A simple device for fixing and injecting laboratory mice via tail vein

Abstract

This utility model relates to a simple experimental mouse fixation and tail vein injection device, including a fixation platform, a transparent isolation cover, and a tail fixation component. The transparent isolation cover is used to cover the experimental mouse on the fixation platform. An isolation cover notch is formed at the edge of the open end of the transparent isolation cover, through which the tail of the experimental mouse protrudes. The tail fixation component is used to fix the protruding tail of the experimental mouse on the fixation platform. This utility model combines experimental mouse fixation, tail fixation, and visual monitoring, achieving a dual improvement in drug administration accuracy and simplified experimental operation. It can be operated by a single person and is suitable for precise drug delivery and real-time image monitoring in small animal experiments, possessing high practical value and promising prospects for widespread application.

Description

Technical Field

[0001] This utility model relates to the field of medical devices, specifically to a simple experimental mouse fixation and tail vein injection device. Background Technology

[0002] Tail vein injection is a common method of drug administration in small animal experiments and is widely used in drug screening, efficacy evaluation, and molecular imaging research.

[0003] However, traditional tail vein injection procedures mostly involve multiple researchers manually fixing and injecting the mouse, while some researchers use mouse fixation devices to assist in the injection. For example, patent 201720001910.0 discloses a tail vein injection device for mice or rats, including a wedge-shaped inclined surface fixing base, a black cup, a magnifying glass base, a rotating bracket, a magnifying glass, a tail hole, and an annular hole. The wedge-shaped inclined surface fixing base has an annular hole on its inclined surface; the top of the wedge-shaped inclined surface fixing base is connected to the bottom of the black cup, the bottom of the black cup has a tail hole, the top of the black cup is connected to the bottom of the magnifying glass base, the top of the magnifying glass base is connected to one end of the rotating bracket, and the other end of the rotating bracket has a magnifying glass.

[0004] However, the device does not fix the tail of the experimental mouse. Due to the instability of the mouse, the accuracy of the injection is difficult to guarantee. Moreover, the device uses a black cup, which makes it impossible to observe the experimental mouse in real time after injection. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the existing technology and provide a simple experimental mouse fixation and tail vein injection device. By combining experimental mouse fixation, tail fixation and visual monitoring, it achieves a dual improvement in drug administration accuracy and simplifies experimental operation. It can be operated by a single person and is suitable for precise drug delivery and real-time image monitoring in small animal experiments. It has high practical value and promotion prospects.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] This utility model provides a simple device for fixing and injecting laboratory mice via the tail vein, comprising:

[0008] Fixed platform;

[0009] A transparent isolation cover is used to cover the laboratory mouse on the fixed platform. The edge of the open end of the transparent isolation cover is formed with an isolation cover notch, and the tail of the laboratory mouse extends out of the transparent isolation cover through the isolation cover notch.

[0010] A tail fixing assembly for securing the tail of a laboratory mouse protruding from the opening of the isolation cover to the fixing platform.

[0011] Preferably, it further includes:

[0012] An isolation cover fixing assembly is disposed on the fixing platform for stabilizing the transparent isolation cover.

[0013] Preferably, the isolation cover fixing assembly includes:

[0014] The fixing frame is provided with a first screw hole;

[0015] A fixing screw is fitted into the first screw hole and corresponds to the transparent isolation cover.

[0016] Preferably, the fixing frame is provided with a plurality of the first screw holes.

[0017] Preferably, the isolation cover fixing assembly further includes a pressure plate, which is disposed at the end of the fixing screw facing the isolation cover.

[0018] Preferably, the pressure plate is covered with a cushioning pad.

[0019] Preferably, it further includes:

[0020] An intravenous injection lamp is positioned on the fixed platform at the location where the tail of the laboratory mouse is placed.

[0021] Preferably, the position of the fixed platform for placing the tail of the experimental mouse is formed with a notch, and the intravenous injection lamp corresponds to the notch.

[0022] Preferably, the intravenous injection lamp has a groove formed on it, and the groove corresponds to the notch of the fixing platform.

[0023] Preferably, a second screw hole is formed on the fixing platform, and the tail fixing assembly includes:

[0024] A fixing plate is provided, wherein a fixing opening is formed on the fixing plate;

[0025] A fixing bolt is used to engage with the fixing port and the second screw hole to fix the fixing plate.

[0026] This utility model has at least the following beneficial effects:

[0027] This invention combines mouse fixation, tail fixation, and visual monitoring to achieve a dual improvement in drug delivery accuracy and simplified experimental operation. It can be operated by a single person and is suitable for precise drug delivery and real-time image monitoring in small animal experiments. It has high practical value and promising prospects for promotion. Attached Figure Description

[0028] Figure 1This is a schematic diagram of a simplified experimental mouse fixation and tail vein injection device according to an embodiment of the present invention;

[0029] Figure 2 This is a top view of the fixing frame of a simplified experimental mouse fixation and tail vein injection device according to an embodiment of the present invention;

[0030] Figure 3 This is a schematic diagram of the intravenous injection lamp of a simplified experimental mouse fixation and tail vein injection device according to an embodiment of the present invention;

[0031] Figure 4 This is a top view of the fixing platform of a simplified experimental mouse fixation and tail vein injection device according to an embodiment of the present invention.

