Flow cytometry signal collection apparatus

Abstract

The utility model discloses a flow cytometer signal collection device. The flow cytometer signal collection device includes base, optical fiber subassembly and filter component, optical fiber subassembly is located on the base, including optical fiber structure, collimation structure and reflection structure, collimation structure is located on the base in the activity, and is located between optical fiber structure and reflection structure, collimation structure has the activity stroke of being close to optical fiber structure to be away from reflection structure and being away from optical fiber structure to be close to reflection structure, filter component is located on the base, and is located one side of optical fiber subassembly, and the filter channel is formed on filter component, and filter channel and reflection structure correspondingly are arranged, so that the fluorescence that reflects through reflection structure can be conducted into filter channel along the layout direction of filter channel. The utility model makes the light that filter component obtains more concentration, and electrical component can better carry out the detection, and effectively promotes the detection result, and the applicability of flow cytometer signal collection device for different wavelength fluorescence is better also.

Description

Technical Field

[0001] This utility model relates to the technical field of biomedical devices, specifically to a flow cytometer signal collection device. Background Technology

[0002] Flow cytometry is a core tool for high-throughput analysis of single cells or biological particles using laser excitation and photoelectric detection technologies. Its core function is to achieve multi-dimensional analysis of cell phenotype, function, and molecular characteristics. The core functional modules of a flow cytometer include four major systems: laser excitation, optical detection, fluid flow control, and data processing. After the laser irradiates a fluorescent label, the generated fluorescence is focused and transmitted through an optical fiber bundle. It then needs to be collimated by a collimating lens to form parallel light, thus making the acquired fluorescence more concentrated and improving the results. However, the same wavelength of laser light will produce different fluorescence wavelengths when irradiated by different fluorescent labels. Therefore, even if the relative position between the collimating lens and the optical fiber bundle remains unchanged, the collimation effect of some wavelengths of light is poor, thus affecting the detection results. Utility Model Content

[0003] To address the aforementioned technical problems, the main objective of this invention is to provide a flow cytometer signal collection device. This device aims to solve the problem that traditional flow cytometer signal collection devices often suffer from unsatisfactory light collimation when transmitting and detecting fluorescence at different wavelengths, thus affecting the overall detection effect.

[0004] To achieve the above objectives, this utility model proposes a flow cytometer signal collection device, comprising:

[0005] Base;

[0006] An optical fiber assembly, disposed on the base, includes an optical fiber structure, a collimating structure, and a reflecting structure. The collimating structure is movably disposed on the base and located between the optical fiber structure and the reflecting structure. The collimating structure has a travel distance that moves towards the optical fiber structure and away from the reflecting structure, and moves away from the optical fiber structure and towards the reflecting structure.

[0007] A filter assembly is disposed on the base and located on one side of the optical fiber assembly. A filter channel is formed on the filter assembly. The filter channel and the reflective structure are arranged correspondingly, so that the fluorescence reflected by the reflective structure can be conducted into the filter channel along the arrangement direction of the filter channel.

[0008] Optionally, an adjustment rod is connected between the optical fiber structure and the collimation structure. The adjustment rod extends along the layout direction of the optical fiber structure and the collimation structure and is screwed to the collimation structure.

[0009] The adjusting rod rotates under the action of an external force, which can drive the collimation structure to move along the adjusting rod to move closer to or away from the optical fiber structure.

[0010] Optionally, the optical fiber structure includes:

[0011] An optical fiber holder is disposed on the base, and the optical fiber holder is provided with a first mounting hole and a second mounting hole;

[0012] An optical fiber bundle is inserted into the first mounting hole, with the light-emitting end of the optical fiber bundle located in the first mounting hole and facing the collimation structure.

[0013] An adjustment seat is disposed in the second mounting hole and connected to the base;

[0014] The adjusting rod passes through the adjusting seat, with the first end of the adjusting rod protruding from the side of the adjusting seat facing away from the collimation structure, and the second end of the adjusting rod being screwed to the collimation structure.

[0015] Optionally, the first end of the adjusting rod is provided with an adjusting hole, which is non-circular.

[0016] Optionally, the section of the adjusting rod that passes through the second mounting hole is partially thinned so that the adjusting rod has stepped portions at both ends corresponding to the second mounting hole, and the two stepped portions are spaced apart from the two ends of the second mounting hole.

