A sustained-release tablet multi-layer press tablet anti-sticking die

Abstract

The utility model relates to pharmaceutical equipment technical field especially relates to a kind of slow-release tablet multilayer tabletting anti-sticking die, including tablet punch, tablet punch inside is sequentially provided with through slot, through hole A, slot cavity B, through hole B and inner embedding groove from top to bottom, and top pressure head, top rod A, top rod B and top block are respectively equipped in through slot, through hole A, slot cavity B, through hole B and inner embedding groove, top rod A and top rod B are connected by connecting sleeve, reset spring is sleeved on top rod B, semicylindrical slot is provided on the ring surface of tablet punch, cover plate is installed in slot, and the same slot cavity A as slot cavity B is provided on the inner side of cover plate. The utility model is by adopting mechanical structure, can push after the tabletting of pressing to tablet, realize the forced separation of tabletting after pressing, reduce the sticking area and adhesion of tablet, effectively prevent tablet sticking, avoid tablet with punch movement to come out, ensure that tablet is normally collected, while guaranteeing subsequent tabletting process stable operation.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical equipment technology, and more specifically, to a multi-layer tableting anti-sticking die for sustained-release tablets. Background Technology

[0002] In pharmaceutical formulation production, the tableting process for sustained-release tablets is crucial, especially for multi-layer tablets of compound sustained-release formulations, which place higher demands on the tableting molds. Currently, during the tableting process of multi-layer tablets of compound sustained-release formulations, due to the inherent viscosity of the raw materials and the differences in properties between the layers, tablets are prone to adhering to the surface of the punch after compression. These adhered tablets will move with the punch and detach from the lower die, affecting tablet collection and disrupting the normal operation of subsequent tableting processes.

[0003] In existing technologies, tablet adhesion is typically addressed by surface coating, high-pressure airflow, or increasing the amount of lubricant. However, these methods have the following drawbacks:

[0004] 1. The surface coating is prone to wear and failure and needs to be replaced regularly;

[0005] 2. High-pressure airflow blowing outwards will disrupt the powder layer distribution and damage the multi-layer structure;

[0006] 3. Increasing the amount of lubricant will change the drug release kinetics, which does not meet the requirements for sustained release.

[0007] Therefore, a multi-layer tableting anti-sticking die for sustained-release tablets is needed to solve the above problems in order to improve production yield and product quality. Utility Model Content

[0008] (a) Purpose of the utility model

[0009] To address the shortcomings of existing technologies, the purpose of this invention is to provide a multi-layer tableting anti-sticking die for sustained-release tablets, thereby solving the problems mentioned in the background art.

[0010] (II) Technical Solution

[0011] To achieve the above objectives, the technical solution adopted by this utility model is as follows:

[0012] A multi-layer tableting anti-sticking die for sustained-release tablets includes a top pressure head and a tableting punch. The tableting punch has a through groove, a through hole A, a cavity B, a through hole B, and an inner groove arranged sequentially from top to bottom inside. The through groove, through hole A, cavity B, through hole B, and inner groove are interconnected. The through groove, through hole A, cavity B, through hole B, and inner groove are respectively provided with a top pressure head, a push rod A, a push rod B, and a push block. The push rod A and push rod B are connected by a connecting sleeve. A return spring is sleeved on the push rod B. A semi-cylindrical slot is opened on the annular surface of the tableting punch. A matching cover plate is installed in the slot. The inner side of the cover plate has a slot A that is the same as the cavity B.

[0013] Furthermore, the diameter of the push rod A is greater than the diameter of the push rod B, the diameter of the connecting sleeve is greater than the diameter of the push rod A, the diameter of the reset spring is less than the diameter of the connecting sleeve, and the inner diameter of the groove B is greater than the diameter of the connecting sleeve.

[0014] Furthermore, the height inside the recessed groove is greater than the height of the top block, with a height difference of 1 mm.