[0032] Reference numerals: 1. Fixing platform; 2. Transparent isolation cover; 3. Tail fixing assembly; 4. Isolation cover fixing assembly; 5. Fixing bracket; 6. First screw hole; 7. Fixing screw; 8. Pressure plate; 9. Buffer pad; 10. Intravenous injection lamp; 11. Fixing platform notch; 12. Groove; 13. Second screw hole; 14. Fixing pressure plate; 15. Fixing bolt. Detailed Implementation

[0033] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the described embodiments of this utility model are within the protection scope of this utility model.

[0034] Unless otherwise defined, the technical or scientific terms used in this invention shall have the ordinary meaning understood by one of ordinary skill in the art to which this invention pertains. The terms "first," "second," and similar terms used in this invention do not indicate any order, quantity, or importance, but are merely used to distinguish different components. Similarly, the terms "a" or "one," etc., do not indicate a quantity limitation, but rather indicate the presence of at least one. The terms "connected" or "linked," etc., are not limited to physical or mechanical connections, but can include electrical connections, whether direct or indirect. "Up," "down," "left," "right," etc., are used only to indicate relative positional relationships; when the absolute position of the described object changes, the relative positional relationship also changes accordingly.

[0035] The embodiments of this utility model are described in detail below with reference to the accompanying drawings.

[0036] like Figure 1As shown, an embodiment of this utility model provides a simple experimental mouse fixation and tail vein injection device, including a fixation platform 1, a transparent isolation cover 2, and a tail fixation component 3. The transparent isolation cover 2 is used to cover the experimental mouse on the fixation platform 1. The edge of the open end of the transparent isolation cover 2 forms an isolation cover notch, through which the tail of the experimental mouse protrudes from the transparent isolation cover 2. The tail fixation component 3 is used to fix the tail of the experimental mouse protruding from the isolation cover notch to the fixation platform 1.

[0037] The mounting platform 1 can be made of wood, with four legs and a height of approximately 5 cm. Before injecting the mouse, the experimenter first covers the mouse with a transparent isolation cover 2, leaving the tail exposed through the opening. The tail is then secured to the mounting platform 1 using a tail-fixing component 3. The injection is then performed on the mouse's tail. After injection, the experimenter can monitor the mouse inside the transparent isolation cover 2 in real time using molecular imaging technology. The transparent isolation cover 2 can be a beaker. This invention combines mouse fixation, tail fixation, and visual monitoring, achieving a dual improvement in drug delivery accuracy and simplified experimental operation. It can be operated by a single person and is suitable for precise drug delivery and real-time image monitoring in small animal experiments, possessing high practical value and promising prospects for widespread application.

[0038] In a preferred embodiment, the simplified experimental mouse fixation and tail vein injection device further includes an isolation cover fixing assembly 4. The isolation cover fixing assembly 4 is disposed on the fixing platform 1 and is used to stabilize the transparent isolation cover 2.

[0039] After the experimenters cover the experimental mouse with the transparent isolation cover 2, they can fix the transparent isolation cover 2 with the isolation cover fixing component 4 to prevent the isolation cover from shifting or tipping over due to the movement of the experimental mouse after injection, so as to avoid affecting subsequent image monitoring.

[0040] like Figure 1-2 As shown, in a preferred embodiment, the isolation cover fixing assembly 4 includes a fixing frame 5 and a fixing screw 7. The fixing frame 5 is provided with a first screw hole 6; the fixing screw 7 is fitted into the first screw hole 6 and corresponds to the transparent isolation cover 2.

[0041] The fixing frame 5 includes a vertical rod and a horizontal rod. The vertical rod is fixed to the fixing platform 1, and the horizontal rod is vertically connected to the vertical rod. The horizontal rod has a first screw hole 6 for engaging the fixing screw 7. Both the fixing frame 5 and the fixing screw 7 can be made of iron. The experimenter raises and lowers the transparent isolation cover 2 by rotating the fixing screw 7, thereby securing it. This structure is simple to operate, highly stable, and cost-effective.

[0042] like Figure 2 As shown, in a preferred embodiment, the fixing frame 5 is provided with a plurality of first screw holes 6. The plurality of first screw holes 6 are distributed at intervals along the length direction of the crossbar.

[0043] The tails of laboratory mice vary in length, requiring the transparent isolation cover 2 to be placed in different positions to accommodate different lengths. The position of the fixing screw 7 in the first screw hole 6 is then adjusted according to the position of the transparent isolation cover 2. This structure can adapt to various body shapes and is simple and stable. Furthermore, a rotating handle can be provided at the upper end of the fixing screw 7 for easy operation by the experimenter.

[0044] In a preferred embodiment, the isolation cover fixing assembly 4 further includes a pressure plate 8, which is disposed at the end of the fixing screw 7 facing the isolation cover.