[0017] The fiber optic assembly also includes two retaining rings, which are respectively engaged in the interval formed by the two stepped portions and the two ends of the second mounting hole.

[0018] Optionally, the collimation structure is provided with an elongated hole, which is arranged parallel to the adjusting rod, and the base is provided with a mating hole; the flow cytometer signal collection device further includes a connector, which passes through the elongated hole and the mating hole, so that the elongated hole can be driven to move relative to the mating hole when the adjusting rod rotates.

[0019] Optionally, the collimation structure includes:

[0020] A collimator is provided opposite to the fiber optic base. The elongated hole is provided on the collimator, and a third mounting hole is provided on the collimator opposite to the first mounting hole.

[0021] A collimating lens is disposed within the third mounting hole, and the light-emitting end of the collimating lens is positioned corresponding to the reflecting structure.

[0022] Optionally, the reflective structure includes:

[0023] A reflector mount is disposed on the base and has a mounting surface that is inclined toward the filter channel on one side along the axial direction of the third mounting hole;

[0024] A reflector is disposed on the mounting surface so that parallel light transmitted from the collimating lens can be reflected by the reflector into the filter channel.

[0025] Optionally, the flow cytometer signal collection device further includes an electrical component, which is disposed on the base and corresponding to the filter component. The electrical component and the optical fiber component are both located on the same surface of the base, and the base has a plurality of heat dissipation fins protruding from the side opposite to the electrical component.

[0026] Optionally, the filter assembly is provided with a plurality of light guide channels communicating with the filter channel, and the extending direction of each light guide channel is perpendicular to the extending direction of the filter channel; the electrical component includes:

[0027] A cooling block is disposed on the base and is located on the same surface of the base as the optical fiber assembly;

[0028] An optoelectronic mounting base is disposed on the cooling block and has multiple mounting holes that correspond one-to-one with the multiple light guide channels;

[0029] Multiple photodiodes are disposed one-to-one in the multiple mounting holes.

[0030] The technical solution provided by this utility model has the following beneficial effects:

[0031] The flow cytometer signal collection device provided by this utility model includes a base, an optical fiber assembly, and a filter assembly. The base is used to support or cover the optical fiber assembly and the filter assembly. The optical fiber assembly includes an optical fiber structure, a collimating structure, and a reflecting structure. The optical fiber structure is used to conduct fluorescence to the collimating structure. After the light is collimated by the collimating structure, it is parallel to the reflecting structure. The reflecting structure deflects the light into the filter channel. The filter assembly then processes the light to better extract fluorescence of different wavelengths for detection and analysis. The collimating structure is movable, with a travel distance that allows it to move closer to the optical fiber structure and further away from the reflecting structure, and further away from the optical fiber structure and closer to the reflecting structure. This allows the distance between the collimating structure and the optical fiber structure to be adjusted accordingly, so that the light collimated by the collimating structure can be emitted in parallel more effectively. The light acquired by the filter assembly is more concentrated, allowing the electrical components to perform better detection, effectively improving the detection results. The flow cytometer signal collection device is also more suitable for fluorescence of different wavelengths. Attached Figure Description

[0032] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0033] Figure 1 A schematic diagram of an embodiment of a flow cytometer signal collection device provided by this utility model;

[0034] Figure 2 for Figure 1 A cross-sectional structural diagram of the flow cytometer signal collection device described herein;

[0035] Figure 3 for Figure 1 Another cross-sectional view of the flow cytometer signal collection device described in the diagram;

[0036] Figure 4 for Figure 3 A magnified structural diagram of detail A in the middle;

[0037] Figure 5 for Figure 1 Another cross-sectional structural diagram of the flow cytometer signal collection device described herein.

[0038] Explanation of icon numbers:

[0039] 100-Flow cytometer signal collection device; 1-Base; 2-Fiber optic assembly; 21-Fiber optic structure; 211-Fiber optic base; 212-Fiber optic bundle; 213-Adjustment base; 214-Adjustment rod; 22-Collimation structure; 221-Collimation base; 2211-Elongated aperture; 222-Collimating lens; 23-Reflection structure; 231-Reflection base; 232-Reflector; 3-Filter assembly; 31-Filter mounting base; 32-Filter support; 33-Filter lens; 4-Electrical assembly; 41-Cooler block; 42-Photoelectric mounting base; 43-Photodiode.

