drug, allowing it to act on the wound. When the wound pH > 7 (infected state), the humidity-sensing layer 2 changes from yellow to purple. At the same time, the chitosan hydrogel degrades more rapidly in an alkaline environment, releasing the drug (the release rate increases from 15% to 45% in 24 hours). Among the drugs, Coptis chinensis extract, borneol, and ozone oil all have antibacterial and anti-inflammatory effects. In addition, the groove structure on the surface of the nano-silver fiber extends the silver ion sustained-release period to 72 hours (compared to 48 hours for untreated fibers), achieving a 99.2% inhibition rate against Staphylococcus aureus.
[0098] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.
[0099] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.
Claims
1. A protective patch with antibacterial and anti-inflammatory properties, comprising, from the outside to the inside, a flexible base layer (1), a humidity sensing layer (2), a drug sustained-release layer (3), an absorbent layer (4), a skin-friendly adhesive layer (5), and a release protective layer (6), characterized in that: The flexible substrate layer (1) is formed by hot pressing medical grade non-woven fabric and nano silver ion antibacterial fiber. Its surface is provided with regularly distributed breathable micropores with a pore size of 50-200μm and a pore density of 20-50 pores / cm2. The humidity sensing layer (2) is composed of a pH-sensitive color-changing material and a polyvinyl alcohol composite film, and is attached to the inner surface of the flexible substrate layer (1). The drug sustained-release layer (3) is a chitosan hydrogel matrix with several microcapsule structures embedded inside; The adsorption layer (4) is a porous carbon fiber with a through-hole microporous channel on its surface. The skin-friendly adhesive layer (5) covers the edge of the adsorption layer (4), and the edge is provided with a breathable groove structure; The release protective layer (6) adopts a double-sided release paper structure, including a central release area and an edge gripping area. The central release area is arranged opposite to the entire flexible substrate layer (1), and the edge gripping area is located outside the edge of the flexible substrate layer (1). The central release area is coated with an organosilicon release agent.
2. The antibacterial and anti-inflammatory protective patch according to claim 1, characterized in that: The nano-silver ion antibacterial fiber has a fiber diameter of 10-50μm, and its surface is formed by plasma etching to create a nano-groove structure with a depth of 50-200nm and a width of 100-500nm.
3. The antibacterial and anti-inflammatory protective patch according to claim 1, characterized in that: The edge of the flexible substrate (1) extends to form an annular pressure-sensitive adhesive layer (7), the thickness of which is 50-150 μm.
4. The antibacterial and anti-inflammatory protective patch according to claim 3, characterized in that: Menthol microspheres (10) are added to the annular pressure-sensitive adhesive layer (7). The particle size of the menthol microspheres (10) is 10-30 μm, and they are uniformly distributed in the pressure-sensitive adhesive layer.
5. The antibacterial and anti-inflammatory protective patch according to claim 1, characterized in that: The adsorption layer (4) has a hexagonal honeycomb arrangement of through-hole micropores, with the center distance between adjacent micropores being 1.5-2 times the pore diameter, and the pore diameter of the micropores being 10-50 μm.
6. The antibacterial and anti-inflammatory protective patch according to claim 1, characterized in that: The skin-friendly adhesive layer (5) contains gelatin microspheres or aloe vera nanofibers loaded with vitamin E, wherein the gelatin microspheres have a particle size of 10-50 μm and the aloe vera nanofibers have a diameter of 100-500 nm.
7. The antibacterial and anti-inflammatory protective patch according to claim 1, characterized in that: The microcapsule structure includes ozone oil microcapsules (11), which adopt a double-layer coating structure, with the inner layer being a sodium alginate-chitosan composite membrane and the outer layer being polylactic acid, with a total wall thickness of 10-20 μm and a particle size range of 50-200 μm.
8. The antibacterial and anti-inflammatory protective patch according to claim 7, characterized in that: The outer surface of the ozone oil microcapsule (11) is loaded with a pH-responsive polymer.