[0045] The pressure plate 8 can be made of wood and can be circular in shape. By using the pressure plate 8 as a protective component between the fixing screw 7 and the transparent isolation cover 2, the pressure exerted by the fixing screw 7 on the transparent isolation cover 2 is reduced, effectively preventing damage to the transparent isolation cover 2.

[0046] In a preferred embodiment, the pressure plate 8 is covered with a cushioning pad 9.

[0047] The cushioning pad 9 can be made of rubber or plastic. The cushioning pad 9 further protects the transparent isolation cover 2 and improves its service life.

[0048] like Figure 3 As shown, in a preferred embodiment, the simple experimental mouse fixation and tail vein injection device further includes an intravenous injection lamp 10, which is disposed on the fixed platform 1 at the position for placing the experimental mouse's tail.

[0049] For laboratory mice with thin veins or whose skin color is obscured, such as black or gray mice, shining red light onto the tail of the mouse using the intravenous injection lamp 10 can make the tail veins clearer and improve the injection accuracy of the experimenter.

[0050] like Figure 4 As shown, in the preferred embodiment, the position of the fixed platform 1 for placing the tail of the experimental mouse is formed with a fixed platform notch 11, and the intravenous injection lamp 10 corresponds to the fixed platform notch 11.

[0051] Before fixing the tail of the experimental mouse, place the tail in the notch 11 of the fixing table, and place the intravenous injection lamp 10 directly below the notch 11 of the fixing table to irradiate the tail of the experimental mouse. The operation is relatively simple.

[0052] In a preferred embodiment, the intravenous injection lamp 10 has a slot 12, which corresponds to the notch 11 of the fixing platform.

[0053] When the tail of the experimental mouse is placed at the notch 11 of the fixed platform, it will naturally droop into the slot 12 of the intravenous injection lamp 10, thereby limiting the tail position.

[0054] In a preferred embodiment, the fixing platform 1 has a second screw hole 13, and the tail fixing assembly 3 includes a fixing plate 14 and a fixing bolt 15. The fixing plate 14 has a fixing opening; the fixing bolt 15 is used to cooperate with the fixing opening and the second screw hole 13 to fix the fixing plate 14.

[0055] The tail of the experimental mouse is fixed by the cooperation of the fixing plate 14 and the fixing bolt 15. Both disassembly and fixation are relatively simple, and the fixing plate 14 exerts little pressure on the tail of the experimental mouse, thus avoiding damage to the experimental mouse.

[0056] The above embodiments are used to further illustrate the present invention, but do not limit the present invention to these specific embodiments. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be understood as being within the protection scope of the present invention.

Claims

1. A simple device for fixing and injecting via tail vein into laboratory mice, characterized in that, include: Fixed platform (1); A transparent isolation cover (2) is used to cover the experimental mouse on the fixed platform (1). The edge of the open end of the transparent isolation cover (2) is formed with an isolation cover notch, and the tail of the experimental mouse extends out of the transparent isolation cover (2) through the isolation cover notch. Tail fixing component (3), the tail fixing component (3) is used to fix the tail of the experimental mouse protruding from the notch of the isolation cover onto the fixing platform (1); Intravenous injection lamp (10), which is set on the fixed platform (1) at the position for placing the tail of the experimental mouse.

2. The simplified experimental mouse fixation and tail vein injection device according to claim 1, characterized in that, Also includes: Isolation cover fixing assembly (4), which is disposed on the fixing platform (1) and is used to stabilize the transparent isolation cover (2).

3. The simplified experimental mouse fixation and tail vein injection device according to claim 2, characterized in that, The isolation shield fixing assembly (4) includes: A fixing frame (5) is provided with a first screw hole (6); A fixing screw (7) is fitted into the first screw hole (6) and corresponds to the transparent isolation cover (2).

4. The simplified experimental mouse fixation and tail vein injection device according to claim 3, characterized in that, The fixing frame (5) is provided with a plurality of the first screw holes (6).

5. The simplified experimental mouse fixation and tail vein injection device according to claim 3 or 4, characterized in that, The isolation cover fixing assembly (4) also includes a pressure plate (8), which is disposed at one end of the fixing screw (7) facing the isolation cover.

6. The simplified experimental mouse fixation and tail vein injection device according to claim 5, characterized in that, The pressure plate (8) is covered with a cushioning pad (9).

7. The simplified experimental mouse fixation and tail vein injection device according to claim 1, characterized in that, The fixed platform (1) has a notch (11) at the position for placing the tail of the experimental mouse, and the intravenous injection lamp (10) corresponds to the notch (11).

8. The simplified experimental mouse fixation and tail vein injection device according to claim 7, characterized in that, The intravenous injection lamp (10) has a slot (12) formed on it, and the slot (12) corresponds to the notch (11) of the fixing platform.

9. The simplified experimental mouse fixation and tail vein injection device according to claim 1 or 2, characterized in that, A second screw hole (13) is formed on the fixed platform (1), and the tail fixing assembly (3) includes: A fixing plate (14) is provided, wherein a fixing opening is formed on the fixing plate (14); A fixing bolt (15) is used to engage with the fixing port and the second screw hole (13) to fix the fixing plate (14).

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