[0040] The realization of the purpose, functional characteristics and excellent effects of this utility model will be further explained below in conjunction with specific embodiments and accompanying drawings. Detailed Implementation

[0041] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0042] It should be noted that if the embodiments of this utility model involve directional indication, the directional indication is only used to explain the relative positional relationship and movement of each component in a specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0043] Furthermore, if the embodiments of this utility model involve descriptions such as "first" or "second," these descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the meaning of "and / or" throughout the text includes three parallel solutions; for example, "A and / or B" includes solution A, solution B, or a solution where both A and B are satisfied simultaneously. Furthermore, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed by this utility model.

[0044] This utility model provides a flow cytometer signal collection device 100. For details, please refer to... Figures 1 to 2 In this embodiment, the flow cytometer signal collection device 100 includes a base 1, an optical fiber assembly 2, and a filter assembly 3. The optical fiber assembly 2 is disposed on the base 1 and includes an optical fiber structure 21, a collimating structure 22, and a reflecting structure 23. The collimating structure 22 is movably disposed on the base 1 and located between the optical fiber structure 21 and the reflecting structure 23. The collimating structure 22 has a travel distance that is close to the optical fiber structure 21 and away from the reflecting structure 23, and a travel distance that is away from the optical fiber structure 21 and close to the reflecting structure 23. The filter assembly 3 is disposed on the base 1 and located on one side of the optical fiber assembly 2. A filter channel is formed on the filter assembly 3. The filter channel and the reflecting structure 23 are correspondingly arranged so that the fluorescence reflected by the reflecting structure 23 can be conducted into the filter channel along the arrangement direction of the filter channel.

[0045] In this embodiment, the base 1 is used to support or cover the optical fiber assembly 2 and the filter assembly 3; the optical fiber structure 21 can be used to conduct fluorescence to the collimating structure 22, after which the light is collimated by the collimating structure 22 and then irradiated parallel to the reflecting structure 23, and the reflecting structure 23 deflects the light into the filter channel, and then the filter assembly 3 processes the light to better extract fluorescence of different wavelengths for detection and analysis; wherein, the collimating structure 22 is movable, having a travel distance that is close to the optical fiber structure 21 and away from the reflecting structure 23, and away from the optical fiber structure 21 and close to the reflecting structure 23, so that the distance between the collimating structure 22 and the optical fiber structure 21 can be adjusted accordingly, so that the light collimated by the collimating structure 22 can be emitted in parallel better, the light obtained by the filter assembly 3 is more concentrated, so that the electrical component 4 can be better detected, effectively improving the detection results, and the flow cytometer signal collection device 100 is also more suitable for fluorescence of different wavelengths.

[0046] It is understood that the movement of the collimation structure 22 can be driven by a driving component (such as an electric cylinder, pneumatic cylinder, etc.), or the collimation structure 22 can be moved manually. Since a small increase or decrease in the distance between the collimation structure 22 and the optical fiber structure 21 results in a relatively large adjustment of the light, the adjustment of the collimation structure 22 is made minute to more accurately ensure its position. The optical fiber structure 21, the collimation structure 22, and the reflection structure 23 are arranged sequentially along the front-back direction of the base 1, with the optical fiber structure 21 located in front of the collimation structure 22 and the reflection structure 23 located behind the collimation structure 22. Unless otherwise specified, all descriptions of orientation in this invention shall be taken as such.

[0047] Preferably, the collimation structure 22 can be adjusted and moved via a lead screw and nut structure, resulting in higher adjustment precision and lower noise during adjustment, thus better ensuring the collimation effect of the collimation structure 22 on light. Specifically, in conjunction with Figure 2 and Figure 3 As shown, an adjusting rod 214 is connected between the optical fiber structure 21 and the collimating structure 22. The adjusting rod 214 extends along the arrangement direction of the optical fiber structure 21 and the collimating structure 22 and is screwed to the collimating structure 22. When the adjusting rod 214 is rotated by an external force, it can drive the collimating structure 22 to move along the adjusting rod 214 to move closer to or further away from the optical fiber structure 21. This allows the collimating structure 22 to be moved more effectively while keeping the position of the optical fiber structure 21 unchanged.