[0015] Furthermore, the upper end of the connecting sleeve is provided with a insertion groove A that matches the push rod A, and the lower end is provided with a insertion groove B that matches the push rod B. The insertion groove A and the insertion groove B are connected. Both the insertion groove A and the push rod A have pin holes A inside. The lower end of the push rod A is inserted into the insertion groove A and connected to the connecting sleeve through the pin hole A and the pin A. Both the insertion groove B and the push rod B have pin holes B inside. The upper end of the push rod B is inserted into the insertion groove B and connected to the connecting sleeve through the pin hole B and the pin B.

[0016] Furthermore, the cover plate has several sets of positioning holes inside, and screws are installed in the positioning holes. A threaded hole is opened at the bottom of the slot corresponding to the positioning hole, and the screw passes through the positioning hole and is screwed into the threaded hole.

[0017] (III) Working Principle

[0018] In actual use, initially, the return spring on push rod B is partially compressed, providing upward elastic force, making the bottom surface of the push block higher than the bottom surface of the tableting punch, and the top surface of the push head slightly higher than the top surface of the tableting punch, protruding from the top surface of the tableting punch. When the external roller pressing mechanism presses down, it first contacts the top surface of the push head. After the push head is subjected to force, it drives push rod A, connecting sleeve, and push rod B to move downward as a whole, compressing the return spring, so that the bottom surface of the push block and the bottom surface of the tableting punch smoothly transition, forming a complete tableting working surface. Then, the tableting punch moves downward as a whole under pressure, cooperating with the pressing die to press the raw material, realizing tableting. After pressing, the tableting punch separates from the external roller pressing mechanism. The return spring pushes push rod B and push block upward to reset. The push block moves upward into the inner groove, reducing the adhesion area and adhesion force between the tablet and the tableting punch, causing the tablet to separate and fall off. The elastic force of the return spring is greater than the adhesion force between the tablet and the punch and push block, forcing the tablet to quickly detach from the punch.

[0019] (iv) Beneficial effects

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] 1. This utility model is based on a mechanical structure linkage and elastic reset mechanism, which achieves the anti-sticking function in the multi-layer tableting process of sustained-release tablets through the coordinated action of multiple components. The set top pressure head, top pressure head, top rod A, top rod B and top block can push the compressed tablet to quickly separate it from the tableting punch, reduce the adhesion area and adhesion force of the tablet, and the elastic force of the reset spring is greater than the adhesion force between the tablet and the tableting punch and top block, which can force the top rod B and top block to return to their original position, realize the rapid separation of the tablet from the bottom surface of the tableting punch, prevent the tablet from falling out with the movement of the punch, ensure the normal collection of tablets, and ensure the stable operation of the subsequent tableting process.

[0022] 2. In this utility model, push rod A and push rod B are connected by a connecting sleeve. The connecting sleeve achieves a rigid connection between push rod A and push rod B, preventing displacement during the push-out process. At the same time, it achieves a detachable connection, which facilitates quick assembly and disassembly of push rod A and push rod B.

[0023] 3. In this utility model, the pressure punch is detachably connected to the cover plate through a semi-cylindrical slot. After the cover plate and the pressure punch are separated, it is convenient to quickly install or replace internal components such as the push rod, connecting sleeve, and return spring, thereby improving the ease of operation. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0025] Figure 2 This is a front view of the present invention.

[0026] Figure 3This is a schematic diagram of the structure of the cover plate and the pressing punch after disassembly in this utility model.

[0027] Figure 4 This is a front sectional view of the present invention.

[0028] Figure 5 This is a schematic diagram of the disassembled structure of this utility model.

[0029] Figure 6 This is a partial disassembly diagram of the present invention.

[0030] Figure 7 This is a cross-sectional view of the connecting sleeve in this utility model.