[0048] Furthermore, combined Figure 3 and Figure 4 As shown, the optical fiber structure 21 includes an optical fiber holder 211, an optical fiber bundle 212, and an adjustment seat 213. The optical fiber holder 211 is disposed on the base 1 and has a first mounting hole and a second mounting hole. The optical fiber holder 211 is generally convex in shape, having two shoulders and a protrusion located between the two shoulders. The first mounting hole is located on the protrusion, and the second mounting hole is located below the first mounting hole. The optical fiber bundle 212 passes through the first mounting hole, and the light-emitting end of the optical fiber bundle 212 is located in the first mounting hole and faces the collimation structure 22, so that the light-emitting end of the optical fiber bundle 212 can be at the same height as the filter channel. The adjusting seat 213 is disposed in the second mounting hole and connected to the base 1; the adjusting rod 214 passes through the adjusting seat 213, with the first end of the adjusting rod 214 protruding from the side of the adjusting seat 213 facing away from the collimation structure 22, and the second end of the adjusting rod 214 being screwed to the collimation structure 22. The adjusting seat 213 and the base 1 are separately connected and fixed, which makes assembly more convenient and also facilitates the replacement and maintenance of the adjusting rod 214.

[0049] Preferably, an adjustment hole is provided at the first end of the adjustment rod 214. The adjustment hole is non-circular and can be easily inserted into the adjustment hole by means of an adjustment tool (such as a hex wrench) to adjust the rotation of the adjustment rod 214, thereby adjusting the movement of the collimation structure 22.

[0050] Furthermore, when the adjusting rod 214 rotates and moves relative to the collimating structure 22, the adjusting rod 214 will not have a relative displacement with respect to the fiber optic base 211 in the front-back direction of the base 1. Specifically, a section of the adjusting rod 214 passing through the second mounting hole is partially thinned, so that both ends of the adjusting rod 214 corresponding to the second mounting hole have stepped portions, and the two stepped portions are spaced apart from the two ends of the second mounting hole. The fiber optic assembly 2 also includes two retaining springs, which are correspondingly engaged with the two stepped portions within the gaps formed by the two ends of the second mounting hole. These two retaining springs ensure the position of the adjusting rod 214 on the adjusting base 213, and allow the collimating structure 22 to move in the front-back direction while the position of the adjusting rod 214 remains unchanged, thereby adjusting the distance between the collimating structure 22 and the fiber optic structure 21 for better collimation of the light.

[0051] Furthermore, an elongated hole 2211 is provided on the collimation structure 22, which is parallel to the adjusting rod 214. A mating hole is provided on the base 1. The flow cytometer signal collection device 100 also includes a connector, which passes through the elongated hole 2211 and the mating hole, so that the elongated hole 2211 can be moved relative to the mating hole when the adjusting rod 214 rotates. The connector can be a bolt or a pin, etc., which can limit the relative position of the collimation structure 22 and the base 1 in the vertical direction, so that the collimation structure 22 can generate displacement in the front-back direction. Moreover, there are two mating holes, which are located on both sides of the collimation structure 22 in the left-right direction, making the collimation structure 22 more stable during movement and less prone to deflection.

[0052] Specifically, for the collimation structure 22, as Figure 4 As shown, the collimation structure 22 includes a collimator 221 and a collimator 222. The collimator 221 is disposed opposite to the fiber optic mount 211. An elongated hole 2211 is disposed on the collimator 221, and a third mounting hole is provided on the collimator 221 opposite to the first mounting hole. The collimator 222 is disposed in the third mounting hole, and the light-emitting end of the collimator 222 is disposed corresponding to the reflection structure 23. The shape of the collimator 221 is similar to that of the fiber optic mount 211, and is roughly convex. The two elongated holes 2211 are respectively disposed on the two shoulders of the collimator 221, and the third mounting hole is disposed on the protrusion of the collimator 221, so that the height of the third mounting hole is the same as the height of the first mounting hole, allowing light to pass through the collimator 222 more evenly. Furthermore, an elongated hole is provided below the third mounting hole, in which at least two pins can be accommodated. The at least two pins are connected to the base 1, which can further limit the range of movement of the collimator 221.