[0031] 1. Top pressure head; 2. Pressing punch; 3. Cover plate; 4. Screw; 5. Groove; 6. Positioning hole; 7. Threaded hole; 8. Groove A; 9. Push rod A; 10. Connecting sleeve; 11. Return spring; 12. Groove B; 13. Push rod B; 14. Top block; 15. Through groove; 16. Through hole A; 17. Through hole B; 18. Embedded groove; 19. Pin hole A; 20. Pin hole B; 21. Pin A; 22. Pin B; 23. Insertion groove A; 24. Insertion groove B. Detailed Implementation

[0032] The technical solutions of this utility model will be clearly and completely described below with reference to the embodiments of this utility model. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of this utility model.

[0033] Example 1:

[0034] like Figures 1 to 7 As shown, a multi-layer tableting anti-sticking die for sustained-release tablets includes a top pressure head 1 and a tableting punch 2. The tableting punch 2 has a through groove 15, a through hole A16, a cavity B12, a through hole B17 and an inner groove 18 arranged sequentially from top to bottom inside. The through groove 15, through hole A16, cavity B12, through hole B17 and inner groove 18 are connected to each other. The top pressure head 1, the push rod A9, the push rod B13 and the push block 14 are respectively provided in the through groove 15, through hole A16, cavity B12, through hole B17 and inner groove 18.

[0035] The push rod A9 and push rod B13 are connected by a connecting sleeve 10, which provides a rigid connection between them to prevent displacement during the ejection process and facilitates quick assembly and disassembly of the push rods A9 and B13. A return spring 11 is fitted on the push rod B13 to provide upward reset force for the push rod A9 after pressing. After pressing, the return spring 11 pushes the push rod B13 and the push block 14 back to their original positions, which enables the tablet to be quickly separated from the bottom surface of the tableting punch 2, preventing adhesion and ensuring continuous production efficiency.

[0036] The tablet punch 2 has a semi-cylindrical slot 5 on its annular surface. A matching cover plate 3 is installed in the slot 5, which can divide the tablet punch 2 into two detachable parts, making it convenient to quickly install or disassemble the internal structural components. The inner side of the cover plate 3 has a slot A8 that is the same as the slot B12, which is used to cooperate with the slot B12 to form a space to accommodate the connecting sleeve 10, the push rod B13 and the return spring 11.

[0037] By adopting the above technical solution, the problem of tablets adhering to the surface of the punch after compression is solved in the process of multi-layer tableting of compound sustained-release preparations by the existing tableting punch 2. This is because the raw materials themselves have a certain degree of viscosity and the properties of the raw materials in each layer of the multi-layer tableting are different. The adhered tablets will follow the movement of the punch and be detached from the lower die, affecting the collection of tablets and also affecting the normal operation of the subsequent tableting process.

[0038] It should be noted that the elastic force of the return spring 11 is greater than the adhesive force between the tablet and the tableting punch 2 and the bottom surface of the top block 14, thus enabling forced separation.

[0039] In this embodiment, the diameter of the push rod A9 is greater than the diameter of the push rod B13, the diameter of the connecting sleeve 10 is greater than the diameter of the push rod A9, the diameter of the return spring 11 is less than the diameter of the connecting sleeve 10, and the inner diameter of the groove B12 is greater than the diameter of the connecting sleeve 10.

[0040] In this embodiment, the height of the inner groove 18 is greater than the height of the top block 14, with a height difference of 1 mm. This design allows the top block 14 to move within a 1 mm range in the inner groove 18, thereby enabling the bottom surface of the top block 14 to separate from the tablet surface after tableting, reducing the adhesion area and adhesion force between the tablet and the tableting punch 2, and causing the tablet to separate and fall off.

[0041] Furthermore, as can be seen from the above, the top pressure head 1 can move within a range of 1mm in the through groove 15 following the change of the top block 14, so that the top surface of the top pressure head 1 is higher than the tableting punch 2, and can first contact the roller pressing mechanism during the tableting process, thereby causing the top pressure head 1 to drive the top block 14 to move down, closing the bottom opening of the inner groove 18, and the bottom surface of the top block 14 and the bottom surface of the tableting punch 2 are smoothly connected for subsequent tableting.