[0053] For the reflective structure 23, preferably, combined with Figure 3 and Figure 4As shown, the reflective structure 23 includes a reflective base 231 and a reflector 232. The reflective base 231 is disposed on the base 1 and has a mounting surface inclined towards the filter channel along the axial direction of the third mounting hole. Preferably, the mounting surface is inclined at 45° in the front-to-back direction. The reflector 232 is planar and disposed on the mounting surface, so that parallel light transmitted from the collimating lens 222 can be reflected into the filter channel by the reflector 232. The height of the reflector 232 is the same as the height of the collimating lens 222. One side of the reflective base 231 is fixed to the base 1 by two pins, and the other side of the reflective base 231 is locked to the base 1 by a connector.

[0054] In one embodiment, the flow cytometer signal collection device 100 further includes an electrical component 4, which is disposed on the base 1 and corresponding to the filter component 3. The electrical component 4 and the optical fiber component 2 are both located on the same surface of the base 1. The base 1 has multiple heat dissipation fins protruding from the side facing away from the electrical component 4. The electrical component 4 converts the received optical signal into an electrical signal, thereby obtaining the detection result. Furthermore, since the electrical component 4 generally generates a significant amount of heat, having multiple heat dissipation fins on the back side of the plane containing the electrical component 4 increases the heat dissipation area at the bottom of the base 1, thereby accelerating heat dissipation efficiency and preventing the temperature of the entire flow cytometer signal collection device 100 from becoming excessively high.

[0055] Preferably, the filter assembly 3 has multiple light guide channels connected to the filter channel, and the extending direction of each light guide channel is perpendicular to the extending direction of the filter channel. Multiple light guide lenses are provided within each light guide channel to process fluorescence of different wavelengths, thereby obtaining a detection value of fluorescence at a preset wavelength. Figure 2 and Figure 5As shown, the electrical component 4 includes a cooling block 41, a photoelectric mounting base 42, and multiple photodiodes 43. The cooling block 41 is disposed on the base 1 and is located on the same surface of the base 1 as the optical fiber component 2. The photoelectric mounting base 42 is disposed on the cooling block 41 and has multiple mounting holes that correspond one-to-one with the multiple light guide channels. The multiple photodiodes 43 are disposed one-to-one in the multiple mounting holes. The photoelectric mounting base 42 is made of copper, and the cooling block 41 is configured as a semiconductor cooling chip. The photoelectric mounting base 42 is placed on the cooling block 41. Utilizing the Peltier effect of the semiconductor material, the contact surface between the cooling chip and the photoelectric mounting base 42 absorbs heat and releases heat through the contact surface of the base 1. Furthermore, the bottom end of the base 1 is processed into fins to increase the heat dissipation area, and a fan can be placed at the lower end of the multiple fins to better dissipate heat from the photodiodes 43.

[0056] The base 1 can be configured as a flat plate, a box, or a support structure, etc. Preferably, the base 1 is box-shaped to protect the optical fiber assembly 2 and the filter assembly 3. One end of the optical fiber bundle 212 of the optical fiber assembly 2 extends from the base 1.

[0057] like Figure 5 As shown, the filter assembly 3 includes a filter mounting base 31, a filter bracket 32, and a filter lens 33. The filter bracket 32 ​​is inserted into the filter mounting base 31 and can be removed from above the filter mounting base 31, making assembly and disassembly convenient. The filter lens 33 includes a first lens and a second lens. The first lens is set at a 45° angle to the filter channel, and the second lens is set perpendicular to the axial direction of the light guide channel. This allows light reflected from the reflector 232 into the filter channel to enter the corresponding light guide channel after being reflected by the first lens, and then pass through the second lens to enter the corresponding photodiode 43. Two filter brackets 32 are also provided, with the first lens on one of the filter brackets 32 and the second lens on the other. Multiple sets of filter assemblies 3 are provided, with each set of filter assemblies 3 corresponding to one light guide channel. Multiple light guide channels can be used to obtain fluorescence of different wavelengths for better and more accurate detection.

[0058] The above description is only a preferred embodiment of the present utility model and does not limit the patent scope of the present utility model. Any equivalent structure made using the contents of the present utility model specification and drawings, or directly or indirectly applied to other related technical fields, are similarly included within the patent protection scope of the present utility model.