[0042] In this embodiment, the upper end of the connecting sleeve 10 has a insertion groove A23 adapted to the top rod A9, and the lower end has a insertion groove B24 adapted to the top rod B13. The insertion grooves A23 and B24 are connected. Both the insertion groove A23 and the top rod A9 have pin holes A19 inside. The lower end of the top rod A9 is inserted into the insertion groove A23 and connected to the connecting sleeve 10 via the pin hole A19 and a pin A21. Both the insertion groove B24 and the top rod B13 have pin holes B20 inside. The upper end of the top rod B13 is inserted into the insertion groove B24 and connected to the connecting sleeve 10 via the pin hole B20 and a pin B22. The connecting sleeve 10 enables a detachable connection between the top rod A9 and the top rod B13, facilitating quick installation and removal of the top rods A9 and B13. The pin connection achieves a rigid connection between the top rod A9, the top rod B13 and the connecting sleeve 10, preventing loosening at the connection and ensuring stability during use.

[0043] In this embodiment, the cover plate 3 has several sets of positioning holes 6 inside, and screws 4 are installed in the positioning holes 6. Threaded holes 7 are provided at the bottom of the slot 5 corresponding to the positioning holes 6. The screws 4 pass through the positioning holes 6 and are screwed into the threaded holes 7. The screws 4, in conjunction with the positioning holes 6 and the threaded holes 7, enable the disassembly and connection of the cover plate 3, and ensure the installation stability of the cover plate 3.

[0044] Example 2:

[0045] First, install all components. Remove screw 4 and open cover plate 3. Then, insert push rod B13 from the bottom recess 18 into through hole B17, so that the upper end of push rod B13 extends into groove cavity B12. Then, sleeve return spring 11 onto push rod B13, and then sleeve connecting sleeve 10 onto push rod B13. Next, insert push rod A9 with push head 1 from the top into through hole A16, so that the lower end of push rod A9 extends into groove cavity B12. Then, move connecting sleeve 10 upward along push rod B13, and sleeve connecting sleeve 10 onto the bottom of push rod A9 through insertion groove A23. Rotate and adjust connecting sleeve 10 and push rod B13 so that pin holes A19 and B20 on connecting sleeve 10 are aligned with pin holes A19 and B20 on push rod A9 and push rod B13, and then connect and fix them respectively through pins A21 and B22. At this time, the lower end of the reset spring 11 abuts against the bottom of the cavity B12, the upper end of the connecting sleeve 10 abuts against the bottom of the cavity B12, and the top block 14 is in the highest position under the push of the reset spring 11. Then, the cover plate 3 is installed in the slot 5 on the pressure punch 2 by the screw 4, thus completing the installation of each structural component.

[0046] Example 3:

[0047] In actual use, in the initial state, the return spring 11 on the push rod B13 is in a partially compressed state, providing an upward elastic force, so that the bottom surface of the push block 14 is higher than the bottom surface of the tableting punch 2, and the top surface of the top pressure head 1 is slightly higher than the top surface of the tableting punch 2, protruding from the top surface of the tableting punch 2. When the external roller pressing mechanism presses down, it first contacts the top surface of the top pressure head 1. After the top pressure head 1 is subjected to force, it drives the push rod A9, the connecting sleeve 10 and the push rod B to move down as a whole, compressing the return spring 11, so that the bottom surface of the push block 14 and the bottom surface of the tableting punch 2 smoothly transition, forming a complete tableting working surface. Then the tableting punch 2 is pressed down as a whole, and cooperates with the pressing bottom mold to press the raw material to achieve tableting. After pressing is completed, the tableting punch 2 separates from the external roller pressing mechanism. The return spring 11 pushes the push rod B and the push block 14 to return to their original position. The push block 14 moves up into the inner groove 18, reducing the adhesion area and adhesion force between the tablet and the tableting punch 2, so that the tablet separates and falls off. The elastic force of the return spring 11 is greater than the adhesive force between the tablet and the punch and top block 14, forcing the tablet to detach from the punch quickly.

[0048] In summary, this mold is based on a mechanical structure linkage and elastic reset mechanism. Through mechanical linkage, it achieves the function of "closing the mold cavity during tableting and actively separating during demolding". Through the coordinated action of multiple components, it achieves the anti-sticking function in the multi-layer tableting process of sustained-release tablets. Combined with the detachable structure, it improves maintenance efficiency and effectively solves the sticking problem in the production of multi-layer sustained-release tablets, ensuring the stability of continuous production and the quality of tablets.

[0049] Obviously, the above embodiments of this utility model are merely examples for clearly illustrating this utility model, and are not intended to limit the implementation of this utility model. For those skilled in the art, other variations or modifications can be made based on the above description. It is impossible to exhaustively list all the implementation methods here. Any obvious variations or modifications derived from the technical solutions of this utility model are still within the protection scope of this utility model.

Claims

1. A multi-layer tableting anti-sticking die for sustained-release tablets, characterized in that: The device includes a top pressure head (1) and a tableting punch (2). The tableting punch (2) has, from top to bottom, a through groove (15), a through hole A (16), a cavity B (12), a through hole B (17), and an inner groove (18). The through groove (15), through hole A (16), cavity B (12), through hole B (17), and inner groove (18) are connected to each other. The through groove (15), through hole A (16), cavity B (12), through hole B (17), and inner groove (18) are connected to each other. The device is provided with a top pressure head (1), a top rod A (9), a top rod B (13) and a top block (14). The top rod A (9) and the top rod B (13) are connected by a connecting sleeve (10). A return spring (11) is sleeved on the top rod B (13). A semi-cylindrical groove (5) is opened on the ring surface of the pressing punch (2). A cover plate (3) that is compatible with it is installed in the groove (5). A groove A (8) that is the same as the groove B (12) is opened on the inner side of the cover plate (3).

2. The multi-layer tableting anti-sticking die for sustained-release tablets according to claim 1, characterized in that: The diameter of the push rod A (9) is greater than the diameter of the push rod B (13), the diameter of the connecting sleeve (10) is greater than the diameter of the push rod A (9), the diameter of the reset spring (11) is less than the diameter of the connecting sleeve (10), and the inner diameter of the groove B (12) is greater than the diameter of the connecting sleeve (10).

3. The multi-layer tableting anti-sticking die for sustained-release tablets according to claim 1, characterized in that: The height of the inner groove (18) is greater than the height of the top block (14), and the height difference between the two is 1 mm.

4. The multi-layer tableting anti-sticking die for sustained-release tablets according to claim 1, characterized in that: The upper end of the connecting sleeve (10) is provided with a insertion groove A (23) that is compatible with the top rod A (9), and the lower end is provided with a insertion groove B (24) that is compatible with the top rod B (13). The insertion groove A (23) and the insertion groove B (24) are connected. The insertion groove A (23) and the top rod A (9) are both provided with pin holes A (19). The lower end of the top rod A (9) is inserted into the insertion groove A (23) and connected to the connecting sleeve (10) through the pin hole A (19) and the pin A (21). The insertion groove B (24) and the top rod B (13) are both provided with pin holes B (20). The upper end of the top rod B (13) is inserted into the insertion groove B (24) and connected to the connecting sleeve (10) through the pin hole B (20) and the pin B (22).

5. The multi-layer tableting anti-sticking die for sustained-release tablets according to claim 1, characterized in that: The cover plate (3) has several sets of positioning holes (6) inside, and screws (4) are installed in the positioning holes (6). The bottom of the slot (5) has a threaded hole (7) corresponding to the positioning hole (6). The screw (4) passes through the positioning hole (6) and is screwed into the threaded hole (7).

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