Claims

1. A flow cytometer signal collection apparatus, characterized by, include: Base; An optical fiber assembly, disposed on the base, includes an optical fiber structure, a collimating structure, and a reflecting structure. The collimating structure is movably disposed on the base and located between the optical fiber structure and the reflecting structure. The collimating structure has a travel distance that moves towards the optical fiber structure and away from the reflecting structure, and moves away from the optical fiber structure and towards the reflecting structure. A filter assembly is disposed on the base and located on one side of the optical fiber assembly. A filter channel is formed on the filter assembly. The filter channel and the reflective structure are arranged correspondingly, so that the fluorescence reflected by the reflective structure can be conducted into the filter channel along the arrangement direction of the filter channel.

2. The flow cytometer signal collection apparatus of claim 1, wherein, An adjusting rod is connected between the optical fiber structure and the collimation structure. The adjusting rod extends along the layout direction of the optical fiber structure and the collimation structure and is screwed to the collimation structure. The adjusting rod rotates under the action of an external force, which can drive the collimation structure to move along the adjusting rod to move closer to or away from the optical fiber structure.

3. The flow cytometer signal collection apparatus of claim 2, wherein, The optical fiber structure includes: An optical fiber holder is disposed on the base, and the optical fiber holder is provided with a first mounting hole and a second mounting hole; An optical fiber bundle is inserted into the first mounting hole, with the light-emitting end of the optical fiber bundle located in the first mounting hole and facing the collimation structure. An adjustment seat is disposed in the second mounting hole and connected to the base; The adjusting rod passes through the adjusting seat, with the first end of the adjusting rod protruding from the side of the adjusting seat facing away from the collimation structure, and the second end of the adjusting rod being screwed to the collimation structure.

4. The flow cytometer signal collection device as described in claim 3, characterized in that, The first end of the adjusting rod is provided with an adjusting hole, which is non-circular.

5. The flow cytometer signal collection device as described in claim 3, characterized in that, The section of the adjusting rod that passes through the second mounting hole is partially thinned so that the adjusting rod has stepped portions at both ends corresponding to the second mounting hole, and the two stepped portions are spaced apart from the two ends of the second mounting hole. The fiber optic assembly also includes two retaining rings, which are respectively engaged in the interval formed by the two stepped portions and the two ends of the second mounting hole.

6. The flow cytometer signal collection device as described in claim 3, characterized in that, The collimation structure has an elongated hole, which is parallel to the adjusting rod. The base has a mating hole. The flow cytometer signal collection device also includes a connector, which passes through the elongated hole and the mating hole, so that the elongated hole can be moved relative to the mating hole when the adjusting rod rotates.

7. The flow cytometer signal collection device as described in claim 6, characterized in that, The collimation structure includes: A collimator is provided opposite to the fiber optic base. The elongated hole is provided on the collimator, and a third mounting hole is provided on the collimator opposite to the first mounting hole. A collimating lens is disposed within the third mounting hole, and the light-emitting end of the collimating lens is positioned corresponding to the reflecting structure.

8. The flow cytometer signal collection device as described in claim 7, characterized in that, The reflective structure includes: A reflector mount is disposed on the base and has a mounting surface that is inclined toward the filter channel on one side along the axial direction of the third mounting hole; A reflector is disposed on the mounting surface so that parallel light transmitted from the collimating lens can be reflected by the reflector into the filter channel.

9. The flow cytometer signal collection device as described in claim 1, characterized in that, The flow cytometer signal collection device also includes an electrical component, which is disposed on the base and corresponding to the filter component. The electrical component and the optical fiber component are both located on the same surface of the base. The base has multiple heat dissipation fins protruding from the side facing away from the electrical component.

10. The flow cytometer signal collection device as described in claim 9, characterized in that, The filter assembly has multiple light guide channels communicating with the filter channel, and the extending direction of each light guide channel is perpendicular to the extending direction of the filter channel; the electrical component includes: A cooling block is disposed on the base and is located on the same surface of the base as the optical fiber assembly; The photoelectric mounting base is disposed on the cooling block and has multiple mounting holes that correspond one-to-one with the multiple light guide channels; Multiple photodiodes are disposed one-to-one in the multiple mounting holes.

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